Article
Agriculture, Dairy & Animal Science
Wioleta Mojsym, Jacek Wawrzykowski, Monika Jamiol, Lukasz Chrobak, Marta Kankofer
Summary: The study aimed to compare the protein patterns between the saliva and plasma of pregnant cows to identify potential markers that are present in both samples. The presence of apolipoproteins related to bovine pregnancy was confirmed in both saliva and plasma. This suggests that saliva can be a valuable diagnostic matrix for assessing the pregnancy status of cattle.
Article
Biochemistry & Molecular Biology
Natalia L. Starodubtseva, Alisa O. Tokareva, Maria V. Volochaeva, Alexey S. Kononikhin, Alexander G. Brzhozovskiy, Anna E. Bugrova, Angelika V. Timofeeva, Evgenii N. Kukaev, Victor L. Tyutyunnik, Natalia E. Kan, Vladimir E. Frankevich, Evgeny N. Nikolaev, Gennady T. Sukhikh
Summary: Intrauterine growth restriction (IUGR) causes disturbances in maternal plasma proteomics, involving plasma lipoprotein assembly, remodeling, and clearance; lipid metabolism; hemostasis; and immune system regulation. Different patterns were observed between early- and late-onset IUGR in terms of coagulation and fibrinolysis systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Emmanuel Bujold, Alexandre Fillion, Florence Roux-Dalvai, Marie Pier Scott-Boyer, Yves Giguere, Jean-Claude Forest, Clarisse Gotti, Genevieve Laforest, Paul Guerby, Arnaud Droit
Summary: This study demonstrated that maternal urine proteomic profiling can differentiate women with and without preeclampsia. Specific proteins like ceruloplasmin and serpin A7 were upregulated in maternal urine before the diagnosis of preeclampsia and fetal growth restriction, suggesting their potential role as biomarkers for early detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemical Research Methods
Yassene Mohammed, David R. Goodlett, Matthew P. Cheng, Donald C. Vinh, Todd C. Lee, Allison Mcgeer, David Sweet, Karen Tran, Terry Lee, Srinivas Murthy, John H. Boyd, Joel Singer, Keith R. Walley, David M. Patrick, Curtis Quan, Sara Ismail, Laetitia Amar, Aditya Pal, Rayhaan Bassawon, Lara Fesdekjian, Karine Gou, Francois Lamontagne, John Marshall, Greg Haljan, Robert Fowler, Brent W. Winston, James A. Russell
Summary: This study conducted longitudinal proteomic analysis of acute-phase COVID-19 patients, revealing changes in lipid-associated functions, complement activation, humoral immune response, and acute inflammatory response-related proteins. The study also identified differentiated proteins between survivors and nonsurvivors.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemical Research Methods
Cameron Lloyd-Jones, Henrique dos Santos Seckler, Nicholas DiStefano, Allan Sniderman, Phillip D. Compton, Neil L. Kelleher, John T. Wilkins
Summary: This study investigated the relationship between the types and abundance of proteins in high-density lipoprotein (HDL) and the size of HDL using a new gel electrophoresis technique combined with intact protein mass spectrometry. The results showed that fatty-acylated forms of APOA1 were associated with larger HDL particles and had four times higher abundance in larger particles compared to total serum. The abundance of APOA2 protein forms was similar across different sizes of HDL particles. These findings suggest a connection between acylated APOA1 protein forms and larger HDL particles.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Nutrition & Dietetics
Chiara Germano, Alessandro Messina, Elena Tavella, Raffaele Vitale, Vincenzo Avellis, Martina Barboni, Rossella Attini, Alberto Revelli, Paolo Zola, Paolo Manzoni, Bianca Masturzo
Summary: The recent outbreak of the novel Coronavirus has raised concerns about the potential negative effects of the virus on pregnancy outcomes and fetal brain development. Studies have suggested a possible risk of fetal brain damage and impairment due to the virus's neurotropism. Various strategies have been proposed to lower the risk of neurologic disease in newborns, and nutrition, such as arginine, n3PUFA, vitamins B1 and B9, choline, and flavonoids, has been found to be promising in mitigating fetal damages.
Article
Endocrinology & Metabolism
Raziel Rojas-Rodriguez, Lori Lyn Price, Jessica Somogie, Sylvie Hauguel-deMouzon, Satish C. Kalhan, Patrick M. Catalano
Summary: Maternal lipid metabolism during pregnancy, especially in late pregnancy, is highly correlated with neonatal adiposity. Late pregnancy basal and clamp glycerol turnover (GLYTO) are significantly associated with neonatal adiposity and explain around 40% of the variation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Clinical Neurology
Andrea Baragetti, Elisa Mattavelli, Liliana Grigore, Fabio Pellegatta, Paolo Magni, Alberico Luigi Catapano
Summary: A new set of circulating proteins have been identified that may serve as markers for the development of preclinical atherosclerosis. The proteins identified to predict SCA development versus IMT progression showed different etiological factors.
Article
Medicine, General & Internal
Anders Gummesson, Elias Bjornson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Baeckhed, Jochen M. Schwenk, Per-Anders Jansson, Mathias Uhlen, Goran Bergstrom
Summary: The study found distinct protein patterns in early-stage type 2 diabetes patients, reflecting key metabolic syndrome features. These patterns improved after treatment, indicating that comprehensive protein profiling can be a useful tool in elucidating the biological effects of diabetes treatments.
Article
Multidisciplinary Sciences
Sophia Harlid, Justin Harbs, Robin Myte, Carl Brunius, Marc J. Gunter, Richard Palmqvist, Xijia Liu, Bethany Van Guelpen
Summary: This study evaluated protein biomarkers in relation to colorectal cancer risk using prospectively collected plasma samples. The main validation analysis did not show statistically significant proteins, but exploratory subgroup analyses found associations between certain proteins and colon or rectal cancer risk. Adding protein markers to basic risk predictive models modestly improved performance.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jose V. Alvarez, Susana B. Bravo, Maria Pilar Chantada-Vazquez, Sofia Barbosa-Gouveia, Cristobal Colon, Olalla Lopez-Suarez, Shunji Tomatsu, Francisco J. Otero-Espinar, Maria L. Couce
Summary: MPS IVA is a lysosomal disease caused by mutations in the GALNS gene, characterized by systemic skeletal dysplasia. ERT has improved daily living activities and endurance tests, but recovery of bone lesions has not been proven. This study identified four potential protein biomarkers for MPS IVA, which may influence bone and cartilage metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Massimiliano Orri, Sahba Besharati, Marilyn N. Ahun, Linda M. Richter
Summary: This study found that maternal postnatal depression was associated with persistently increased internalizing symptoms among offspring from adolescence to adulthood in a middle-income country, with variations by socioeconomic adversity and sex.
Article
Immunology
Mingrui Wu, Qianwei Yang, Caiting Yang, Jie Han, Hai Liu, Lingran Qiao, Huiping Duan, Li Xing, Qunqun Liu, Li Dong, Quanhong Wang, Lin Zuo
Summary: This study analyzed the proteomics of exosomes in tuberculosis patients and found differential protein expression between drug-resistant and non-drug-resistant individuals. The identified proteins may be involved in the pathogenesis of drug-resistant tuberculosis.
Article
Biochemical Research Methods
Antoine Lesur, Francois Bernardin, Ois Bernardin, Eric Koncina, Elisabeth Letellier, Gary Kruppa, Pierre-Olivier Schmit, Gunnar Dittmar
Summary: Blood analysis is a crucial part of clinical diagnostics, and mass spectrometry has made significant advancements in protein analysis in blood samples. The prm-PASEF method combines ion mobility as an additional separation dimension, increasing proteome coverage and allowing for shorter chromatographic gradients. An alternative method, g-dia-PASEF, is described as a less time-consuming approach.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Medicine, General & Internal
Gabriel Cote-Corriveau, Gilles Paradis, Thuy Mai Luu, Aimina Ayoub, Marianne Bilodeau-Bertrand, Nathalie Auger
Summary: Preterm birth may have an impact on maternal mental health. This study found an association between preterm birth and the risk of maternal hospitalization for mental illness after pregnancy, with the highest risk around 34 weeks of gestation.
Article
Biophysics
Jeremy D. Scheff, Jonathan D. Stallings, Jaques Reifman, Vineet Rakesh
BIOPHYSICAL JOURNAL
(2015)
Article
Toxicology
Danielle L. Ippolito, Mohamed Diwan M. AbdulHameed, Gregory J. Tawa, Christine E. Baer, Matthew G. Permenter, Bonna C. McDyre, William E. Dennis, Molly H. Boyle, Cheryl A. Hobbs, Michael A. Streicker, Bobbi S. Snowden, John A. Lewis, Anders Wallqvist, Jonathan D. Stallings
TOXICOLOGICAL SCIENCES
(2016)
Article
Biotechnology & Applied Microbiology
Mohamed Diwan M. AbdulHameed, Danielle L. Ippolito, Jonathan D. Stallings, Anders Wallqvist
Article
Pharmacology & Pharmacy
Young S. Lee, John A. Lewis, Danielle L. Ippolito, Naissan Hussainzada, Pamela J. Lein, David A. Jackson, Jonathan D. Stallings
Article
Public, Environmental & Occupational Health
Steven L. Patterson, Blair C. R. Dancy, Danielle L. Ippolito, Jonathan D. Stallings
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2017)
Meeting Abstract
Nursing
Lois Stallings Welden, Mary Doerner, Elizabeth (Libby) Ketchem, Laura Benkert, Susan Alka, Michael Aders, Jonathan D. Stallings
JOURNAL OF PERIANESTHESIA NURSING
(2017)
Article
Nursing
Lois M. Stallings-Welden, Mary Doerner, Elizabeth (Libby) Ketchem, Laura Benkert, Susan Alka, Jonathan D. Stallings
JOURNAL OF PERIANESTHESIA NURSING
(2018)
Article
Biotechnology & Applied Microbiology
Matthew G. Permenter, Bonna C. McDyre, Danielle L. Ippolito, Jonathan D. Stallings
Review
Pharmacology & Pharmacy
Jason M. Koontz, Blair C. R. Dancy, Cassandra L. Horton, Jonathan D. Stallings, Valerie T. DiVito, John A. Lewis
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2019)
Article
Nursing
Lois M. Stallings Welden, Pam Leatherland, Mary B. Schitter, Andee Givens, Jonathan D. Stallings
Summary: This study evaluated the effectiveness of aromatherapy for postoperative abdominal pain in hospitalized patients through a randomized controlled trial design. While overall results did not show significant benefits in improving pain scores or reducing medication use, a subgroup analysis revealed that patients who received a regional nerve block experienced significant improvement in pain scores after using aromatherapy.
JOURNAL OF PERIANESTHESIA NURSING
(2021)
Article
Nursing
Katelyn Russell, Marilyn Ostendorf, Lois M. Stallings Welden, Jonathan D. Stallings
Summary: The study evaluated the implementation of a normothermia bundle, including preoperative forced-air warming blankets, in reducing the incidence of inadvertent perioperative hypothermia. The findings suggest that implementing this bundle can lower the incidence of perioperative hypothermia, especially in surgical cases lasting over 120 minutes.
JOURNAL OF PERIANESTHESIA NURSING
(2022)
Article
Critical Care Medicine
Julie A. Rizzo, Nehemiah T. Liu, Elsa C. Coates, Maria L. Serio-Melvin, James K. Aden, Jonathan D. Stallings, Kevin N. Foster, Kareem R. AbdelFattah, Tam N. Pham, Jose Salinas
Summary: This study examined the utilization of the clinical decision support tool Burn Navigator (BN) in burn resuscitation across five major burn centers in the United States. The results showed that experienced burn centers using BN were able to successfully titrate resuscitation to adhere to 24-hour goals with low prevalence of complications.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Critical Care Medicine
Thomas R. Stark, Nathan L. Davidson, Jeremy W. Cannon, Travis M. Polk, Stacy A. Shackelford, Jonathan D. Stallings, Andrew P. Cap
Summary: The battlefield pain summit resulted in 7 consensus statements regarding ideal analgesic properties, delivery systems, operational performance concerns, and pain training. Ketamine was identified as safe and effective for battlefield use, and further research into nonopioid analgesics represented a high priority.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Critical Care Medicine
Julie A. Rizzo, Elsa C. Coates, Maria L. Serio-Melvin, James K. Aden, Jonathan D. Stallings, Kevin N. Foster, Kareem R. AbdelFattah, Tam N. Pham, Jose Salinas
Summary: The impact of initial fluid rates on 24-hour volumes and outcomes in burn patients was studied using the Burn Navigator. Higher initial fluid rates resulted in significantly higher volumes at 24 hours, without an increase in mortality or complications.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Veterinary Sciences
Jason M. Koontz, David M. Kumsher, Richard Kelly, Jonathan D. Stallings
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2016)