Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Cell Biology
Alfred C. O. Vertegaal
Summary: Sumoylation is an essential post-translational modification that regulates many nuclear processes. Recent studies have revealed its roles in liquid-liquid phase separation, immunity, pluripotency, and disease, offering new therapeutic opportunities.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Genetics & Heredity
Fengguang Zhai, Jingyun Li, Meng Ye, Xiaofeng Jin
Summary: CUL3 is a scaffold protein that forms ubiquitin ligases with the substrate recognition adaptor and RING-finger protein 1. Through non-degradative ubiquitination, CUL3-E3 ligases play crucial roles in cell cycle regulation, protein transportation, and tumorigenesis.
Article
Cell Biology
Nicole Schwarz, Rudolf E. Leube
Summary: Cytoplasmic intermediate filaments provide cells with mechanical stability and can undergo changes in morphology and composition. They play a crucial role in regulating multiple cellular functions.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Review
Cell Biology
Shuang Li, Yang Song, Kexin Wang, Guoxiang Liu, Xiaolei Dong, Fanghao Yang, Guang Chen, Can Cao, Huhu Zhang, Mengjun Wang, Ya Li, Teng Zeng, Chunyan Liu, Bing Li
Summary: The ubiquitin-proteasome pathway is an important protein regulatory system in cells. Deubiquitinating enzymes (DUBs) hydrolyze ubiquitin molecules from ubiquitin-linked proteins and inversely regulate protein degradation. The ubiquitin-specific peptidase 32 (USP32) is a key member of the ubiquitin-specific protease family and has been associated with multiple cancer types. USP32 controls the stability of various proteins and is a promising therapeutic target for tumor therapy.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Xinbo Huang, Mingxia Wang, Yuchen Liu, Yaoting Gui
Summary: This study developed an aptazyme switch that could sense wild-type p53 protein and flexibly regulate downstream gene function, achieving targeted killing effect on tumor cells in combination with other synthetic biological tools. The aptazyme successfully inhibited tumor growth by specifically recognizing p53 and provided a modular strategy for binding to cellular proteins.
Article
Plant Sciences
Honglei Wang, Chao Han, Jia-Gang Wang, Xiaoqian Chu, Wen Shi, Lianmei Yao, Jie Chen, Wei Hao, Zhiping Deng, Min Fan, Ming-Yi Bai
Summary: This study reveals that SnRK1 negatively regulates the nitrate signalling pathway, inhibiting the effects of nitrate on plant growth under carbon deficiency conditions. KIN10 phosphorylates NLP7 to affect the regulatory activity of the nitrate signalling pathway.
Review
Cell Biology
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali, Giovanni Lombardi
Summary: The locomotor system, consisting of skeletal muscles and bones, plays a vital role in maintaining function and preventing frailty. As individuals age, chronic disorders of the locomotor system may arise, negatively impacting bone and muscle function. Senescent cells, which accumulate in muscle tissue with advancing age or under pathological conditions, impair muscle regeneration and contribute to muscle weakness. Additionally, senescence in the bone microenvironment affects bone turnover, increasing the risk of osteoporosis. Understanding the mechanisms underlying cellular senescence in musculoskeletal tissues may aid in developing effective biomarkers for early detection of tissue flaws.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Thomas S. Lumpe, Tino Stankovic
Summary: The study systematically explores crystallographic network topologies and provides a comprehensive catalog of unit cells, revealing the relationship between crystallographic symmetries and mechanical properties of structures. By interpreting molecular crystal networks as cellular structures, new structures with extremal properties have been identified, while also shedding light on the characteristics of known structures such as the octet-truss or the Kelvin cell.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Kyung Ah Han, Jaewon Ko
Summary: Brain disorders: Multiple roles of protein complex need further exploration。 Extensive research is needed to understand how the components of a critical protein complex at synapses influence the properties of neural circuits. Dysfunction of the WRC components are associated with various brain disorders。
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Marta Irla, Sigrid Hakvag, Trygve Brautaset
Summary: Genome-wide transcriptomic data from RNA-seq experiments can help identify novel regulatory elements. Riboswitches, such as the lysine riboswitch in Bacillus methanolicus, are useful tools for regulating gene expression. Promoters are easily identifiable in prokaryotic genomes and can be combined with riboswitches to create novel tools for inducible gene expression, as demonstrated in this study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Guoqiang Yuan, Huanhuan Gao, Tao Yang
Summary: The plant actin cytoskeleton and its associated proteins play a crucial role in plant growth and development, regulating dynamic processes through cell signaling pathways. Understanding the structure, dynamics, and functions of actin filaments provides insights into vital cellular activities and has potential applications in improving crop biomass and production efficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Information Systems
Lixing Yu, Ming Li, Wenqiang Jin, Yifan Guo, Qianlong Wang, Feng Yan, Pan Li
Summary: Traffic modeling and prediction are crucial for providing high-quality telecommunication services in cellular networks, but are proven to be extremely challenging due to the diverse network demand of Internet-based apps. This paper proposes a spatio-temporal fine-granular user traffic prediction mechanism, named STEP, which utilizes a deep graph convolution network (GCGRN) combining graph neural network and gated recurrent units for efficient prediction. Experimental results show that STEP outperforms state-of-the-art time-series based approaches with minimal energy consumption, communication overhead, and system resource occupancy on mobile devices. Furthermore, NS-3 based simulations confirm the efficacy of STEP in reducing session dropping ratio in cellular networks.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2021)
Article
Chemistry, Multidisciplinary
Zhi Lin, Yuka Amako, Farah Kabir, Hope A. Flaxman, Bogdan Budnik, Christina M. Woo
Summary: This study reports the development of photolenalidomide (pLen), a Len probe with a photoaffinity label and enrichment handle, designed for target identification by chemical proteomics. Using pLen, the known targets IKZF1 and CRBN were captured, and a new target, eIF3i, was identified. These data suggest the existence of a broader array of targets induced by ligands to CRBN, which can be identified using pLen in additional biological systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Duy N. Do, Pier-Luc Dudemaine, Manisha Mathur, Prashanth Suravajhala, Xin Zhao, Eveline M. Ibeagha-Awemu
Summary: miRNAs are small endogenous RNAs that play key roles in regulating gene expression in a wide range of biological processes. The advancements in transcriptomics technologies have provided great opportunities for exploring the involvement of miRNAs in farm animal diseases. Furthermore, there is increasing interest in using miRNAs as biomarkers and molecular therapy for livestock disease management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tae Hwan Kim, Soo-Eun Sung, Jae Cheal Yoo, Jae-Yong Park, Gwan-su Yi, Jun Young Heo, Jae-Ran Lee, Nam-Soon Kim, Da Yong Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Jae Cheal Yoo, Nammi Park, Hye Young Choi, Jae-Yong Park, Gwan-Su Yi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
So Young Kim, MiNa Hong, Seung-Ho Heo, Sojung Park, Taeg Kyu Kwon, Young Hoon Sung, Yumin Oh, Seulki Lee, Gwan-Su Yi, Inki Kim
MOLECULAR CARCINOGENESIS
(2018)
Article
Biochemistry & Molecular Biology
Yi Li, Nan-Young Jung, Jae Cheal Yoo, Yul Kim, Gwan-Su Yi
BIOMOLECULES & THERAPEUTICS
(2018)
Article
Biochemistry & Molecular Biology
Yoon Hyeok Lee, Gwan-Su Yi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Boah Lee, Jeong A. Min, Abdullateef Nashed, Sang-Ok Lee, Jae Cheal Yoo, Seung-Wook Chi, Gwan-Su Yi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Min-Sung Lee, Sang-Ok Lee, Mi-Kyung Lee, Gwan-Su Yi, Chong-Kil Lee, Kyoung-Seok Ryu, Seung-Wook Chi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemical Research Methods
Jin-Woo Chung, Wonsuk Yang, Jong C. Park
BMC BIOINFORMATICS
(2020)
Article
Biochemistry & Molecular Biology
Maryam Yavartanoo, Gwan-Su Yi
Summary: Melanoma is a highly aggressive type of skin cancer with significant heterogeneity in overall survival. Current TNM staging is inadequate for accurate survival prediction, particularly for melanoma patients, highlighting the need for reliable prognosis biomarkers. A gene signature was constructed to stratify melanoma risk and identify the Wnt/beta-catenin activation pathway as a primary risk factor for low tumor immunity. The gene signature improved overall survival prediction compared to standard clinicopathological features, providing valuable biomarkers for better clinical decision making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Seongyong Park, Gwansu Yi
Summary: This study developed a random forest model based on 86 genes to predict the response of patients with triple negative breast cancer to neoadjuvant chemotherapy. The model showed high sensitivity and specificity and could effectively explain the patients' recurrence-free survival.
Article
Biochemistry & Molecular Biology
Joo Yeon Jeong, Haangik Park, Hong Yoo, Eun-Jin Kim, Borami Jeon, Jong Deog Lee, Dawon Kang, Changjoon Justin Lee, Sun Ha Paek, Eun Joo Roh, Gwan-Su Yi, Sang Soo Kang
Summary: Despite advances in diagnostic and therapeutic technologies, lung cancer remains a major cause of cancer-related deaths worldwide. This study explores the effects of antipsychotic drugs on non-small cell lung cancer (NSCLC). The results suggest that certain antipsychotics, including trifluoperazine (TFP) and its synthetic analogs, can inhibit the proliferation and migration of lung cancer cells, and promote apoptosis. Additionally, a synthetic TFP analog shows even stronger anticancer effects than TFP. This study provides insights into the potential of antipsychotics as a preventive and therapeutic approach for NSCLC.
Article
Biology
Young-Sun Lee, Osung Kwon, Geuk-Rae Jeong, Junyeol Noh, Sung Eun Kim, Gwan-Su Yi, Eun Mi Hwang, Jae-Yong Park
Summary: The expression of TTYH1 is associated with the migration and invasion of osteosarcoma cells. Silencing TTYH1 expression using siRNA significantly inhibits cell migration and invasion, as well as reduces the expression of epithelial-mesenchymal transition markers and matrix metalloproteinases.
Article
Linguistics
Soo Hyun Ryu, Wonsuk Yang, Jong C. Park
Summary: This study proposes a way to formalize the semantics of generics by constructing flexible acceptance conditions with comparative probabilities. The findings from a psycholinguistic experiment suggest that cue validity and prevalence indeed play a crucial role in the acceptance conditions of generics, indicating a great potential for the formalization of their semantics.
JOURNAL OF PSYCHOLINGUISTIC RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Najoung Kim, Jung-Ho Kim, Maria K. Wolters, Sarah E. MacPherson, Jong C. Park
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Computer Science, Information Systems
Junseok Park, Seongkuk Park, Gwangmin Kim, Kwangmin Kim, Jaegyun Jung, Sunyong Yoo, Gwan-Su Yi, Doheon Lee