Article
Biochemistry & Molecular Biology
Till F. M. Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria Jose Gonzalez, Susana Gil Flores, Francisco J. Cabaleiro Fabeiro, Francisco del Rio Noriega, Fermin Perez Perez, Jesus Haro Gonzalez, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Kustner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C. Foo, Jens Treutlein, Stephanie H. Witt, Sven Cichon, Manolis Kogevinas, Fabio Rivas, Fermin Mayoral, Bertram Mueller-Myhsok, Andreas J. Forstner, Markus M. Nothen, Marcella Rietschel
Summary: This study analyzed whether the risk for bipolar disorder in BD multiplex families is influenced by common genetic variants. The results showed that familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders, indicating a high baseline risk in the families; familial BD cases had significantly higher BD PRS than unaffected family members and unrelated BD cases, suggesting that development of BD in these families is attributable to common variants with specific risk for BD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Marianna Puccini, Kai Jakobs, Leander Reinshagen, Julian Friebel, Philipp-Alexander Schencke, Emily Ghanbari, Ulf Landmesser, Arash Haghikia, Nicolle Kraenkel, Ursula Rauch
Summary: This study aimed to evaluate the association of galectin-3 with thrombogenicity in COVID-19. It was found that galectin-3 levels were higher in patients with COVID-19 than in those without COVID-19, and they correlated positively with thrombotic markers and disease severity. Galectin-3 could be considered as a marker for both disease severity and increased hypercoagulability in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yunting Zhu, Maree J. Webster, Adam K. Walker, Paul Massa, Frank A. Middleton, Cynthia Shannon Weickert
Summary: The study found that elevated levels of IL cytokine proteins, decreased levels of TNF alpha proteins, and increased densities of CD163+ macrophages, especially along small blood vessels, are associated with neuroinflammatory schizophrenia. Two-step recursive clustering analysis showed that IL6, IL18, and CD163 protein levels could be used as predictors of high and low inflammatory subgroups. The density of CD163+ macrophages was higher in the high inflammatory subgroup of schizophrenia cases compared to the low inflammatory subgroup.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Gastroenterology & Hepatology
Zarwa Saqib, Giada De Palma, Jun Lu, Michael Surette, Premysl Bercik, Stephen Michael Collins
Summary: This study found that changes in the composition of the gut microbiota may be the basis for Irritable Bowel Syndrome (IBS), but there are currently no biomarkers available for directing microbiota-directed therapy. By studying a mouse model, it was discovered that changes in fecal β-defensin could be a marker of dysbiosis. This provides a potential method to identify IBS patients who may benefit from microbiota-directed therapeutic interventions by monitoring changes in fecal β-defensin.
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez, Gustavo Rojas-Velasco, Alberto Lopez-Reyes, Laura Martinez-Gomez, Silvestre Ortega-Pena, Isela Montufar-Robles, Rosa Elda Barbosa-Cobos, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: In a case-control study, ABO gene polymorphisms were found to be associated with a higher risk of developing COVID-19. Specific genotypes and haplotypes were also related to the risk of disease development and platelet concentration in COVID-19 patients.
Article
Multidisciplinary Sciences
Xianyi Cheng, Dezhi Li, Tiangyang Qi, Jia Sun, Tao Zhou, Wei Zheng
Summary: DTNBP1 is upregulated in hepatocellular carcinoma (HCC) and is associated with clinicopathologic variables and patient survival status. Differential expression of DTNBP1 can be used to determine risk stratification in HCC patients. DTNBP1 regulates cell cycle progression and may serve as a prognostic marker for HCC.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Nueluefer Kilic, Gulay Tasci, Seda Yilmaz, Pinar Oner, Sevda Korkmaz
Summary: This study examined the role of inflammatory factors in schizophrenia by investigating MHR levels and comparing cardiovascular disease risk between schizophrenia patients and healthy controls. The results showed that MHR was higher in schizophrenia patients and HDL-C levels were lower, indicating the importance of inflammation in the pathophysiology of schizophrenia. Managing MHR levels may be beneficial in protecting patients against cardiovascular diseases and early death.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Microbiology
Fabiola Puertolas-Balint, Bjoern O. O. Schroeder
Summary: Diet has a stronger impact on shaping the gut microbial community composition than defensins. However, defensins can modulate specific microbial taxa and protect the host from diet-induced metabolic dysfunction.
MICROBIOLOGY SPECTRUM
(2023)
Letter
Medicine, General & Internal
Andrzej Wedrychowicz, Przemyslaw Tomasik, Kinga Kowalska-Duplaga, Stanislaw Pieczarkowski, Krzysztof Fyderek
Summary: The study found increased levels of Elafin, Cathelicidin, and alpha-defensins in children with the inflammatory phenotype of Crohn's disease, and differences in antimicrobial peptide levels based on disease location were also observed. This suggests that assessing antimicrobial peptides may be helpful in estimating the phenotype and location of CD lesions.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Shabnam Fayezi, Amir Mehdizadeh, Ariane Germeyer, Thomas Strowitzki, Parisa Fayyazpour, Zahra Nowrouzi, Reza Zarezadeh
Summary: During pregnancy, the demand for fatty acids increases to support maternal health and fetal development. Measuring fatty acid levels in different blood compartments can provide a more accurate reflection of nutritional and tissue composition compared to self-reporting methods. Evaluating erythrocyte fatty acid levels offers a superior possibility as it represents the fatty acid profiles of tissues with low biological fluctuation.
Review
Psychiatry
Dhenni Hartopo, Royke Tony Kalalo
Summary: A language disorder is a significant symptom of schizophrenia, and can be identified through interviews with psychiatrists. Analyzing language aspects in schizophrenia from a language level perspective provides a foundation for intervention strategies, and modern technology allows for computational analysis of language through Natural Language Processing. This review proposes the use of language disorders in schizophrenia as biomarkers, and highlights the potential for objective and accurate detection of such disorders for screening, diagnosis, prognosis, therapy evaluation, and recurrence monitoring.
ASIA-PACIFIC PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Ruo Zhang, Hema Viswambharan, Chew Weng Cheng, Malgorzata Anna Garstka, Kirti Kain
Summary: This study found that there is a relationship between blood pressures and blood glucose that differs by ethnicity. In Asian pregnant women, the difference in ankle systolic blood pressure was positively associated with blood glucose, suggesting its potential as a new non-invasive screening tool for gestational diabetes risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
MariaAnna Messina, Federica Raudino, Riccardo Iacobacci, Concetta Meli, Agata Fiumara
Summary: The study utilized tandem mass spectrometry to analyze the Gln/Glu ratio in blood specimens of patients with proximal urea cycle disorders (PUCDs) and found a significant elevation of the ratio in PUCD patients, suggesting it could be a useful diagnostic marker. Further analysis of blood spots from neonatal populations may lead to the inclusion of this ratio in newborn screening panels.
CLINICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Christian Urzi, Christoph Meyer, Jean-Marc Nuoffer, Peter Vermathen
Summary: This study describes the use of nuclear magnetic resonance (NMR) techniques to measure oxygen levels in tissue cultures and body fluids. The study presents methods for monitoring oxygen tension in culture media and 3D cell cultures using relaxation times of water without the need for external sensors. The results can provide information about mitochondrial respiration and metabolic changes.
ANALYTICAL CHEMISTRY
(2023)
Article
Psychiatry
Koen Bolhuis, Ulla Lang, David Gyllenberg, Antti Kaariala, Juha Veijola, Mika Gissler, Ian Kelleher
Summary: Expanding clinical strategies to identify high-risk groups for psychotic and bipolar disorders is important in research. This study found a relationship between self-harm and the subsequent development of psychotic/bipolar disorders, especially in young people presenting with self-harm. Young individuals who present to hospital with self-harm are at high risk of developing psychotic and bipolar disorders in the future, indicating the importance of prevention strategies for serious mental illness.
SCHIZOPHRENIA BULLETIN
(2021)
Letter
Critical Care Medicine
Jeffrey T. -J. Huang, Elena Kuzmanova, Alison J. Dicker, Holly R. Keir, Simon Finch, Stefano Aliberti, Thomas C. Fardon, James D. Chalmers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Allergy
Alison J. Dicker, Jeffrey T. J. Huang, Mike Lonergan, Holly R. Keir, Christopher J. Fong, Brandon Tan, Andrew J. Cassidy, Simon Finch, Hana Mullerova, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers
Summary: The study found that the sputum microbiome of COPD patients is closely related to disease severity, frequent exacerbations, blood eosinophil levels, etc., and different dominant microbiomes have different impacts. The diversity of sputum microbiomes is closely related to the development and mortality of COPD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiong Weng, De Lin, Jeffrey T. J. Huang, Roland H. Stimson, David H. Wasserman, Li Kang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Critical Care Medicine
Holly R. Keir, Amelia Shoemark, Alison J. Dicker, Lidia Perea, Jennifer Pollock, Yan Hui Giam, Guillermo Suarez-Cuartin, Megan L. Crichton, Mike Lonergan, Martina Oriano, Erin Cant, Gisli G. Einarsson, Elizabeth Furrie, J. Stuart Elborn, Christopher J. Fong, Simon Finch, Geraint B. Rogers, Francesco Blasi, Oriol Sibila, Stefano Aliberti, Jodie L. Simpson, Jeffrey T. J. Huang, James D. Chalmers
Summary: Bronchiectasis is a neutrophilic inflammatory disease, and research has shown that neutrophilic inflammation is associated with disease severity and treatment response. Studying the role of NETs in bronchiectasis can help develop new treatment strategies.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Alison J. Dicker, Mike Lonergan, Holly R. Keir, Alexandria H. Smith, Jennifer Pollock, Simon Finch, Andrew J. Cassidy, Jeffrey T. J. Huang, James Chalmers
Summary: The microbiome in bronchiectasis patients is relatively stable over time, with lower diversity associated with disease severity, decreased lung function, and worsened symptoms. Dominance of certain bacteria, such as Pseudomonas, is linked to severe disease, increased inflammation, and more frequent exacerbations. Patients with a Pseudomonas-dominant microbiome have a higher risk of mortality and experience more exacerbations during follow-up compared to those with other dominant genera.
LANCET RESPIRATORY MEDICINE
(2021)
Letter
Respiratory System
Holly R. Keir, Amelia Shoemark, Jeffrey T. J. Huang, James D. Chalmers
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Kashan Ali, Chim C. C. Lang, Jeffrey T. J. Huang, Anna-Maria Choy
Summary: Atherosclerosis is the leading cause of arterial thrombosis, resulting in acute occlusive cardiovascular syndromes. Existing risk prediction models for cardiovascular events do not typically incorporate biomarkers that may improve their accuracy. Various biomarkers related to cardiac stress, inflammation, matrix remodeling, and endothelial dysfunction have been investigated, as well as imaging biomarkers that show promise in detecting atherosclerosis and predicting cardiovascular events. Further research is ongoing to identify biologically relevant biomarkers and improve risk prediction models. This article provides an overview of the current literature on blood-based and imaging biomarkers of atherosclerosis, as well as potential future directions.
CARDIOLOGY IN REVIEW
(2023)
Article
Critical Care Medicine
Rebecca C. Hull, Jeffrey T. J. Huang, Alun K. Barton, Holly R. Keir, Huw Ellis, William C. Cookson, Miriam F. Moffatt, Michael R. Loebinger, James D. Chalmers
Summary: Sputum proteomics can be used to identify NTM-associated inflammatory profiles in sputum. NTM severity and treatment response are related to sputum protein profiles, while underlying lung disease and typical bacterial pathogens also play a key role.
Article
Critical Care Medicine
Jeffrey T-J Huang, Erin Cant, Holly R. Keir, Alun K. Barton, Elena Kuzmanova, Morven Shuttleworth, Jennifer Pollock, Simon Finch, Eva Polverino, Mathieu Bottier, Alison J. Dicker, Amelia Shoemark, James D. Chalmers
Summary: This study investigated the sputum microbiome and proteome in patients with bronchiectasis, COPD, and the COPD-bronchiectasis association, proposing five endotypes with differential inflammatory, mucin, and microbiological features. The key traits related to the COPD-bronchiectasis association include neutrophilic inflammation, differential mucin expression, and Gram-negative infection.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kashan Ali, Muhammad Zubair Israr, Leong L. Ng, Ify Mordi, Chim C. Lang, Elena Kuzmanova, Jeffrey T-J Huang, Anna-Maria Choy
Summary: This study investigated the potential role of plasma desmosine (pDES) as a marker of clinical outcome in patients with acute myocardial infarction (AMI). The results showed that elevated pDES levels were associated with death or myocardial infarction (MI) at 2 years. pDES also demonstrated the ability to predict clinical outcomes in AMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Alison R. McNeilly, Jennifer L. Gallagher, Mark E. Evans, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Bernard T. Thorens, Albena Dinkova-Kostova, Jeffrey-T. Huang, Michael L. J. J. Ashford, Rory McCrimmon
Summary: Chronic hyperglycaemia and recurrent hypoglycaemia are independently associated with accelerated cognitive decline in type 1 diabetes. This study examines the hypothesis that post-hypoglycaemic hyperglycaemia exacerbates hippocampal oxidative stress and explores potential contributory mechanisms.
Meeting Abstract
Cardiac & Cardiovascular Systems
Zaid Iskandar, Matthew Dodd, Graham Stuart, Massimo Caputo, Tim Clayton, Calvin Chin, Jack Gibb, Anne Child, Jose Antonio Aragon-Martin, Xu Yu Jin, Marcus Flather, Jeffrey T. J. Huang, Anna Maria Choy
Meeting Abstract
Cardiac & Cardiovascular Systems
Maaz Syed, Zaid Iskander, Alexander Fletcher, Samuel Debono, Marc Dweck, Jeffrey T. J. Huang, Calvin Chin, David Newby, Anna Maria Choy
Meeting Abstract
Cardiac & Cardiovascular Systems
Z. Iskandar, S. Patel, T. Lancefield, M. Freeman, M. Horrigan, O. Farouque, J. T. J. Huang, C. C. Lang, L. M. Burrell, A. M. Choy
EUROPEAN HEART JOURNAL
(2020)
Review
Cardiac & Cardiovascular Systems
Zaid Iskandar, Ify Mordi, Chim C. Lang, Jeffrey T. J. Huang, Anna-Maria Choy
CARDIOLOGY IN REVIEW
(2020)