☆ 4.2 Article

The rapid efficacy of abatacept in a patient with rheumatoid vasculitis

MODERN RHEUMATOLOGY (2012)

期刊

MODERN RHEUMATOLOGY

卷 22, 期 4, 页码 630-634

出版社

SPRINGER

DOI: 10.1007/s10165-011-0559-8

关键词

Abatacept; Cytotoxic T lymphocyte-associated antigen 4 (CTLA4); Rheumatoid vasculitis

类别

Rheumatology

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Reagent

摘要

We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept.

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