Article
Oncology
Ran Song, Dong-Eun Lee, Eun-Gyeong Lee, Seeyoun Lee, Han-Sung Kang, Jai Hong Han, Keun Seok Lee, Sung Hoon Sim, Heejung Chae, Youngmee Kwon, Jaeyeon Woo, So-Youn Jung
Summary: This retrospective study identified clinicopathological factors that can predict the Oncotype DX (ODX) risk group in early breast cancer patients, providing alternative options to the costly and time-consuming ODX test. The factors predicting the ODX risk group differ according to age, and can help guide decision-making on adjuvant chemotherapy.
Article
Oncology
Joshua A. Bloom, Yurie Sekigami, Rebekah Young, Lisa Macera, Christy A. Russell, Yu Cao, Rachel J. Buchsbaum, Stephen P. Naber, Abhishek Chatterjee
Summary: This study demonstrates that a clinically significant rate of discordance in Oncotype DX results among patients with bilateral breast cancer may impact discussions regarding chemotherapy treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ran Cheng, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang, Liqiang Qi
Summary: In this study, a method was developed to provide a single score for patients with hormone receptor-positive, HER2-negative, node-negative breast cancer and midrange Oncotype DX breast recurrence scores, aiming to individualize chemotherapy treatment decisions. The analysis showed that chemotherapy benefit was associated with specific tumor characteristics for patients with RS = 16-25, suggesting personalized chemotherapy recommendations can be made based on these factors.
Article
Oncology
Jaleesa Moore, Fei Wang, Tuya Pal, Sonya Reid, Hui Cai, Christina E. Bailey, Wei Zheng, Loren Lipworth, Xiao-Ou Shu
Summary: This study found disparities in the uptake of ODX RS testing and risk distribution among different race/ethnicity groups. However, ODX RS was prognostic for overall mortality across all races/ethnicities, particularly in younger patients.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Rima Patel, Malin Hovstadius, Melanie W. Kier, Erin L. Moshier, Brittney S. Zimmerman, Krystal Cascetta, Shabnam Jaffer, Joseph A. Sparano, Amy Tiersten
Summary: There is no significant correlation between Ki67 and Oncotype DX RS in early-stage hormone receptor-positive breast cancer patients, although there is fair agreement between high Ki67 values and high RS values.
Article
Oncology
Richard Buus, Ivana Sestak, Ralf Kronenwett, Sean Ferree, Catherine A. Schnabel, Frederick L. Baehner, Elizabeth A. Mallon, Jack Cuzick, Mitch Dowsett
Summary: The molecular features driving Oncotype DX, Prosigna PAM50, EndoPredict, and Breast Cancer Index are identified, with varying degrees of correlation between the molecular scores. While RS is more influenced by estrogen-related features, EP, BCI, and ROR scores are largely determined by proliferative features.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Salvatore Pece, Ivana Sestak, Francesca Montani, Micol Tillhon, Patrick Maisonneuve, Stefano Freddi, Kim Chu, Marco Colleoni, Paolo Veronesi, Davide Disalvatore, Giuseppe Viale, Richard Buus, Jack Cuzick, Mitch Dowsett, Pier Paolo Di Fiore
Summary: This study compared two molecular tests for breast cancer patients and found that the StemPrintER Risk Score (SPRS) demonstrated better predictive performance in assessing the risk of distant recurrence. It can help identify high-risk patients and provide guidance for personalized treatment decisions.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Michelle Zhang, Meredith Sadinski, Dana Haddad, Min Sun Bae, Danny Martinez, Elizabeth A. Morris, Peter Gibbs, Elizabeth J. Sutton
Summary: The study revealed an association between BPE metrics in the non-tumor breast and tumor Oncotype Dx recurrence score, suggesting a potential relationship between the breast microenvironment and likelihood of recurrence and response to chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Luca Licata, Giulia Viale, Mario Giuliano, Giuseppe Curigliano, Mariana Chavez-MacGregor, Julia Foldi, Oluchi Oke, Joseph Collins, Lucia Del Mastro, Fabio Puglisi, Filippo Montemurro, Claudio Vernieri, Lorenzo Gerratana, Sara Giordano, Alessia Rognone, Lorenzo Sica, Oreste Davide Gentilini, Stefano Cascinu, Lajos Pusztai, Antonio Giordano, Carmen Criscitiello, Giampaolo Bianchini
Summary: This study evaluates whether Oncotype DX improves confidence and agreement among oncologists in adjuvant chemotherapy recommendations for ER+/HER2- early-stage breast cancers. The study found that using Oncotype DX significantly reduces discordance and uncertainty among oncologists, and improves agreement in adjuvant chemotherapy recommendations for patients.
Article
Oncology
Xiaofu Zhu, Susan Dent, Lise Paquet, Tinghua Zhang, Daniel Tesolin, Nadine Graham, Olexiy Aseyev, Xinni Song
Summary: Canadian medical oncologists preferentially use the ODX assay to avoid unnecessary chemotherapy for breast cancer patients, especially those with intermediate clinical and pathologic features.
Article
Oncology
Vikram R. Shaw, Christopher I. Amos, Chao Cheng
Summary: In this study, a machine learning method is applied to determine the optimal threshold for using the Oncotype DX score to guide chemotherapy treatment. The results show that more lymph-node-negative and lymph-node-positive patients may benefit from chemotherapy at a lower Oncotype DX score than current guidelines suggest. Additionally, the study reveals a racial difference in chemotherapy benefit, providing evidence for tailored treatment for specific patients.
Article
Oncology
Caglar Unal, Tolga Ozmen, Cetin Ordu, Kezban Nur Pilanci, Ahmet Serkan Ilgun, Erhan Gokmen, Elvina Almuradova, Mustafa Ozdogan, Niluefer Guler, Cihan Uras, Halil Kara, Orhan Demircan, Selver Isik, Gul Alco, Pinar Saip, Esra Aydin, Tomris Duymaz, Filiz Celebi, Kanay Yararbas, Gursel Soybir, Vahit Ozmen
Summary: This study aimed to evaluate survival and its correlation with ODx-RS in pT1-2, N0-N1mic patients treated with adjuvant therapy. The findings suggest that the addition of chemotherapy to endocrine therapy improves disease-free survival in patients aged <= 45 years with ODx-RS scores of >= 18.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Valeria Romeo, Renato Cuocolo, Luca Sanduzzi, Vincenzo Carpentiero, Martina Caruso, Beatrice Lama, Dimitri Garifalos, Arnaldo Stanzione, Simone Maurea, Arturo Brunetti
Summary: In this study, a machine learning model was developed to predict the Oncotype DX score using DCE-MRI images of breast cancer patients. The model achieved an accuracy of 60% in the training set and 63% (AUC = 0.66) in the test set. These findings support the use of radiomics and machine learning for prognostic data prediction in breast cancer, with potential clinical applications.
Article
Oncology
Arya Mariam Roy, Changchuan Jiang, Stuthi Perimbeti, Lei Deng, Charles L. Shapiro, Shipra Gandhi
Summary: This study examined the interaction between HER2-low expression, oncotype recurrence score (RS), and prognosis in HR+/HER2- breast cancer. The results showed that HER2-low tumors had higher RS distribution and better 5-year overall survival compared to HER2-zero tumors, especially in HR-negative patients and those who received adjuvant chemotherapy.
Article
Oncology
Rachel M. Layman, Heather Lin, Angelica M. Gutierrez Barrera, Meghan S. Karuturi, Clinton Yam, Banu K. Arun
Summary: BRCA-associated early-stage hormone receptor-positive breast cancers have distinctive features compared to those without mutations. However, BRCA status does not significantly impact relapse-free survival and overall survival.
Article
Oncology
David T. Pointer, Diane M. Durgan, Bela Kis, Nazanin Khakpour, John Kiluk
Article
Oncology
Erin E. Burke, Christine Laronga, Weihong Sun, Steven DeBiase, Syeda Mahrukh Hussnain Naqvi, Brooke Fridley, Brian J. Czerniecki, Susan J. Hoover, Nazanin Khakpour, John Kiluk, Marie Catherine Lee
CLINICAL BREAST CANCER
(2020)
Article
Oncology
Brittany J. Mathias, James Sun, Weihong Sun, Jun-Min Zhou, William J. Fulp, Christine Laronga, M. Catherine Lee, John Kiluk
Summary: The study evaluates the factors that led surgeons to forego CALND in cN0 mastectomy patients with positive SLNB. Younger age, larger tumors, increased number of positive sentinel nodes, invasive lobular carcinoma, extranodal extension, and lymphovascular invasion were significantly associated with delayed CALND.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
James Sun, Danielle A. Henry, Michael J. Carr, Adel Yazdankhahkenary, Christine Laronga, M. Catherine Lee, Susan J. Hoover, Weihong Sun, Brian J. Czerniecki, Nazanin Khakpour, John Kiluk
Summary: Radar reflector localization (RRL)-guided targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC) is a safe and feasible approach for assessing nodal involvement in breast cancer patients, confirming the excision of positive axillary nodes, and reducing false-negative rates.
CLINICAL BREAST CANCER
(2021)
Article
Surgery
Lauren R. Strang, James Sun, Weihong Sun, David Boulware, John V. Kiluk, M. Catherine Lee, Laila Khazai, Christine Laronga
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Oncology
James Sun, Brittany J. Mathias, Christine Laronga, Weihong Sun, Jun-Min Zhou, William J. Fulp, John Kiluk, M. Catherine Lee
Summary: The study found that completion axillary lymph node dissection (CLND) after mastectomy did not significantly reduce recurrence or improve overall survival (OS) in clinically node-negative, sentinel lymph node (SLN)-positive breast cancer patients. However, completion of postmastectomy radiotherapy was associated with improved OS.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Puja Parikh, Zena Jameel, Shannon Falcon, Marilin Rosa, John Kiluk, Susan Hoover, Hatem Soliman, Dana Ataya
Summary: Adenomyoepithelioma of the breast is a rare tumor composed of epithelial and myoepithelial cells, with the potential for malignant transformation. Imaging features, clinical presentation, and management are important aspects to consider in the diagnosis and treatment of this condition.
Meeting Abstract
Oncology
Hatem Hussein Soliman, Hyo S. Han, Deanna Hogue, Blaise Mooney, Ricardo L. Costa, Marie Catherine Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Nazanin Khakpour, Aixa Soyano, Avan J. Armaghani, Robert J. Weinfurtner, Susan Hoover, John Kiluk, Marilin Rosa, Brooke Fridley, Hung T. Khong, Brian J. Czerniecki
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
Kelly Walton, Kirsti Walker, Megan Riddle, Brent H. Koehn, Jordan Reff, Elizabeth M. Sagatys, Michael A. Linden, Joseph Pidala, Jongphil Kim, Marie C. Lee, John Kiluk, Jane Yuet Ching Hui, Sang Y. Yun, Yan Xing, Heather Stefanski, Harshani R. Lawrence, Nicholas J. Lawrence, Jakub Tolar, Claudio Anasetti, Bruce R. Blazar, Said M. Sebti, Brian C. Betts
Summary: AJI-100, a dual inhibitor of JAK2 and Aurora kinase A, ameliorates skin graft rejection by human T cells and provides durable allo-inactivation. It reduces allograft invasion by limiting skin-homing CLA(+) donor T cells and suppresses pathogenic Th1 and Th17 cells while sparing regulatory T cells. Additionally, AJI-100 enhances human type 2 innate lymphoid cell responses for tissue repair by maintaining pSTAT5 levels and blocking interference by STAT3.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Pathology
Zena Jameel, John Kiluk, Marilin Rosa
Summary: Adenomyoepithelioma is a spectrum of lesions with variable morphology and clinical behavior. It is characterized by proliferation of epithelial and myoepithelial cells and can be benign, atypical or malignant. Malignant cases may require additional treatments such as radiotherapy and lymph node biopsy.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Oncology
James Sun, Xiaojun Zhong, Junjie Ma, Weihong Sun, Hyo S. Han, Hatem H. Soliman, Loretta S. Loftus, Ricardo L. B. Costa, Avan J. Armaghani, Aixa E. Soyano-Muller, Brian J. Czerniecki, M. Catherine Lee, John Kiluk, Nazanin Khakpour, Susan J. Hoover, Christine Laronga, Hung T. Khong
Summary: The combination of CDK4/6 inhibitor and endocrine therapy shows similar efficacy in real-world settings for the treatment of HR-positive, HER2-negative mBC patients compared to the PALOMA-2 trial. Lower neutrophil count may be associated with a reduced risk of early disease progression.
Article
Nursing
Jong Y. Park, Cecile A. Lengacher, Richard R. Reich, Hyun Y. Park, Junmin Whiting, Anh Thy Nguyen, Carmen Rodriguez, Hongdao Meng, Sara Tinsley, Katterine Chauca, Liliana Gordillo-Casero, Trudy Wittenberg, Anisha Joshi, Katherine Lin, Roohi Ismail-Khan, John Kiluk, Kevin E. Kip
Summary: This preliminary study aims to investigate the relationship between genetic variants and cognitive/cardiac phenotypes in breast cancer survivors treated with chemotherapy. The study found significant relationships between certain genetic variants and cognitive functioning as well as cardiac outcomes, providing initial targets for interventions to improve cognitive and cardiac functioning following chemotherapy.
BIOLOGICAL RESEARCH FOR NURSING
(2022)
Article
Oncology
Julia M. Selfridge, Heather F. Sinner, Junmin Whiting, Weihong Sun, Melissa A. Mallory, Susan J. Hoover, John Kiluk, Nazanin Khakpour, Brian J. Czerniecki, Christine Laronga, Qianxing Mo, Marie C. Lee
Summary: Microporous polysaccharide particles (MPP) were evaluated as a hemostatic agent for post-operative outcomes. The study found no significant difference in infection, seroma, or hematoma between patients treated with and without MPP. However, it was noted that patients undergoing lymphovenous anastomosis (LVA) were more at risk of seroma and less likely to receive MPP. Consideration should be given to utilizing MPP in this LVA population.
CLINICAL BREAST CANCER
(2022)
Correction
Biochemistry & Molecular Biology
Hatem Soliman, Deanna Hogue, Hyo Han, Blaise Mooney, Ricardo Costa, Marie C. C. Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Aixa Soyano, Avan Armaghani, Nazanin Khakpour, Robert J. J. Weinfurtner, Susan Hoover, John Kiluk, Christine Laronga, Marilin Rosa, Hung Khong, Brian Czerniecki
Article
Biochemistry & Molecular Biology
Hatem Soliman, Deanna Hogue, Hyo Han, Blaise Mooney, Ricardo Costa, Marie C. Lee, Bethany Niell, Angela Williams, Alec Chau, Shannon Falcon, Aixa Soyano, Avan Armaghani, Nazanin Khakpour, Robert J. Weinfurtner, Susan Hoover, John Kiluk, Christine Laronga, Marilin Rosa, Hung Khong, Brian Czerniecki
Summary: This article presents the phase 2 trial of T-VEC plus NAC for triple-negative breast cancer (TNBC). The study found that T-VEC plus NAC may increase RCB0-1 rates in TNBC patients, supporting further investigation of this treatment approach.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.