Review
Biochemistry & Molecular Biology
Zodwa Dlamini, Mzwandile Mbele, Tshepiso J. Makhafola, Rodney Hull, Rahaba Marima
Summary: Globally, HIV/AIDS and cancer are significant public health problems, with sub-Saharan Africa bearing the largest burden. While AIDS-defining cancers are decreasing, non-AIDS defining cancers are on the rise in HIV-positive individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Zhao Jing, Kai Chen, Ling Gong
Summary: Esophageal cancer is a common malignancy in China with high mortality, and understanding the role of exosomes in cancer progression can help improve prognosis. Exosomes are small vesicular structures that contain various components involved in cell-to-cell communication and material exchange, playing a role in cancer growth, metastasis, and angiogenesis. They also have potential as diagnostic and prognostic markers in cancer. This review discusses the significance of exosomes in esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression, as well as their utility as diagnostic and prognostic biomarkers and therapeutic tools.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemical Research Methods
Fatemeh Tavakoli, Sara Sadat Khatami, Fatemeh Momeni, Javid Azadbakht, Faezeh Ghasemi
Summary: Cervical malignancy, originating from the cervix, is observed in women infected with papillomavirus who have certain risk factors. Early diagnosis and imaging techniques play crucial roles in the treatment and management of cervical cancer, although they come with limitations such as cost and invasiveness. Additionally, research suggests that biomarkers could also be utilized for prognostic, diagnostic, and therapeutic purposes in cervical cancer therapy.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Review
Biochemistry & Molecular Biology
Natalia Georgantzoglou, Alexandros Pergaris, Christos Masaoutis, Stamatios Theocharis
Summary: Exosomes, extracellular vesicles containing biomolecular cargo, play a crucial role in intercellular communication and oncogenesis. Urine is suggested as a rich source of exosomal biomarkers with potential applications in bladder cancer management. Further studies optimizing sample collection procedures and analytical methods are needed to enhance the diagnostic and therapeutic potential of exosomal biomarkers in bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Min Jiang, Jing Zhou, Xiaobo Xie, Zili Huang, Rui Liu, Yi Lv
Summary: This study established a novel nanoparticle counting strategy to simultaneously analyze three breast cancer-associated miRNAs for breast cancer diagnosis. The strategy showed great potential for cancer diagnosis with high sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Min Jiang, Jing Zhou, Xiaobo Xie, Zili Huang, Rui Liu, Yi Lv
Summary: Liquid biopsy is a sought-after technique for disease diagnosis, providing real-time, dynamic, and comprehensive information. This novel nanoparticle counting strategy allows for simultaneous analysis of multiple miRNAs for breast cancer diagnosis, showing potential for significant impact in cancer diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Dan Meng, Hua Jin, Xing Zhang, Wenjing Yan, Qianqian Xia, Siyuan Shen, Shuqian Xie, Mengjing Cui, Bo Ding, Yun Gu, Shizhi Wang
Summary: RNA sequencing data from TCGA and GTEx databases were used to identify prognostic biomarkers in cervical cancer. The study identified autophagy-related risk signatures that could serve as diagnostic and therapeutic biomarkers, providing a reference for precision medicine.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Xiaoshuang Feng, David C. Muller, Hana Zahed, Karine Alcala, Florence Guida, Karl Smith-Byrne, Jian-Min Yuan, Woon-Puay Koh, Renwei Wang, Roger L. Milne, Julie K. Bassett, Arnulf Langhammer, Kristian Hveem, Victoria L. Stevens, Ying Wang, Mikael Johansson, Anne Tjonneland, Rosario Tumino, Mahdi Sheikh, Mattias Johansson, Hilary A. Robbins
Summary: This study aimed to evaluate the association between circulating proteins and survival after lung cancer diagnosis, as well as their potential for improving prognosis prediction. The results showed that only CDCP1 remained statistically significant after accounting for multiple testing. In conclusion, blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival and did not significantly improve prognosis prediction beyond clinical information.
Review
Oncology
Milena Matuszczak, Jack A. Schalken, Maciej Salagierski
Summary: In prostate cancer, overdiagnosis and overtreatment are common problems. New liquid biopsy biomarker tests have been developed to improve diagnosis, prognosis, and decision-making. The current gold standard for diagnosing prostate cancer relies on digital rectal examination and elevated prostate-specific antigen levels before biopsy.
Review
Oncology
Jinhua He, Feifeng Wu, Zeping Han, Min Hu, Weida Lin, Yuguang Li, Mingrong Cao
Summary: Recent advancements in the diagnosis and treatment of colorectal cancer have not significantly improved the high mortality rate, particularly in late-stage patients. Current blood markers for screening CRC have limitations, leading to a shift towards developing minimally invasive or noninvasive biomarkers, such as non-coding RNA molecules. These molecules, including microRNAs and circular RNAs, hold promise for early diagnosis and prognosis of tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
M. Abdul-Latif, H. Tharmalingam, Y. Tsang, P. J. Hoskin
Summary: Cervical Cancer is the fourth most common cancer in women worldwide, and there is a need for predictive and prognostic biomarkers to identify populations at risk of poorer treatment response and survival. Magnetic resonance imaging (MRI) is routinely used in cervical cancer and has the potential to provide biomarkers. However, most studies focus on single MRI techniques, highlighting the need for combined approaches to better characterize tumors and identify biomarkers.
Review
Pathology
Alireza Azani, Sima Parvizi Omran, Haniyeh Ghasrsaz, Asra Idani, Mahdis kadkhodaei Eliaderani, Niloufar Peirovi, Negar Dokhani, Mohamad hassan Lotfalizadeh, Mohammadhadi mohammadzadeh Rezaei, Mehrnoosh shahgholian Ghahfarokhi, Sepideh Karkonshayan, Parisa najari Hanjani, Zahra Kardaan, Jamshid Gholizadeh Navashenagh, Meysam Yousefi, Mitra Abdolahi, Arash Salmaninejad
Summary: Prostate cancer is a leading cause of cancer-related deaths in men worldwide, due to late detection. Current diagnostic methods have low accuracy, so there is a need for new biomarkers. Recent studies suggest that microRNAs play a role in the initiation and progression of prostate cancer and can be used as biomarkers for diagnosis, prognosis, and disease relapse.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Nanoscience & Nanotechnology
Fangfei Yin, Haipei Zhao, Shasha Lu, Juwen Shen, Min Li, Xiuhai Mao, Fan Li, Jiye Shi, Jiang Li, Baijun Dong, Wei Xue, Xiaolei Zuo, Xiurong Yang, Chunhai Fan
Summary: The article introduces a DNA-encoded molecular classifier that can classify multidimensional molecular clinical data and has been tested in prostate cancer patients.
NATURE NANOTECHNOLOGY
(2023)
Review
Oncology
Sergio Antonio Oropeza-de Lara, Idalia Garza-Veloz, Bertha Berthaud-Gonzalez, Margarita L. Martinez-Fierro
Summary: In developed countries, endometrial cancer is a common neoplasm of the female reproductive system. MicroRNAs, single-stranded noncoding RNA molecules, have been studied for their diagnostic, prognostic, and treatment response potential in EC. However, the heterogeneity in research methodologies, sample types, selection criteria, and results makes it challenging to identify potential miR biomarkers. This study aimed to summarize the current knowledge on miRs that have shown the most suitability as potential markers for EC.
Review
Oncology
David S. Lakomy, Juliana Wu, Dorothy Lombe, Emmanouil Papasavvas, Susan Citonje Msadabwe, Yimin Geng, Luis J. Montaner, Elizabeth Chiao, Lilie L. Lin
Summary: Immune markers have been shown to correlate with prognosis in patients with cervical cancer treated with chemoradiation, with lymphopenia and elevated neutrophil-to-lymphocyte ratio being identified as strong prognostic indicators. Other potential markers include HPV-specific lymphocyte response, cytokine profile, and tumor-associated immune cell infiltration.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
