Article
Oncology
Lucy M. Han, Tara A. Saunders, Sarah M. Calkins
Summary: HRHPV ISH can be reliably used in cytology cell blocks of cystic neck lesions, especially when positive. A negative or equivocal interpretation of C-HRHPV ISH may warrant repeat testing. Compared to C-p16, C-HRHPV ISH is more frequently diagnostic and could be helpful for HPV-OSCC diagnosis and management.
CANCER CYTOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Mario Perez-Sayans, Cintia M. Chamorro-Petronacci, Fatima Baltazar, Fabio Ramoa Pires, Angel Insua, Juan A. Suarez-Quintanilla, Jose M. Suarez-Penaranda
Summary: The study indicates that nestin immunohistochemical expression has clinical significance in the diagnosis and prognosis of head and neck lesions, and may serve as a useful marker for detecting the presence of stem cells in tumors.
Article
Oncology
Cindy Simoens, Ivana Gorbaslieva, Tarik Gheit, Dana Holzinger, Eric Lucas, Ruediger Ridder, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken, Rekha Vijay Kumar, Nitin Gangane, Alessandro Caniglia, Fausto Maffini, Maria Belen Lloveras Rubio, Devasena Anantharaman, Susanna Chiocca, Paul Brennan, Madhavan Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Johannes Bogers, Michael Pawlita, Massimo Tommasino, Marc Arbyn
Summary: The study shows that the prevalence of HPV infection varies across anatomical sites in HNC patients in Belgium, with HPV16 being the most common genotype. The proportion of HPV-driven HNC is 10 times higher in OPC compared to OCC and LC in Belgium from 1980 to 2014.
CANCER EPIDEMIOLOGY
(2021)
Review
Oncology
Fabricio dos Santos Menezes, Gisele Aparecida Fernandes, Jose Leopoldo Ferreira Antunes, Luisa Lina Villa, Tatiana Natasha Toporcov
Summary: The incidence of HPV-related HNC subsites is rising globally, while most of the HPV-unrelated subsites are declining or stable. Regardless of age group, the incidence trends for HPV-related HNC subsites are increasing, highlighting a distinct global pattern between sexes. Recent cohorts from Australia and the United States also show similar peaks in increased risk.
Article
Dentistry, Oral Surgery & Medicine
Xian Jun David Lu, Kelly Yi Ping Liu, Eitan Prisman, Jonn Wu, Yuqi Sarah Zhu, Catherine Poh
Summary: This study assessed the prognostic values of p16 and HPV markers in oropharyngeal squamous cell carcinoma (OpSCC). The results showed that human papillomavirus (HPV) is more prognostic than p16 for OpSCC. HPV-positive patients have better clinical outcomes.
Article
Microbiology
Carina Strohmayer, Andrea Klang, Stefan Kummer, Ingrid Walter, Christoph Jindra, Christiane Weissenbacher-Lang, Torben Redmer, Sibylle Kneissl, Sabine Brandt
Summary: This study found that (partial) epithelial-mesenchymal transition events occur in equine HNSCCs, suggesting CD44 and CD271 as potential malignancy markers.
Article
Oncology
Catherine T. Haring, Lulia A. Kana, Sarah M. Dermody, Collin Brummel, Jonathan B. McHugh, Keith A. Casper, Steven B. Chinn, Kelly M. Malloy, Michelle Mierzwa, Mark E. P. Prince, Andrew J. Rosko, Jennifer Shah, Chaz L. Stucken, Andrew G. Shuman, J. Chad Brenner, Matthew E. Spector, Francis P. Worden, Paul L. Swiecicki
Summary: A retrospective analysis of 447 patients with HNSCC revealed that HPV negativity, high neutrophil/lymphocyte ratio, disease-free interval ≤6 months, and poor performance status were predictors of worse survival. Furthermore, the majority of recurrences and metastases occurred within 6 months to 2 years after treatment completion.
Article
Pathology
Yuxin Liu, W. Glenn McCluggage, Teresa M. Darragh, Nada Farhat, Morgan Blakely, Keith Sigel, Wenxin Zheng, William H. Westra, Michael M. Gaisa
Summary: p16 is a valuable diagnostic marker for HPV-associated anogenital lesions, especially for identifying AIN 2/3. Its immunoreactivity correlates well with morphologic diagnoses in the anal region, where block staining offers optimal diagnostic value for AIN 2/3.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pathology
Hang Yang, Noorah Almadani, Emily F. Thompson, Basile Tessier-Cloutier, Julia Chen, Julie Ho, Janine Senz, Melissa K. McConechy, Christine Chow, Monica Ta, Angela Cheng, Anthony Karnezis, Jutta Huvila, Jessica N. McAlpine, Blake Gilks, Amy Jamieson, Lynn N. Hoang
Summary: There is evidence that VSCC can be divided into three subclasses based on HPV and p53 status: HPV+, HPV-/p53wt, and HPV-/p53abn. This study aimed to use p16 and p53 immunohistochemistry to classify VSCC and its precursors into these three groups.
Article
Pathology
Darcy A. Kerr, Lester D. R. Thompson, Laura J. Tafe, Vickie Y. Jo, Azfar Neyaz, Prashanthi Divakar, Joseph A. Paydarfar, David A. Pastel, Keisuke Shirai, Ivy John, Raja R. Seethala, Claudia M. Salgado, Vikram Deshpande, Julia A. Bridge, Karl Kashofer, Iva Brcic, Konstantinos Linos
Summary: Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with distinct clinicopathologic and molecular characteristics, especially in the head and neck region. This study analyzed a cohort of head and neck IMTs, revealing that a majority of cases had underlying fusion gene events, with ALK rearrangements being the most common driver. The study underscores the importance of molecular analysis in increasing diagnostic accuracy and expanding therapeutic options for IMT patients.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Raluca-Maria Closca, Adrian Nicoara, Marina Rakitovan, Ion Cristian Mot, Flavia Baderca
Summary: This paper presents three rare cases of unusual metastases, including metastases of clear cell renal cell carcinoma in the gingiva and nasal cavity, as well as mandibular metastasis of hepatocellular carcinoma. Two cases had a previous histopathological diagnosis of a primary tumor, while the third case represented the first manifestation of neoplastic disease.
Article
Oncology
Cecilie D. de la Cour, Christian von Buchwald, Christian Dehlendorff, Martin Garset-Zamani, Christian Gronhoj, Amanda-Louise F. Carlander, Soren Friis, Susanne K. Kjaer
Summary: This nationwide cohort study did not find an association between postdiagnostic low-dose aspirin use and cancer-specific mortality in patients with head and neck squamous cell cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Otorhinolaryngology
Frans J. Mulder, Damiana D. C. G. Pierssens, Laura W. J. Baijens, Bernd Kremer, Ernst-Jan M. Speel
Summary: Head and neck squamous cell carcinoma (HNSCC) in nonsmokers and nondrinkers (NSND) is more often associated with HPV and p16 overexpression, while TP53 mutations are linked to aging and ultraviolet light exposure rather than tobacco consumption.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Andrejs Lifsics, Maksims Cistjakovs, Liba Sokolovska, Renars Deksnis, Modra Murovska, Valerija Groma
Summary: The study examined the role of tumor suppressor proteins and HPV16 E6 and E7 oncoproteins in the survival assessment of patients with oropharyngeal squamous cell carcinoma (OPSCC), laryngeal squamous cell carcinoma (LSCC), and hypopharyngeal squamous cell carcinoma (HPSCC) associated with high-risk and low-risk HPV infections. The presence of HPV DNA was associated with better survival in OPSCC and LSCC, while the overexpression of HPV16 E6 protein and p16 protein was associated with better survival in OPSCC and HPSCC. The overexpression of p53 was associated with better survival in OPSCC. The study highlights the significant role of HPV infection in the development of head and neck squamous cell carcinoma and suggests that HPV16 E6 protein expression could be a useful prognostic marker for OPSCC and HPSCC.
Article
Immunology
Babatunde Y. Alli, Robert D. Burk, Mahnaz Fatahzadeh, Julie Kazimiroff, Robert M. Grossberg, Richard Smith, Thomas J. Ow, Mauricio Wiltz, Jacqueline Polanco, Marie-Claude Rousseau, Belinda Nicolau, Nicolas F. Schlecht
JOURNAL OF INFECTIOUS DISEASES
(2020)
Letter
Medicine, Research & Experimental
Thomas J. Ow, Carlos Thomas, Cory D. Fulcher, Jianhong Chen, Andrea Lopez, Denis E. Reyna, Michael B. Prystowsky, Richard V. Smith, Bradley A. Schiff, Gregory Rosenblatt, Thomas J. Belbin, Thomas M. Harris, Geoffrey C. Childs, Nicole Kawachi, Nicolas F. Schlecht, Evripidis Gavathiotis
Article
Public, Environmental & Occupational Health
Li Niu, Lindsay Till Hoyt, Anthony Salandy, Anne Nucci-Sack, Viswanathan Shankar, Howard Strickler, Robert D. Burk, Nicolas F. Schlecht, Angela Diaz
PREVENTIVE MEDICINE
(2020)
Article
Oncology
Nicholas J. Gadsden, Cory D. Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E. Segall, Michael B. Prystowsky, Nicolas F. Schlecht, Evripidis Gavathiotis, Thomas J. Ow
Summary: Inhibition of CDK4/6 leads to senescence in HPV- HNSCC, which can be effectively eliminated by combining palbociclib and navitoclax. This combination therapy decreases cell survival and increases apoptosis levels in HPV- HNSCC cell lines.
MOLECULAR CANCER RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Alyson Moadel-Robblee, Fernando Camacho, Gabrielle E. Milner, Alexander Kertzner, Nicolas F. Schlecht
Summary: Peer navigators (PNs), such as trained cancer survivor volunteers, play a crucial role in reducing barriers to screening, treatment, and psychosocial care in underserved communities through outreach, education, advocacy, and peer support. Research shows strong interest in both providing and receiving peer support, as well as in mind-body practices like meditation, among low-income populations. Pilot studies have demonstrated that peer-led interventions, such as Loving Kindness Meditation, can have positive effects on emotional well-being and relaxation.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Article
Psychology, Developmental
Li Niu, Lindsay T. Hoyt, Sarah Pickering, Anne Nucci-Sack, Anthony Salandy, Viswanathan Shankar, Elisa M. Rodriguez, Robert D. Burk, Nicolas F. Schlecht, Angela Diaz
Summary: The study aimed to identify distinct neighborhood profiles in New York City and found that living in Low SES/High Activity neighborhoods was associated with lower BMI and slower increase in BMI compared to High Disadvantage profiles. This suggests that improving neighborhood environments may help promote healthy weight and reduce health disparities during adolescence and young adulthood.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Virology
Ana Gradissimo, Viswanathan Shankar, Fanua Wiek, Lauren St. Peter, Yevgeniy Studentsov, Anne Nucci-Sack, Angela Diaz, Sarah Pickering, Nicolas F. Schlecht, Robert D. Burk
Summary: The study aimed to investigate the serological levels of antibodies against HPV16 prior to incident infections, finding that high-risk controls had higher antibody levels compared to incident cases and randomly selected controls after completing the three doses of the 4vHPV vaccine.
Article
Medicine, General & Internal
Nicolas F. Schlecht, Angela Diaz, Anne Nucci-Sack, Kathleen Shyhalla, Viswanathan Shankar, Mary Guillot, Dominic Hollman, Howard D. Strickler, Robert D. Burk
Summary: The study assessed the impact of HPV vaccination on infection rates among adolescent and young adult women in New York City. The results showed a decrease in infection rates for vaccine-related HPV types, but higher rates for some nonvaccine high-risk HPV types, indicating the importance of continued monitoring of HPV prevalence.
Article
Psychology, Clinical
Kathleen Shyhalla, Danielle M. Smith, Angela Diaz, Anne Nucci-Sack, Mary Guillot, Dominic Hollman, Maciej L. Goniewicz, Richard J. O'Connor, Viswanathan Shankar, Robert D. Burk, Nicolas F. Schlecht
Summary: In an inner-city population in New York City, there is a significant increase in cannabis use among adolescent and young adult females, while tobacco use is declining. Factors associated with cannabis use include African American race, engagement in sexual behaviors with both men and women, concurrent tobacco and alcohol use, and use of other drugs.
ADDICTIVE BEHAVIORS
(2021)
Article
Psychology, Developmental
Angela Diaz, Anne Nucci-Sack, Rachel Colon, Mary Guillot, Dominic Hollman, Marie Brunelli, Robert D. Burk, Nicolas F. Schlecht
Summary: New York City was heavily impacted by the COVID-19 pandemic in 2020, with vulnerable populations of adolescent and young adult females experiencing significant negative effects. A longitudinal study conducted at Mount Sinai Adolescent Health Center found that a large percentage of participants, especially youth of color, had lost loved ones and experienced financial losses. Food insecurity and instances of sexual abuse or partner violence were also reported. Additionally, depressive symptoms significantly increased during the shelter in place period. This study highlights the potential long-term consequences of the pandemic on inner-city female youth.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Multidisciplinary Sciences
Mykhaylo Usyk, Nicolas F. Schlecht, Sarah Pickering, LaShanda Williams, Christopher C. Sollecito, Ana Gradissimo, Carolina Porras, Mahboobeh Safaeian, Ligia Pinto, Rolando Herrero, Howard D. Strickler, Shankar Viswanathan, Anne Nucci-Sack, Angela Diaz, Robert D. Burk
Summary: Burk et al. developed an algorithm called molBV, which uses the 16S rRNA gene to diagnose bacterial vaginosis (BV) and predict the progression of human papillomavirus infection to cervical pre-cancer. They found that an increase in BV activity directly predicts the clearance of high-risk HPV infection, and also identified an alternative inflammatory BV signature associated with infection progression.
NATURE COMMUNICATIONS
(2022)
Article
Virology
James Riddell Iv, Andrew F. Brouwer, Heather M. Walline, Lora P. Campredon, Rafael Meza, Marisa C. Eisenberg, Emily C. Andrus, Rachel L. Delinger, Monica L. Yost, Jodi K. McCloskey, Trey B. Thomas, Suiyuan Huang, Robert L. Ferris, Dong Moon Shin, Carole Fakhry, Thomas Ow, Daniel Li, Ashley Berlot, Thomas E. Carey, Nicolas F. Schlecht
Summary: This study evaluated the risk of oral HPV infection in HIV infected patients compared with HIV-negative controls. The results showed that HIV-positive individuals had a significantly higher prevalence of oral HPV infection and persistence compared to HIV-negative individuals. Male participants had a higher oral HPV prevalence than female participants.
TUMOUR VIRUS RESEARCH
(2022)
Article
Oncology
Walid A. Al-Soneidar, Sam Harper, Sreenath A. Madathil, Nicolas F. Schlecht, Belinda Nicolau
Summary: Alpha-HPV, especially HPV16, increases the risk for head and neck cancers, while there is little evidence for an effect of Beta-HPV and Gamma-HPV. Beta-HPV may have a preventive effect, while Gamma-HPV may increase the risk of head and neck cancers, although to a lesser extent than Alpha-HPV. Results for cutaneous HPV were imprecise and less conclusive.
CANCER EPIDEMIOLOGY
(2022)
Article
Psychology, Educational
Li Niu, Joshua Brown, Lindsay Till Hoyt, Anthony Salandy, Anne Nucci-Sack, Viswanathan Shankar, Robert D. Burk, Nicolas F. Schlecht, Angela Diaz
Summary: This study of 882 sexually active adolescent girls found that individuals who experienced moderate emotional neglect and severe sexual abuse exhibited more sexual risk behaviors in late adolescence, with those in the severe sexual abuse profile showing a faster increase. Understanding the heterogeneity within maltreated populations has important implications for promoting healthy sexual development.
Article
Oncology
Ashley E. Stenzel, Nicolas F. Schlecht, Kirsten B. Moysich
Summary: Non-Hispanic Black women with anal cancer have lower survival rates compared to Non-Hispanic White women, while no disparities were identified for Hispanic women.
JOURNAL OF GASTROINTESTINAL CANCER
(2021)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.