Article
Cell Biology
Yunliang Tang, Yanxia Jiang, Cheng Qing, Jiao Wang, Zhenguo Zeng
Summary: In this study, a prognostic signature of nine unique EMT-related genes was established for predicting the survival of patients with LUAD. A nomogram incorporating this signature and clinical features showed a good ability to predict patient survival. This novel EMT-related gene signature provides valuable insights for clinical prognosis in LUAD.
Article
Oncology
Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li, Sheng Yan
Summary: The study showed that high vimentin expression with loss of E-cadherin expression in patients with grade 1 and 2 pNETs undergoing resection was correlated with risks of lymph node metastasis, distant metastasis, disease progression, and poor prognosis.
Article
Biochemistry & Molecular Biology
Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou
Summary: This study provides preliminary evidence suggesting that overexpression of SOX11 might promote EMT in metastatic serous ovarian cancer, thereby enhancing tumor metastasis.
Article
Oncology
Leonardo Franz, Lorenzo Nicole, Anna Chiara Frigo, Giancarlo Ottaviano, Piergiorgio Gaudioso, Tommaso Saccardo, Francesca Visconti, Rocco Cappellesso, Stella Blandamura, Ambrogio Fassina, Gino Marioni
Summary: The mechanism of epithelial-mesenchymal transition (EMT) plays a crucial role in cancer development, tumor progression, and therapy resistance. In laryngeal carcinoma, the predictive value of pN+ status and Slug expression on disease-free survival was identified, supporting the hypothesis of a mutual concurrence of EMT and angiogenesis in driving aggressive phenotype in LSCC. Further studies are needed to characterize the predictive performance of prognostic models based on EMT and angiogenesis.
Article
Ophthalmology
Jiayi Wei, Liangjing Wu, Shuai Yang, Conghui Zhang, Le Feng, Minli Wang, Hui Li, Fang Wang
Summary: Proliferative vitreoretinopathy (PVR) is a serious ocular fibrotic disease that can lead to blindness. This study focuses on the pathogenesis of PVR and the mechanism behind the epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells. The results show that the loss of E-cadherin leads to changes in the catenin-cadherin complex, activating zinc finger E-box binding homeobox 1 (ZEB1) and promoting the upregulation of N-cadherin. Overexpression of E-cadherin inhibits the EMT process and cell proliferation in RPE cells.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiaoru Zhang, Vinay Singh Tanwar, Cynthia C. Jose, Hyun-Wook Lee, Suresh Cuddapah
Summary: This study demonstrates that nickel exposure leads to persistent downregulation of E-cadherin by causing loss of Sp1 binding at the CDH1 promoter, which induces EMT. Continuous upregulation of ZEB1 is also a key factor in the loss of E-cadherin, and knocking out ZEB1 using CRISPR-Cas9 technology can restore E-cadherin expression.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Joerg Kaiser, Ulf Hinz, Philipp Mayer, Thomas Hank, Willem Niesen, Thilo Hackert, Matthias M. Gaida, Markus W. Buechler, Oliver Strobel
Summary: Adenosquamous carcinoma of the pancreas (ASCP) is a more aggressive subtype of pancreatic adenocarcinoma compared to pancreatic ductal adenocarcinoma (PDAC), with poorer differentiation and higher rates of lymph node metastases. Despite a shorter median survival, 5-year survival rates after surgical resection of about 18% can be expected in ASCP, supporting resection as part of a multimodal therapy as the treatment of choice in this rare cancer.
Article
Oncology
Jianguang Shi, Zishan Wang, Jing Guo, Yingqi Chen, Changyong Tong, Jingjie Tong, Wentao Hu, Chenwei Li, Xinjian Li
Summary: This study constructed a multigene predictor for lung adenocarcinoma (LUAD) prognosis by analyzing EMT-related genes, providing potential prognostic biological markers for LUAD patients. The research confirmed EMT as a key mechanism in LUAD progression, with HGF, PTX3, and S100P identified as independent predictors of LUAD prognosis. High expressions of these genes were significantly associated with immune cell infiltration in LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Samer George Hakim, Clara Taubitz, Steffen Hoppe, Daniel Steller, Dirk Rades, Julika Ribbat-Idel, Ubai Alsharif, Mohamed Falougy
Summary: The epithelial-mesenchymal transition (EMT) is a biological mechanism that plays a crucial role in multiple pathophysiological diseases. The cadherin switch, characterized by the de novo development of N-cadherin (N-CAD) and loss of E-cadherin (E-CAD) expression, is a hallmark of EMT and has been studied in various cancer entities. The loss of E-CAD expression in re-OSCC is an independent risk factor for poor survival and may be used to stratify therapy and de/escalate the multimodal treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yujin Pan, Deyu Li, Jiuhui Yang, Ning Wang, Erwei Xiao, Lianyuan Tao, Xiangming Ding, Peichun Sun, Dongxiao Li
Summary: This study demonstrates the preferability of portal venous for CTC testing and the association of high PoV M-CTC count with increased risk of metastasis and shorter survival time in resectable PDAC patients. PoV CTC phenotype detection shows potential as a reliable and accurate tool for identifying high-risk PDAC patients for better management strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Enke Baldini, Chiara Tuccilli, Daniele Pironi, Antonio Catania, Francesco Tartaglia, Filippo Maria Di Matteo, Piergaspare Palumbo, Stefano Arcieri, Domenico Mascagni, Giorgio Palazzini, Domenico Tripodi, Alessandro Maturo, Massimo Vergine, Danilo Tarroni, Eleonora Lori, Iulia Catalina Ferent, Corrado De Vito, Poupak Fallahi, Alessandro Antonelli, Simona Censi, Matteo D'Armiento, Susy Barollo, Caterina Mian, Aldo Morrone, Vito D'Andrea, Salvatore Sorrenti, Salvatore Ulisse
Summary: The study revealed that during thyroid cancer progression, the role of EMT-TFs is incomplete, with Twist1 possibly playing a key role in EMT but lacking significant prognostic value.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Omar Abdel-Rahman, Jennifer Spratlin, Sheryl Koski
Summary: The study aimed to analyze the real-world treatment patterns of adjuvant chemotherapy for resected pancreatic adenocarcinoma patients. Factors associated with lower probability of receiving adjuvant chemotherapy included older age, node negativity, higher comorbidity index, and living in the Northern zone. Worse overall survival was associated with higher comorbidity index and node-positive disease among patients who received adjuvant gemcitabine +/- capecitabine.
Article
Health Care Sciences & Services
Constantin Busuioc, Cristina Alexandra Ciocan-Cartita, Cornelia Braicu, Oana Zanoaga, Lajos Raduly, Monica Trif, Mihai-Stefan Muresan, Calin Ionescu, Cristina Stefan, Carmen Crivii, Nadim Al Hajjar, Simona Margarit, Ioana Berindan-Neagoe
Summary: The study utilized bioinformatics approaches to investigate alterations in EMT-related genes in colon adenocarcinoma patients, identifying key gene changes related to prognosis in COAD. These findings may help develop biomarkers for recurrence prediction in COAD patients and improve risk stratification for patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri
Summary: The study indicates that partial epithelial to mesenchymal transition is associated with metastasis in pancreatic ductal adenocarcinoma (PDAC), and genetic suppression can lead to epithelial stabilization and increased liver metastasis.
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Gastroenterology & Hepatology
Jung Min Youn, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Seung-Mo Hong
Summary: This study retrospectively evaluated the clinicopathological features and long-term outcomes of 146 patients with intraductal papillary neoplasm of the bile duct (IPNB) of the liver. The study found that surgical curability is the most important prognostic factor for IPNB.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Pathology
Sung Joo Kim, Se Jin Choi, Junmo Yang, Deokhoon Kim, Dong Wook Kim, Jae Ho Byun, Seung-Mo Hong
Summary: The clinical significance of pancreatic ductal adenocarcinomas (PDACs) with a large duct pattern (PLDP) has not been systematically evaluated. This study compared the clinicopathological, immunohistochemical, and mutational characteristics of PDACs with PLDP with conventional PDACs, and found that PLDP PDACs have unique histologic features, longer survival, and better prognosis.
Article
Gastroenterology & Hepatology
Sun-Young Jun, Jihyun Chun, Sung Joo Kim, Dongwook Oh, Jin Hee Kim, Myung-Hwan Kim, Seung-Mo Hong
Summary: This study evaluated granulocytic epithelial lesions (GEL) and related clinicopathologic factors in heterotopic pancreata. The results showed that GELs were detected in a subset of pancreata without clinical evidence of autoimmune pancreatitis (AIP), highlighting the importance of interpreting GEL findings in the context of other histologic, clinical, and radiologic findings for diagnosing AIP.
Article
Gastroenterology & Hepatology
Min Kyu Sung, Hosub Park, Guisuk Park, Seo Young Park, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang, Seung Mo Hong
Summary: This study investigated the prognostic implications of extranodal extension (ENE) in patients with surgically resected pancreatic cancer. The results showed that patients with ENE had lower disease-free survival rates, especially those with nodal metastasis. Therefore, ENE should be considered a prognostic factor in the staging system of pancreatic cancer.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Pathology
Andrea Mafficini, Michele Simbolo, Tatsuhiro Shibata, Seung-Mo Hong, Antonio Pea, Lodewijk A. Brosens, Liang Cheng, Davide Antonello, Concetta Sciammarella, Cinzia Cantu, Paola Mattiolo, Sergio Taormina, Giuseppe Malleo, Giovanni Marchegiani, Elisabetta Sereni, Vincenzo Corbo, Gaetano Paolino, Chiara Ciaparrone, Nobuyoshi Hiraoka, Daniel Pallaoro, Casper Jansen, Michele Milella, Roberto Salvia, Rita T. Lawlor, Volkan Adsay, Aldo Scarpa, Claudio Luchini
Summary: This study provides important insights into the clinicopathologic and molecular features of pancreatic intraductal tubulopapillary neoplasm (ITPN). It confirms ITPN as the origin of invasive pancreatic adenocarcinoma and identifies novel genetic alterations associated with this disease. The study also highlights the potential use of TP53 mutation status as a prognostic biomarker.
Article
Gastroenterology & Hepatology
Yuri Kim, Bokyung Ahn, Kee Don Choi, Beom-Su Kim, Jeong-Hwan Yook, Gin Hyug Lee, Seung-Mo Hong, Jeong Hoon Lee
Summary: This study systematically evaluated the clinical and pathologic characteristics of gastric neuroendocrine tumors (NETs) based on the 2019 WHO classification. The results showed that grade 2 and grade 3 gastric NETs are associated with larger size, deeper invasion, and extragastric recurrence, requiring active treatment.
Editorial Material
Gastroenterology & Hepatology
Christine A. Iacobuzio-Donahue
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Editorial Material
Oncology
Christine A. Iacobuzio-Donahue
Article
Oncology
Deepti Mathur, Chen Liao, Wendy Lin, Alessandro La Ferlita, Salvatore Alaimo, Samuel Taylor, Yi Zhong, Christine Iacobuzio-Donahue, Alfredo Ferro, Joao B. Xavier
Summary: Understanding the rewired metabolism underlying organ-specific metastasis in breast cancer is essential for improving the treatment and prevention of metastatic disease. A systems biology approach was used to compare metabolic fluxes in breast cancer cells and their derivatives with a tendency to metastasize to the brain or lung. The results showed that lung-homing cells had high glycolytic flux and a strong Warburg effect, associated with a high lactate dehydrogenase to pyruvate dehydrogenase ratio. This ratio was a significant predictor of lung metastasis, independent of other transcriptomic signatures, suggesting its potential as a biomarker.
Article
Pathology
Jihyun Chun, Yeon Wook Kim, Seo-rin Jeong, Hyung Jun Cho, Kyu-Pyo Kim, Dae Wook Hwang, Seung-Mo Hong
Summary: Although nodal metastasis is an important prognostic factor in ampullary adenocarcinoma, the prognostic significance of extranodal extension (ENE) is not well defined. This study investigated the presence of nodal metastasis with ENE in 279 surgically resected patients and compared it with other clinicopathological factors, including overall survival and recurrence-free survival. The results showed that ENE was associated with poorly differentiated tumors and had worse overall survival and recurrence-free survival rates. Evaluation of ENE can provide additional survival information for patients with surgically resected ampullary carcinoma.
Review
Pathology
Paola Mattiolo, Huamin Wang, Olca Basturk, Lodewijk A. A. Brosens, Seung-Mo Hong, Volkan Adsay, Aldo Scarpa, Claudio Luchini
Summary: This study aimed to conduct a systematic review on acinar cystic transformation (ACT) of the pancreas. The findings showed that ACT is a benign entity and does not require surgical resection except for symptomatic cases. Intracystic pancreatic intraepithelial neoplasia (PanIN) and driver mutations were rare, suggesting the need for preoperative diagnosis and long-term follow-up of ACT.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Baylee F. Bakkila, Victoria A. Marks, Daniel Kerekes, John W. Kunstman, Ronald R. Salem, Kevin G. Billingsley, Nita Ahuja, Maxwell Laurans, Kelly Olino, Sajid A. Khan
Summary: This study evaluated the impact of COVID-19 on the presentation and surgical care of patients with gastrointestinal cancers. The study found that the weekly volume of GI cancer cases decreased during the first wave of COVID-19 but remained stable during the second wave. Preoperative chemotherapy and telemedicine were utilized to mitigate the impact of the pandemic.
Article
Biotechnology & Applied Microbiology
Palash Sashittal, Haochen Zhang, Christine A. Iacobuzio-Donahue, Benjamin J. Raphael
Summary: This article introduces a new evolutionary model and algorithm, ConDoR, for inferring phylogeny in tumors. The model uses SNVs as phylogenetic markers and constrains losses of SNVs according to clusters of cells. The advantages of ConDoR are demonstrated through simulations and real data.
Article
Medicine, General & Internal
Sang-Woo Ha, Shin Hwang, Hyejin Han, Song Ie Han, Seung-Mo Hong
Summary: This case report presents a patient with mucinous cystic neoplasm of the liver who had a successful outcome after surgical resection.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2022)
Article
Surgery
Jin Uk Choi, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Jae Seung Kim, Seung-Mo Hong
Summary: IPNB-L is a rare type of biliary neoplasm ranging from benign disease to invasive carcinoma. FDG-PET SUVmax cutoff of 3.0 effectively discerns high-grade neoplasia/carcinoma from low-grade neoplasia, assisting in surgical strategy for these cases.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.