Article
Dermatology
Chryssoula Papageorgiou, Aimilios Lallas, Sofia Magdalini Manoli, Caterina Longo, Michela Lai, Konstantinos Liopyris, Konstantinos Lallas, Elizabeth Lazaridou, Zoe Apalla
Summary: The aim of this study was to investigate the clinical and dermatoscopic criteria that could suggest early invasion and serve as potent predictors to discriminate early SCC from AK. The main positive dermatoscopic predictors of early SCC were dotted/glomerular vessels, hairpin vessels, and white structureless areas, whereas background erythema represented a negative SCC predictor.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Jack Lee, Vernon J. Forrester, Wendy M. Novicoff, Darren J. Guffey, Mark A. Russell
Summary: In a retrospective analysis of SCCs and basal cell carcinomas treated with Mohs surgery at a single institution, the study identified an association between surgical delays and tumor growth for higher-grade SCCs, suggesting potential clinical significance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Niina Korhonen, Leea Ylitalo, Tiina Luukkaala, Julius Itkonen, Henni Haihala, Juha Jernman, Erna Snellman, Johanna Palve
Summary: In a cohort of 774 cutaneous squamous cell carcinoma (cSCC) patients in the Pirkanmaa region of Finland from 2006-2015, 72% had premalignant lesions, 41% had basal cell carcinoma, and 6% had cutaneous melanoma. Patients with cSCC are at high risk of developing multiple skin cancers and require long-term follow-up.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Dermatology
Chryssoula Papageorgiou, Ioannis Spyridis, Sofia Magdalini Manoli, Iuliana Busila, Irina Elena Nasturica, Konstantinos Lallas, Angeliki Panagopoulou, Ilias Papadimitriou, Nikolaos Sideris, Theodosia Gentsidi, Ruben Gonzalez-Cuevas, Andjelka Ilieva, Dimitrios Ioannides, Zoe Apalla, Aimilios Lallas
Summary: The study aimed to investigate dermoscopic criteria for the differential diagnosis between irritated seborrheic keratosis (ISK) and squamous cell carcinoma (SCC), finding significant predictors for each entity that can help distinguish between the two conditions.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Wan, Hongji Dai, Xiaoli Zhang, Sheng Liu, Yuan Lin, Ally-Khan Somani, Jingwu Xie, Jiali Han
Summary: The majority of non-melanoma skin cancer cases are basal cell carcinoma and squamous cell carcinoma which originate from keratinocytes. The incidence of keratinocyte carcinomas in the US is over 5 million per year, three times higher than all other types of cancer combined. Research has shown significant variations in gene expression in these tumors, with novel findings including up-regulation of zinc finger encoding genes in human BCC and a novel link between hedgehog signaling, Wnt signaling, and the cilium.
Article
Biochemistry & Molecular Biology
Sarai Pongjantarasatian, Nunthawan Nowwarote, Varumporn Rotchanakitamnuai, Watcharee Srirodjanakul, Ritmongkol Saehun, Kajohnkiart Janebodin, Jeeranan Manokawinchoke, Benjamin P. J. Fournier, Thanaphum Osathanon
Summary: Notch signaling plays an important regulatory role in oral squamous cell carcinoma (OSCC), promoting cell growth, cell cycle progression, cell migration, and invasion. Blocking Notch signaling can significantly inhibit the proliferation and progression of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Shin-ichi Ansai, Yoshihiro Umebayashi, Noriyuki Katsumata, Hiroshi Kato, Takafumi Kadono, Toshihiro Takai, Takeshi Namiki, Masahiro Nakagawa, Toshinori Soejima, Hiroshi Koga, Makoto Sugaya
Summary: This article presents the English version of the 2020 edition of the Japanese SCC guidelines, covering an overview of SCC and discussion of three clinical questions. The evaluation processes were strictly implemented according to the Grading of Recommendations, Assessment, Development, Evaluation system, with recommendations determined by a multidisciplinary expert panel.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
D. Y. Lee, B. R. Kim, S. Yang, M. Kim, T. Y. Yoon, S. W. Youn
Summary: This study quantitatively assessed histopathological findings of actinic keratosis (AK) and identified bowenoid type, epidermal thickening, and higher proportion of keratinocytic atypia as significant factors associated with progression to invasive squamous cell carcinoma (SCC). Multivariate analysis revealed that the proportion of keratinocytic atypia was the only independent predisposing factor for SCC progression.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Oncology
Elizabeth Chiang, Haleigh Stafford, Jane Buell, Uma Ramesh, Moran Amit, Priyadharsini Nagarajan, Michael Migden, Dan Yaniv
Summary: Non-melanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are extensively influenced by the tumor microenvironment. The interactions within this microenvironment play a crucial role in the promotion of tumor growth and progression. Understanding these interactions has led to the development of immunotherapeutic agents, with ongoing research aiming to discover novel treatments.
Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: In this study, the researchers found that Suprabasin protein is increased in expression in squamous cell carcinoma (SCC) and decreases with increasing grade. They also observed no expression of Suprabasin in basal cell carcinoma (BCC). Therefore, Suprabasin can be used as a biomarker to differentiate SCC from BCC.
Article
Oncology
Conrad Falkenberg, Thomas Dirschka, Georgia Gilbert, Eggert Stockfleth, Bernhard Homey, Lutz Schmitz
Summary: The study compared epidermal AKs from organ transplant recipients and immunocompetent control group, and found that AKs with marked basal proliferation (PRO III) and acantholysis (AK I) were more common in transplant recipients. Acantholytic AKs were significantly associated with advanced basal proliferation. Therefore, AKs with marked basal proliferation and acantholysis may represent histological high-risk factors for the progression into iSCC.
Article
Oncology
Valeria Righi, Camilla Reggiani, Elisabetta Tarentini, Adele Mucci, Alessia Paganelli, Anna Maria Cesinaro, Ema Mataca, Shaniko Kaleci, Barbara Ferrari, Marco Meleti, Cristina Magnoni
Summary: The study assessed the metabolomic fingerprints of AK I, AK II, AK III and SCC, finding that AK I are metabolically active lesions with profiles similar to high-grade AKs and SCC. The negative association of AKs with parakeratosis and positive association with hypertrophy suggest a similar behavior between AKs and SCCs. The findings support the notion that all AKs should be treated independently, as they may be associated with SCC.
Article
Medicine, General & Internal
Ming-Jun Wu, Yu-Chun Chen, Xiao-Li Cui, Qian Yang, Qing-Liang Xue
Summary: This case study demonstrates the positive effect of the PD-1 immunosuppressant tislelizumab in treating basal cell carcinoma.
Article
Biology
Carmen Giuglea, Andrei Marin, Iulia Gavrila, Alexandra Paunescu, Nicoleta Amalia Dobrete, Silviu Adrian Marinescu
Summary: Basal cell carcinoma (BCC) is the most common cancer in humans characterized by slow growth and rare metastases. A retrospective study was conducted on 180 patients who underwent surgery for various skin tumors between January 2019 and August 2022, and histopathological examination confirmed the presence of BCC. The study aimed to provide observational data on BCC, including histopathology, diagnostic, and therapeutic management, and integrate this information into current knowledge of the pathology.
Article
Dermatology
Yoon-Seob Kim, Seung-Hyun Jung, Young Min Park, Gyeong Sin Park, Hei Sung Kim, Lee-So Maeng, Yeun-Jun Chung
Summary: This study investigates the genomic alterations between actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC), and identifies TP53 and NOTCH1 as common driver mutations in cSCC. The study also reveals that cSCC has a higher abundance of somatic mutations and copy number alterations (CNAs) compared to AK/CIS, and that ultraviolet is the main cause of these mutations in both AK/CIS and cSCC.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Werner Kempf, Tony Petrella, Rein Willemze, Patty Jansen, Emilio Berti, Marco Santucci, Eva Geissinger, Lorenzo Cerroni, Eve Maubec, Maxime Battistella, John Goodlad, Emmanuella Guenova, Katariina Lappalainen, Annamari Ranki, Paul Craig, Eduardo Calonje, Blanca Martin, Sean Whittaker, Ilske Oschlies, Ulrike Wehkamp, Jan P. Nicolay, Marion Wobser, Julia Scarisbruck, Nicola Pimpinelli, Rudi Stadler, Katrin Kerl French, Pietro Quaglino, Jinran Lin, Lianjun Chen, Michaela Beer, Patrick Emanuel, Stephane Dalle, Alistair Robson
Summary: The study retrospectively analyzed a series of 46 patients and biopsies by the international EORTC Cutaneous Lymphoma Group. The dermal CD8(+) lymphoproliferations were categorized into three groups: cutaneous acral CD8(+) T-cell lymphoma, primary cutaneous CD8(+) peripheral T-cell lymphoma, unspecified/NOS, and cutaneous CD8(+) lymphoproliferations associated with congenital immunodeficiency syndromes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Roberto Maglie, Stefano Senatore, Gioia Di Stefano, Marta Barzacchi, Vincenza Maio, Francesca Montefusco, Maria Efenesia Baffa, Beatrice Bianchi, Marco Santucci, Emiliano Antiga
Summary: We describe an unusual case of myelodysplasia cutis in a patient with chronic myelomonocytic leukaemia.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alice Indini, Fausto Roila, Francesco Grossi, Daniela Massi, Mario Mandala
Summary: Mucosal melanoma is a rare and aggressive subtype of melanoma that has shown poor response to novel treatment approaches. Recent molecular studies have revealed potential therapeutic targets and the potential benefits of immunotherapy in this disease. However, further research is needed to confirm these findings in different studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
C. Pellegrini, S. Raimondi, L. Di Nardo, P. Ghiorzo, C. Menin, M. A. Manganoni, G. Palmieri, G. Guida, P. Quaglino, I. Stanganelli, D. Massi, L. Pastorino, L. Elefanti, G. Tosti, P. Queirolo, A. Leva, A. Maurichi, M. Rodolfo, M. C. Fargnoli
Summary: The study analyzed major high and intermediate melanoma risk genes in a large multicentre cohort of Italian children and adolescents. Results showed most patients carried MC1R variants, while CDKN2A pathogenic variants were found in 9% of cases. Children under 12 years old more frequently presented Spitzoid histotype, with melanoma located on the head/neck and upper limbs and higher Breslow thickness.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Federica Scarfi, Luciana Trane, Vincenza Maio, Flavia Silvestri, Federico Venturi, Biancamaria Zuccaro, Daniela Massi, Vincenzo De Giorgi
Summary: This study analyzed facial pigmented lesions using FAV technology to establish morphologic descriptors and standardized terminology for diagnosis. FAV features can assist physicians in diagnosing suspicious flat facial pigmented lesions, providing an improved diagnostic approach.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniele Palatresi, Filippo Fedeli, Ginevra Danti, Elisa Pasqualini, Francesca Castiglione, Luca Messerini, Daniela Massi, Silvia Bettarini, Paolo Tortoli, Simone Busoni, Silvia Pradella, Vittorio Miele
Summary: The purpose of this study was to identify CT radiomic features that could correlate with the risk class and treatment response of gastrointestinal stromal tumors (GISTs). By analyzing CT images, the study found several statistically significant features that could be used to assess the risk class and prognosis of GISTs.
Article
Anatomy & Morphology
Filippo Ugolini, Gianna Baroni, Romina Nassini, Francesco De Logu, Daniela Massi
Summary: The study proposes a new fast and fully automated bleaching method for highly pigmented melanoma samples. The protocol involves pretreating the samples with 0.5% hydrogen peroxide and a Tris base pH 10 solution before antigen retrieval, effectively removing excess melanin without affecting tissue antigenicity and cytoarchitecture.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2022)
Review
Oncology
Ignazio Stanganelli, Francesco Spagnolo, Giuseppe Argenziano, Paolo A. Ascierto, Franco Bassetto, Paolo Bossi, Vittorio Donato, Daniela Massi, Cesare Massone, Roberto Patuzzo, Giovanni Pellacani, Pietro Quaglino, Paola Queirolo, Iris Zalaudek, Giuseppe Palmieri, Italian MelanomaIntergrp IMI
Summary: Cutaneous squamous cell carcinoma is a common form of cancer with a high risk of relapse. Chemotherapy is not curative with severe toxicities. Anti-PD-1 inhibitors have shown potential in the treatment of this cancer.
Article
Dermatology
Vincenzo De Giorgi, Flavia Silvestri, Imma Savarese, Federico Venturi, Federica Scarfi, Luciana Trane, Federica Bellerba, Biancamaria Zuccaro, Vincenza Maio, Daniela Massi, Sara Gandini
Summary: This study retrospectively analyzed 53 cases of porocarcinoma in 52 patients and evaluated their characteristics and prognosis. The study found that PC has a less aggressive behavior with low rates of local recurrence, lymph node metastasis, and mortality.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Valentina Audrito, Enrico Moiso, Filippo Ugolini, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Ilaria Manfredonia, Simonetta Bianchi, Francesco De Logu, Romina Nassini, Anna Szumera-Cie, Daniela Taverna, Daniela Massi, Silvia Deaglio
Summary: The study reveals an association between BRAF mutations and NAMPT expression, with tumor samples carrying BRAF mutations showing over-expression of NAMPT. Furthermore, the over-expression of NAMPT is confirmed in BRAF wt MM and THCA cell lines modified to over-express the BRAF V600E construct. Treatment of BRAF-mutated cell lines with NAMPT inhibitors results in significant reduction of tumor growth. Additionally, NAMPT gene amplification is observed in several tumors. These findings highlight the potential for novel combination therapies targeting NAMPT in tumors carrying BRAF mutations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Pathology
Alice Indini, Maurizio Lombardo, Angelo Sidoni, Andrea Gianatti, Mario Mandala, Daniela Massi
Summary: Immune checkpoint inhibitors (ICIs) have shown remarkable anti-tumor activity in melanoma patients, but they are only beneficial to a minority due to resistance mechanisms. This resistance is complex and involves genetic and epigenetic factors that affect the interaction between cancer cells and the tumor microenvironment. There is ongoing research on predicting response and toxicity to ICIs and identifying biomarkers for resistant patients. This article reviews the changes in the tumor microenvironment induced by ICIs, summarizes clinical trial evidence, and discusses potential biomarkers for predicting response.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Article
Pathology
Filippo Ugolini, Anna Szumera-Cieckiewicz, Gianna Baroni, Gabriella Nesi, Mario Mandala, Soldano Ferrone, Daniela Massi
Summary: The expression level of HLA class I subunits in primary and metastatic lesions has been studied in various cancer types. However, there is limited information about HLA class I subunit expression in normal tissues. In this study, the expression level of HLA-A, HLA-B, HLA-C heavy chains, and beta 2-microglobulin was examined in normal tissues. The results showed that HLA class I subunit expression is not detectable in all nucleated cells, but is found only at the endothelial level. This information is important for evaluating changes in HLA class I subunit expression associated with malignant cell transformation.
Review
Medicine, General & Internal
Raymond L. Barnhill, David E. Elder, Michael W. Piepkorn, Stevan R. Knezevich, Lisa M. Reisch, Megan M. Eguchi, Boris C. Bastian, Willeke Blokx, Marcus Bosenberg, Klaus J. Busam, Richard Carr, Alistair Cochran, Martin G. Cook, Lyn M. Duncan, Rosalie Elenitsas, Arnaud de la Fouchardiere, Pedram Gerami, Iva Johansson, Jennifer Ko, Gilles Landman, Alexander J. Lazar, Lori Lowe, Daniela Massi, Jane Messina, Daniela Mihic-Probst, Douglas C. Parker, Birgitta Schmidt, Christopher R. Shea, Richard A. Scolyer, Michael Tetzlaff, Xiaowei Xu, Iwei Yeh, Artur Zembowicz, Joann G. Elmore
Summary: The revised version 2.0 of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) aims to provide a more standardized classification and diagnostic reporting of melanocytic lesions, as well as explicit treatment guidance. This version includes clearly-defined histopathological criteria for classifying benign lesions and provides guidance for differentiating intermediate tumors from melanoma. It also recognizes a subset of low-risk melanomas.
Article
Oncology
Paolo. A. Ascierto, Eleonora Cioli, Vanna Chiarion-Sileni, Pietro Quaglino, Francesco Spagnolo, Massimo Guidoboni, Michele Del Vecchio, Ketty Peris, Paola Queirolo, Luisa Fioretto, Corrado Caraco, Miriam Paone, Antonio Sorrentino, Mariaelena Capone, Diana Giannarelli, Gerardo Ferrara, Daniela Massi, Claudia Trojaniello
Summary: This study aims to investigate the efficacy of neoadjuvant plus adjuvant combined or sequenced vemurafenib, cobimetinib and atezolizumab in patients with high-risk, resectable BRAF-mutated and wild-type melanoma. The study is a phase II, open-label, non-comparative trial in patients with stage IIIB/C/D surgically resectable melanoma. It is expected that the combination of neoadjuvant and adjuvant treatment may reduce the incidence of relapse and improve survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Cinzia Mazzini, Giulio Vicini, Laura Di Leo, Daniela Massi, Stanislao Rizzo, Fabrizio Giansanti
Summary: This study evaluated the anatomical and functional outcomes of endoresection and adjuvant ruthenium-106 brachytherapy for uveal melanoma. The results showed that this treatment option can control melanoma, avoid enucleation, reduce radiation-related complications, and provide tumor tissue for chromosomal analysis and prognostic testing.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
