Article
Cell Biology
Shengkui Qiu, Bowen Li, Yiwen Xia, Zhe Xuan, Zheng Li, Li Xie, Chao Gu, Jialun Lv, Chen Lu, Tianlu Jiang, Lang Fang, Penghui Xu, Jing Yang, Ying Li, Zetian Chen, Lu Zhang, Linjun Wang, Diancai Zhang, Hao Xu, Weizhi Wang, Zekuan Xu
Summary: This study identified circTHBS1 as an oncogenic circRNA that enhances the malignancy of gastric cancer by elevating the expression of INHBA. It provides new insights and a feasible target for the diagnosis and treatment of gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Hiwot T. Workneh, Bijal Mehta, Anjali Grover
Summary: Bariatric surgery can lead to complications, including hypoglycemia. This case report describes a 78-year-old male who developed severe hypoglycemia despite no history of diabetes. Further investigation revealed a possible diagnosis of nesidioblastosis, an uncommon hypoglycemic syndrome associated with bariatric surgery. The patient was treated with medication and dietary guidance to manage the condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Immunology
Xinru Gong, Zhoutong Han, Hongli Fan, Yuqi Wu, Yuanqiong He, Yijie Fu, Tianmin Zhu, Hui Li
Summary: This review examines the potential role of immune cells and cytokines in regulating inflammation and remodeling of chronic rhinosinusitis (CRS) mucosa. The study highlights the important connection between inflammation and remodeling in CRS and provides novel ideas for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Shenshuo Gao, Zhikai Zhang, Xubin Wang, Yan Ma, Chensheng Li, Hongjun Liu, Changqing Jing, Leping Li, Xiaobo Guo
Summary: In this study, it was found that miR-875-5p can inhibit the proliferation, migration, and invasion of gastric cancer cells by directly targeting USF2. Overexpression of miR-875-5p was also shown to suppress the TGF-beta signaling pathway. MiR-875-5p has the potential to be a target for the diagnosis and treatment of gastric cancer in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyue Li, Jing Luo, Kelin Mou, Lin Peng, Huan Zhou, Yulin Lei, Huan Wang, Zhengfei Zhao, Jianmei Wang, Jianhua Wu, Runlan Wan, Sheng Lin, Li Xiang, Yuhao Luo
Summary: Our previous studies have shown that TGF-beta is involved in tumor metastasis and that SDPR may be a downstream target of TGF-beta. This study demonstrated that SDPR is downregulated in gastric cancer and participates in TGF-beta-mediated tumour metastasis. Mechanistically, SDPR interacts with ERK and inhibits the expression of CPT1A, a key gene involved in fatty acid metabolism. This suggests that the TGF-beta/SDPR/CPT1A axis plays an important role in the fatty acid oxidation of gastric cancer and may provide a potential therapeutic target for gastric cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Gonzalo-Martin Perez-Arana, Jose Fernandez-Vivero, Alonso Camacho-Ramirez, Alfredo Diaz Gomez, Jose Bancalero de los Reyes, Antonio Ribelles-Garcia, David Almorza-Gomar, Carmen Carrasco-Molinillo, Jose-Arturo Prada-Oliveira
Summary: This study focuses on the effects of pancreatic-cell populations after sleeve gastrectomy and Roux-en-Y gastric bypass, aiming to explain the pathophysiological mechanisms underlying these surgeries and improve their outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Xingyun Wang, Xiao Shi, Hongcheng Lu, Chen Zhang, Xiang Li, Tiancheng Zhang, Jiajia Shen, Jianfei Wen
Summary: The study reveals that succinylation modification of fibrillin 1 (FBN1) in gastric cancer blocks its degradation by matrix metalloproteinases (MMPs), leading to its long-term accumulation and deposition in the extracellular matrix. This promotes tumor progression through the activation of TGF-beta 1 and the intracellular PI3K/Akt pathway.
Article
Oncology
Xiao-Ning Yuan, Qin Liu, You-Cheng Shao, Xiao-Qing Guan, Ze-Lin Yang, Meng-Fei Chu, Jing-Wei Zhang, Yi-Hao Tian, Lei Wei
Summary: This study identified the TGF-beta/Smad2/3 axis as an important carcinogenic pathway in gastric cancer, significantly promoting its proliferation and metastasis. Furthermore, it was discovered that Smad3 mRNA could be modified by m6A and stabilized by IGF2BP2, enhancing Smad3 protein expression and activating the TGF-beta/Smad pathway. Additionally, METTL3 was found to interact with phosphorylated Smad3, regulating the transcription of downstream target genes. Therefore, this study reveals a novel mechanism by which METTL3 synergistically regulates TGF-beta/Smad2/3 signaling and provides a new potential therapeutic target for gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Genetics & Heredity
Siyuan Liu, Zhenghao Li, Huihuang Li, Xueyi Wen, Yu Wang, Qilin Chen, Xundi Xu
Summary: A TGF beta-associated signature has been developed and validated, which is capable of predicting the survival outcome and depicting the tumor microenvironment immune characteristics in gastric carcinoma (GC).
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Wafaa S. Ramadan, Saleh Alkarim, Mohammed Moulay, Ghadeer Alrefeai, Fatma Alkudsy, Khalid Rehman Hakeem, Ashwaq Iskander
Summary: The challenges in treating hepatocellular carcinoma (HCC) are largely due to drug resistance or relapse, which is attributed to the presence of hepatic cancer stem cells (HCSCs). In this study, the therapeutic effect of ellagic acid (EA) on HCC and the reaction of the HCC microenvironment and HCSCs to EA therapy were evaluated.
Article
Cell Biology
Zhuqing Zhou, Wei Gao, Biao Yuan, Shun Zhang, Kaijing Wang, Tao Du
Summary: The study found that TRIM22 plays a crucial role in gastric cancer development and may inhibit the proliferation of gastric cancer cells through Smad2.
CELL DEATH DISCOVERY
(2021)
Article
Nutrition & Dietetics
Paulina Iwaniak, Ewa Tomaszewska, Siemowit Muszynski, Marta Marszalek-Grabska, Stefan Grzegorz Pierzynowski, Piotr Dobrowolski
Summary: This study investigated the effects of dietary alpha-ketoglutarate (AKG) on the structure and function of the small intestine after gastric bypass surgery. The results showed that AKG supplementation partially improved small intestinal morphology and epithelial integrity following the surgical procedure.
Article
Neurosciences
Ute Haeussler, Joao Neres, Catherine Vandenplas, Caroline Eykens, Irena Kadiu, Carolin Schramm, Renaud Fleurance, Phil Stanley, Patrice Godard, Laurane de Mot, Jonathan van Eyll, Klaus-Peter Knobeloch, Carola A. Haas, Stefanie Dedeurwaerdere
Summary: Structural epilepsies display complex immune activation signatures, but the specific neuroinflammatory pathways driving the pathology are unclear. Transcriptome studies in patients with mesial temporal lobe epilepsy (mTLE) identified dysregulation of transforming growth factor beta, interferon alpha/beta, and nuclear factor erythroid 2-related factor 2 pathways. However, in a mouse model, lack of Usp15 did not significantly affect severity of status epilepticus or the expression of inflammatory pathways.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
J. J. Staudacher, Alexander Arnold, A. A. Kuehl, M. Poetzsch, S. Daum, M. Winterfeld, E. Berg, M. Hummel, B. Rau, U. Stein, C. Treese
Summary: This study aimed to investigate the prognostic role of activin tumor protein expression in esophageal and gastric adenocarcinomas. The results showed that higher levels of activin subunits were associated with lower cancer stage and longer overall survival. Furthermore, tumors with higher activin subunit expression also had higher CD4(+) T-cell infiltration, and the longer overall survival effect was only observed in tumors with high CD4(+) T-cell infiltration.
Article
Nutrition & Dietetics
Hongbo Jiang, Pei Ma, Zhiguang Duan, Yannan Liu, Shihong Shen, Yu Mi, Daidi Fan
Summary: This study confirmed the inhibitory effect of Ginsenoside Rh4 on gastric cancer and discovered that it can suppress the migration and invasion of gastric cancer cells by reversing epithelial-mesenchymal transition (EMT) through the inhibition of the SIX1-TGF-beta/Smad2/3 signaling axis.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.