Review
Pathology
Annikka Weissferdt, Cesar A. Moran
Summary: Thymomas composed predominantly of epithelioid tumor cells with scattered lymphocytes have been recognized and named variously in the literature. However, the interpretation and diagnosis of these tumors may be challenging due to their spectrum of histopathological growth patterns, especially in small mediastinoscopic biopsies. Sufficient sampling is important for the diagnosis of a specific subtype, especially when the tumor is rich in epithelioid cells and has a scant lymphocytic component.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hai-Yan Chen, Yao Pan, Jie-Yu Chen, Lu-lu Liu, Yong-Bo Yang, Kai Li, Ri-Sheng Yu, Guo-Liang Shao
Summary: This study aimed to identify quantitative CT features for distinguishing well-differentiated pancreatic neuroendocrine tumors (PNETs) from poorly differentiated pancreatic neuroendocrine carcinomas (PNECs). The results showed that arterial/portal absolute enhancements were independent predictors with good diagnostic accuracy for differentiating between PNETs and PNECs. Arterial lesion enhancement had the highest diagnostic performance.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Dauren Adilbay, Avery Yuan, Paul B. Romesser, Richard J. Wong, Jatin P. Shah, Ashok R. Shaha, Michael R. Tuttle, Snehal Patel, Nancy Y. Lee, Ian Ganly
Summary: This study aimed to report the experience of patients with well-differentiated thyroid cancer (WDTC) who received postoperative radiation therapy (PORT). The results showed that patients who received PORT had improved locoregional recurrence-free probability, but it did not translate into improved disease-specific survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Jisun Lim, Yeon Bi Han, Soo Young Park, Soyeon Ahn, Hyojin Kim, Hyun Jung Kwon, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung
Summary: The study identified gene expression patterns and immune tumor microenvironment behaviors in the continuum from atypical adenomatous hyperplasia (AAH) to lung adenocarcinoma (ADC). Up-regulated genes with stepwise change of expression from AAH to ADC were found, as well as differences in immune cell profiles between AAH and ADC. The differential expression during ADC development was found to potentially affect immune function in synchronous precursors and tumor lesions in patients with lung cancer.
Article
Surgery
Xinyu Wang, Jingyu Deng, Han Liang
Summary: The study found that patients with papillary gastric adenocarcinoma (PGC) were generally older and had tumors located in the upper 1/3 of the stomach, with characteristics such as serosal infiltration and early lymph node metastasis. The risk factor for poor survival in PGC patients was papillary adenocarcinoma.
Article
Oncology
Medard F. M. van den Broek, Sonja Levy, Wieneke A. Buikhuisen, Kim Dijke, Koen J. Hartemink, Rachel S. van Leeuwaarde, Menno R. Vriens, Margot E. T. Tesselaar, Gerlof D. Valk
Summary: This study compared the disease course and survival outcomes of sporadic bronchopulmonary neuroendocrine tumors (sp-bpNET), MEN1-related, and DIPNECH-related bpNET. The results showed that patients with sp-bpNET had significantly higher disease-specific mortality compared to MEN1 or DIPNECH-related bpNET, suggesting that not all bpNET are similar entities.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
Alex J. Liu, Benjamin E. Ueberroth, Patrick W. McGarrah, Skye A. Buckner Petty, Ayse Tuba Kendi, Jason Starr, Timothy J. Hobday, Thorvardur R. Halfdanarson, Mohamad Bassam Sonbol
Summary: This study evaluated metastatic NET G3 response to different treatment regimens, showing that CAPTEM was the most commonly used treatment with clinically meaningful efficacy and disease control. FOLFOX or PRRT are other potentially active treatment options, while EP has limited activity with short-lived responses in NET G3.
Article
Pathology
Satsuki Kishikawa, Takuo Hayashi, Tsuyoshi Saito, Kazuya Takamochi, Shinji Kohsaka, Kei Sano, Noriko Sasahara, Keita Sasa, Taisei Kurihara, Kieko Hara, Yoshiyuki Suehara, Fumiyuki Takahashi, Kenji Suzuki, Takashi Yao
Summary: This study evaluated the clinicopathological, immunohistochemical, and molecular characteristics of 70 cases of invasive mucinous adenocarcinoma (IMA) of the lung, revealing a significant association between diffuse expression of MUC6 and KRAS-wild-type tumors, smaller tumor size, and female patients. Patients with tumors exhibiting diffuse MUC6 expression had significantly favorable outcomes, suggesting a distinct clinicopathological subset characterized by wild-type KRAS and possibly less aggressive clinical course.
Article
Multidisciplinary Sciences
K. Lithgow, H. Venkataraman, S. Hughes, H. Shah, J. Kemp-Blake, S. Vickrage, S. Smith, S. Humphries, M. Elshafie, P. Taniere, S. Diaz-Cano, B. V. M. Dasari, M. Almond, S. Ford, J. Ayuk, S. Shetty, T. Shah, I. Geh
Summary: Neuroendocrine neoplasms, particularly G3 tumors, exhibit heterogeneous behavior with poor prognosis, limited treatment options, and potential response to somatostatin analogs and chemotherapy. Further research is needed to compare the effectiveness of different treatment strategies for this disease.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Lea Payen, Younes Mahi, Berengere Vire, Madison Sands, B. Mark Evers, Dominique Joubert, Lowell Anthony
Summary: Current blood-based biomarkers for neuroendocrine neoplasms lack sensitivity and specificity. This study examined the potential of human circulating progastrin as a biomarker for neuroendocrine neoplasms. The results showed that levels of circulating progastrin were significantly higher in neuroendocrine neoplasms patients and demonstrated high sensitivity and specificity. Plasma circulating progastrin may be a diagnostic blood biomarker for both low- and high-grade neuroendocrine neoplasms, but further research is needed.
Editorial Material
Medicine, General & Internal
Florian Rosar, Caroline Burgard, Maximilian Linxweiler, Phillip R. Stahl, Fadi Khreish, Samer Ezziddin
Summary: This article presents a case of pancreatic adenocarcinoma that mimicked metastasis of differentiated thyroid cancer during radioiodine therapy. The case highlights the importance of considering pancreatic adenocarcinoma in radioiodine-positive pancreatic lesions.
Article
Medicine, General & Internal
Lifeng Liu, Lin Han, Qingzhu Ma, Jinliang Zhang
Summary: Gastric adenocarcinoma of fundic gland (chief cell predominant type) is a rare variant characterized by mild nuclear atypia and specific immunohistochemical markers, often coexisting with well-differentiated tubular adenocarcinoma. It presents in the deep mucosal layer and muscularis mucosa, undetectable by endoscopy but discernible in pathology with mild nuclear atypia and special biomarkers.
Article
Oncology
Wei Li, Yingying Yang, Menghang Yang, Nan Song, Ziwei Wan, Qing Lu, Jingyun Shi
Summary: This study analyzed the clinicopathologic, radiologic, and prognostic characteristics of primary lung mucinous adenocarcinomas (LMAs) based on radiologic classification. Patients with pure-solid and part-solid types had good prognoses, while those with pneumonic type had poor prognoses.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Samer S. AlMasri, Abdulrahman Y. Hammad, Aatur D. Singhi, Alessandro Paniccia, Amer H. Zureikat, James P. Celebrezze, Haroon A. Choudry, Ibrahim Nassour
Summary: This study analyzed data from a national cancer database to compare the oncologic outcomes of appendectomy and right hemicolectomy for T1 appendiceal adenocarcinoma. The results showed that appendectomy is equivalent to right hemicolectomy in terms of survival for well-differentiated T1 adenocarcinoma, but right hemicolectomy is superior for moderately and poorly differentiated disease.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Oncology
Fumihiko Matsumoto, Katsuhisa Ikeda
Summary: Tracheal invasion in well-differentiated thyroid cancer is a negative prognostic factor, with different resection methods having varying impacts on prognosis. Patients with well-differentiated thyroid cancer generally have a good prognosis, but factors such as quality of life and surgical risks need to be considered.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.