Review
Biochemistry & Molecular Biology
Marco D'Amato, Francesca Morra, Ivano Di Meo, Valeria Tiranti
Summary: Mitochondrial diseases are genetic conditions caused by mutations in nuclear or mitochondrial DNA. Existing therapies are insufficient for treating the wide range of mtDNA mutations. Mitochondrial transplantation offers a potential solution by transferring healthy mitochondria to dysfunctional cells or tissues. This review explores the mechanisms and methods of intercellular mitochondrial transfer and discusses its potential therapeutic applications. Mitochondrial transplantation could induce a shift in heteroplasmy and potentially attenuate or prevent pathological phenotypes. However, further research is needed before its widespread use in mitochondrial medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jean-Luc Cracowski, Jean-Sebastien Hulot, Silvy Laporte, Mathieu Charveriat, Matthieu Roustit, Dominique Deplanque, Pierre-Olivier Girodet
Summary: Clinical pharmacology focuses on studying the use of drugs in humans and aims to present innovative approaches that could transform drug development in the future. Reliable data on drug mechanism of action and rigorous study design are essential before conducting pharmacological studies in humans. Randomized controlled trials (RCTs) are currently the gold standard for evaluating drug efficacy, but alternative designs and new technologies show promise for improving drug development. Precision medicine may benefit from identifying new disease phenotypes and endotypes to determine new therapeutic targets and identify patients who respond to treatment or are at risk for adverse drug events. It is important to prioritize translational research, transparent sharing of clinical trial data, and enhanced interactions between drug experts, patients, and the general public.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Management
Yong-Hong Kuo, Janny M. Y. Leung, Yimo Yan
Summary: The concept of a smart city uses IoT technologies and data analytics to optimize city operations and services, aiming to provide a high quality of life for citizens. Public transport in smart cities should focus on providing mobility for living rather than just moving people. This presents challenges in terms of designing a coordinated multi-modal system to cope with changing habitation and work patterns.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Review
Cell Biology
Jannik Prasuhn, Ryan L. Davis, Kishore R. Kumar
Summary: Parkinson's disease is complicated and mitochondrial dysfunction plays a key role in its pathophysiology. While there are still gaps in knowledge, targeting various aspects of mitochondrial function and using combined therapeutic approaches may offer the best chance for developing effective novel therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhihui Song, Zhihua Yang, Lin Tian, Yangxi Liu, Zehui Guo, Qiuju Zhang, Yuhang Zhang, Tao Wen, Haowei Xu, Zhenzhen Li, Yi Wang
Summary: Coronary artery disease has a high mortality rate and traditional Chinese medicine can effectively alleviate myocardial ischaemia-reperfusion injury through regulating mitochondrial circadian rhythms and the biological clock transcription factor.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Rilan Bai, Jiuwei Cui
Summary: Cancer cells adapt to increasing energy and biosynthetic demands by reprogramming their metabolic pathways via mitochondria, which play crucial roles in the survival, immune evasion, tumor progression, and treatment resistance of the hypoxic tumor microenvironment. Targeting the mitochondria-related pathway with anticancer drugs can enhance the immune recognition of cancer cells, tumor antigen presentation ability, and anti-tumor function of immune cells. This review focuses on the effects of mitochondrial morphology and function on immune cells, the impact of mitochondrial changes on tumor immune escape and immune cell function, and the research progress and challenges of novel anti-tumor immunotherapy strategies targeting mitochondria.
Review
Energy & Fuels
Shuyan Chen, Na Liu, Fan Xu, Guodan Wei
Summary: This review comprehensively presents and discusses the research status, main challenges, and possible strategies to overcome the instability issues in perovskite solar cells (PSCs) from four main perspectives: perovskite, charge transport materials, electrodes, and encapsulations. The review also summarizes related testing standards and scalable fabrications to provide essential guidance toward future stable perovskite photovoltaics.
Review
Chemistry, Medicinal
Xin Sun, Guiqin Ye, Yuanyuan Mai, Yuhan Shu, Lei Wang, Jianbin Zhang
Summary: The role of PARKIN in Parkinson's disease is well understood, but its recent emerging role in cancer has brought new insights. PARKIN acts as a tumor suppressor in many cancers, but its tumor-suppressive function is compromised due to loss of heterozygosity and DNA copy number variations. This viewpoint suggests that PARKIN exerts its anti-cancer activity by targeting mitochondria, which play a crucial role in various signaling pathways and biological processes. Future studies in this area may lead to novel therapeutic targets and strategies for cancer therapy.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Wioleta M. Zelek, Paul Morgan
Summary: This article summarizes the role of complement in neurodegenerative diseases and makes a case for testing anti-complement drugs. It also discusses how drugs can be modified or designed to inhibit complement in neurodegeneration.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Benjamin H. Jenkins, Josephine F. Buckingham, Christopher J. Hanley, Gareth J. Thomas
Summary: Cancer-associated fibroblasts (CAFs) are common cells in the tumor microenvironment with diverse tumor-promoting functions. Precise characterization of CAFs and the development of therapeutic strategies are of great importance.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Plant Sciences
Zhixi Tian, Jia-Wei Wang, Jiayang Li, Bin Han
Summary: Crop production is facing unprecedented challenges due to booming world population, land scarcity, and climate change. Future crop design projects aim to ensure food and ecosystem security by using cutting-edge technologies to rapidly design customized crops, focusing on improving current well-cultivated crops and utilizing omics tools, genome editing, and synthetic biology approaches to achieve ambitious goals.
Review
Pharmacology & Pharmacy
Qing Li, Changying Xing, Yanggang Yuan
Summary: Chronic kidney disease is a global public health issue, and patients often seek traditional Chinese medicine as an alternative treatment option. Mitochondrial dysfunction plays a crucial role in CKD, and herbal medicine can alleviate renal injury by restoring mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yan Zhao, Yuansong Bai, Meili Shen, Yapeng Li
Summary: Gastric cancer is a highly prevalent and lethal malignancy, and immunotherapy has shown survival benefits for GC patients. Targeted immune cells have emerged as a promising therapeutic strategy in the field of oncology. This review discusses the role and significance of immune cells in the tumor microenvironment of GC and summarizes the current landscape of immunotherapy, including immune checkpoint inhibitors and adoptive cell therapy. While more clinical data is needed, targeting immune cells provides a new direction for GC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Studies
Bishwambhar Mishra, Sunita Varjani, Gopalakrishnan Kumar, Mukesh Kumar Awasthi, Sanjeev Kumar Awasthi, Raveendran Sindhu, Parameswaran Binod, Eldon R. Rene, Zengqiang Zhang
Summary: This paper discusses the environmental pollution issues caused by Persistent organic pollutants (POPs) and the importance of bioremediation, highlighting the helpfulness of scientific knowledge on microbial interactions with pollutants in alleviating environmental pollution. It proposes the development of new bioremediation methods and discusses the applications of microbial analysis and electrochemical technologies for pollutant remediation in polluted sites.
ENERGY & ENVIRONMENT
(2021)
Review
Pharmacology & Pharmacy
Takashi Nakamura, Yusuke Sato, Yuma Yamada, Mahmoud M. Abd Elwakil, Seigo Kimura, Mahmoud A. Younis, Hideyoshi Harashima
Summary: This review summarizes the new era of nanomedicines in nucleic acids/gene therapy and discusses the possibilities and expectations of extrahepatic delivery. Passive targeting, active targeting, and controlled intracellular trafficking are important factors for successful therapeutic results. Additionally, mitochondrial delivery is introduced as a novel strategy to expand the therapeutic dimension of nucleic acids/gene therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Immunology
Yann Saint-Georges-Chaumet, Marvin Edeas
PATHOGENS AND DISEASE
(2016)
Article
Hematology
Pierre-Yves Durand, Carole Nicco, Didier Serteyn, David Attaf, Marvin Edeas
BLOOD PURIFICATION
(2018)
Review
Food Science & Technology
Francesco Visioli, Catalina Alarcon-de-la-Lastra, Cristina Andres-Lacueva, Michael Aviram, Conceicao Calhau, Alfredo Cassano, Massimo D'Archivio, Ana Faria, Gaelle Fave, Vincenzo Fogliano, Rafael Llorach, Paola Vitaglione, Mario Zoratti, Marvin Edeas
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2011)
Editorial Material
Food Science & Technology
Andreas Schieber, Marvin Edeas
FOOD RESEARCH INTERNATIONAL
(2014)
Editorial Material
Pathology
M. Edeas, L. Robert
PATHOLOGIE BIOLOGIE
(2010)
Article
Chemistry, Multidisciplinary
Marvin Edeas
PHARMACEUTICAL RESEARCH
(2011)
Article
Infectious Diseases
Marvin Edeas, Jumana Saleh, Carole Peyssonnaux
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Cell Biology
Jumana Saleh, Carole Peyssonnaux, Keshav K. Singh, Marvin Edeas
Review
Food Science & Technology
Hiba N. Rajha, Armelle Paule, Gerard Aragones, Mariana Barbosa, Carla Caddeo, Esperance Debs, Rada Dinkova, Gunter P. Eckert, Ariel Fontana, Prisca Gebrayel, Richard G. Maroun, Alessandra Napolitano, Lucia Panzella, Giulio Maria Pasinetti, Jan F. Stevens, Andreas Schieber, Marvin Edeas
Summary: Polyphenols have attracted researchers from various disciplines due to their diverse biological activities. The latest scientific research has focused on polyphenol interactions with the microbiome and mitochondria, as well as their potential applications in cosmetics, dietary supplements, and functional foods. Polyphenols may play a key role in disease prevention and have promising prospects in future food and nutrition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Infectious Diseases
Catherine Claise, Jumana Saleh, Marwa Rezek, Sophie Vaulont, Carole Peyssonnaux, Marvin Edeas
Summary: The study found that severe COVID-19 patients have low serum iron levels and high ferritin levels. Transferrin is strongly associated with the inflammatory and immune state of the disease and can be used as a predictor of disease severity and progression.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Medicine, Research & Experimental
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra, Marcin Ufnal, Romain Villeger, Chantal Pichon, Peter Konturek, Marvin Edeas
Summary: The human gastrointestinal tract is home to a large microbial community called gut microbiota, which plays important roles in immune function, nutrient absorption, and protection against pathogens. The interaction between gut microbiota and various organs within the human body is bidirectional, and microbial alteration has been shown to be a key factor in the pathogenesis of many diseases. Understanding the mechanisms behind gut microbial symbiosis/dysbiosis is crucial for clinical and health fields.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yasmeen Daou, Marion Falabregue, Charareh Pourzand, Carole Peyssonnaux, Marvin Edeas
Summary: This article discusses the impact of extracellular vesicles (EVs) on iron metabolism and homeostasis, as well as the role of gut microbiota in iron homeostasis, suggesting that EVs play a crucial role in the complex iron metabolism process.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, Research & Experimental
Carole Nicco, Armelle Paule, Peter Konturek, Marvin Edeas
Article
Biochemistry & Molecular Biology
Y. Saint-Georges-Chaumet, D. Attaf, E. Pelletier, M. Edeas
CELLULAR AND MOLECULAR BIOLOGY
(2015)
