期刊
MITOCHONDRION
卷 12, 期 4, 页码 441-448出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2012.05.005
关键词
ATAD3A; ATAD3; HSP60; Stem cells; Mitochondria; Glioma
资金
- Association contre le Cancer [ARC-SFI20101201517]
Here we report on the identification of a human pluripotent embryonic stem cell (hESC) specific mitochondrial protein that is re-expressed in cancer cells, ATAD3B. ATAD3B belongs to the AAA+ATPase ATAD3 protein family of mitochondrial proteins specific to multicellular eukaryotes. Using loss- and gain-of-function approaches, we show that ATAD3B associates with the ubiquitous ATAD3A species, negatively regulates the interaction of ATAD3A with matrix nucleoid complexes and contributes to a mitochondria fragmentation phenotype. We conclude that ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in hESCs and cancer cells. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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