期刊
MINIMALLY INVASIVE NEUROSURGERY
卷 52, 期 1, 页码 17-24出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1104566
关键词
blood oxygen level-dependent functional magnetic resonance imaging; primary brain tumours; image-guided surgery; neuronavigation; functional magnetic resonance imaging
Objective: The aims of this Study of patients with high-grade gliomas in eloquent brain areas were 1) to assess the postoperative functional outcome, 2) to determine the extent of tumour resection in these difficult locations, 3) to evaluate the practical usefulness of navigated blood oxygenation level-dependent functional magnetic resonance imaging and diffusion tensor tractography. Patients and Methods: 25 consecutive patients were included in the study. The patients' gross functional neurological status was determined using the 7-step modified Rankin scale. The extent of tumour resection was determined using pre- and postoperative T(1)-weighted or T(1)-weighted, contrast-enhanced MRI images. Results: The average preoperative modified Rankin scale was 1.56 +/- 0.77, whereas the average postoperative modified Rankin scale was 1.08 +/- 1.29. There was a significant improvement in mean modified Rankin scale score after Surgery. The mean percentage of residual tumour was calculated to 16 +/- 22% of the original tumour Volume (median 8%). Blood oxygenation level-dependent functional magnetic resonance imaging and diffusion tensor tractography were performed in 23 and 18 patients, respectively. Blood oxygenation level-dependent functional magnetic resonance imaging and diffusion tensor tractography facilitated identification of probable functional regions in 91% and 94% of the respective investigations. Conclusion: We feel that the combination of blood oxygenation level-dependent functional magnetic resonance imaging, diffusion tensor tractography, and 3D ultrasound facilitated maximal tumour resection with minimal deficits. The method permits an image-based functional monitoring of the brain during surgery that may aid the preservation of motor and language function.
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