期刊
MINI-REVIEWS IN ORGANIC CHEMISTRY
卷 10, 期 2, 页码 198-206出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570193X11310020008
关键词
Titanium catalyst; asymmetric catalysis; sulfide oxidation; chiral sulfoxides; chiral drugs
资金
- Chengdu University of Technology
Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogen-containing sulfide precursors than other catalysts. The ligands of these titanium catalysts have tartarate, BINOL and other diols, salens and others. Proton pump inhibitors, anti-inflammatory drugs, anti-cancer drugs, antibiotics, platelet adhesion inhibitors, antipsychotic drugs, lipid regulators, potassium channel openers, neurokinin inhibitors and so on are valuable chiral sulfoxide drugs. The research advances of synthesis of various chiral sulfoxide drugs catalyzed by titanium are described in this review.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据