Review
Biology
Giovannamaria Petrocelli, Pasquale Marrazzo, Laura Bonsi, Federica Facchin, Francesco Alviano, Silvia Canaider
Summary: Phytochemicals from medicinal plants have antioxidant properties and anti-cancer effects. Some of these compounds show anti-inflammatory effects, including naphthoquinones. Plumbagin, a plant-derived naphthoquinone, has shown potential anti-inflammatory effects, but further scientific research is needed to fully understand its beneficial effects and potential as a drug against human diseases.
Article
Biochemistry & Molecular Biology
Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb
Summary: This study evaluated the antioxidant, anti-inflammatory, and anti-arthritic activities of Coronopus didymus. The extracts showed significant free radical scavenging activity and inhibited protein denaturation, as well as reducing inflammation and edema in arthritic rats. The extracts also had positive effects on blood parameters and oxidative stress biomarkers. These activities may be attributed to the presence of quercetin, ferulic acid, dihydromyricetin, apigenin, vitexin, and kaempferol in the extracts.
Article
Pharmacology & Pharmacy
Hua Fan, Qianqian Bai, Yang Yang, Xiaofei Shi, Ganqin Du, Junqiang Yan, Jian Shi, Dongmei Wang
Summary: Aberrant innate immunity in the brain is associated with several CNS disorders. Microglia, the main immune cells in the CNS, and endogenous antioxidant systems play important roles in regulating neuroinflammation. Sulfur-containing compounds that modulate these systems may have therapeutic potential for neuroinflammation-related diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guya Diletta Marconi, Ylenia Della Rocca, Luigia Fonticoli, Simone Guarnieri, Simone Carradori, Thangavelu Soundara Rajan, Jacopo Pizzicannella, Francesca Diomede
Summary: This study investigated the protective role of carvacrol (CAR) in the inflammatory process by modulating the TLR4/NF kappa B/NALP3/IL-1 beta pathway and ROS production. CAR demonstrated significant anti-inflammatory effects by reducing TLR4, NF kappa B, NALP3, and IL-1 beta expression, and also showed protective effects against ROS. CAR could potentially be used as a therapeutic agent against inflammatory stimuli.
Review
Biochemistry & Molecular Biology
Camila dos Santos Leite, Gabriel Alves Bonafe, Juliana Carvalho Santos, Carlos Augusto Real Martinez, Manoela Marques Ortega, Marcelo Lima Ribeiro
Summary: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), pose a significant health burden globally. Licorice, a traditional Chinese medicine, exhibits anti-inflammatory and antioxidant properties that may have therapeutic potential for intestinal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yamei Li, Yifang Yang, Xingdong Kang, Xiaofeng Li, Yongzhong Wu, Junping Xiao, Yang Ye, Jianqiong Yang, Yang Yang, Hai Liu
Summary: This study established a method for rapid screening of potential anti-inflammatory active ingredients from Callicarpa nudiflora. The fingerprint of C. nudiflora extracts was established using high-performance liquid chromatography. The anti-inflammatory activity of C. nudiflora extracts was evaluated, and a group of potential anti-inflammatory compounds were identified through spectral-effect relationship analysis. The study found that some compounds in C. nudiflora have significant anti-inflammatory potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Laura Gambari, Antonella Cellamare, Francesco Grassi, Brunella Grigolo, Alessandro Panciera, Alberto Ruffilli, Cesare Faldini, Giovanna Desando
Summary: Knee osteoarthritis (OA) is a joint disorder characterized by degenerative and inflammatory processes. Bioactive dietary molecules (BDMs), especially polyphenols (PPs), have shown potential in targeting inflammation and pain. However, there are still limitations in terms of biosafety and bioavailability that need to be addressed before their clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Carlos Barba-Ostria, Saskya E. Carrera-Pacheco, Rebeca Gonzalez-Pastor, Jorge Heredia-Moya, Arianna Mayorga-Ramos, Cristina Rodriguez-Polit, Johana Zuniga-Miranda, Benjamin Arias-Almeida, Linda P. Guaman
Summary: Natural compounds with diverse structures are important for the food, cosmetic, and pharmaceutical industries. Understanding their structure, concentrations, and biological activity potential is essential for their application. New methodologies have emerged to overcome the limitations of traditional techniques and expand the analysis capacity of biomolecules.
Article
Biochemistry & Molecular Biology
Achille Parfait Nwakiban Atchan, Orissa Charlene Monthe, Armelle Deutou Tchamgoue, Yeshvanthi Singh, Shilpa Talkad Shivashankara, Moorthy Karthika Selvi, Gabriel Agbor Agbor, Paolo Magni, Stefano Piazza, Uma Venkateswaran Manjappara, Jules-Roger Kuiate, Mario Dell'Agli
Summary: This study characterized four Cameroonian spice extracts and investigated their antioxidant and synergistic anti-inflammatory activities in human gastric adenocarcinoma cells. The extracts showed high amounts of phenolic and flavonoid compounds with antioxidant properties, and their combination exerted synergistic effects on inflammatory markers in gastric epithelial cells.
Review
Biochemistry & Molecular Biology
Erick Poulsen-Silva, Felipe Gordillo-Fuenzalida, Patricia Velasquez, Felipe M. Llancalahuen, Rodrigo Carvajal, Mauricio Cabana-Brunod, Maria Carolina Otero
Summary: Honey is a highly appreciated mixture of compounds produced by bees, with multiple uses and potential nutritional and healing properties. This article focuses on the biological properties of different types of honey from Chile, specifically their antimicrobial, antioxidant, and anti-inflammatory activities. The review highlights the remarkable bioactive properties of Chilean honey, particularly its antimicrobial and antioxidant activities, with limited research on its anti-inflammatory effects. These properties are attributed to the presence of various bioactive components, such as phenolic compounds, hydrogen peroxide, enzymes, proteins, and carbohydrates. The biodiversity and environmental conditions of Chile contribute to the diverse bioactive compounds and biological properties found in Chilean honey. Further research is needed to explore the medicinal potential of these native honeys.
Article
Chemistry, Multidisciplinary
Yun-Mi Kang, Jeonghoon Lee, Wonnam Kim, Jong-Sik Jin, Jong-Hyun Lee, Hyo-Jin An
Summary: Wongam, a novel variety of Glycyrrhiza developed by the Korea Rural Development Administration, shows anti-allergic inflammatory effects by reducing mortality and serum IgE levels in a compound-48/80-induced anaphylaxis mouse model, as well as downregulating proinflammatory cytokines and chemokines. Wongam also decreases histamine release and proinflammatory cytokine expression in HMC-1 and RBL-2H3 cells, while downregulating chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells through the inhibition of the MAPK and NF-kappa B signaling pathways.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Won Young Jang, Mi-Yeon Kim, Jae Youl Cho
Summary: Lignans, plant compounds with anti-inflammatory and antioxidant activities, have potential therapeutic value in modulating chronic inflammation and treating various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Nadjat Righi, Sabah Boumerfeg, Amirouche Deghima, Pedro A. R. Fernandes, Elisabete Coelho, Faiza Baali, Susana M. Cardoso, Manuel A. Coimbra, Abderrahmane Baghiani
Summary: The hydromethanolic extract of Salvia verbenaca showed strong antioxidant and anti-inflammatory activities both in vitro and in vivo, with no acute/subacute toxicity effects on mice. This indicates its potential as a safe and effective option for wound healing and anti-ulcer treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Long Li, Yu Zhu, Ying-Guang Huang, De-Zhi Hou, Mohamed Samir, Abulqasim M. Sideeg, Heitham Mohammed, Attalla F. El-kott, A. Fatimah, Ping Ling
Summary: This study investigated the effects of natural compounds on cancer cells and enzymes, and evaluated their interactions with receptor proteins through molecular docking calculations. The results showed that these compounds have potential anticancer and antidiabetic properties.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Immunology
Sepide Behrouz, Saeideh Saadat, Arghavan Memarzia, Hadi Sarir, Gert Folkerts, Mohammad Hossein Boskabady
Summary: Camel milk has various health benefits and has the potential to treat diseases caused by inflammation, oxidative stress, and immune dysregulation. Its bioactive components, including lactoferrin, alpha-lactalbumin, beta-caseins, and vitamin C, contribute to its therapeutic properties.
FRONTIERS IN IMMUNOLOGY
(2022)