Review
Chemistry, Multidisciplinary
Ryan Holman, Orane Lorton, Pauline C. Guillemin, Stephane Desgranges, Christiane Contino-Pepin, Rares Salomir
Summary: Perfluorocarbon emulsions have various applications in medical imaging. They can be used in different radiological imaging modalities including magnetic resonance imaging, ultrasonography, computed tomography, and positron emission tomography. Recently, they have gained interest for both imaging and therapeutic purposes. With improvements in MRI sequences and increased availability of F-19-MRI coils, perfluorocarbon emulsions have great potential as new commercial imaging agents. This review discusses the chemistry and physics of these contrast agents and highlights past, recent, and potential applications.
FRONTIERS IN CHEMISTRY
(2022)
Review
Medicine, General & Internal
Xin Zhou, Meng Yang, Jing Jin, Jie Chen, Zhi Li
Summary: Periplaneta americana extracts have a wide range of therapeutic activities, including antifibrotic, anti-inflammatory, antioxidative, and tissue repair effects. It may have potential therapeutic options for scar, pulmonary fibrosis, liver fibrosis, and kidney fibrosis. However, further research is needed to investigate the antifibrogenic mechanism before its clinical application in treating organ fibrosis.
Article
Chemistry, Organic
Kuldeep Singh Bhati, Riya Nagar, Bhanwar Kumar Malviya, Monika Shukla, Amanpreet Kaur Jassal, Ved Prakash Verma, Dinesh Kumar Yadav, Neetu Kumari, Siddharth Sharma
Summary: A novel electrochemical method for the synthesis of thiol-functionalized 2H-indazoles has been reported. This method does not require catalysts, oxidants, or metals, and only produces harmless hydrogen as a byproduct. By using a graphite/Ni flow cell under continuous electrochemical flow conditions, gram-scale production of 3-(arylthio)-2H-indazole compounds can be achieved in a short residence time of 39 minutes. Detailed mechanistic studies, including control experiments and cyclic voltammetry, support the presence of a radical-radical cross-coupling pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Kelin Wang, Xia Song, Yongdi Xin, Xinying Zhang, Xuesen Fan
Summary: In this study, a condition-controlled selective synthesis of pyranone-tethered indazoles or carbazole derivatives was achieved via cascading reactions of N-nitrosoanilines with iodonium ylides. The formation mechanisms of the products were elucidated, and the developed protocols demonstrated easily controllable selectivity, mild reaction conditions, a clean and sustainable oxidant (air), and structurally diverse valuable products. Furthermore, the utility of the products was showcased by their facile and diverse transformations into synthetically and biologically interesting compounds.
Article
Chemistry, Organic
Manzhu Zhao, Haiyan Yuan, Jingping Zhang
Summary: Computational studies revealed that the Pd-II-π-allyl coordinated mechanism is the most preferred pathway in the Pd-catalyzed regiodivergent coupling reaction of indazoles and isoprene. The regioselectivity of 1,2-insertion is influenced by the noncovalent interactions between the less bulky ligand L1, substrates, and (PhO)2PO2-. On the other hand, the regioselectivity of 4,3-insertion is primarily controlled by the steric repulsion of the t-Bu group of the bulky ligand L2 and substrate, as well as the geometry distortion. Similarly, the nucleophilic site selectivity at N-1 or N-2 of indazoles is determined by the cooperative effect of acid BF3 and solvent (PrOH)-Pr-i.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Energy & Fuels
Xinan Yan, Jun Huang, Limin Guo, Chuntai Liu, Shaojun Dong, Zhangquan Peng
Summary: Various advanced characterization technologies have been employed to understand and improve the electrochemical performance of aprotic lithium-oxygen batteries, with isotope labeling proving to be a particularly powerful technique. This review focuses on the current understanding of reactions and chemistry in Li-O-2 batteries using isotope-labeling techniques, emphasizing the formation mechanism of product species and identification of reaction interfaces. The authors call for isotope-labeling-related kinetic analysis to clarify remaining controversial issues.
Review
Environmental Sciences
Shaochun Yuan, Min Wang, Bo Lv, Jinhua Wang
Summary: The environmental presence and ecological risks of chlorinated paraffins, including short-chain and medium-chain CPs, have been receiving increasing attention worldwide. Various transformation pathways and products of CPs in the environment, with dechlorination considered as the major reaction pathway, were evaluated. Additionally, the significant environmental impacts of waste incineration of CPs were highlighted.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Organic
Saikumar Banda, Alexander Villinger, Malte Brasholz
Summary: The dihydroazepino[1,2-a]indole diones 3 can be easily synthesized by catalytic photooxygenation of cyclohepta[b]indoles 1 followed by dehydration. A Lewis acid-catalyzed oxa Diels-Alder reaction of enones 3 with enol ethers 4 has been developed, leading to the formation of novel tetracyclic azepane-fused pyrano[3,2-b]indoles 5 with high stereoselectivity under mild reaction conditions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Debabrata Chatterjee, Olga Impert, Rudi van Eldik
Summary: The nitrogen cycle is a critical biogeochemical cycle involving redox conversions, such as nitrogen fixation and nitrification/denitrification pathways. This review focuses on the application of Ru(edta) complexes in electrochemical transformations related to the nitrogen cycle, providing mechanistic insights into their roles in nitrogen fixation and denitrification reactions.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Maurycy Prystupa, Tilo Sohnel, Jonathan Sperry
Summary: The deacetylation of a diacetoxytetraindole led to unexpected results in the synthetic route towards the alkaloid bisindigotin, forming novel nine-ring heteroaromatic scaffolds. Acid-mediated hydrolysis triggered skeletal rearrangement, while treatment with base and silica-mediated autoxidation generated another novel nine-ring scaffold through a distinct cascade process. Mechanistic rationale for these observations was provided.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Sandip Kumar Baidya, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinases (MMPs) play roles in various pathological and physiological functions, with gelatinases as therapeutic targets against cancer. Although gelatinase inhibitors have shown effectiveness in several diseases, developing them as therapeutic agents is a challenging task. Various studies and patents have been ongoing to expand knowledge and develop better gelatinase inhibitors in recent years.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Organic
Bendi Anjaneyulu, Sangeeta, Naina Saini
Summary: Natural compound camphor, found in two enantiomeric forms, R and S, is widely utilized in medicinal chemistry for the synthesis of biologically active substances. Its chirality and affordable cost make it a valuable starting material for various derivatives with antimicrobial, antiviral, antioxidant, analgesic, and anti-cancer properties. Commercially available camphor derivatives, like camphor sulfonic acid, can be easily produced from camphor, making it a versatile compound for applications in drug development.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Qian Cheng, Fangyi Li, Xiaohui Yan, Jingtao He, Hongmei Zhang, Chunhua Wang, Yongzhi He, Zheng Li
Summary: There are only 3 plants in the genus Arcangelisia used as folk medicines by local residents. The main compounds are alkaloids with berberine analogues, showing a wide range of pharmacological activities. This review aims to compile the phytochemical progress and bring attention from researchers for further study to find new active compounds.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
News Item
Multidisciplinary Sciences
Amber Dance
Summary: A team led by a Nobel-prizewinning scientist has made significant progress in reconstructing early-Earth RNA capable of protein synthesis.
Article
Chemistry, Multidisciplinary
Suvam Bhattacharjee, Sudip Laru, Alakananda Hajra
Summary: A new, efficient, and metal-free protocol has been developed for the remote difunctionalization of unreactive C-H bonds at the benzene core of 2H-indazole by using Koser's reagents as sulfonyloxylating and iodinating agents. This methodology provides easy access to C-4-sulfonyloxylated and C-7-iodinated 2H-indazole derivatives with high regioselectivity, wide functional group tolerance, and broad substrate scope in good to excellent yields, leading to the formation of 4,7 disubstituted 2H-indazoles which serve as precursors for various C-4,7-functionalized 2H-indazoles through simple transformations.
CHEMICAL COMMUNICATIONS
(2022)
