Article
Pharmacology & Pharmacy
Annamaria Fidilio, Margherita Grasso, Rita Turnaturi, Giuseppe Caruso, Federica Maria Spitale, Nunzio Vicario, Rosalba Parenti, Salvatore Spoto, Nicolo Musso, Agostino Marrazzo, Santina Chiechio, Filippo Caraci, Lorella Pasquinucci, Carmela Parenti
Summary: The study suggests that LP2, a dual-target MOPr/DOPr agonist, can attenuate mechanical allodynia induced by CCI through rescuing TGF-beta 1 signaling via DOPr activation in spinal microglia. The dual-target approach with LP2 may represent a novel pharmacological strategy to enhance the analgesic efficacy of MOPr agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Gianfranco Balboni, Olga Pol
Summary: Recent studies have shown that hydrogen sulfide (H2S) enhances the analgesic effects of the delta-opioid receptor (DOR) in inflammatory pain. It is still unknown whether two slow-releasing H2S donors, DADS and GYY4137, can improve the analgesic effects of mu-opioid receptor (MOR) and DOR agonists on neuropathic pain. This study found that both DADS and GYY4137 improved the antiallodynic effects of MOR and DOR agonists, possibly by up-regulating MOR and DOR expression in the dorsal root ganglia.
Article
Biology
Kieran A. Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C. Dickie, Andrew H. Cooper, Andrew M. Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I. Hughes, Gregory A. Weir, John S. Riddell, Andrew J. Todd
Summary: This study investigates the role of interneurons that continue to express neuropeptide Y (NPY-INs) in the adult mouse spinal cord. The findings suggest that activation of NPY-INs reduces acute pain and pruritogen-evoked itch, while silencing them causes exaggerated itch responses. Silencing another population of inhibitory interneurons also increases itch, but to a lesser extent.
Review
Anesthesiology
Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern, Danielle M. Santarelli
Summary: Ambroxol is a versatile drug with multiple therapeutic actions, including mucoactive, secretolytic, anti-inflammatory, antioxidant, and local anesthetic properties. It has a long history of use in respiratory diseases and has shown efficacy in relieving sore throat. Recent research has focused on its potential for neuropathic pain treatment, despite slow progress. Ambroxol is an inhibitor of Na(v)1.8, an important player in neuropathic pain, and Na(v)1.7, a promising target for chronic pain treatment. This review discusses its analgesic mechanisms, synergistic properties, preclinical and clinical results in managing persistent pain and neuropathic pain symptoms. It is a safe drug with extensive data, encouraging further investigation for repurposing, and urging the pharmaceutical industry to develop optimized formulations for neuropathic pain.
Review
Clinical Neurology
Johnny P. Tran, Storm Horine
Summary: This paper discusses the role of ss2-agonists as adjunctive therapy for chronic pain based on current literature. Recent studies have shown the significant role of the ss2-adrenergic system in the analgesic properties of antidepressant drugs used to treat neuropathic pain.
CURRENT PAIN AND HEADACHE REPORTS
(2022)
Article
Multidisciplinary Sciences
Zheng Gan, Vijayan Gangadharan, Sheng Liu, Christoph Koerber, Linette Liqi Tan, Han Li, Manfred Josef Oswald, Juhyun Kang, Jesus Martin-Cortecero, Deepitha Maennich, Alexander Groh, Thomas Kuner, Sebastian Wieland, Rohini Kuner
Summary: The primary motor cortex (M1) regulates the sensory and aversive-emotional components of neuropathic pain through distinct pathways, offering potential for pain relief.
Article
Multidisciplinary Sciences
Christopher R. Donnelly, Changyu Jiang, Amanda S. Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S. Lee, Yu L. Lei, William Maixner, Mei-Chuan Ko, Ru-Rong Ji
Summary: STING is a critical immune regulator that induces type-I interferons and other cytokines to promote immune-cell-mediated clearance of pathogens and neoplastic cells. STING also plays a role in antitumour immunity and has potential as a target for cancer immunotherapy. Additionally, STING is shown to regulate nociception through IFN-I signaling, leading to pain relief in mice and non-human primates.
Article
Anesthesiology
Mimmi Gillving, Dyveke Demant, Jakob V. Holbech, Sandra Sif Gylfadottir, Flemming W. Bach, Troels S. Jensen, Nanna B. Finnerup, Soren H. Sindrup
Summary: The experimental study found that the beta(2)-agonist terbutaline had no effect on painful polyneuropathy, while imipramine showed improvement in secondary outcomes.
Article
Biochemistry & Molecular Biology
Eun Yeong Lim, Changho Lee, Yun Tai Kim
Summary: This study examined the antinociceptive efficacy and mechanism of Camellia japonica leaf extract (CJE) in neuropathic pain models. The results suggest that CJE and its active components may have potential antinociceptive effects against neuropathic pain by activating MAPK in the DRG and microglia in the spinal cord.
Review
Medicine, Research & Experimental
Aditi Sharma, Tapan Behl, Lalit Sharma, Om Prakash Shah, Shivam Yadav, Monika Sachdeva, Summya Rashid, Simona Gabriela Bungau, Cristiana Bustea
Summary: Recently, there has been increasing focus on the chronic neuro-inflammatory condition causing neuropathic pain, characterized by thermal hyperalgesia and tactile allodynia, which results from injury or infection in the nervous system. Angiogenesis, chemokines, and cytokines play important roles in the pathophysiology of neuropathic pain, contributing to inflammation and detrimental effects. Various mechanisms, including VEGF signaling, Tie-1 and Tie-2 receptor signaling, and erythropoietin pathway promoting axonal growth, have been identified as potential targets for therapeutic interventions in neuropathic pain associated with angiogenesis. Synthetic and herbal treatments targeting angiogenesis in neuropathic pain have also been explored.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Mengmeng Zhou, Qingxiang Zhang, Mingzhu Huo, Huijun Song, Hongen Chang, Jiaojiao Cao, Yuxin Fang, Di Zhang
Summary: Nociceptive signaling responses to painful stimuli are transmitted to the central nervous system (CNS) from the afferent nerves of the periphery. Electroacupuncture (EA) is a widely used pain management strategy that can alleviate neuropathic pain in the CNS. This review discusses the mechanisms and pathways, such as serotonin/norepinephrine, endogenous opioid, endogenous cannabinoid, amino acid neurotransmitter, and purinergic pathways, through which EA can provide analgesic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Valeria Oliva, Rob Gregory, Wendy-Elizabeth Davies, Lee Harrison, Rosalyn Moran, Anthony E. Pickering, Jonathan C. W. Brooks
Summary: Pain can be alleviated by shifting attention elsewhere, and the brainstem regions including locus coeruleus, rostral ventromedial medulla, and periaqueductal grey are involved in attentional analgesia. Functional interactions between these regions and the cortex modulate nociceptive input to reduce pain, particularly in situations requiring conflicting attentional demands.
Review
Biology
Yuan-Yuan Tsai, Wei-Ting Wu, Der-Sheng Han, Kamal Mezian, Vincenzo Ricci, Levent Ozcakar, Po-Cheng Hsu, Ke-Vin Chang
Summary: Neuropathic pain has a negative impact on patients' quality of life, and rTMS has been increasingly used as a safe and non-invasive technique for treating this condition. However, the mechanism of rTMS is not well understood, and its efficacy in neuropathic pain treatment lacks sufficient evidence due to inconsistent results in different settings/parameters.
Article
Pharmacology & Pharmacy
Fangyu Du, Ruolin Cao, Lu Chen, Jianwen Sun, Yajie Shi, Yang Fu, Bruce D. Hammock, Zhonghui Zheng, Zhongbo Liu, Guoliang Chen
Summary: A new memantyl urea derivative, A20, was identified as a potent sEH inhibitor that can alleviate pain and improve the health status of rats, making it a promising candidate for the treatment of neuropathic pain.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Oncology
Morena Shkodra, Augusto Caraceni
Summary: This review discusses treatment approaches for neuropathic cancer pain caused by nerve damage due to the tumor. Diagnosing and treating neuropathic cancer pain remains difficult and evidence for the best treatments is limited. This review summarizes current management options and provides insights on new promising treatments for neuropathic cancer pain.
