Article
Endocrinology & Metabolism
Linda A. Jahn, Brent Logan, Kaitlin M. Love, William B. Horton, Natalie Z. Eichner, Lee M. Hartline, Arthur L. Weltman, Eugene J. Barrett
Summary: Arterial stiffness and endothelial dysfunction are reported in children with type 1 diabetes and may predict future cardiovascular events. Impairment of NO-dependent macro- and microvascular function is observed in DM1 patients early in the disease course, preceding increases in arterial stiffness.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Medicine, General & Internal
Erica Rocco, Maria Chiara Grimaldi, Alessandro Maino, Luigi Cappannoli, Daniela Pedicino, Giovanna Liuzzo, Luigi Marzio Biasucci
Summary: Coronary microvascular dysfunction (CMD) is often underdiagnosed and its clinical importance underestimated, with invasive and expensive techniques currently used for measurement. Research on potential biomarkers linked to microvascular dysfunction could improve diagnosis, risk stratification, disease progression, and therapy response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jerremy Weerts, Sanne G. J. Mourmans, Arantxa Barandiaran Aizpurua, Blanche L. M. Schroen, Christian Knackstedt, Etto Eringa, Alfons J. H. M. Houben, Vanessa P. M. van Empel
Summary: Heart failure with preserved ejection fraction (HFpEF) is a disease with increasing incidence and no effective treatment. Coronary microvascular dysfunction plays a key role in the pathophysiology of HFpEF, possibly due to a low-grade pro-inflammatory state caused by systemic comorbidities. The presence or absence of peripheral microvascular dysfunction in HFpEF may reflect whether it is predominantly a cardiac or a systemic disease.
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Giuseppe Loffredo, Luca Rinaldi, Christian Catalini, Klodian Gjeloshi, Gaetana Albanese, Anna Di Martino, Giovanni Docimo, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic patients are often affected by coronary microvascular dysfunction, a complex condition whose pathogenesis involves hyperglycemia and insulin resistance. This dysfunction contributes to cardiac events and heart failure, and no specific treatment exists. However, certain antidiabetic drugs may have protective effects.
Article
Biochemistry & Molecular Biology
Karen Axelgaard Lorentzen, Raquel Hernanz, Estefano Pinilla, Jens Randel Nyengaard, Lise Wogensen, Ulf Simonsen
Summary: Diabetic macroangiopathy is characterized by extracellular matrix deposition, vessel thickening, and endothelial dysfunction. The overexpression of hyaluronan in the tunica media was found to induce endothelial dysfunction, oxidative stress, and increased EC-EC distances in the aortas of male mice. These findings suggest a sex-specific decrease in NO levels and impaired endothelial function in male mice with excessive hyaluronan accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Javier Marques, Joaquin Fernandez-Irigoyen, Elena Ainzua, Maria Martinez-Azcona, Adriana Cortes, Carmen Roncal, Josune Orbe, Enrique Santamaria, Guillermo Zalba
Summary: NADPH oxidases (NOX) are the main source of reactive oxygen species (ROS) in blood vessels. NOX5, the latest member of the NOX family, plays a role in endothelial dysfunction and the onset of cardiovascular diseases. Overexpression of NOX5 inhibits cell proliferation, promotes apoptosis, alters metabolism, and increases cell migration in endothelial cells.
Article
Biochemistry & Molecular Biology
Fabio Bertani, Dalila Di Francesco, Maria Dolores Corrado, Maria Talmon, Luigia Grazia Fresu, Francesca Boccafoschi
Summary: Cardiovascular diseases, including ischemic heart disease and stroke, are the leading cause of global mortality, with almost all sharing a common feature of endothelial dysfunction. Research suggests that ECs stimulated at low shear stress may be involved in paracrine induction of peripheral endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zheyi Yan, Xiaoming Cao, Chunfang Wang, Sha Liu, Yanjie Li, Gan Lu, Wenjun Yan, Rui Guo, Dajun Zhao, Jimin Cao, Yong Xu
Summary: CTRP3 improves vasodilation of microvasculature in diabetes by enhancing endothelial cell function through the AMPK/eNOS/NO. signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Cell Biology
Fujie Zhao, Ganesh Satyanarayana, Zheng Zhang, Jianli Zhao, Xin-Liang Ma, Yajing Wang
Summary: Coronary microvascular dysfunction is a type of abnormality in coronary microcirculation that leads to impaired coronary blood flow and myocardial ischemia, associated with various cardiovascular diseases. Insufficient or uncontrolled activation of endothelial autophagy plays a significant role in the pathogenesis of CMD.
Article
Immunology
Changcheng Zhou, Jiani Bei, Yuan Qiu, Qing Chang, Emmanuel Nyong, Nikos Vasilakis, Jun Yang, Balaji Krishnan, Kamil Khanipov, Yang Jin, Xiang Fang, Angelo Gaitas, Bin Gong
Summary: Spotted fever group rickettsioses caused by Rickettsia (R) can induce lethal endothelial cell barrier dysfunction. Exosomes derived from infected endothelial cells can impair the barrier function of normal recipient cells by delivering miR23a, which targets the TJ protein ZO-1 mRNA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Priya Balasubramanian, Tamas Kiss, Stefano Tarantini, Adam Nyul-Toth, Chetan Ahire, Andriy Yabluchanskiy, Tamas Csipo, Agnes Lipecz, Adam Tabak, Adam Institoris, Anna Csiszar, Zoltan Ungvari
Summary: Over two-thirds of individuals aged 65 and older in the United States are obese or overweight, with an association between adiposity and cognitive dysfunction. This review discusses the pathophysiological roles of microvascular mechanisms in cognitive impairment in geriatric obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Camila B. Vidigal, Kawane F. Moura, Tiago J. Costa, Lorena Borges, Pedro M. M. Figaro, Ingrid C. Pinto, Fabio G. de Andrade, Daniela C. C. Gerardin, Rubia Casagrande, Rita C. Tostes, Maria do Carmo Franco, Graziela S. Ceravolo
Summary: This study found that treatment with TPM during childhood leads to altered aortic reactivity in adult male and female rats. The mechanism underlying the vascular effects of TPM is sex-specific.
Article
Cardiac & Cardiovascular Systems
Rongjun Zou, Wanting Shi, Junxiong Qiu, Na Zhou, Na Du, Hao Zhou, Xinxin Chen, Li Ma
Summary: Empagliflozin can protect microvasculature during myocardial ischemia reperfusion injury (I/R) by inhibiting the DNA-PKcs/Fis1/mitochondrial fission pathway.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
James D. Theuerle, Ali H. Al-Fiadh, Fakir M. Amirul Islam, Sheila K. Patel, Louise M. Burrell, Tien Yin Wong, Omar Farouque
Summary: Assessing retinal microvascular endothelial dysfunction can predict long-term cardiovascular events. Retinal arteriolar dysfunction is an independent predictor of MACE in patients with CAD. Dynamic retinal vessel analysis may enhance risk stratification for cardiovascular events.
CARDIOVASCULAR RESEARCH
(2021)
Article
Critical Care Medicine
Binu Tharakan, Felicia A. Hunter, Saravanakumar Muthusamy, Sonya Randolph, Crystal Byrd, Veena N. Rao, E. Shyam P. Reddy, Ed W. Childs
Summary: This study determined the specific role of ERG in regulating microvascular permeability in human lung microvascular endothelial cells and evaluated the protective effect of exogenous ERG on barrier dysfunction. The results demonstrate that ERG is a potent regulator of barrier integrity and permeability, and enhancing ERG provides protection against barrier dysfunction and hyperpermeability.
Article
Obstetrics & Gynecology
L. H. A. da Silva, D. G. Panazzolo, M. Ferreira Marques, M. G. C. Souza, B. Dias Paredes, J. F. Nogueira Neto, L. M. C. S. M. Leao, V. Morandi, E. Bouskela, L. G. Kraemer-Aguiar
Article
Obstetrics & Gynecology
Diogo G. Panazzolo, Lucia H. A. da Silva, Priscila A. Maranhao, Maria G. C. Souza, Jose F. Nogueira Neto, Lenora M. C. S. M. Leao, Eliete Bouskela, Luiz G. Kraemer-Aguiar
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2016)
Article
Peripheral Vascular Disease
Priscila A. Maranhao, Maria das Gracas Coelho de Souza, Luiz Guilherme Kraemer-Aguiar, Eliete Bouskela
MICROVASCULAR RESEARCH
(2016)
Article
Multidisciplinary Sciences
Curt Treu, Maria das Gracas Coelho de Souza, Omar Lupi, Fernando Lencastre Sicuro, Priscila Alves Maranhao, Luiz Guilherme Kraemer-Aguiar, Eliete Bouskela
Article
Peripheral Vascular Disease
Wellington Santana da Silva Junior, Maria das Gracas Coelho de Souza, Jose Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
MICROVASCULAR RESEARCH
(2018)
Review
Medicine, General & Internal
Tassia Braga, Luiz G. Kraemer-Aguiar, Neil G. Docherty, Carel W. Le Roux
Article
Biotechnology & Applied Microbiology
Priscila Alves Maranhao, Maria das Gracas Coelho de Souza, Diogo Guarnieri Panazzolo, Jose Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Endocrinology & Metabolism
Wellington S. Silva Junior, Maria das Gracas C. Souza, Jose Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
JOURNAL OF DIABETES RESEARCH
(2019)
Article
Surgery
Tassia Gomide Braga, Maria das Gracas Coelho de Souza, Priscila Alves Maranhao, Michel Menezes, Ludmilla Dellatorre-Teixeira, Eliete Bouskela, Carel W. Le Roux, Luiz Guilherme Kraemer-Aguiar
Article
Surgery
Tassia Gomide Braga, Maria Das Gracas Coelho de Souza, Michel Menezes, Jose Firmino Nogueira Neto, Ludmilla Dellatorre-Teixeira, Eliete Bouskela, Carel W. le Roux, Luiz Guilherme Kraemer-Aguiar
Summary: The study found that bariatric surgery had a more significant impact on glucose metabolism, gut hormones, and inflammation, resulting in more extensive changes compared to medical treatment.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Medicine, General & Internal
Alessandra Schiappacassa, Priscila A. Maranhao, Maria das Gracas Coelho de Souza, Diogo G. Panazzolo, Jose Firmino Nogueira Neto, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Surgery
Eline Coan Romagna, Diogo Menezes Ferrazani Mattos, Karynne Grutter Lopes, Luiz Guilherme Kraemer-Aguiar
Summary: This study investigated alcohol use, depressive symptoms, and health-related quality of life (HRQoL) in post-bariatric patients without medical follow-up, and compared these results between different levels of weight regain (RWR) and correlated with surgical outcomes. The findings showed that patients with higher weight regain had poorer health scores in physical functioning, physical role limitations, bodily pain, and vitality. The RWR was inversely correlated to physical/social functioning and vitality in the low RWR group, while positively associated with depressive symptoms and negatively associated with physical functioning and general health perception in the high RWR group.
Article
Nutrition & Dietetics
Karynne Grutter Lopes, Maria das Gracas Coelho de Souza, Eliete Bouskela, Luiz Guilherme Kraemer-Aguiar
Summary: Weight loss after bariatric surgery improves vascular function and metabolic/inflammatory profiles, reducing cardiovascular mortality. However, the effects of weight regain on vascular health are not well understood. This study compared post-bariatric patients with high weight regain to non-surgical controls and found that despite similar vascular function, post-bariatric patients still retained some metabolic/inflammatory benefits.
Article
Endocrinology & Metabolism
Karynne Grutter Lopes, Vicente Lopes da Silva Junior, Fernanda de Azevedo Marques Lopes, Eliete Bouskela, Maria das Gracas Coelho de Souza, Luiz Guilherme Kraemer-Aguiar
Summary: In this study, the biological behavior of ghrelin and glucagon-like peptide-1 (GLP-1) after a standard liquid meal was investigated, and it was found that the changes in ghrelin and GLP-1 were not influenced by body adiposity and glucose homeostasis.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Psychiatry
Karynne Grutter Lopes, Gabriel Pires dos Santos, Eline Coan Romagna, Diogo Menezes Ferrazani Mattos, Tassia Gomide Braga, Carolina Bastos Cunha, Priscila Alves Maranhao, Luiz Guilherme Kraemer-Aguiar
Summary: Long-term changes in appetite and taste were frequent among post-bariatric surgery patients. Different surgery types did not significantly affect sensory changes, with lower rate of weight regain associated with more taste and smell changes. Shorter time since surgery was linked to more frequent changes in appetite, taste, and smell.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)