Review
Biochemistry & Molecular Biology
Ying Hao, Zhuang Wang, Francis Frimpong, Xingjuan Chen
Summary: This short review focuses on the up-to-date research and provides insight into the contribution of calcium influx via ion channels to the disruption of lung microvascular endothelial-barrier function during acute lung injury (ALI).
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yu-wei Wang, Yun-hao Wu, Jia-zhi Zhang, Jia-hui Tang, Rui-ping Fan, Fang Li, Bo-yang Yu, Jun-ping Kou, Yuan-yuan Zhang
Summary: The active ingredient ruscogenin in Ophiopogonis japonicus was found to effectively alleviate particulate matter-induced acute lung injury by reducing pathological damage, lung edema, and vascular leakage, as well as inhibiting the TLR4/MyD88 signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Physiology
Joshua H. Jones, Richard D. Minshall
Summary: Acute Lung Injury (ALI) is a severe condition that leads to respiratory compromise and death in many patients. The inflammation and damage caused by the loss of endothelial barrier integrity, pneumocyte necrosis, and leukocyte recruitment contribute to the progression of ALI. In addition, pulmonary microvascular damage by bacteria or viruses further impairs lung function. Transcytosis, the transport of protein through caveolar vesicles, has been found to occur in the early phase of ALI and may play a role in the disease process. This article discusses the role of transcytosis in healthy and injured endothelium and the potential use of caveolar transport for delivering therapeutics to the lungs to prevent further injury or improve recovery.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Jeremie Joffre, Lauren Rodriguez, Zachary A. Matthay, Elliot Lloyd, Alexander T. Fields, Roland J. Bainton, Philip Kurien, Anita Sil, Carolyn S. Calfee, Prescott G. Woodruff, David J. Erle, Carolyn Hendrickson, Matthew F. Krummel, Charles R. Langelier, Michael A. Matthay, Lucy Z. Kornblith, Judith Hellman
Summary: This study found that COVID-19 infection can lead to endothelial dysfunction and increased permeability. Additionally, factors in the patients' serum can also cause abnormalities in endothelial cell function. These findings suggest that both systemic factors acting on lung endothelial cells and viral infection of endothelial cells play a role in COVID-19-associated endotheliopathy.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Pratap Karki, Boyoung Cha, Chen-Ou Zhang, Yue Li, Yunbo Ke, Kamoltip Promnares, Kozo Kaibuchi, Akihiko Yoshimura, Konstantin G. Birukov, Anna A. Birukova
Summary: SOCS1 negatively regulates inflammatory reaction and controls endothelial dysfunction by targeting microtubules, which is essential for its protective effects against endothelial permeability and inflammation.
Article
Physiology
Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul E. Marik, John D. Catravas
Summary: Research suggests that intratracheal instillation of the S1 subunit of the SARS-CoV-2 spike protein in K18-hACE2 transgenic mice can induce COVID-19-associated lung injury, characterized by weight loss, increased white blood cells and protein concentration, upregulated inflammatory cytokines, histological evidence of lung injury, and activation of specific pathways.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Nishant Johri, Prithpal S. Matreja, Shalabh Agarwal, Priya Nagar, Deepanshu Kumar, Aditya Maurya
Summary: This article aims to analyze the role of activated protein C (APC) in the pathogenesis of ischemic heart disease, heart failure, and myocardial ischemia-reperfusion injury, as well as discuss the potential of APC-based therapeutics.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mengyuan Wang, Xingfang Zhang, Juan Guo, Shangze Yang, Fang Yang, Xingjuan Chen
Summary: Inhibition of TRPC6 can ameliorate LPS-induced acute lung injury (ALI), which may be achieved by acting on the cell adhesion molecule signaling pathway and participating in the regulation of eNOS levels in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiao Ran, Qin Zhang, Shaoping Li, Zhen Yu, Li Wan, Bin Wu, Rongxue Wu, Shusheng Li
Summary: This study revealed a significant association between TK levels and severity/mortality of sepsis, suggesting TK as a potential diagnostic and prognostic marker for sepsis. Inhibition of TK may serve as a novel therapeutic target for sepsis by regulating endothelial permeability.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Marco A. Colamonici, Yulia Epshtein, Weiguo Chen, Jeffrey R. Jacobson
Summary: Haloperidol increases the expression levels of claudin-5, occludin, and ZO-1 in lung ECs, leading to attenuation of thrombin-induced barrier disruption. Furthermore, pretreatment with haloperidol in mice demonstrates lung vascular-protective effects in a murine ALI model, suggesting its potential as a novel therapy for ALI.
Article
Physiology
Weiguo Chen, Jamie M. C. Gard, Yulia Epshtein, Sara M. Camp, Joe G. N. Garcia, Jeffrey R. Jacobson, Anne E. Cress
Summary: In this study, the researchers found that simvastatin can increase the expression of ITGB4E in endothelial cells, which has effects on cell protein expression and inflammatory responses. They also observed that overexpression of ITGB4E can decrease angiogenesis, migration, and increase the expression of certain proteins associated with endothelial-to-mesenchymal transition. Furthermore, ITGB4E overexpression can attenuate cellular inflammatory responses and maintain cell barrier function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Zhe Jin, Meng-Yun Li, Lijuan Tang, Yufeng Zou, Kai Chen
Summary: This study found that ulinastatin (UTI) can effectively reduce acute lung injury (ALI) induced by diabetic sepsis in rats by inhibiting inflammatory response, reducing oxidative stress, regulating hypoxia response pathway, and improving pulmonary microvascular permeability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Ruifeng Bai, Jianqiu Pei, Shengqiang Pei, Xiangfeng Cong, Jerold Chun, Fang Wang, Xi Chen
Summary: The study found that the expression of atypical protein kinase C-iota (aPKC-ι) was increased in septic acute lung injury (ALI). In a mouse model, the absence of aPKC-ι led to worsened ALI, while regulating the activation of aPKC-ι through the agonist DBIBB can alleviate the damage of ALI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shi-Jye Chu, Shih-En Tang, Hsin-Ping Pao, Shu-Yu Wu, Wen- Liao
Summary: This study demonstrates that the PAR-1 antagonist SCH530348 exerts protective effects by blocking PAR-1 expression and modulating the downstream PI3K, NF-kappa B, and MAPK pathways, reducing IR-induced acute lung injury. These findings suggest that PAR-1 antagonist could be a potential therapeutic candidate for lung protection following IR injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Shao-Xian Li, Si-Wei Wang, Lin-Hai Chen, Qing Zhang, Dan Lu, Jing Chen, You-Chen Fang, Min Gu, Xin Xie, Fa-Jun Nan
Summary: GPR84 is a proinflammatory G protein-coupled receptor that plays a role in myeloid immune cell functions. A series of unsymmetrical phosphodiesters were designed and tested as GPR84 antagonists. The representative compound 37 showed increased blood exposure and efficacy in reducing lung inflammation in a mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)