Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Oncology
Nahid Nafissi, Maryam Mohammadlou, Mohammad Esmaeil Akbari, Seyed Rabie Mahdavi, Maryam Sheikh, Mohammad Borji, Ebrahim Babaee, Rasoul Baharlou
Summary: This study compared the impact of intraoperative radiotherapy (IORT) on the levels of angiogenic factors in the blood and surgical wound fluids of breast cancer patients. The results showed significant differences in the levels of EGF, DLL4, and VEGF before and after surgery, and TGF-beta and DLL4 were able to differentiate between early-stage and late-stage disease. Interestingly, IORT also reduced the rate of death and recurrence in breast cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Hui Wang, Wei Guo, Wei Qiu, Luo-Quan Ao, Meng-Wei Yao, Wei Xing, Yang Yu, Quan Chen, Xiao-Feng Wu, Zhan Li, Xue-Ting Hu, Xiang Xu
Summary: This study reveals a novel function of PD-L1 in wound healing, showing that PD-L1 acts as a positive regulator by forming an immunosuppressive microenvironment, modulating macrophage polarization and promoting inflammation resolution. Loss of PD-L1 delays wound healing, especially in the presence of severe inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wisdom O. Maduabuchi, Felista L. Tansi, Regine Heller, Ingrid Hilger
Summary: This study investigated the impact of hyperthermia treatment on endothelial cells in human pancreatic adenocarcinoma cells and found that strong hyperthermia promotes endothelial cell sprouting and inhibits the secretion of pro-angiogenic factors by cancer cells. These findings may have implications for the hyperthermic treatment of pancreatic cancer in the future.
Article
Nanoscience & Nanotechnology
Abdulrahman E. Koshak, Mardi M. Algandaby, Mohammad Mujallid, Ashraf B. Abdel-Naim, Nabil A. Alhakamy, Usama A. Fahmy, Anas Alfarsi, Shaimaa M. Badr-Eldin, Thikryat Neamatallah, Mohammed Z. Nasrullah, Hossam M. Abdallah, Ahmed Esmat
Summary: OFI and OFI-SNEDDS demonstrated superior wound healing activity in a rat model of full-thickness skin excision, with enhanced antioxidant and anti-inflammatory properties. OFI-SNEDDS showed higher activity compared to OFI seed oil, improving collagen and angiogenesis expression.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mei Li, Hongmei Zhu, Xiaoyan Hu, Fuhua Gao, Xinxin Hu, Ying Cui, Xiaoqing Wei, Ce Xie, Guangxin Lv, Ying Zhao, Ying Gao
Summary: TMEM98, by promoting the expression of ICAM-1 and VCAM-1, enhances EC adhesion, while triggering VSMC proliferation and migration through activation of the ERK and AKT/GSK3 beta signaling pathways. TMEM98 may serve as a potential therapeutic target for the clinical treatment of vascular endothelial and smooth muscle cell dysfunction.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nigeste Carter, Allison H. Mathiesen, Noel Miller, Michael Brown, Ruben M. L. Colunga Biancatelli, John D. Catravas, Anca D. Dobrian
Summary: Cardiovascular disease is the leading cause of death for adults in the United States. The coronary endothelium plays a crucial role in the recovery of ischemic myocardium. Extracellular vesicles (EVs) produced by endothelial cells have the potential to impact tissue function. Inflammatory conditions can increase EV release and alter their cargo. EVs may compete with pro-angiogenic cues in the ischemic myocardium, slowing down the repair response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anna T. Hofmann, Paul Slezak, Sabine Neumann, James Ferguson, Heinz Redl, Rainer Mittermayr
Summary: In this study, the dose-dependent effects of rhVEGF(165) in fibrin sealant on ischemic and non-ischemic wounds were investigated. Lower doses of VEGF were found to promote angiogenesis and wound healing, and the use of fibrin sealant alone accelerated wound closure.
Article
Biochemistry & Molecular Biology
Sergio Liarte, Angel Bernabe-Garcia, Monica Rodriguez-Valiente, Jose M. Moraleda, Gregorio Castellanos, Francisco J. Nicolas
Summary: Unsuccessful wound closure in chronic wounds is associated with altered keratinocyte activation and impaired re-epithelization. This study utilized an in vitro model of chronified keratinocytes continuously exposed to TGF-beta 1 to investigate their wound recovery capabilities. Treatment with AM was found to restore migration and promote proliferation in these chronified keratinocytes, suggesting its potential in managing chronic wounds. These findings provide further evidence for the role of sustained TGF-beta in wound chronification and validate the TGF-beta chronified HaCaT in vitro model for studying chronic wound physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
L. Anna Sheba, V Anuradha, M. Syed Ali, N. Yogananth
Summary: This study investigated the wound healing potential of Couroupita guianensis fruit pulp in rats. The results showed that the ointment prepared from the extract of C. guianensis fruit pulp promoted wound contraction, reduced the wound area, shortened the epithelialization period, and increased hydroxyproline content. The study also found that the extract influenced the expression of VEGF and TGF-beta genes, which are associated with wound healing. These findings provide scientific evidence for the traditional use of this plant in wound healing and suggest its potential as a therapeutic strategy.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ying Zhang, Yi-yuan Zhang, Zhen-wei Pan, Qing-qi Li, Li-hua Sun, Xin Li, Man-yu Gong, Xue-wen Yang, Yan-ying Wang, Hao-dong Li, Li-na Xuan, Ying-chun Shao, Meng-meng Li, Ming-yu Zhang, Qi Yu, Zhange Li, Xiao-fang Zhang, Dong-hua Liu, Yan-meng Zhu, Zhong-yue Tan, Yuan-yuan Zhang, Yun-qi Liu, Yong Zhang, Lei Jiao, Bao-feng Yang
Summary: This study found that GDF11 can accelerate the healing of diabetic wounds by promoting neovascularization and regeneration of skin tissues through cellular and molecular mechanisms. Topical application of GDF11 stimulates the mobilization of endothelial progenitor cells and enhances neovascularization through the HIF-1 alpha-VEGF/SDF-1 alpha pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Yongxin Guo, Guodong Chu, Weijia Cai, Yaying Li, Xinxin Lan, Jing Li, Linna Du, Jing Yang
Summary: In this study, human fibroblast growth factor 1 was successfully fused with oleosomes, and the beneficial effects of the fusion product on wound healing were explored. The results showed improvements in angiogenesis, vascular integrity, collagen, and inflammation in rat models with skin defects. In vivo and in vitro experiments clarified the positive role of the fusion product in promoting angiogenesis and provided insights into its potential mechanisms. These findings suggest that the fusion product has promising prospects for developing drugs for wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Barbara Sterczala, Agnieszka Chwilkowska, Urszula Szwedowicz, Magdalena Kobielarz, Bartlomiej Chwilkowski, Marzena Dominiak
Summary: This study compared the effects of using A-PRF+ alone and A-PRF+ combined with autologous gingival fibroblasts. The results showed that the combination of A-PRF+ and fibroblasts had higher values of VEGF and TGF beta 2 released, and significantly increased fibroblast proliferation after 72 hours. In terms of wound healing, the factors released from A-RRF+ alone and the factors released from A-RRF+ combined with fibroblasts showed significantly better results.
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)