Article
Endocrinology & Metabolism
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David B. MacLeod, Philip N. Ainslie, Zeljko Dujic
Summary: In this study, it was found that prolonged apnea duration during voluntary asphyxia leads to increased cerebral blood flow and blood-brain barrier permeability. The study highlights the critical role of hypoxemia and hypercapnia in BBB disruption.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Ophthalmology
Raymond L. Warner, Thomas J. Gast, Kaitlyn A. Sapoznik, Alessandra Carmichael-Martins, Stephen A. Burns
Summary: The study investigated the spatial and temporal variability of blood velocity in small retinal vessels using a dual-beam adaptive optics scanning laser ophthalmoscope. The results showed that there are inherent variations in blood velocity in capillaries, with different levels of physiological variability in arterioles, capillaries, and venules. The study provides a foundation for future research on vascular regulation in individual capillaries.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Chun-Ming Chen, Hui-Chieh Yang, Hsin-Hua Hsieh, Tsai-Ying Liao, Yen-Chih Huang, Shin-Lei Peng
Summary: Cerebrovascular reactivity (CVR) is influenced by baseline vascular dilation and shows spatial variation in different cerebral regions. Resting cerebral blood flow (CBF) differs between sexes, while CVR does not. The frontal lobe has the highest resting perfusion but minimal response to hypercapnia, while the occipital lobe has the lowest baseline CBF but the highest reactivity to hypercapnia. Sex-related differences were observed in CBF, but not in CVR.
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Kinga Howorka, Rene M. Werkmeister, Doreen Schmidl, Leopold Schmetterer, Gerhard Garhoefer
Summary: The aim of this study is to assess the retinal oxygen metabolism in patients with type 2 diabetes and different stages of nonproliferative diabetic retinopathy. The results indicate that retinal oxygen metabolism is altered in patients with type 2 diabetes and retinal oxygen extraction decreases with increasing severity of DR.
Article
Multidisciplinary Sciences
Alessandro Invernizzi, Marco Schiuma, Salvatore Parrulli, Alessandro Torre, Federico Zicarelli, Valeria Colombo, Sara Marini, Elena Villella, Alice Bertoni, Spinello Antinori, Giuliano Rizzardini, Massimo Galli, Luca Meroni, Andrea Giacomelli, Giovanni Staurenghi
Summary: This study found that COVID-19 patients had significantly larger retinal vessel diameters during the acute phase, but decreased after recovery, remaining higher than unexposed subjects. The transient retinal vessels dilation may serve as a biomarker for systemic inflammation, while long-term changes in severe COVID-19 could reflect irreversible structural damage to the vessel walls.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Ece Su Sayin, James Duffin, Julien Poublanc, Lashmikumar Venkatraghavan, David John Mikulis, Joseph Arnold Fisher, Olivia Sobczyk
Summary: The evaluation of cerebrovascular reactivity (CVR) is a valuable test for assessing vasodilatory reserve. This study aimed to investigate the effects of mild hyperoxia on CVR. The results showed that mild hyperoxia did not significantly affect CVR.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Computer Science, Interdisciplinary Applications
Maciej Czepita, Anna Fabijanska
Summary: An automated pipeline was proposed for analyzing blood flow through retinal vessels to replace time-consuming manual methods. Using convolutional neural networks and full width at half maximum analysis, blood flow was successfully detected in 18 retinal blood vessels. The average difference between manual and automatic measurements was 4.96%, with an average relative error of 8% for single vessel measurements.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Endocrinology & Metabolism
Wouter Schellekens, Alex A. Bhogal, Emiel C. A. Roefs, Mario G. Baez-Yanez, Jeroen C. W. Siero, Natalia Petridou
Summary: Ultra-high field functional magnetic resonance imaging (fMRI) provides high spatial resolution for measuring neuronal activity at the scale of cortical layers. The current study investigates the influence of different vascular compartments on laminar BOLD fMRI using hypercapnic and hyperoxic breathing conditions. The results show that all venous vascular and micro-vascular compartments have comparable maximum signal intensities, but the capacity for vessel dilation is larger for venous vascular compartments. This study suggests that differences in dilation properties between macro- and micro-vascular compartments may contribute to BOLD signal differences across cortical depth.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
L. N. Shoemaker, L. C. Wilson, S. J. E. Lucas, L. Machado, R. J. Walker, J. D. Cotter
Summary: The study found that cognitive function remains largely resilient against acutely reduced cerebral blood flow in healthy adults, with no significant impairment observed. Older adults showed poorer cognitive performance and lower cerebral blood flow compared to younger adults, but similar cerebrovascular reactivity and autoregulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Computer Science, Interdisciplinary Applications
D. Relan, R. Relan
Summary: This study proposed an unsupervised method to extract and classify retinal vessels into arterioles and venules from fundus camera images. By utilizing homomorphic filtering for preprocessing, unsupervised multiscale line operator segmentation technique for segmentation, and Locally Consistent Gaussian Mixture Model for sorting, a high classification rate was achieved.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Robert Arnar Karlsson, Olof Birna Olafsdottir, Vedis Helgadottir, Soumaya Belhadj, Thorunn Scheving Eliasdottir, Einar Stefansson, Sveinn Hakon Hardarson
Summary: Automated measurements of retinal oximetry values are more repeatable compared to measurements where vessels are selected manually, with higher ICC values for the automated version than the semiautomatic version.
Article
Mechanics
Erfan Kosari, Kambiz Vafai
Summary: As the number of patients with neurodegenerative disorders continues to grow, finding effective therapies becomes a major concern. Utilizing magnetothermal stimulation to activate nanoparticles within brain capillaries may offer a non-invasive treatment option. This article presents a theoretical study on the transport and dynamic interactions of blood flow with magnetic nanoparticles through a brain capillary.
Article
Multidisciplinary Sciences
Zhongnan Li, Guiling Li, Yongjian Li, Yuexin Chen, Jiang Li, Haosheng Chen
Summary: An air embolism is a high-risk condition caused by the blockage of blood flow by intravascular bubbles, with research showing that bubbles gradually stop and form clots in small vessels. The formation of embolism is attributed to the clot breaking the lubrication film, increasing friction force and stopping the bubble's movement.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Ronney B. Panerai, Aaron Davies, Rebecca H. Clough, Lucy C. Beishon, Thompson G. Robinson, Jatinder S. Minhas
Summary: The cerebral circulation responds differently to changes in mean arterial pressure (MAP) caused by hypercapnia. This study found that hypercapnia significantly reduces the autoregulation index of cerebral blood flow, but does not affect the directional sensitivity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Ophthalmology
Xiuqian Yi, Jie Sun, Jiang Qian, Jie Guo, Kang Xue
Summary: The study evaluated changes in retinal microvasculature and retrobulbar blood flow in retinoblastoma patients after intravenous chemotherapy using OCTA and CDI. Results showed no significant differences in retinal thickness and vessel density in the IVC-treated eyes, but a slight reduction was observed in bilateral RB eyes. Retrobulbar blood flow parameters remained unchanged.
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)
