Article
Engineering, Electrical & Electronic
Gerard Aliana Cervera, Santiago Andres Solis Paiva, Pablo Serrano Galvez, Jorge Sola Merino, Mark Butcher, Eloise Matheson, Mario di Castro
Summary: This article presents a radiation-tolerant opto-mechanical sensor that utilizes an absolute measurement inertial accelerometer. The experimental results demonstrate that the device has high sensitivity and a wide working bandwidth, and it operates properly under different conditions.
IEEE SENSORS JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Andrew F. Uehlin, Jeremy B. Vines, Dale S. Feldman, Elijah Nyairo, Derrick R. Dean, Vinoy Thomas
Summary: In this study, a biohybrid fibrous scaffold based on nanofibers was developed and shown to have improved mechanical properties suitable for ligament-replacement grafts. The use of NaOH treatment and the immobilization of fibrin enhanced the osteogenic differentiation of cells, leading to potential applications in tissue engineering.
Article
Chemistry, Multidisciplinary
Bing-Chang Zhang, Yi-Hao Shi, Jie Mao, Si-Yi Huang, Zhi-Bin Shao, Cai-Jun Zheng, Jian-Sheng Jie, Xiao-Hong Zhang
Summary: A new type of Si microstructure, named single-crystalline Si frameworks (sc-SiFs), is developed through a combination of wet-etching and microfabrication technologies. These sc-SiFs are self-supported, flexible, lightweight, tailorable, and highly transparent.
ADVANCED MATERIALS
(2021)
Article
Engineering, Marine
Teguh Putranto, Mihkel Korgesaar, Jasmin Jelovica, Kristjan Tabri, Hendrik Naar
Summary: Steel stiffened panels are commonly used in engineering design and construction, but the numerical modeling and analysis of 3D stiffened panels can be complex. A homogenization method has been developed to transform 3D stiffened panels into an Equivalent Single Layer (ESL) to study their mechanical behavior effectively.
Article
Engineering, Mechanical
Zhipeng Gao, Hai Zhang, Jian Zhao, Dong Ruan
Summary: This paper investigates the enhanced crushing performance of bio-inspired hierarchical multi-cell hexagonal tubes (BHMH) through numerical analysis and theoretical prediction, showing improved peak crushing force and energy absorption compared to traditional hexagonal tubes.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jialun Liang, Jiaxi Li, Zhensheng Zhong, Thitima Rujiralai, Jie Ma
Summary: The study quantitatively evaluated the hydrodynamic drag of DNA using the tethered-bead assay and demonstrated a linear relationship between the flow rate and total hydrodynamic force on the bead-DNA system in a wide force range (0-110 pN). This research provides insights into the force in flow-cell based single-molecule stretching experiments and establishes flow-cells as a flexible and precise tool for single-molecule force measurements.
Article
Chemistry, Analytical
Minhui Liang, Dahou Yang, Yinning Zhou, Peixian Li, Jianwei Zhong, Ye Ai
Summary: The study introduces a high-throughput cellular mechanical phenotyping technique based on a microfluidic system, which extracts cell mechanical characteristics through rapid single-cell hydrodynamic stretching and successfully measures the deformability differences of cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Multidisciplinary
Kun Li, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan
Summary: In this study, oriented hydrogel film and chitosan hydrogel film with gradient nanofibrous structure and mechanical property were prepared using the stretching-drying method. These films show great potential in inducing cell migration, orientation, and differentiation.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Debjyoti Chowdhury, Madhurima Chattopadhyay
Summary: This research developed a microcapacitive sensor-based low-impedance classification system to identify malignant cells in biological tissue samples. By analyzing the change in electrical properties of cells, an artificial neural network achieved a classification accuracy of up to 95.0%.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Engineering, Mechanical
Ngoc San Ha, Thong M. Pham, Hong Hao, Guoxing Lu
Summary: This study investigated the dynamic crushing behavior and energy absorption characteristics of a novel bio-inspired hierarchical multi-cell square (BHMS) tubes numerically and theoretically. The results showed that the BHMS tube has higher specific energy absorption (SEA) and lower undulation of load-carrying capacity (ULC) compared to conventional square and multi-cell tubes under dynamic crushing. The theoretical study for mean crushing force (MCF) was in good agreement with the numerical results, providing an effective guide for designing multi-cell energy absorbers with excellent energy absorption efficiency.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Katharina Gensowski, Melanie Palme, Ivy Langhof, Resul Akyuz, Simon Auerbach, Sebastian Tepner, Florian Clement
Summary: The availability of silver as an electrically conductive filler is a crucial issue for large-scale solar cell production. This study explores the use of alternative conductive filler materials and the phenomenon of filament stretching during microextrusion to reduce silver consumption. Nine low-temperature curing pastes with different particle systems and binder resins are investigated, and their rheological and thermal behavior are analyzed. The impact of paste compositions on microextrusion behavior and solar cell performance is evaluated based on printing tests and microstructure analyses. The developed paste formulations exhibit strong filament stretching, resulting in a significant reduction in silver laydown and improved efficiency.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Maria G. G. Bauer, Oliver Lieleg
Summary: Thin elastomeric polymer materials, like PDMS and PU, are both compliant and resilient, making them suitable for applications in limited space and repeated deformations in the human body. The autohesive behavior of these materials, which causes them to stick to themselves, limits their medical applications. However, different bio-macromolecular coatings, such as mucin coating, can effectively suppress the autohesive behavior while maintaining flexibility and transparency. These coatings not only broaden the medical application range of elastomeric devices, but also have potential benefits for soft robotics.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Jiaxin Lian, Wenxian Tang, Ying Yang, Ramanathan Vaidyanathan, Vinicius R. Goncales, Seyed Yousef Arman, Richard D. Tilley, J. Justin Gooding
Summary: In this study, a new photoelectrochemical surface was developed for selectively isolating individual rare cells from complex biological samples. The surface was constructed using a transparent electrode and orthogonal surface chemistry, and the capture and release of single cells were achieved through the co-stimulation of light and electric potential.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Instruments & Instrumentation
Sajjad Habashi Youvalari, Arash Olianezhad, Saeid Afrang
Summary: The purpose of this paper is to design and simulate a piezoelectric micropump using microelectromechanical systems technology for drug delivery applications. Two piezoelectric actuators are used to actuate and bend the diaphragms in the proposed structure. In this micropump, the liquid flow is rectified by two silicon check valves.
Article
Environmental Sciences
Qingyu Qiao, Xiangzheng Kong, Shufeng Wu, Guochang Liu, Guojun Zhang, Hua Yang, Wendong Zhang, Yuhua Yang, Licheng Jia, Changde He, Jiangong Cui, Renxin Wang
Summary: AUV coordinated formation can improve detection range and efficiency, and requires each AUV to track and locate. We developed a lateral line-inspired MEMS wake detector based on the pressure gradient sensing mechanism, with a sensitivity of 147 mV.(m/s)(-1) and a detection threshold of 0.3 m/s. The detector has vector-detecting capacity and can be promising in AUV positioning and coordinated formation.
Article
Nanoscience & Nanotechnology
Silvio Greco, Simone Dal Zilio, Alpan Bek, Marco Lazzarino, Denys Naumenko
Article
Chemistry, Physical
Silvia Nappini, Federica Bondino, Igor Pis, Raffaele Chelleri, Silvio Luciano Greco, Marco Lazzarino, Elena Magnano
APPLIED SURFACE SCIENCE
(2019)
Article
Biophysics
Elena Giolo, Monica Martinelli, Stefania Luppi, Federico Romano, Giuseppe Ricci, Marco Lazzarino, Laura Andolfi
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
Article
Engineering, Biomedical
Laura Andolfi, Silvio L. M. Greco, Domenico Tierno, Roberto Chignola, Monica Martinelli, Elena Giolo, Stefania Luppi, Ines Delfino, Michele Zanetti, Alice Battistella, Giovanna Baldini, Giuseppe Ricci, Marco Lazzarino
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Physical
Valentina Masciotti, Luca Piantanida, Denys Naumenko, Heinz Amenitsch, Mattia Fanetti, Matjaz Valant, Dongsheng Lei, Gang Ren, Marco Lazzarino
Article
Biochemical Research Methods
Barbara Troian, Rita Boscolo, Giuseppe Ricci, Marco Lazzarino, Gabriella Zito, Stefano Prato, Laura Andolfi
JOURNAL OF BIOPHOTONICS
(2020)
Article
Cell Biology
Luca Puzzi, Daniele Borin, Priyatansh Gurha, Raffaella Lombardi, Valentina Martinelli, Marek Weiss, Laura Andolfi, Marco Lazzarino, Luisa Mestroni, Ali J. Marian, Orfeo Sbaizero
Article
Physics, Nuclear
G. L. Orlandi, C. David, E. Ferrari, V. A. Guzenko, R. Ischebeck, E. Prat, B. Hermann, M. Ferianis, G. Penco, M. Veronese, N. Cefarin, S. Dal Zilio, M. Lazzarino
PHYSICAL REVIEW ACCELERATORS AND BEAMS
(2020)
Review
Biochemistry & Molecular Biology
Laura Andolfi, Alice Battistella, Michele Zanetti, Marco Lazzarino, Lorella Pascolo, Federico Romano, Giuseppe Ricci
Summary: The use of scanning probe microscopies in reproductive medicine research offers new insights into cellular structures and functions, allowing for in-depth studies on gamete morphology, mechanical properties, and molecular interactions. These techniques have the potential to provide valuable information for understanding reproductive disorders and improving assisted reproductive technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Aleksandra Makowiecka, Ewa Mazurkiewicz, Ewa Mrowczynska, Natalia Malek, Alice Battistella, Marco Lazzarino, Dorota Nowak, Antonina Joanna Mazur
Summary: Silencing TMSB4X expression alters actin cytoskeleton organization and subcellular relocalization of intermediate filament proteins in A375 melanoma cells, leading to changes in cell topology and biomechanical properties. Despite the decrease in T beta 4 levels, not all A375 clones show reduced colony formation ability in soft agar or changes in stemness marker Nanog's expression level, indicating phenotypic heterogeneity in this cell line.
Article
Biophysics
Michele Zanetti, Suet Nee Chen, Martina Conti, Matthew R. G. Taylor, Orfeo Sbaizero, Luisa Mestroni, Marco Lazzarino
Summary: The study introduces a novel approach to improve single-cell adhesion measurement by fabricating large cantilevers and directly culturing cells on them. This method can significantly enhance cell adhesion statistics, reduce experiment time, and investigate the adhesion properties of cells that do not grow well in solution or on low adherent substrates.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Mladenka Malenica, Marija Vukomanovic, Mario Kurtjak, Valentina Masciotti, Simone dal Zilio, Silvio Greco, Marco Lazzarino, Vedrana Krusic, Marko Percic, Ivana Jelovica Badovinac, Karmen Wechtersbach, Ivona Vidovic, Vanja Baricevic, Srecko Valic, Pero Lucin, Nika Kojc, Kristina Grabusic
Summary: Extracellular vesicles (EVs) are nanometric membranous structures secreted by cells and found in biofluids, with potential for diagnostic and prognostic purposes related to tissue states. Detailed characterisation through imaging techniques like atomic force microscopy (AFM) and electron microscopy (EM) is essential for EV usage. This study examines EV preparation protocols for AFM and EM, highlighting challenges in imaging EVs in different environments and discussing approaches for imaging with potential benefits and drawbacks. Examples using cerebrospinal fluid illustrate the complexities of EV morphology research, aiming to improve standardisation in sample preparation and microscopy methods.
Article
Biochemistry & Molecular Biology
Nicoletta Braidotti, Maria Augusta do R. B. F. Lima, Michele Zanetti, Alessandro Rubert, Catalin Ciubotaru, Marco Lazzarino, Orfeo Sbaizero, Dan Cojoc
Summary: This study investigates the relationship between cytoskeleton alterations and diseases through examining primary rat cardiac fibroblasts. The results show that changes in the cytoskeleton can affect cell adhesion, rheological behavior, and morphology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Martina Conti, Ilaria Bolzan, Simone Dal Zilio, Pietro Parisse, Laura Andolfi, Marco Lazzarino
Summary: Cell migration plays a crucial role in physiological and pathological contexts, but its mechanisms are still not fully understood due to the complex interaction between cells and their surroundings. Traditional assays lack the ability to capture this complexity, while a novel approach using 2D micro-patterned substrates provides a promising tool to investigate cell migration in complex environments. The developed method was tested with breast cancer cell lines and revealed that invasive cells are more responsive to the size of the water meniscus and exhibit significative matrix deposition process connected to cell migration.
Article
Biochemistry & Molecular Biology
Domenico Tierno, Eros Azzalini, Rossella Farra, Sara Drioli, Fulvia Felluga, Marco Lazzarino, Gabriele Grassi, Barbara Dapas, Serena Bonin
Summary: Epithelial ovarian cancers (EOCs) are a heterogeneous group of tumors with different molecular and clinical features. Few improvements have been achieved in terms of EOC management and treatment efficacy, and the 5-year survival rate of patients remained almost unchanged. A better characterization of EOCs' heterogeneity is needed to identify vulnerabilities, stratify patients, and adopt proper therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
