期刊
SCHIZOPHRENIA RESEARCH
卷 166, 期 1-3, 页码 17-23出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2015.04.036
关键词
Functional MRI; Antipsychotic medication; Cingulate cortex; Insula
类别
资金
- Swiss National Science Foundation [3232BO_119382]
Background: Deficits in motivational salience processing have been related to psychotic symptoms and disturbances in dopaminergic neurotransmission. We aimed at exploring changes in salience processing and brain activity during different stages of psychosis and antipsychotic medication effect. Methods: We used fMRI during the Salience Attribution Task to investigate hemodynamic differences between 19 healthy controls (HCs), 34 at-risk mental state (ARMS) individuals and 29 individuals with first-episode psychosis (PEP), including a subgroup of 17 FEP without antipsychotic medication (FEP-UM) and 12 PEP with antipsychotic medication (FEP-M). Motivational salience processing was operationalized by brain activity in response to high-probability rewarding cues (adaptive salience) and in response to low-probability rewarding cues (aberrant salience). Results: Behaviorally, adaptive salience response was not accelerated in PEP, although they correctly distinguished between trials with low and high reward probability. In comparison to HC, ARMS exhibited a lower hemodynamic response during adaptive salience in the right inferior parietal lobule and PEP-UM in the left dorsal cingulate gyrus. The FEP-M group exhibited a lower adaptive salience response than HC in the right insula and than ARMS in the anterior cingulate gyrus. In unmedicated individuals, the severity of hallucinations and delusions correlated negatively with the insular- and anterior cingulate hemodynamic response during adaptive salience. We found no differences in aberrant salience processing associated with behavior or medication. Conclusion: The changes in adaptive motivational salience processing during psychosis development reveal neurofunctional abnormalities in the somatosensory and premotor cortex. Antipsychotic medication seems to modify hemodynamic responses in the anterior cingulate and insula. (C) 2015 The Authors. Published by Elsevier B.V.
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