Review
Cell Biology
Louis Hardan, Rim Bourgi, Carlos Enrique Cuevas-Suarez, Walter Devoto, Maciej Zarow, Paulo Monteiro, Natalia Jakubowicz, Amine El Zoghbi, Dariusz Skaba, Davide Mancino, Naji Kharouf, Youssef Haikel, Monika Lukomska-Szymanska
Summary: This study systematically reviewed the literature to evaluate the bonding performance of adhesive systems to dentin using different application modalities. It found that using alternative techniques or additional strategies during the application of adhesive systems can improve their bond strength to dentin.
Article
Polymer Science
Samar Al-Saleh, Abdullah Alateeq, Abdulaziz H. Alshaya, Amal S. Al-Qahtani, Huda Tulbah, Mashael Binhasan, Sara Shabib, Imran Farooq, Fahim Vohra, Tariq Abduljabbar
Summary: In this study, an experimental adhesive was formulated and reinforced with titanium dioxide (TiO2) or zirconium oxide (ZrO2) nanoparticles to investigate their impact on various mechanical properties. Characterization of the nanoparticles, analysis of mechanical properties, and examination of the resin-dentin interface showed that reinforcement with TiO2 or ZrO2 led to increased shear-bond strength and affected the hybrid layer and resin tag formation. Further studies on the impact of different filler concentrations are recommended.
Article
Dentistry, Oral Surgery & Medicine
Rui Guo, Wenan Peng, Hongye Yang, Chenmin Yao, Jian Yu, Cui Huang
Summary: The study demonstrated that resveratrol-doped adhesive significantly improved the durability of dentin bonding and secondary caries management.
Additionally, the resveratrol-doped adhesive exhibited antibiofilm properties and acceptable biocompatibility.
Therefore, the application of resveratrol-doped adhesive holds promise for increasing the lifetime of composite restorations.
JOURNAL OF DENTISTRY
(2021)
Article
Chemistry, Physical
Ekta Varma Sengar, Sanjyot Mulay, Lotika Beri, Archana Gupta, Thamer Almohareb, Sultan Binalrimal, Ali Robaian, Maha A. Bahammam, Hammam Ahmed Bahammam, Sarah Ahmed Bahammam, Bassam Zidane, Nassreen H. Albar, Shilpa Bhandi, Deepti Shrivastava, Kumar Chandan Srivastava, Shankargouda Patil
Summary: This study evaluated and compared the microleakage of Universal Flo composite resin using different bonding systems in Class V cavities. The results showed that total etch and rinse bonding systems had less microleakage compared to self-etch bonding systems and self-adhesive flowable composite resin.
Article
Polymer Science
Madalena Belmar da Costa, Antonio H. S. Delgado, Tomas Amorim Afonso, Luis Proenca, Ana Sofia Ramos, Ana Mano Azul
Summary: Comparing the adhesive interface of eroded dentin, the study found that Clearfil SE Protect exhibited similar mechanical and adhesive performance to Clearfil SE Bond 2, with promising long-term results in eroded dentin due to increased enzymatic activity and the need for remineralization.
Article
Anatomy & Morphology
Bojana D. Ramic, Igor Lj Stojanac, Milan R. Drobac, Ivana R. Kantardzic, Aleksandra Z. Maletin, Milica T. Cvjeticanin, Katarina S. Otasevic, Ljubomir M. Petrovic
Summary: The study observed the adhesive interface on original tooth samples and their epoxy replicas under SEM, finding that marginal adaptation was mostly of acceptable quality, but issues such as marginal gap formation and resin tag breakdown were also noted, mainly attributed to polymerization shrinkage. A profound understanding of ultrastructural morphology is important for achieving a more predictable and durable margin between composite restorations and surrounding tooth structures, and SEM analysis can serve this purpose.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isadora Martini Garcia, AbdulRahman A. Balhaddad, Maria S. Ibrahim, Michael D. Weir, Hockin H. K. Xu, Fabricio Mezzomo Collares, Mary Anne S. Melo
Summary: This study formulated and evaluated an experimental dental adhesive containing ZnO nanoparticles, assessing its chemical and mechanical properties, as well as its antibacterial response against oral microcosm biofilm. The results showed that the dental adhesive with 7.5% ZnO effectively restricted the growth of oral microcosm biofilm.
Article
Anatomy & Morphology
Shahram Solaymani, Negin Beryani Nezafat, Stefan Talu, Azizollah Shafiekhani, Vali Dalouji, Ali Amiri, Sahar Rezaee, Ilya A. Morozov
Summary: The main goal of this work is to explore the 3-D atomic force microscopy images of human teeth and investigate their micromorphology. The study reveals relationships between the micromorphology of the surface and the structural properties of these tissues. The surface of cementum is found to be the most irregular, while dentin has the most regular topography.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Review
Polymer Science
Louis Hardan, Rim Bourgi, Naji Kharouf, Davide Mancino, Maciej Zarow, Natalia Jakubowicz, Youssef Haikel, Carlos Enrique Cuevas-Suarez
Summary: The study found that using specific techniques and additional strategies can significantly improve the bond strength of universal adhesives to dentin, and inhibitors and specific operating methods can enhance the bonding effect. However, certain methods such as shortening application time and dentin desensitizers may decrease the bond strength of universal adhesives to dentin.
Article
Nanoscience & Nanotechnology
Camila Leiva-Sabadini, Simon Alvarez, Nelson P. Barrera, Christina M. A. P. Schuh, Sebastian Aguayo
Summary: The study aims to characterize the molecular and nanomechanical properties of honey-derived EVs to elucidate their antibacterial effects, and to determine their differential antibiofilm activity against oral streptococci. The molecular analysis identified important exosome markers and antibacterial molecules in the EVs, while nanomechanical characterization showed their potential impact on altering cell wall elasticity. The differential effects of honey-derived EVs on different oral streptococci could provide a novel strategy for modulating biofilm formation in dental caries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Physical
Konstantin Johannes Scholz, Aleksandra Bittner, Fabian Cieplik, Karl-Anton Hiller, Gottfried Schmalz, Wolfgang Buchalla, Marianne Federlin
Summary: Interfaces between dentin, enamel, and luting agents were characterized using low vacuum SEM, showing that different luting agents had varying effects on the micromorphology of adhesive interfaces under different curing modes.
Article
Polymer Science
Joana Vasconcelos e Cruz, Antonio H. S. Delgado, Samuel Felix, Jose Brito, Luisa Goncalves, Mario Polido
Summary: A Bisphenol A-free adhesive with favorable interfacial properties and similar bond strength to dentin as commercial adhesives was developed and tested. It exhibited lower nanoleakage means compared to other adhesives when applied in an etch-and-rinse mode.
Article
Dentistry, Oral Surgery & Medicine
T. Shan, L. Huang, F. R. Tay, L. Gu
Summary: The concept of extrafibrillar demineralization involves selectively removing apatite crystallites from the spaces between mineralized dentin fibers without affecting the minerals within the collagen fibers. Quaternized carboxymethyl chitosan (QCMC)-based demineralization is effective in improving resin-dentin bond durability by retaining intrafibrillar minerals, preserving the elastic modulus of collagen fibers, reducing proteolytic activity, and inhibiting bacteria biofilms.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Engineering, Chemical
Priscila Raquel Schiroky, Isadora Martini Garcia, Fernanda Coradini Noal, Vicente Castelo Branco Leitune, Fernando Borba de Araujo, Fabricio Mezzomo Collares
Summary: The study evaluated the influence of alpha-TCP on the physical-chemical properties of an experimental adhesive resin and the immediate and long-term properties of caries-affected dentin. The addition of alpha-TCP increased the initial Knoop hardness of the adhesive resin and the hardness of caries-affected dentin. There was no significant difference in other properties such as softening in solvent, polymerization rate, degree of conversion, microtensile bond strength, and mineral deposition.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2021)
Article
Engineering, Chemical
Asuka Hayashi, Yu Sekiguchi, Chiaki Sato
Summary: The composition of adhesive-adherend interfaces plays a crucial role in adhesive joint strength. By studying the formation and physical properties of sea-island structures, the relationship between interface structure and bonding strength was revealed, which is closely related to the wettability of the adhesive to the adherends.
JOURNAL OF ADHESION
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. T. Arias-Moliz, P. Baca, C. Solana, M. Toledano, A. L. Medina-Castillo, M. Toledano-Osorio, R. Osorio
Summary: Un-functionalized NPs exhibited strong antimicrobial activity against E. faecalis biofilms, reducing biovolume and increasing the percentage of dead/injured cells. Doxycycline-loaded NPs showed the highest inhibition of biofilm formation, with reduced biofilm biovolume and a high percentage of dead/injured bacterial cells. The un-functionalized NPs did not reduce biomass growth but had the highest percentage of compromised cells, capable of disrupting biofilm formation.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Review
Dentistry, Oral Surgery & Medicine
Manuel Toledano-Osorio, Francisco Javier Manzano-Moreno, Concepcion Ruiz, Manuel Toledano, Raquel Osorio
Summary: GBR is used to handle maxillofacial bone defects, but current membranes do not completely fulfill requirements, driving need for ideal membrane development; New membrane features require specific evaluation techniques, while nanotechnology and osteoimmunomodulation have impacted cells-membranes interaction.
JOURNAL OF DENTISTRY
(2021)
Article
Engineering, Biomedical
Manuel Toledano, Raquel Osorio, Marta Vallecillo-Rivas, Estrella Osorio, Christopher D. Lynch, Fatima S. Aguilera, Raquel Toledano, Salvatore Sauro
Summary: This study aimed to explore the role of zinc-doped cements in promoting dentin remineralization through a literature review, finding that zinc enhances the bioactivity and mineralization of dentin, leading to increased hardness and resistance to deformation. Oxipatite-based cements mechanically reinforce dentin structure, promoting remineralization, but also result in high solubility and instability due to the formation of immature crystallites.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Fatima S. Aguilera, Estrella Osorio, Manuel Toledano-Osorio, Germaine Escames, Antonio L. Medina-Castillo, Raquel Toledano, Christopher D. Lynch, Raquel Osorio
Summary: The study investigated the effectiveness of novel polymeric nanoparticles doped with melatonin in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment. Results showed that melatonin-doped nanoparticles effectively sealed dentinal tubules, strengthened the structure of radicular dentin, and promoted durable remineralization. This may provide a new approach for improving root canal treatment outcomes.
Review
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Marta Vallecillo-Rivas, Fatima S. Aguilera, Maria T. Osorio, Estrella Osorio, Raquel Osorio
Summary: Polymeric zinc-doped nanoparticles effectively loaded with zinc can promote dentin remineralization, increase mechanical properties, and exhibit antibacterial properties. The application of these nanoparticles can reduce biofilm formation and achieve durable sealing ability by generating new zinc-based salt minerals that cover the dentin surface.
JOURNAL OF DENTISTRY
(2021)
Article
Polymer Science
Manuel Toledano-Osorio, Francisco J. Manzano-Moreno, Manuel Toledano, Antonio L. Medina-Castillo, Victor J. Costela-Ruiz, Concepcion Ruiz, Raquel Osorio
Summary: The study found that blending silica nanoparticles improved proliferation and differentiation of osteoblasts, while scaffolds doped with doxycycline achieved the best results. Doxycycline functionalized membranes showed higher immunomodulation activity in osteoblasts, indicating their potential as candidates for use in GBR procedures for challenging pathologies.
Review
Polymer Science
Manuel Toledano-Osorio, Manuel Toledano, Francisco Javier Manzano-Moreno, Cristina Vallecillo, Marta Vallecillo-Rivas, Alberto Rodriguez-Archilla, Raquel Osorio
Summary: The study concludes that using polymeric membranes for guided bone regeneration (GBR) is an effective technique for achieving horizontal bone augmentation, facilitating proper implant placement.
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano-Osorio, Francisco Javier Manzano-Moreno, Manuel Toledano, Raquel Osorio, Antonio L. Medina-Castillo, Victor J. Costela-Ruiz, Concepcion Ruiz
Summary: The study investigated the impact of novel silicon dioxide composite membranes functionalized with zinc or doxycycline on osteoblastic cell gene expression. Results showed that the use of SiO2-NPs in polymeric scaffolds improved osteogenic gene expression, with the best results achieved by doxycycline doping. Zinc and doxycycline functionalized membranes significantly influenced the expression of several osteogenic gene markers, highlighting their potential for use in GBR procedures.
JOURNAL OF DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fei Chen, Yu Toida, Rafiqul Islam, Arefin Alam, Abu Faem Mohammad Almas Chowdhury, Monica Yamauti, Hidehiko Sano
Summary: This study evaluated the shade matching ability of a novel supra-nano filled esthetic resin composite using structural color technology in simplified simulated clinical cavities. The results showed that the supra-nano filled resin composite had lower color differences in A2, A3, and A4 shades compared to other types of filled resin composites. The use of spherical supra-nano filler particles contributed most to shade matching by stimulating structural color, suggesting potential benefits of structural color technology for shade matching in resin composites.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2021)
