Article
Immunology
Aiste Lengvenyte, Raoul Belzeaux, Emilie Olie, Hind Hamzeh-Cognasse, Maude Seneque, Robertas Strumila, Fabrice Cognasse, Philippe Courtet
Summary: An increasing body of evidence suggests that suicidal ideation and behaviors have biological bases. This study examined the association of various peripheral cells and proteins with suicidal behaviors and ideation in individuals with mood disorders. The results showed that plasma levels of certain proteins were associated with past month suicide attempts and current suicidal ideation. Additionally, higher levels of certain proteins predicted future suicidal events.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Wassim Guidara, Meriam Messedi, Manel Naifar, Manel Maalej, Walid Khrouf, Sahar Grayaa, Mohamed Maalej, Dominique Bonnefont-Rousselot, Foudil Lamari, Fatma Ayadi
Summary: Evidence suggests a correlation between the profile of oxysterols in plasma and clinical factors in patients with schizophrenia, potentially implicating oxysterols in the pathophysiology of the disorder. The ratio of cholestane-313,5 alpha,613-triol to total cholesterol (Tchol) may be considered an independent risk factor for schizophrenia, while cholestane-313,5 alpha,613-triol, 27-hydroxycholesterol, and cholestanol show promise as potential biomarkers for the disease.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Hematology
Alex R. Schuurman, Valentine Leopold, Liza Pereverzeva, Osoul Chouchane, Tom D. Y. Reijnders, Justin de Brabander, Renee A. Douma, Michel van Weeghel, Eric Wever, Bauke V. Schomaker, Frederic M. Vaz, Willem Joost Wiersinga, Cornelis van't Veer, Tom van der Poll
Summary: This study reveals the profound impact of COVID-19 infection on the lipid composition of human platelets, and identifies associations between platelet lipid composition and reactivity.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Chemistry, Physical
Katie A. Wilson, Stephen J. Fairweather, Hugo I. MacDermott-Opeskin, Lily Wang, Richard A. Morris, Megan L. O'Mara
Summary: A coarse-grain model of the epithelial plasma membrane was developed and simulated to characterize its biophysical properties, revealing minimal impact of plasmalogen lipids and the formation of glycosphingolipid-rich nanoscale lipid domains upon introduction of Forssman lipids. Hydroxylation of Forssman glycosphingolipids and sphingomyelin further modulates the lateral organization of the membrane. This study contributes to understanding the impact of membrane lipid composition on membrane properties.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Shin Koike, Yusuke Miyaji, Kazuhiro Suzuki, Mitsuhiro Miyashita, Masanari Itokawa, Makoto Arai, Yuki Ogasawara
Summary: This study measured bile acids in plasma from patients with schizophrenia and healthy subjects and found significant differences in unconjugated bile acid levels between the two groups. The results suggest that plasma bile acid levels may serve as diagnostic markers for schizophrenia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Alex M. Dickens, Partho Sen, Matthew J. Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rossler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G. Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyotylainen, Matej Oresic, Philip McGuire
Summary: The study discovered that abnormalities in blood lipidomics predate the onset of psychosis in individuals at clinical high risk for psychosis, and can help predict which individuals are most likely to develop psychosis.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Yihe Jiang, Xiujia Sun, Miaowen Hu, Lei Zhang, Nan Zhao, Yifeng Shen, Shunying Yu, Jingjing Huang, Huafang Li, Wenjuan Yu
Summary: This study investigated the metabolic characteristics of cognitive impairment in schizophrenia using metabolomics. Several differentially expressed metabolites were identified, and new biomarkers related to cognitive impairment in schizophrenia were discovered. Pathway analysis also revealed important metabolic pathways involved in the disease.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Meng Song, Ya Liu, Jiahui Zhou, Han Shi, Xi Su, Minglong Shao, Yongfeng Yang, Xiujuan Wang, Jingyuan Zhao, Dong Guo, Qing Liu, Luwen Zhang, Yan Zhang, Luxian Lv, Wenqiang Li
Summary: Using liquid chromatography mass spectrometry, the study identified potential biomarkers associated with the diagnosis and treatment of schizophrenia. Biomarker panels were selected to distinguish between schizophrenia and healthy controls, as well as between schizophrenia before and after medication. Disturbances in lipid metabolism, sulfation modification, tryptophan metabolism, anti-inflammatory and antioxidant systems, and unsaturated fatty acids metabolism were observed in schizophrenia. These findings could contribute to the development of objective diagnostic and drug treatment monitoring tools for schizophrenia.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Yiyun Liu, Xuemian Song, Xinyu Liu, Juncai Pu, Siwen Gui, Shaohua Xu, Lu Tian, Xiaogang Zhong, Libo Zhao, Haiyang Wang, Lanxiang Liu, Guowang Xu, Peng Xie
Summary: This study aimed to identify plasma lipid and amino acid biomarkers for schizophrenia using LC/MS-based metabolomics. It found significant dysregulation in plasma lipids and amino acids between schizophrenia patients and controls, with a selected panel showing good diagnostic performance, especially in the drug-treated group. The LC/MS/MS-based approach provides reliable data for objective diagnosis of schizophrenia.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Nutrition & Dietetics
Bridget E. Young, Gertrude Kyere-Davies, Jacob W. Farriester, Rohan Varshney, Paul S. MacLean, Nancy F. Krebs, Michael C. Rudolph
Summary: The prevalence of childhood obesity has increased nearly ten times over the last 40 years, influenced by early life nutrients that have persistent effects on life-long metabolism. A low arachidonic to docosahexaenoic acid ratio in infants is associated with more fat-free mass accumulation in the first four months of life.
Article
Oncology
Martina Hinterleitner, Bence Sipos, Verena Wagner, Julia M. Grottenthaler, Ulrich M. Lauer, Lars Zender, Clemens Hinterleitner
Summary: This study demonstrated significantly upregulated expression of platelet-expressed synaptophysin in NEN patients, which was correlated with tumor progression and prognosis. Platelet-expressed synaptophysin might serve as a novel biomarker in NEN reflecting tumor stages and prognosis.
Article
Biochemistry & Molecular Biology
Hyunsin (Hedy) Sung, Andrew J. Sinclair, Xiao Q. Su
Summary: This study compared the effects of krill oil (KO) and fish oil (FO) on the enrichment of molecular species of plasma phospholipids in young women after a 30-day consumption. The results showed that after 30 days of supplementation, molecular species containing EPA, DHA, and DPAn-3 had a significantly higher concentration in the KO group compared to the FO group. These findings suggest that KO, which is rich in ether phospholipids, can enrich n-3 PUFA in plasma phospholipids.
Article
Chemistry, Organic
Yiwen Ding, Chu Zhang, Min Zhou, Yu Xiang, Aijun Tong
Summary: In this study, a highly efficient fluorescent labeling method based on hetero-Diels-Alder cycloaddition reaction is developed for selective labeling and identification of Plasmalogens (Pls) from complex lipid samples. By combining this method with high-performance liquid chromatography, individual chromatographic signatures of Pls from human plasma samples can be accurately identified. This technique is cost-effective and simple in terms of instrumentation, suggesting its promising potential for early screening and diagnosis of diseases associated with Pls abnormalities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Oncology
Siamack Sabrkhany, Marijke J. E. Kuijpers, Mirjam G. A. Oude Egbrink, Arjan W. Griffioen
Summary: Platelets play a crucial role in tumor angiogenesis, growth, and metastasis, with interactions between cancer and platelets leading to changes in platelet characteristics. Researchers are investigating whether analyzing these platelet features could offer a new strategy in the search for biomarkers of cancer.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Hematology
Dario Bongiovanni, Nina Schreiner, Rosanna Gosetti, Katharina Mayer, Dominick J. Angiolillo, Dirk Sibbing, Stefan Holdenrieder, Aida Anetsberger, Moritz von Scheidt, Heribert Schunkert, Karl-Ludwig Laugwitz, Stefanie Schuepke, Adnan Kastrati, Isabel Fegers-Wustrow, Isabell Bernlochner
Summary: This study aimed to evaluate immature or reticulated platelets as a predictive biomarker for adverse cardiovascular events in patients with acute coronary syndrome treated with potent P2Y(12) receptor inhibitors. The findings showed that immature platelets were significantly associated with the incidence of the primary endpoint, indicating their potential as a predictive marker for adverse cardiovascular events in these patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)