Article
Medicine, General & Internal
Gonzalo Salazar de Pablo, Filippo Besana, Vincenzo Arienti, Ana Catalan, Julio Vaquerizo-Serrano, Anna Cabras, Joana Pereira, Livia Soardo, Francesco Coronelli, Simi Kaur, Josette da Silva, Dominic Oliver, Natalia Petros, Carmen Moreno, Ana Gonzalez-Pinto, Covadonga M. Diaz-Caneja, Jae Il Shin, Pierluigi Politi, Marco Solmi, Renato Borgatti, Martina Maria Mensi, Celso Arango, Christoph U. Correll, Philip McGuire, Paolo Fusar-Poli
Summary: The meta-analysis study revealed that CHR-P individuals show improvements in symptoms and functional outcomes over time, but sustaining these improvements in the long term is challenging, with less than half of patients achieving full remission.
Review
Medicine, General & Internal
Ernest Swora, Monika Boberska, Ewa Kulis, Nina Knoll, Jan Keller, Aleksandra Luszczynska
Summary: This study found a consistent pattern of associations between higher levels of physical activity and lower positive, negative, and general psychopathology symptoms in individuals with schizophrenia and other psychotic disorders.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Feten Fekih-Romdhane, Romy Hajje, Chadia Haddad, Souheil Hallit, Jocelyne Azar
Summary: In this study, cluster analysis was used to identify subgroups of Lebanese patients diagnosed with schizophrenia or schizoaffective disorder based on negative symptoms (NS) clusters, and to relate these subgroups to clinically relevant external validators. The results revealed the existence of three distinct NS subgroups, suggesting that each subgroup may have unique underlying mechanisms and require different treatment approaches.
Review
Clinical Neurology
Christy Au-Yeung, Danielle Penney, Jesse Rae, Hannah Carling, Libby Lassman, Martin Lepage
Summary: Negative symptoms (NS) are core symptoms in schizophrenia spectrum disorders and are closely related to neurocognitive functioning. This review synthesizes close to two decades of research and finds a nonspecific relationship between neurocognition and NS, with a stronger correlation observed with the expressive NS dimension.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
B. Romeo, L. Willaime, E. Rari, A. Benyamina, C. Martelli
Summary: Negative symptoms of schizophrenia have a significant impact on prognosis and are difficult to treat with antipsychotic medication. A meta-analysis was conducted to evaluate the efficacy of 5-HT2A antagonist treatments on negative symptoms. The analysis found that 5-HT2A antagonists demonstrated a greater decrease in negative symptoms compared to placebo, but no difference in positive symptoms. The study suggests that 5-HT2A antagonists may be useful in treating negative symptoms in schizophrenia patients.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Thole Hilko Hoppen, Nexhmedin Morina
Summary: Positive psychotherapy (PPT) shows moderate efficacy in increasing positive outcomes and reducing negative outcomes, with significant effects compared to waitlist control conditions. Further high-quality trials with follow-up assessments are needed to draw stronger conclusions on the long-term efficacy of PPT.
Article
Psychiatry
Stephanie Grot, Charles-Edouard Giguere, Salima Smine, Violaine Mongeau-Perusse, Dana Diem Nguyen, Adrian Preda, Stephane Potvin, Theo G. M. van Erp, Pierre Orban
Summary: This study aimed to provide conversion equations for subdomains of positive and negative symptomatology in schizophrenia, allowing for a better understanding of symptom profile diversity. The findings demonstrate that symptom severity scores can be accurately converted between different clinical scales, with high reliability except for the cognition factor.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Nina B. Paul, Gregory P. Strauss, Jessica J. Woodyatt, Michelle G. Paul, Jennifer R. Keene, Daniel N. Allen
Summary: The heterogeneity of schizophrenia has been acknowledged for decades. This study used cluster analysis to examine whether heterogeneity in negative symptoms might be useful in establishing schizophrenia subtypes. The findings suggest that schizophrenia heterogeneity can be parsed according to negative symptom subtypes that have distinct clinical and neuropsychological profiles.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Psychiatry
Alan Shafer, Federico Dazzi
Summary: Previous meta-analyses of the BPRS-E and PANSS were combined to analyze a total of 77 factor analyses from 68 studies involving 32,896 individuals. Five consistent factors were identified across all solutions: Positive Symptoms, Affect, Negative Symptoms, Disorganization, and Activation-Mania. The factors were defined by a combination of original BPRS items, additional PANSS items, and additional BPRS-E items. The results were more comprehensive and clearer compared to previous analyses, suggesting future research could benefit from utilizing all items from both scales.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Psychiatry
Tingting Zhu, Zixu Wang, Chao Zhou, Xinyu Fang, Chengbing Huang, Chunming Xie, Honglin Ge, Zheng Yan, Xiangrong Zhang, Jiu Chen
Summary: This study conducted a meta-analysis to identify abnormalities in structural and functional brain regions in patients with persistent negative symptoms (PNS) compared to healthy controls. The results showed consistent structural brain abnormalities in prefrontal, temporal, limbic, and subcortical regions, as well as functional alterations in thalamo-cortical circuits and the default mode network (DMN). These findings provide new insights for targeted treatment and intervention to delay further progression of negative symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Laura E. Grover, Rebecca Jones, Nicholas J. Bass, Andrew McQuillin
Summary: Negative symptoms are associated with a reduced risk of suicidality, while positive symptoms are associated with an increased risk of suicidality. Depressive symptoms may confound or mediate these associations.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Psychiatry
Ana Catalan, Joaquim Radua, Robert McCutcheon, Claudia Aymerich, Borja Pedruzo, Miguel Angel Gonzalez-Torres, Helen Baldwin, William S. Stone, Anthony J. Giuliano, Philip McGuire, Paolo Fusar-Poli
Summary: This study aimed to examine the variability in neurocognitive functioning among young people at Clinical High-Risk for psychosis (CHR-P) compared to healthy controls and first-episode psychosis patients. The results showed that the CHR-P group exhibited higher variability in various cognitive domains, particularly in executive functioning. This finding highlights the importance of further research and precision medicine approaches in this population.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Psychiatry
Sophia Wehr, Lucia Weigel, John Davis, Silvana Galderisi, Armida Mucci, Stefan Leucht
Summary: This study evaluated the quality of CAINS as a clinician-rated outcome measurement using the COSMIN systematic review guideline. The results showed good structural validity, internal consistency, and reliability, but poorer hypothesis testing and indeterminate results for cross-cultural validity. The study suggests that further research is needed to assess the quality of CAINS, particularly in areas such as content validity, internal consistency, and cross-cultural validity.
SCHIZOPHRENIA BULLETIN
(2023)
Editorial Material
Psychiatry
Lisette van der Meer, Stefan Kaiser, Stynke Castelein
Summary: Negative symptoms of schizophrenia have been studied for over a century, yet effective interventions remain elusive. By re-analysing existing evidence on treatment, using narrower definitions for symptom dimensions, we aim to better understand which interventions work for whom.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Emma R. Stanislawski, Zarina R. Bilgrami, Cansu Sarac, Sahil Garg, Stephen Heisig, Guillermo A. Cecchi, Carla Agurto, Cheryl M. Corcoran
Summary: Aberrant pauses characteristic of schizophrenia are also associated with negative symptoms in individuals at clinical high risk for psychosis. The study found that pause behavior correlated with measures of syntactic complexity that had been previously shown to help predict psychosis, suggesting a common impairment in discourse planning and verbal self-monitoring that impacts both speech and language.
Article
Psychology, Clinical
Monika A. Waszczuk, Jiaju Miao, Anna R. Docherty, Andrey A. Shabalin, Katherine G. Jonas, Giorgia Michelini, Roman Kotov
Summary: This study systematically tested which polygenic risk scores (PRSs) are associated with various forms of childhood psychopathology. The results indicate that PRSs developed to predict vulnerability to emotional difficulties and chronic pain generally capture genetic risk for all forms of childhood psychopathology, while PRSs developed to predict vulnerability to externalizing difficulties tend to be more specific in predicting behavioral problems.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Amanda Bakian, Danli Chen, Chong Zhang, Heidi A. Hanson, Anna R. Docherty, Brooks Keeshin, Douglas Gray, Ken R. Smith, James A. VanDerslice, David Z. Yu, Yue Zhang, Hilary Coon
Summary: This study examines the familial risk of suicide in Utah and explores whether the risk varies based on the characteristics of the suicides and their relatives. The findings suggest that there is a significantly elevated risk of suicide in family members of female and younger suicide probands. This highlights the importance of targeting prevention efforts towards specific risk groups, such as suicidal young adults and women with a strong family history of suicide.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Kenneth S. Kendler, Henrik Ohlsson, Silviu Bacanu, Jan Sundquist, Kristina Sundquist
Summary: Genetic risk profiles for DUD, MD, and ADHD vary significantly depending on age at onset, recurrence, mode of ascertainment, and treatment. Replication of psychiatric studies, particularly those examining genetic factors, may be challenging without considering important clinical characteristics.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qingqin S. Li, Andrey A. Shabalin, Emily DiBlasi, Srihari Gopal, Carla M. Canuso, Aarno Palotie, Wayne C. Drevets, Anna R. Docherty, Hilary Coon
Summary: This study aimed to identify genetic risk variants associated with suicide death and suicidal behavior. The results showed that a locus in the neuroligin 1 (NLGN1) gene was associated with suicide death, while ROBO2 and ZNF28 genes were associated with suicidal behavior. Additionally, variants near SOX5 and LOC101928519 were found to be associated with suicidal attempts. Suicide death and suicidal behavior showed positive correlations with depression, schizophrenia, pain, and suicidal attempt, and negative correlation with educational attainment.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Frank D. Mann, Sean A. P. Clouston, Adolfo Cuevas, Monika A. Waszczuk, Pei-Fen Kuan, Melissa A. Carr, Anna R. Docherty, Andrea A. Shabalin, Sam E. Gandy, Benjamin J. Luft
Summary: This study investigates the association between genetic liability for Alzheimer's disease, PTSD, and educational attainment with cognitive impairment among World Trade Center responders, while considering demographic factors and indicators of 9/11 exposure severity. The results show that genetic liability for Alzheimer's disease and educational attainment are significantly associated with mild cognitive impairment, but PTSD and work type during rescue and recovery efforts have larger effect sizes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Psychology, Developmental
Salahudeen Mirza, Anna R. Docherty, Eric T. Monson, Hilary Coon, Brooks Keeshin, Gabriel R. Fries
Summary: Preventing suicidal thoughts and behaviors among youth is a global public health priority. Genetic and environmental factors play a key role in the development of risk for STB. A recent study by Lannoy et al. found that polygenic risk for suicide attempt and recent negative life events were associated with suicidal ideation in adolescents. This highlights the importance of further research in suicide genetics to better understand and address the underlying pathways to STB.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Monika A. Waszczuk, Olga Morozova, Elizabeth Lhuillier, Anna R. Docherty, Andrey A. Shabalin, Xiaohua Yang, Melissa A. Carr, Sean A. P. Clouston, Roman Kotov, Benjamin J. Luft
Summary: Genetic risk scores for asthma and allergic disease are associated with the severity and symptoms of COVID-19, while risk scores for coronary artery disease and type II diabetes are not.
Editorial Material
Psychiatry
Anna R. Docherty
SCHIZOPHRENIA BULLETIN
(2023)
Editorial Material
Genetics & Heredity
Zeeshan Ahmed, Saman Zeeshan, Donghyung Lee
FRONTIERS IN GENETICS
(2023)
Article
Multidisciplinary Sciences
Yu-Han Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, Apri Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K. T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage
Summary: Genetics have identified many schizophrenia risk genes and found common signals between schizophrenia and neurodevelopmental disorders. However, there is often a lack of functional interpretation of these genes in relevant brain cell types. In this study, the researchers investigated the protein network of six schizophrenia risk genes in induced cortical neurons, finding that it is enriched for common variant risk of schizophrenia and down-regulated in affected individuals. They also identified a sub-network centered on HCN1 that is enriched for common variant risk and contains proteins associated with rare protein-truncating mutations in schizophrenia and bipolar disorder. This study highlights the importance of brain cell-type-specific interactomes in interpreting genetic and transcriptomic data in schizophrenia and related disorders.
Review
Biochemistry & Molecular Biology
Monika A. Waszczuk, Katherine G. Jonas, Marina Bornovalova, Gerome Breen, Cynthia M. Bulik, Anna R. Docherty, Thalia C. Eley, John M. Hettema, Roman Kotov, Robert F. Krueger, Todd Lencz, James J. Li, Evangelos Vassos, Irwin D. Waldman
Summary: Genome-wide association studies (GWAS) have the potential to provide biological insights into disease mechanisms and offer clinically useful biomarkers. This review examines the use of quantitative and transdiagnostic phenotypes in GWAS for major psychiatric disorders. The authors discuss themes and recommendations, including issues of sample size, phenotypic reliability, sources of phenotypic information, and the use of biological and behavioral markers. The review also highlights the importance of multi-trait methods and the potential of dimensional and transdiagnostic phenotypes for gene discovery in psychiatric conditions.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Anna R. Docherty
SCHIZOPHRENIA BULLETIN
(2023)
Article
Physiology
Alisha Tromp, Haitao Wang, Thomas E. Hall, Bryan Mowry, Jean Giacomotto
Summary: We introduced Cre/Lox technology in our laboratory for transient and stable/transgenic experiments, but encountered problems such as silencing, mosaicism, and partial recombination. These issues are common among the zebrafish community using the Cre/Lox system. To improve the system, we developed a codon-improved Cre version and established tol2-kit compatible vectors to facilitate the generation of iCre-mRNA or iCre-transgenes.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Eduardo A. Maury, Maxwell A. Sherman, Giulio Genovese, Thomas G. Gilgenast, Tushar Kamath, S. J. Burris, Prashanth Rajarajan, Erin Flaherty, Schahram Akbarian, Andrew Chess, Steven A. McCarroll, Po-Ru Loh, Jennifer E. Phillips-Cremins, Kristen J. Brennand, Evan Z. Macosko, James T. R. Walters, Michael O'Donovan, Patrick Sullivan, Jonathan Sebat, Eunjung A. Lee, Christopher A. Walsh
Summary: This study suggests that somatic copy-number variants (sCNVs) may play a potential role in the risk of schizophrenia (SCZ). Early-developmental sCNVs were more common in SCZ cases, including recurrent somatic deletions in the NRXN1 gene. Additionally, recurrent intragenic deletions of the ABCB11 gene were observed in treatment-resistant SCZ cases.
