期刊
MICROSCOPY AND MICROANALYSIS
卷 16, 期 6, 页码 653-660出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1431927610093864
关键词
transmission electron microscopy; electron tomography; eosinophils; cell secretion; vesicular transport; inflammation; immune system; cytokines
资金
- National Institutes of Health (USA) [AI020241, AI051645, AI022571]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, Brazil) [CBB-APQ-01294-08]
Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.
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