Article
Materials Science, Multidisciplinary
Bence Feher, Imre Varga, Jan Skov Pedersen
Summary: PNIPAAM polymers have a lower critical solution temperature at 32 degrees C, which can be finely tuned by changing physical chemical parameters. Studies have shown that in the presence of NaCl, the radius of the polymer increases, while an increase in temperature causes polymer chain shrinkage, leading to aggregation at the LCST.
Article
Chemistry, Multidisciplinary
Luyao Wang, Qingbo Wang, Anna Slita, Oskar Backman, Zahra Gounani, Emil Rosqvist, Jouko Peltonen, Stefan Willfor, Chunlin Xu, Jessica M. Rosenholm, Xiaoju Wang
Summary: The study developed a bio-based antimicrobial resin for DLP printing, incorporating methacrylated O-acetyl-galactoglucomannan (GGMMA) and lignin nanoparticles embedded with silver nanoparticles (LNP@Ag) as a high-performance antimicrobial reagent. Through in situ reduction of silver nanoparticles and modulation of lignin polymerization degree, LNPs were upgraded for alkali-resistance. The encapsulation of LNP@Ag into GGMMA hydrogel did not alter its properties, enabling the fabrication of stable hydrogel constructs with high antimicrobial activity through layer-by-layer photocuring in DLP printing.
Article
Materials Science, Biomaterials
Didem Sen Karaman, Christa Kietz, Prakirth Govardhanam, Anna Slita, Alexandra Manea, Aysenur Pamukcu, Annika Meinander, Jessica M. Rosenholm
Summary: By utilizing mesoporous silica as a carrier, this study successfully fabricated a core-shell structured nanocomposite with a combinatory antibacterial mode of action. In vitro and in vivo experiments demonstrated its significant antibacterial effect against Escherichia coli, and its non-toxic nature to mammalian cells, suggesting its potential as a next-generation non-toxic nanoantibiotic with flexible design options.
BIOMATERIALS ADVANCES
(2022)
Review
Pharmacology & Pharmacy
Deepa Nakmode, Valamla Bhavana, Pradip Thakor, Jitender Madan, Pankaj Kumar Singh, Shashi Bala Singh, Jessica M. Rosenholm, Kuldeep K. Bansal, Neelesh Kumar Mehra
Summary: Poor aqueous solubility of drugs remains a major challenge in pharmaceutical product development. Utilizing lipids in formulation design offers an opportunity to enhance the solubility and bioavailability of drugs. This review comprehensively summarizes the classification, absorption mechanisms, and lipid-based product development of lipid excipients, as well as discusses the preparation methodologies, applications, phase behavior, and regulatory perspective of solid and semi-solid lipid formulations.
Review
Pharmacology & Pharmacy
Mijanur Rahman, Aliaa Ali, Erica Sjoholm, Sebastian Soindinsalo, Carl-Eric Wilen, Kuldeep Kumar Bansal, Jessica M. Rosenholm
Summary: This review article discusses the synthesis methods and post-synthesis modifications of allyl-terminated polymers, as well as their biomedical applications.
Article
Materials Science, Biomaterials
Kuldeep Kumar Bansal, Aliaa A. Ali, Mijanur Rahman, Erica Sjoholm, Carl-Eric Wilen, Jessica M. Rosenholm
Summary: Achieving high solubilization capacity with the aid of polymeric micelles is challenging. In this study, novel PJL-based PMs were developed and found to have significantly higher solubility compared to Soluplus and poly(lactide) copolymer. The presence of appropriate functional groups on the polymer chain was demonstrated to facilitate the solubilization potential of PM.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Polymer Science
Jarvi M. Spanjers, Edit Brodszkij, Noga Gal, Jan Skov Pedersen, Brigitte Stadler
Summary: Materials containing zwitterionic polymers have versatile properties and can be used for various applications. This study investigated the self-assembly of a block copolymer with different phospholipids into small and giant vesicles, analyzing their morphology, size, and membrane properties. It was found that DOPC was more suitable for assembling small vesicles, while vesicles containing DOPS and DOPE showed stronger association with HepG2 cells.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Mariana Kober, Silvia Illa-Tuset, Lidia Ferrer-Tasies, Evelyn Moreno-Calvo, Witold I. Tatkiewicz, Natascia Grimaldi, David Pina, Alejandro Perez Perez, Vega Lloveras, Jose Vidal-Gancedo, Donatella Bulone, Imma Ratera, Jan Skov Pedersen, Dganit Danino, Jaume Veciana, Jordi Faraudo, Nora Ventosa
Summary: This study investigates the stability and formation mechanism of CHOL/CTAB quatsomes, which are nanovesicles formed through the self-assembly of cholesterol and cetyltrimethylammonium bromide in water. Experimental and simulation results show that CHOL/CTAB quatsomes are thermodynamically stable nanovesicles, but they do not exhibit the classical membrane curvature induced by composition asymmetry.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ye Zhou, Jannik Nedergaard Pedersen, Jacob Nedergaard Pedersen, Nykola C. Jones, Soren Vronning Hoffmann, Steen Vang Petersen, Jan Skov Pedersen, Adam Perriman, Renjun Gao, Zheng Guo
Summary: This study focuses on the anionization of a carboxylate-enriched mutant of Bacillus subtilis lipase A (8M) to produce biofluids with enhanced hydrolytic activity. The resulting biofluids show a 2.5-fold increase in activity compared to those based on anionic polymer surfactants. Additionally, the use of anion-type biofluids with Myoglobin (Mb) is evaluated, revealing partial recovery of the active alpha-helix level in the biofluids. These highly active solvent-free liquid enzymes exhibit increased thermal stability and open up new possibilities in solvent-free liquid protein research.
Article
Biochemistry & Molecular Biology
Helena O. Rasmussen, Amit Kumar, Ben Shin, Fisentzos Stylianou, Lee Sewell, Yingqi Xu, Daniel E. Otzen, Jan Skov Pedersen, Steve J. Matthews
Summary: Bacterial functional amyloids contribute to biofilm development and serve as a protective mechanism against the immune system and antibiotics. Recent interest has focused on strategies to target amyloid formation and interrupt biofilm formation due to their antimicrobial potential. The interaction between the components FapA, FapB, and FapC is crucial for Fap fibril biogenesis, with FapA acting as a chaperone to prevent FapC fibrillation in the periplasm.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Edit Brodszkij, Isabella Nymann Westensee, Steffen Friis Holleufer, Carina Ade, Paula De Dios Andres, Jan Skov Pedersen, Brigitte Stadler
Summary: The properties of hybrid vesicle membranes can be altered by varying the chemical composition of the hydrophobic block in the amphiphilic block copolymers.
APPLIED MATERIALS TODAY
(2022)
Article
Nanoscience & Nanotechnology
Ewan K. S. McRae, Helena Ostergaard Rasmussen, Jianfang Liu, Andreas Boggild, Michael T. A. Nguyen, Nestor Sampedro Vallina, Thomas Boesen, Jan Skov Pedersen, Gang Ren, Cody Geary, Ebbe Sloth Andersen
Summary: RNA origami is a method for designing RNA nanostructures that can self-assemble through co-transcriptional folding. This study uses cryogenic electron microscopy to determine the structure of RNA origami sheets and bundles, revealing structural parameters and folding principles. The study also combines sheets and bundles to construct a multidomain satellite shape and characterizes its flexibility using cryo-electron tomography.
NATURE NANOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christian E. Rusbjerg-Weberskov, Mette Liere Johansen, Jan S. Nowak, Daniel E. Otzen, Jan Skov Pedersen, Jan J. Enghild, Nadia Sukusu Nielsen
Summary: Human periostin is a matricellular protein that plays important roles in extracellular matrix remodeling, tumor development, and inflammatory diseases. The C-terminal domain of periostin interacts with other domains and proteins, potentially contributing to the pathogenesis of diseases such as atopic dermatitis.
Article
Chemistry, Physical
Jan Skov Pedersen, Thea Lykkegaard Moller, Norbert Raak, Milena Corredig
Summary: This article investigates the hierarchical structure and scattering properties of casein micelles extracted from milk. By developing a new model, a detailed description of the casein micelles is provided, which is consistent with the available information in the literature.
Article
Nanoscience & Nanotechnology
Wali Inam, Rajendra Bhadane, Rukiye Nur Akpolat, Rifahul Abrar Taiseer, Sergey K. Filippov, Outi M. H. Salo-Ahen, Jessica M. Rosenholm, Hongbo Zhang
Summary: Zeta potential is an important parameter for characterizing nanoparticles, which is influenced by the presence of buffer solutions. Buffers can alter the electrokinetic properties of nanoparticles through specific molecular interactions. A thorough understanding of buffer-nanoparticle interactions is necessary for accurate zeta potential measurements.
Article
Chemistry, Applied
Lulu Wan, Gan Ye, Yuying Chang, Zhaohan Yang, Guangming Shi, Qiuli Zhang, Jin Wang
Summary: This study developed an efficient approach to upgrade the oxidative desulfurization (ODS) performance of Zr-MOFs with proton stimulation. Experimental results showed that the introduction of protons can significantly improve the ODS efficiency. This work provides a facile and efficient strategy for enhancing the ODS performance of pristine MOFs.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Qiqi Lu, Xiu-Zhi Wei, Qi Zhang, Xinghua Zhang, Lungang Chen, Jianguo Liu, Yubao Chen, Longlong Ma
Summary: The application of Pd-M bimetallic clusters in the selective hydrogenation reaction was investigated, and the Pd0.6Ni@S-1 catalyst was found to exhibit high selectivity in the conversion of phenylacetylene to styrene. The confinement effect of zeolite inhibited over-hydrogenation and improved the stability of the catalysts. Furthermore, the solvent properties also influenced the product distribution.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Review
Chemistry, Applied
Bo Li, Lumin Hong, Changdi Jing, Xianyang Yue, Huabo Huang, Qianqian Jiang, Jianguo Tang
Summary: MOF materials with adjustable pore structure and polymetallic sites have been explored as electrocatalysts for OER. Bimetallic materials show higher electrocatalytic activity than monometallic materials, while carbon-coated and doped MOF catalysts exhibit stable and good OER activity. The synergistic interaction between polymetallic active sites effectively improves the intrinsic activity of MOF on OER.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shichun Gu, Ruyi Wang, Junxiong Zhang, Hairong Dong, Liping Deng, Xue Wang, Yapeng He
Summary: In this study, monodispersed hollow mesoporous organosilica nanospheres with controlled core cavity and mesoporous shell were successfully synthesized. These hollow nanospheres showed a high adsorption capacity for Pb2+ in water solution and exhibited acceptable recycling and stability.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Lucie Havelkova, Bogdana Bashta, Michaela Vankova, Jiri Zednik, Jiri Brus, Jan Svoboda, Alice Vagenknechtova, Jan Sedlacek
Summary: An atom-economic one-step chain-growth coordination homopolymerization providing high yields of functionalized hyper-cross-linked polyacetylenes with a permanent micro/mesoporous texture and a BET area of up to 1062 m2/g is reported. The homopolymerization is highly compatible with the heteroatom groups of the monomers and allows the preparation of well-defined porous networks with a wide spectrum of univalent groups.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Shirui Pang, Yuxin Liu, Zhe Zhang, Yuxin Li, Chunguang Li, Zhan Shi, Shouhua Feng
Summary: This study focuses on using a functional separator to suppress the shuttle effect of soluble lithium polysulfides in Li-S batteries. It is found that the functionalized sulfonic acid group not only accelerates the conduction of lithium ions, but also repels polysulfide anions through electrostatic interactions. The performance of the batteries is significantly improved with the use of this functionalized separator.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Pingping Li, Lei Han, Donghun Kim, Kemal Celebi
Summary: This study presents a fast synthetic strategy for the preparation of high-quality platelike MFI crystals using a thin-wall tubular reactor. The strategy is efficient, time-saving, and can be optimized, making it applicable to the preparation and optimization of other important materials.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Haitao Yin, Wei Wang, Yuxin Li, Hu Wen, Shuang Chen, Nanzhe Jiang
Summary: This study presents a template-free and solid-state-like crystallisation method for the synthesis of ZSM-5 zeolite, which can be scaled-up in production. Mechanical mixing of starting material components improves the dispersion of materials, leading to ZSM-5 zeolite with high crystallinity and size uniformity.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Congli Li, Jiang Wang, Zhenfei Wang, Jinxiang Dong, Qi Shi
Summary: This study investigates the evolution and autoreduction behavior of Cu species in CuCl/NaY adsorbent during vacuum thermal activation. It is found that Cu species migrate from supercages to the nearby plane of the six-membered ring connecting the supercage and sod cage during vacuum activation. At 150 degrees C, vacuum autoreduction occurs, resulting in the formation of Cu+Cl- species. The results provide reference for the preparation of pi-complex adsorbents.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Irena Khatrin, Iman Abdullah, Alan J. Mccue, Yuni K. Krisnandi
Summary: Hierarchical porous system with two types of mesopores provides a solution to the diffusion limitation in conventional zeolites. Cobalt oxide impregnated hierarchical ZSM-5 zeolite samples with intra- and inter-crystalline mesopores were synthesized using two different strategies. The physicochemical properties of the modified catalysts were analyzed, revealing distinct features given by the two mesoporous configurations. Catalytic activity analysis showed that Co-oxide/ZSM-5 with inter-crystalline mesopores exhibited higher activity in methane partial oxidation reaction compared to Co-oxide/ZSM-5 with intra-crystalline mesopores.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Nataliia Reinders, Martin Durovic, Pavla Honcova, Zaneta Dohnalova, Jana Luxova, Stanislav Slang, Jhonatan Rodriguez-Pereira, Petra S. Sulcova
Summary: This study presents a new method for preparing a microporous Ni2P/C catalyst with high catalytic activity. The redox reaction and carbon matrix formation during high-temperature treatment contribute to the stability and activity of the catalyst. Experimental and analytical results suggest that the microporous structure of the composite plays a crucial role in its catalytic performance. These findings are important for practical applications of efficient hydrogen production by water electrolysis.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Ana Raquel Bertao, Viktoriya Ivasiv, Cristina Almeida-Aguiar, Patricia R. Correia, Antonio M. Fonseca, Manuel Banobre-Lopez, Fatima Baltazar, Isabel C. Neves
Summary: This study developed a zeolite-based delivery system (ZDS) using silver and 5-Fluorouracil as antimicrobial and antineoplastic agents. The ZDS was characterized and its antimicrobial properties were investigated, showing better antibacterial effectiveness for the ZDS containing both silver and 5-FU.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Naonobu Katada, Nobuki Ozawa, Etsushi Tsuji, Keigo Kanehara, Akiho Otsuka, Taiga Sakamoto, Kirari Umezawa, Hitoshi Matsubara, Satoshi Suganuma, Momoji Kubo
Summary: First principles calculations were used to investigate the pathway for methylation of benzene with methane catalyzed by MFI type zeolite-supported Co species. The strong adsorption of benzene on Co is found to lower the activation energy for methane dissociation and promote the formation of toluene precursor. The activation energy of methane dissociation is also affected by the Al-Al distance.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Yuan Liu, An T. Ta, Kyoung Chul Park, Shenyang Hu, Natalia B. Shustova, Simon R. Phillpot
Summary: We use density functional theory to investigate the interactions of cerium, americium, and curium cations with crown ethers. Our results demonstrate that crown ethers can capture cerium, americium, and curium ions, and modifying the crown ether structure by substituting nitrogen atoms for oxygen atoms significantly increases their binding energies with radionuclides.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
Article
Chemistry, Applied
Zhengwu Peng, Shixing Wang, Yihui Wu, Xiang Liu, Hongliang Liu, Dekun Zhang, Likang Fu
Summary: An efficient adsorbent for recovery of germanium was prepared and characterized in this study. The adsorption behavior of Ge(IV) on the adsorbent was analyzed, and the results showed that it follows pseudo-secondary kinetic model and Langmuir isotherm model. The adsorbent exhibited good anionic anti-interference ability and can still maintain high adsorption efficiency after repeated adsorption.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)