Article
Chemistry, Analytical
Gui-Ping Zhu, Qi-Yue Wang, Zhao-Kun Ma, Shi-Hua Wu, Yi-Pan Guo
Summary: The magnetic manipulation of droplets is an emerging technology that integrates multiple disciplines and enables remote and programmable control. It has great potential for research and engineering applications. However, there are still challenges related to magnetic field design, material selection, and droplet performance stability.
Article
Nanoscience & Nanotechnology
Sagar N. Agnihotri, Mohammad Reza Raveshi, Rajneesh Bhardwaj, Adrian Neild
Summary: This paper demonstrates a selective multisite splitting and merging system using single-layer microfluidic valves, offering simplicity, biocompatibility, and high-speed operation. These valves control the generation of droplets and splitting locations, as well as allow for merging different types of droplets.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Computer Science, Software Engineering
Nghia Truong, Cem Yuksel, Chakrit Watcharopas, Joshua A. Levine, Robert M. Kirby
Summary: The article introduces a simple scheme for handling collisions in large particle simulations, using particle merging and splitting to prevent penetrations and numerical instabilities. It demonstrates the effectiveness of this method in handling collisions and coupling different simulation systems.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2022)
Article
Chemistry, Analytical
Siqi Qian, Han Wu, Bin Huang, Qi Liu, Yan Chen, Bo Zheng
Summary: This study presents a method for sub-micron resolution patterning of perfluorinated surfaces and its application in digital immunoassays without beads. By using negative microcontact printing and a composite stamp, polydopamine patterns are successfully fabricated on perfluorinated surfaces, enabling the creation of microspot arrays for digital assays. The high-resolution polydopamine patterned perfluorinated substrate offers a highly-sensitive and low-cost approach for digital immunoassays, showing great potential in high-throughput and digital bioassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Multidisciplinary
Kim Tien Nguyen, Minh Phu Bui, Tuan-Anh Le, Van Du Nguyen, Jungwon Yoon, Jong-Oh Park, Jayoung Kim
Summary: This paper investigates the feasibility of integrating MPI functionality in anisotropic magnetic platforms. A method for generating FFP in anisotropic structures with various magnetic sources is derived and numerically investigated. The tracking performances are demonstrated in both in-vitro and in-vivo experiments using one of the selected anisotropic structures. The proposed system currently has the function of tracking particles with an accuracy of around 1 mm, and allows for simultaneous manipulation and localization.
Article
Mathematics, Applied
Xiang Li, Peng Yu, Xiao-Dong Niu, De-Cai Li, Hiroshi Yamaguchi
Summary: This study focuses on the dynamics of ferrofluid droplets in a Newtonian fluid, utilizing a magnetic field coupling lattice Boltzmann model to solve the incompressible Navier-Stokes equations and the Cahn-Hilliard equation. The addition of a mass-correcting term in the C-H equation enforces mass conservation, and the method is capable of simulating magnetic multiphase flows.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Article
Chemistry, Multidisciplinary
Vahid Nasirimarekani, Fernando Benito-Lopez, Lourdes Basabe-Desmonts
Summary: The technology involves manipulating droplets using a magnetic field through the addition of magnetic particles or using magneto responsive surfaces. The experimental study presented and characterized a tunable superparamagnetic ring which stabilizes and enables physical manipulation of droplets on a surface. This work opens new applications in microfluidics and studies on tunable interfaces between immiscible liquids.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Maren Umlandt, Alexey Kopyshev, Sergey Pasechnik, Alexandre Zakharov, Nino Lomadze, Svetlana Santer
Summary: Researchers have developed a method of light-triggered droplet manipulation, which includes reversible wetting, splitting, merging, and transport. By applying soft optical stimuli, they are able to change the wetting properties and surface morphology of microscopic droplets, allowing for precise manipulation and movement of the droplets.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Sebastian A. Altmeyer
Summary: This research studies the influence of time-periodic modulation on ferrofluidic Couette flow in a spatially homogeneous magnetic field. The study finds that the transition scenarios between different flow structures, non-propagating vortex (nV) states, are affected by the amplitude and frequency modulation, with the system response being highly sensitive to the driving frequency and exhibiting notable delay. In addition, the inertia of the ferrofluid leads to the emergence of temporary nV states within an alternating field, which are unstable under static fields. Furthermore, even within the same nV state, significant discrepancies in angular momentum and torque can be observed.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Chemistry, Analytical
Wensyang Hsu, Yu-Teng Shih, Meng-Shiue Lee, Hong-Yuan Huang, Wan-Ning Wu
Summary: This study investigated whether using a fixed number of beads in a bead-based digital microfluidic immunoassay could provide more stable results. The results showed that a fixed number of beads had smaller coefficient of variation compared to varying bead numbers, especially in the range of 1 pg/mL to 100 pg/mL. The use of a fixed number of beads significantly reduced the limit of detection.
Article
Chemistry, Multidisciplinary
Jian Wang, Zhengxu Zhu, Pengfei Liu, Shengzhu Yi, Lelun Peng, Zhilun Yang, Xuelin Tian, Lelun Jiang
Summary: A novel magneto-responsive shutter (MRS) design is developed for on-demand droplet manipulation, allowing reversible swing and rotation of microblades over a large rotation range with precise control. Different functionalized MRSs enable a wide range of droplet manipulations, such as switchable wettability, directional droplet bounce, droplet distribution, merging, and continuous transport along straight or curved paths. MRS provides a new paradigm for efficient and on-demand multimode droplet manipulation under magnetic actuation.
Article
Biochemical Research Methods
Renchang Zhang, Chang Gao, Lu Tian, Ronghang Wang, Jie Hong, Meng Gao, Lin Gui
Summary: This study introduces a convenient method for gathering, splitting, merging, and sorting microdroplets in double-layered microfluidic devices using dynamic pneumatic rails. By controlling air pressure, different components consisting of pneumatic rails can manipulate droplets effectively.
Article
Nanoscience & Nanotechnology
Tao Sun, Zhiyuan Tang, Wenjie Zang, Zejun Li, Jing Li, Zhihao Li, Liang Cao, Jan Sebastian Dominic Rodriguez, Carl Osby M. Mariano, Haomin Xu, Pin Lyu, Xiao Hai, Huihui Lin, Xiaoyu Sheng, Jiwei Shi, Yi Zheng, Ying-Rui Lu, Qian He, Jingsheng Chen, Kostya S. Novoselov, Cheng-Hao Chuang, Shibo Xi, Xin Luo, Jiong Lu
Summary: Heterogeneous single-atom spin catalysts combined with magnetic fields have been designed for accelerated chemical reactions. A hydrothermal approach was used to synthesize single-atom spin catalysts with various substitutional magnetic atoms in a MoS2 host. The Ni-1/MoS2 catalyst with a distorted tetragonal structure showed global room-temperature ferromagnetism, and the addition of a mild magnetic field significantly enhanced the oxygen evolution reaction magnetocurrent, leading to excellent activity and stability in water splitting cells.
NATURE NANOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Jiyao Wang, Ling Qin, Wei Xu
Summary: Manipulation of small liquid droplets is crucial in various research and applications in fields such as chemistry and biology. Existing magnetic manipulation methods mainly focus on specially treated solid surfaces, which limit surface reusability and make it difficult to balance droplet size and quantity. Our proposed method offers high precision and resolution for controlling both single and swarm droplets, providing an efficient and reliable strategy for ferrofluid droplet manipulation.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xueshan Jing, Huawei Chen, Liwen Zhang, Song Zhao, Yan Wang, Zelinlan Wang, Yu Zhou
Summary: A novel magnetic micropillars array (MMA) is developed for multi-dimensional droplet manipulation, allowing precise control of droplets on an open surface. The behavior of droplets and the driving force acting on them are derived from the deformation of the micropillars. Different modes of horizontal transport, propelling and rolling, can achieve accurate and rapid droplet transportation. This technology shows great potential for accurate 3D droplet manipulation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemical Research Methods
Linfeng Xu, Hun Lee, Mariana Vanderlei Brasil Pinheiro, Phil Schneider, Deekshitha Jetta, Kwang W. Oh
Review
Biochemical Research Methods
Linfeng Xu, Hun Lee, Deekshitha Jetta, Kwang W. Oh
Article
Chemistry, Analytical
Hun Lee, Domin Koh, Linfeng Xu, Sindhu Row, Stelios T. Andreadis, Kwang W. Oh
Article
Biochemical Research Methods
Hun Lee, Linfeng Xu, Kwang W. Oh
Article
Biochemical Research Methods
Linfeng Xu, Hun Lee, Rajagopal Panchapakesan, Kwang W. Oh
Article
Biochemical Research Methods
Jing Xu, Byungwook Ahn, Hun Lee, Linfeng Xu, Kangsun Lee, Rajagopal Panchapakesan, Kwang W. Oh
Article
Nanoscience & Nanotechnology
Linfeng Xu, Hun Lee, Kwang W. Oh
MICROFLUIDICS AND NANOFLUIDICS
(2014)
Review
Chemistry, Analytical
Hun Lee, Linfeng Xu, Domin Koh, Nikhila Nyayapathi, Kwang W. Oh
Article
Biochemical Research Methods
Bin Yang, Xingye Chen, Yina Wang, Siyu Feng, Veronica Pessino, Nico Stuurman, Nathan H. Cho, Karen W. Cheng, Samuel J. Lord, Linfeng Xu, Dan Xie, R. Dyche Mullins, Manuel D. Leonetti, Bo Huang
Review
Biochemical Research Methods
Linfeng Xu, Anyang Wang, Xiangpeng Li, Kwang W. Oh
Article
Chemistry, Multidisciplinary
Linfeng Xu, Xiangpeng Li, Wenzong Li, Kai-chun Chang, Hyunjun Yang, Nannan Tao, Pengfei Zhang, Emory M. Payne, Cyrus Modavi, Jacqueline Humphries, Chia-Wei Lu, Adam R. Abate
Summary: This paper describes a simple method to fabricate substrates patterned with micrometer-scale wells, which can enhance the sensitivity of laser desorption ionization mass spectrometry and concentrate cells and beads for cell-based assays.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Linfeng Xu, Kai-Chun Chang, Emory M. Payne, Cyrus Modavi, Leqian Liu, Claire M. Palmer, Nannan Tao, Hal S. Alper, Robert T. Kennedy, Dale S. Cornett, Adam R. Abate
Summary: Enzymes have diverse activities that surpass chemical catalysts, but engineering them for novel or enhanced activity is hampered by limited technologies for sensing product formation. This study presents a general and scalable approach that uses host cell metabolism as a biosensor to infer product formation, enabling the discovery of unexpected products and mapping the effects of mutagenesis through mass spectrometry. Additionally, a screening method combining microfluidics and mass spectrometry is reported for mapping catalysis, characterizing product range, and recovering sequences of variants with desired activities.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Justin L. Madrigal, Nathan G. Schoepp, Linfeng Xu, Codian S. Powell, Cyrille L. Delley, Christian A. Siltanen, Jay Danao, Maithreyan Srinivasan, Russell H. Cole, Adam R. Abate
Summary: Cell-cell interactions play a crucial role in biological systems, but current methods for studying these interactions are limited in scalability. This study presents a novel approach for cell interaction profiling using high-throughput droplet microfluidics, allowing for accurate grouping and characterization of cell interactions on a large scale.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Proceedings Paper
Engineering, Biomedical
Hun Lee, Linfeng Xu, Kwang W. Oh
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2014)