Article
Chemistry, Physical
Weian Wang, Jiahe Zhang, Peng Ye, Wei Liu, Wangqi Mao, Zengliang Shi, Qiannan Cui, Mingliang Wang, Gangyi Zhu, Chunxiang Xu
Summary: In this study, an optofluidic surface-enhanced Raman scattering (SERS) sensing chip is proposed for dynamic monitoring of protein aggregation. The chip utilizes a combination of gold nanoparticles and microdisks to enhance the Raman scattering signal, enabling real-time detection of slight changes in protein aggregation and potential applications in biological fluid and cellular microenvironment monitoring.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Optics
Danheng Gao, Xinghua Yang, Pingping Teng, Meng Luo, Haoxin Zhang, Zhihai Liu, Jun Yang, Zhanao Li, Xingyue Wen, Libo Yuan, Kang Li, Mark Bowkett, Nigel Copner
Summary: In this study, a microstructured in-fiber optofluidic SERS sensor is proposed for the initial detection of uremia by detecting unlabeled urea and creatinine. The self-assembled SERS substrate using silver nanoparticles and graphene oxide sheets successfully enhances Raman signals. Experimental results demonstrate good detection performance for urea and creatinine under simulated conditions.
Article
Food Science & Technology
Sara Asgari, Rajiv Dhital, Azlin Mustapha, Mengshi Lin
Summary: In this study, a surface-enhanced Raman spectroscopy (SERS) optofluidic sensor was developed to simultaneously separate and detect Escherichia coli O157:H7 and Salmonella in lettuce and packed salad. The method showed high sensitivity and low detection limit, with a short analysis time. It can be considered as a promising rapid and efficient approach for pathogen screening in food samples.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Seyedabadi, Mehdi Gharghabi, Eugenia V. Gurevich, Vsevolod V. Gurevich
Summary: Arrestins are a small family of proteins found in most vertebrates, binding to a variety of G protein-coupled receptors and playing key roles in preventing further receptor-G protein coupling, promoting receptor internalization, and initiating specific signaling pathways. Research on the molecular mechanisms of arrestin-GPCR interactions has focused on arrestin elements in receptor binding, but further investigations are needed on the receptor elements involved in arrestin binding to fill existing knowledge gaps. Understanding how receptor elements activate arrestin and contribute to high-affinity binding is crucial for developing arrestin mutants with desired functional characteristics.
Article
Materials Science, Multidisciplinary
Samir Kumar, Takao Fukuoka, Ryo Takahashi, Mitsuhiro Yoshida, Yuchi Utsumi, Akinobu Yamaguchi, Kyoko Namura, Motofumi Suzuki
Summary: Surface-enhanced Raman spectroscopy (SERS) is a sensitive vibrational spectroscopy technique that allows for fast and non-destructive detection of trace molecules. By incorporating unique Au nanorod arrays (AuNRA) into microfluidic devices, rapid and sensitive chemical sensing can be achieved efficiently.
Article
Food Science & Technology
Yuying Wang, Jing Shen, Bowen Zou, Ling Zhang, Xianbing Xu, Chao Wu
Summary: The study successfully prepared cod protein-curcumin composite particles using the pH-shift method, and found that pH 10 is the critical pH for cod protein structure unfolding. The results showed that cod protein treated at the critical pH could encapsulate more curcumin, leading to an increased encapsulation efficiency. The study indicated that the critical pH is necessary for improving the encapsulation effect.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Shiwani Randhawa, Syed M. S. Abidi, Aqib Iqbal Dar, Amitabha Acharya
Summary: Protein corona formation is a major obstacle in achieving the desired efficacy of nanomedicine, as proteins interacting with nanoparticle surfaces undergo structural and biological changes. However, nanoparticles also exhibit anti-amyloidogenic behavior, preventing alterations in their native structure, posing a paradox that requires further investigation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Qiaojing Huang, Luhua Lai, Zhirong Liu
Summary: Dynamic allosteric regulation refers to a type of regulation that does not involve noticeable conformational changes. By developing a unified anisotropic elastic network model, the contribution of pure dynamic allosteric regulation was quantitatively estimated. The study found that pure dynamic allosteric regulation has a generally small contribution, which decays exponentially with the distance between the substrate and the allosteric ligand. Toy models were also used to analyze the factors determining dynamic allosteric regulation in proteins.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Nanoscience & Nanotechnology
Cheng-Zhe Xie, Cheng-Han Li, You-Chia Chang, Yih-Fan Chen
Summary: This paper introduces a gel-based 3D substrate for enhanced SERS detection by utilizing photonic nanojets (PNJs). The porous structure of the gel-based substrate allows small molecules to diffuse, while silica beads on the surface generate PNJs during SERS measurements. By coating the substrate with a close-packed array of silica beads, multiple PNJs can be generated, resulting in significantly enhanced Raman signals and improved detection sensitivity. This enhancement scheme can be applied to achieve high-sensitivity SERS detection for various molecules in diverse applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Seul Hoo Lee, Hogyun Seo, Hwaseok Hong, Mijeong Kim, Kyung-Jin Kim
Summary: Researchers found that IsTBP in Ideonella sakaiensis has high specificity and affinity for TPA, which helps in the degradation of PET plastic. They also developed an IsTBP variant with enhanced sensitivity, which can be used as a biosensor for PET degradation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Milosz Ruszkowski, Giuseppe Forlani
Summary: This study determined the structure of EPSPS from the plant model species Arabidopsis thaliana and explored its susceptibility to glyphosate inhibition. The crystal structure of the enzyme was resolved, providing insights for the design of novel EPSPS inhibitors.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Akinobu Senoo, Satoru Nagatoishi, Daisuke Kuroda, Sho Ito, Go Ueno, Jose M. M. Caaveiro, Kouhei Tsumoto
Summary: Small molecules that regulate protein-protein interactions have potential as valuable drugs. In this study, we propose that modulating the conformational ensemble of the proteins involved in an interaction can interfere with protein-protein interactions. We applied this concept to P-cadherin and found that a small molecule inhibitor modulates the conformational ensemble of P-cadherin, resulting in the inhibition of cell adhesion.
Article
Chemistry, Physical
Wenjia Hou, Songze Wu, Yi Liu, Hua Li
Summary: In this study, the interaction between silver ions (Ag+) and serum immunoglobulin G (IgG) was investigated and its impact on the adhesion of Escherichia coli and macrophages to biomaterial surfaces was explored. The results suggested that the presence of Ag+ altered the secondary structure of IgG and changed its role from promotion to inhibition in bacterial and macrophage adhesion. These findings provide insights into the interactions between Ag+ and IgG for the rational design of antibacterial biomaterials.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Spectroscopy
Muhammad Haroon, Wissam Iali, Abdulaziz A. Al-Saadi
Summary: Linuron, a commonly used organic herbicide, was studied using NMR and Raman spectroscopic techniques to investigate its conformational behavior and electronic aspects. The SERS technique with gold nanoparticles was implemented for concentration monitoring, successfully enhancing the Raman responses of four vibrational modes. Simulations predicted that the most pronounced binding of linuron with gold nanoclusters occurs at the benzene ring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Tong-Jiang Li, Bao-Ying Wen, Xiao-Hui Ma, Wan-Ting Huang, Jin-Zhun Wu, Xiu-Mei Lin, Yue-Jiao Zhang, Jian-Feng Li
Summary: A convenient method using a portable Raman spectrometer was developed to quickly detect the secondary structure of human pepsin, showing improved sensitivity in detection. The detection limit of human pepsin was found to be 2 μg/mL, with a standard recovery rate of 80.7-92.3%.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Chao-Kai Chou, Po-Jung Huang, Pei-Hsiang Tsou, Yongkun Wei, Heng-Huan Lee, Ying-Nai Wang, Yen-Liang Liu, Colin Shi, Hsin-Chih Yeh, Jun Kameoka, Mien-Chie Hung
BIOSENSORS & BIOELECTRONICS
(2018)
Article
Polymer Science
D. Steck, J. Qu, S. B. Kordmahale, D. Tscharnuter, A. Muliana, J. Kameoka
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Article
Materials Science, Multidisciplinary
Sravani Jaligama, Jun Kameoka
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Engineering, Electrical & Electronic
Onder Dincel, Tsuyoshi Ueta, Jun Kameoka
SENSORS AND ACTUATORS A-PHYSICAL
(2019)
Article
Chemistry, Analytical
Zheyuan Chen, Christopher Wright, Onder Dincel, Ting-Yen Chi, Jun Kameoka
Article
Chemistry, Multidisciplinary
Chao-Kai Chou, Yen-Liang Liu, Yuan- Chen, Po-Jung Huang, Pei-Hsiang Tsou, Chun-Te Chen, Heng-Huan Lee, Ying-Nai Wang, Jennifer L. Hsu, Jin-Fong Lee, Thomas E. Yankeelov, Jun Kameoka, Hsin-Chih Yeh, Mien-Chie Hung
Article
Biochemical Research Methods
Zheyuan Chen, Yi Yang, Hirohito Yamaguchi, Mien-Chi Hung, Jun Kameoka
Article
Chemistry, Analytical
Ting-Yen Chi, Zheyuan Chen, Jun Kameoka
Article
Chemistry, Analytical
Sina Baghbani Kordmahale, Jitae Do, Kuang-An Chang, Jun Kameoka
Summary: This paper introduces a new open-water wave energy converter made of a soft platform, integrating piezoelectric macro-fiber composites and bubble wrap, demonstrating promising energy conversion performance at low frequencies in experiments. The elastomer effectively protects internal components and can be folded to reduce deployment costs, potentially advancing the platform for real-world applications.
Article
Chemistry, Analytical
Jaskirat Singh Batra, Ting-Yen Chi, Mo-Fan Huang, Dandan Zhu, Zheyuan Chen, Dung-Fang Lee, Jun Kameoka
Summary: This study developed a wearable paper-based virus sensor based on molecular imprinting technique and conductive polyaniline, which can detect and monitor potential virus infections. This sensor can be integrated with a face mask, offering an alternative approach to virus monitoring in communities.
Proceedings Paper
Engineering, Biomedical
Zheyuan Chen, Ting-Yen Chi, Onder Dincel, Lin Tong, Jun Kameoka
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)
Proceedings Paper
Engineering, Biomedical
Zheyuan Chen, Hirohito Yamaguchi, Jun Kameoka
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2019)
Article
Materials Science, Multidisciplinary
Sina Baghbani Kordmahale, Jitae Do, Kuang-An Chang, Jun Kameoka
Article
Radiology, Nuclear Medicine & Medical Imaging
Po-Jung Huang, Jian Qu, Pradip Saha, Anastasia Muliana, Jun Kameoka
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2019)
Article
Chemistry, Multidisciplinary
Po-Jung Huang, Myung Hwangbo, Zheyuan Chen, Yina Liu, Jun Kameoka, Kung-Hui Chu
