期刊
MICROELECTRONIC ENGINEERING
卷 111, 期 -, 页码 384-390出版社
ELSEVIER
DOI: 10.1016/j.mee.2013.03.152
关键词
Neurophysiology; Beam induced deposition; Cell engulfment
Ion Beam Induced Deposition (IBID) is employed to fabricate three-dimensional nanoprotrusions on top of the recording pads of an active pixel sensor array (APS-MEA) featuring 4096 microelectrodes. Modified APS-MEAs are envisioned as enhanced tools to achieve real-time in-cell recordings from thousands of sensing elements, thus aiming to large-scale in-vitro registrations with unprecedented signal quality. A generalized electric model is proposed to address the revealed complexity of the neuron/electrode interface, and simulations have been conducted revealing the most advantageous cell/electrode coupling conditions. Preliminary results on the recording of spontaneous activity in cultured neuronal networks by means of nanostructured microelectrodes demonstrate the compatibility of IBID technology and APS-MEA infrastructure. The interface between cultured mammalian neurons and modified microelectrodes is revealed by FIB/SEM analysis, fostering the employment of the proposed electrical model for interpretation of electrical recordings from nanostructured microelectrodes. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据