期刊
MICROCIRCULATION
卷 10, 期 3-4, 页码 313-323出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mn.7800196
关键词
CCL25; CCL28; IgA; GALT; homing
资金
- NHLBI NIH HHS [HL-67674] Funding Source: Medline
- NIAID NIH HHS [AI-47822] Funding Source: Medline
- NIDDK NIH HHS [DK-56339] Funding Source: Medline
- NIGMS NIH HHS [GM-37734] Funding Source: Medline
Lymphocyte migration through gut-associated lymphoid tissues (GALT) and into intestinal effector sites is critical to intestinal immune system function and homeostasis. Chemokines contribute to lymphocyte trafficking by triggering integrin activation and firm arrest in the vasculature and mediating chemotactic localization within tissues. Several chemokines have been identified that are expressed in the GALT and/or the intestines themselves (TECK/CCL25, MEC/CCL28, and MIP-3alpha/CCL20) and play a role in intestinal lymphocyte localization, including unification of intestinal and other mucosa-associated effector sites; segmental specialization of the intestines; and subset selective localization to the intestines. This review examines the role of these chemokines ( and their receptors CCR9, CCR10, and CCR6, respectively) in lymphocyte homing to the GALT, in the induction and differentiation of intestinal effector and memory lymphocytes, and in the homeostatic and inflammatory localization of lymphocytes to the intestines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据