期刊
MICROCHIMICA ACTA
卷 180, 期 3-4, 页码 269-277出版社
SPRINGER WIEN
DOI: 10.1007/s00604-012-0925-z
关键词
Nanosensor; Dopamine; Glutathione; CdTe quantum dots
资金
- National Natural Science Foundation of China [21075050, 21005029]
We have constructed a fluorescent nanosensor for dopamine (DA) and glutathione (GSH) in physiologically relevant concentrations. CdTe quantum dots (QDs) were coated with silica, and dopamine-quinone (formed by oxidation of DA) is captured on the surface of silica via dual interactions (hydrogen bonding and electrostatic interaction) and quenches the photoluminescence of the modified QDs by an electron transfer process. GSH, in being a strong reducing agent, can chemically reduce the dopamine-quinone on the QDs, and this results in recovered photoluminescence. There are linear relationships between the concentrations of dopamine and GSH respectively and the intensity of the photoluminescence intensity of the QDs both in the quenched and regenerated form, the ranges being 0.0005 to 0.1 mmol L-1 for dopamine, and 0.1 to 10 mmol L-1 for GSH. The method was applied to the determination of dopamine and GSH in human serum samples with satisfactory results.
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