Article
Chemistry, Analytical
Mengke Wang, Ning Li, Shun Wang, Junyang Chen, Mengjun Wang, Lu Liu, Xingguang Su
Summary: The study developed a ratiometric fluorescent sensing platform based on Ag-AuNCs@SiNPs nanohybrids for detecting AChE activity, which showed high sensitivity and stability, making it suitable for reliable detection of AChE activity in human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Xiaoying Yuan, Wendi Lv, Bing Wang, Chenglu Yan, Qiuting Ma, Baozhan Zheng, Juan Du, Dan Xiao
Summary: In this work, a ratiometric fluorescence sensing platform was successfully created using silicon nanoparticles and lanthanide metal ion Eu3+, allowing for the detection of ciprofloxacin and Cu2+ through visible color changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Kyuyoung Bae, Bo Xu, Ananda Das, Connor Wolenski, Eric Rappeport, Wounjhang Park
Summary: The combination of plasmonic nanostructures with upconversion nanoparticles has led to an enhanced sensing platform through ratiometric sensing, which improves sensing capabilities for biomedical applications.
Article
Chemistry, Analytical
Serkan Erdemir, Sait Malkondu, Mehmet Oguz, Ozcan Kocyigit
Summary: Viscosity inside cells plays a crucial role in mass and signal transfer, dispersion of reactive metabolites, and biomacromolecular interactions. This study introduces a new fluorescence probe that responds to intracellular viscosity and detects hydrazine. The probe shows good sensing features with high adaptability, selectivity, sensitivity, ratiometric and fast response, low cytotoxicity, low detection limit, and high signal-to-noise ratio.
Article
Biophysics
Lijun Liu, Lu Ga, Jun Ai
Summary: This paper discusses the basic principles of logic functions in ratiometric fluorescence detection and summarizes the strategies for constructing logic systems. Despite some limitations, ratiometric fluorescence sensing logic circuits combining logic operation visualization and accuracy are still worthy of in-depth study.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Shuyi He, Steven Wu
Summary: This article reports a ratiometric temperature sensing technology based on polymer dots-Eu nanoparticles, which have unique characteristics such as high water solubility, good light stability, excellent biocompatibility, and low cost. The probe utilizes the red/blue fluorescence intensity ratio to monitor temperature change, and shows good accuracy and high sensitivity for temperature detection in vitro, making it suitable for monitoring temperature change in cells.
Review
Chemistry, Multidisciplinary
Hui Jin, Meng Yang, Rijun Gui
Summary: This review provides an overview of the recent advances in ratiometric upconversion luminescence (UCL) nanoprobes, particularly in the areas of sensing, imaging, and phototherapy. It discusses the construction strategies, sensing applications, and phototherapeutic applications of these nanoprobes. The review also presents the current state, challenges, and future perspectives in this field. Overall, it highlights the potential of these luminescent nanoprobes for various applications in significant fields.
Article
Biochemical Research Methods
Dandan Ma, Huiyun Bai, Junbo Li, Yintao Li, Lihua Song, Jinping Zheng, Congxiu Miao
Summary: The developed amplified fluorescence resonance energy transfer (FRET) nanoprobe offers highly sensitive and reliable monitoring of intracellular telomerase activity, making it a potential platform for efficient tumor diagnosis and screening of telomerase-related inhibitors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Lei Shang, Bing-Jiao Shi, Wei Zhang, Li-Ping Jia, Rong-Na Ma, Qing-Wang Xue, Huai-Sheng Wang
Summary: This study developed a dual-potential ratiometric ECL sensor for sensitive detection of CEA using a single luminophore and a single coreactant. The sensor showed a wide linear range and high reliability.
ANALYTICAL CHEMISTRY
(2022)
Article
Spectroscopy
Xiao-Lei Xue, Yang Wang, Shaojin Chen, Kun-Peng Wang, Shu-Yan Niu, Qian-Shou Zong, Yi Jiang, Zhi-Qiang Hu
Summary: Monitoring intracellular pH using ratiometric fluorescent probes is important for studying biological processes including diseases. This study presents a new hemicyanine-based ratio-metric fluorescent probe with a hydroxyl group, which exhibits dual emission and can selectively respond to micro-environmental pH conditions in a range of 6.0 to 8.0. The probe can enter and accumulate in mitochondria and monitor pH microenvironmental conditions through fluorescence imaging in HepG2 cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Jiating Cao, Meiting Xie, Xinyu Gao, Zhuoyong Zhang, Jianguo Wang, Wenjuan Zhou, Weijiang Guan, Chao Lu
Summary: The study explores a charge neutralization strategy using multicharged cationic nanocarriers to efficiently assemble with the pH-sensitive HPTS, leading to improved salt tolerance, satisfactory cell permeability, and dual-emission properties of the resulting nanoprobes. The fluorescence ratio demonstrates a linear response over the pH range of 3.0-9.0, and the probes successfully enable the determination and visualization of lysosomal pH variations in living cells, showing great potential for biosensing and bioimaging applications in living systems.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Yixia Yang, Li Li, Liyun Lin, Xianfeng Wang, Jiawei Li, Huan Liu, Xiaofang Liu, Danqun Huo, Changjun Hou
Summary: A dual-signal sensing strategy based on ratiometric fluorescence and colorimetry has been developed for the detection of Cu2+ and glyphosate. This strategy utilizes the fluorescence resonance energy transfer and absorption characteristics of specific substances generated through oxidation reactions. Under the optimized conditions, this sensing system demonstrates good selectivity and sensitivity, and performs well in real samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Henry J. Braddick, William J. Tipping, Liam T. Wilson, Harry S. Jaconelli, Emma K. Grant, Karen Faulds, Duncan Graham, Nicholas C. O. Tomkinson
Summary: This article reports the first ratiometric sensor for carboxylesterase (CE) activity using Raman spectroscopy based on a bisarylbutadiyne scaffold. The sensor showed high sensitivity and specificity for CE detection with low cellular cytotoxicity. It was successfully used for ratiometric detection of esterase activity in hepatocyte cells and detection of localized ultraviolet damage in a mixed cell population using stimulated Raman scattering microscopy coupled with spectral phasor analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Haiyan Wang, Pengpeng Lv, Cheng Liu, Ren Tang, Chenxi Zhao, Qiujun Lu, Fuyou Du
Summary: In this manuscript, a multi-modal detection method based on cerium-based nanoparticles (Ce NPs) was developed for the sensitive detection of vitamin C (VC). The method utilizes the catalytic activity of Ce NPs in the reaction of H2O2 with OPD to generate detectable signals. The presence of VC inhibits the signal generation, allowing for visual observation and monitoring through absorbance and fluorescence intensity measurements.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Inorganic & Nuclear
Christopher M. Lemon, Deirdre Hanley, Allison E. Batka, Michael A. Marletta
Summary: Ratiometric sensors are a type of self-referencing constructs that can function in cells and tissues, and their read-out is not affected by sensor concentration. This study developed protein-based ratiometric oxygen sensors using heme nitric oxide/oxygen-binding protein (H-NOX) and oxygen-responsive fluorescent probes. By modifying the amino acid residues on the protein surface, the oxygen sensitivity of the sensor can be adjusted.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chao Zhou, Wu-xing Zhao, Fang-tian You, Zhao-xin Geng, Hong-shang Peng
Article
Materials Science, Multidisciplinary
Zhenyu Zhao, Wen Xu, Gencai Pan, Yanan Liu, Mu Yang, Siwei Hua, Xu Chen, Hongshang Peng, Hongwei Song
MATERIALS RESEARCH BULLETIN
(2019)
Article
Nanoscience & Nanotechnology
Jian-tao Ping, Fang-tian You, Zhao-xin Geng, Hong-shang Peng
Article
Polymer Science
Wu-xing Zhao, Chao Zhou, Hong-shang Peng
Article
Chemistry, Multidisciplinary
Jian-tao Ping, Jing-lei Qin, Chao Zhou, Lan-ying Guo, Bei Liu, Zhi-hua Chen, Zhao-xin Geng, Hong-shang Peng
Article
Biochemical Research Methods
Chao Zhou, Li Ma, Jian-tao Ping, Lan-ying Guo, Jing-lei Qin, Man Yuan, Zhao-xin Geng, Fang-tian You, Hong-shang Peng
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Lanying Guo, Jiantao Ping, Jinglei Qin, Mu Yang, Xi Wu, Mei You, Fangtian You, Hongshang Peng
Summary: The study found that oily drugs can be efficiently loaded into both types of HMSNs, while HMSNs are not good carriers for hydrophobic drugs especially planar drugs. HMSNs have high loading efficiency for oppositely charged hydrophilic drugs, which alters the zeta potential of drug-loaded HMSNs.
Review
Chemistry, Analytical
Tingyu Yang, Jinglei Qin, Jinling Zhang, Lanying Guo, Mu Yang, Xi Wu, Mei You, Hongshang Peng
Summary: This review summarizes the mechanisms, synthesis methods, luminescence enhancement strategies, sensing mechanisms, and targeted biological/chemical categories of NIR-II LnNCs-based bio/chemosensors, which are based on lanthanide nanocrystals with a second near-infrared emission. The existing problems and future development trends of LnNCs-based bio/chemosensors are also discussed.
Article
Materials Science, Multidisciplinary
Mu Yang, Qilin Dai, Aiwei Tang, Feng Teng, Hong-shang Peng
Summary: To improve the luminescence efficiency and stability of chloride-bromine mixed perovskite quantum dots (PQDs), a novel type of CH3NH3Pb(Cl/Br)3 PQDs (Cl/Br-PQDs) were synthesized using anion exchange and in-situ growth of silica shell. The Cl/Br-PQDs showed a strong emission at 464nm, a high photoluminescence quantum yield of 94.6%, and ultrahigh stability, which were attributed to efficient defects passivation by doped Cl- ions and silica-shell-locked OAm+ ligands, as well as the restricted migration of halogen ions.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Yuxin Bao, Xi Wu, Bingyang Bo, Jinglei Qin, Yafei Zhang, Xiaojia Wu, Xiang Li, Yiquan Wang, Hongshang Peng
Summary: In this study, a reprecipitation-encapsulation method was used to co-load near infrared II (NIR-II) fluorescent Ag2S quantum dots (QDs) and photosensitizer zinc phthalocyanine (ZnPc) into single nanoparticles (NPs). The resulting Ag2S/ZnPc NPs, coated by a poly-L-lysine (PLL) layer, showed good biocompatibility and exhibited strong NIR-II fluorescence. They demonstrated efficient phototherapeutic efficacy on HeLa cells and achieved a deep tissue penetration depth of 1.4 mm. These findings indicate that the facilely prepared Ag2S/ZnPc NPs hold great promise for NIR-II fluorescence imaging-guided in vivo PDT.
Article
Materials Science, Multidisciplinary
Jinglei Qin, Bingyang Bo, Tingyu Yang, Zhi Wang, Fang Xie, Hongshang Peng
Summary: In this study, multifunctional nanoparticles were developed for synergistic photodynamic therapy and chemodynamic therapy. The nanoparticles loaded with photosensitizer ZnPc and coated with Fe2+ ions-chelated polydopamine shell could generate 1O2 and & BULL;OH upon photo-irradiation and exposure to H2O2, respectively. In vitro cell experiments showed that the nanoparticles achieved a higher therapeutic effect compared to single-modality photodynamic therapy.
Article
Materials Science, Multidisciplinary
Xianyao Wu, Kai Yin, Mu Yang, Yufeng Hu, Hongshang Peng
Summary: In this study, silica-coated CsPbBr3 perovskite quantum dots (PQDs) were prepared using ethyl acetate as an environmentally friendly anti-solvent. The as-prepared PQDs showed tunable emission wavelength and a medium photoluminescence quantum yield (PLQY) of 60%. Furthermore, post-treatment with different ligands successfully mitigated surface defects and improved the PLQY (up to 73%) and stability of the PQDs.
FLEXIBLE AND PRINTED ELECTRONICS
(2023)
Review
Chemistry, Analytical
Lan-Ying Guo, Jin-Song Zhao, Hong-Shang Peng
Summary: This review provides a summary and classification of H2S-activated fluorescent probes over the past 5 years according to sensing modality, and mainly discusses their biological applications, including detection of physiological and pathological processes, diagnosis of diseases, and disease treatments.
ANALYSIS & SENSING
(2022)
Article
Chemistry, Multidisciplinary
Bei Liu, Lirong Sun, Xijian Lu, Yuping Yang, Hongshang Peng, Zhaogang Sun, Juan Xu, Hongqian Chu
Summary: This study presents a metal-organic framework (MOF)-based nanotheranostic system that enables real-time drug release monitoring and combined chemo-photothermal therapy. By encapsulating photothermal agents (CuS) and therapeutic drug (DOX), the system achieves effective treatment while allowing drug release behaviors to be monitored in real-time. Moreover, the addition of folic acid-conjugated polyethylene glycol (FA-PEG) antennas enhances the active targeting effect of the system towards cancer cells.
Article
Materials Science, Multidisciplinary
Ming Liu, Jianli Miao, Jian Wang, Zijin Zhao, Kaixuan Yang, Xiaoli Zhang, Hongshang Peng, Fujun Zhang
JOURNAL OF MATERIALS CHEMISTRY C
(2020)