Article
Spectroscopy
Zhifeng Cai, Shulin Pang, Liangliang Wu, Erxiao Hao, Jiaxin Rong
Summary: Dopamine-protected copper nanoclusters were utilized as a novel fluorescent nanosensor for the detection of nitrofurantoin. The sensor demonstrated good linear relationship and low detection limit, and was successfully applied for NFT detection in bovine serum samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Nanoscience & Nanotechnology
Han Sun, Kirk S. Schanze
Summary: This article comprehensively reviews the synthetic chemistries used to covalently link biofunctional groups onto water-soluble conjugated polymer platforms, including different types of backbones. It also discusses the applications and challenges of functionalized conjugated polymers.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nanoscience & Nanotechnology
Han Sun, Kirk S. Schanze
Summary: This article comprehensively reviews the various synthetic chemistries that have been used to covalently link biofunctional groups onto water-soluble conjugated polymer (WS-CP) platforms. It also presents examples of biofunctionalized WS-CPs used in protein sensing, flow cytometry labeling, and cancer therapy. Additionally, the major challenges and future development in functionalized conjugated polymers are discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Jincheng Zhang, Huatian Duan, Ying Hong, Jingyu Deng, Li-Juan Fan
Summary: A series of cationic conjugated polymers were synthesized for the detection of ATP, and the fluorescence of the polymers was quenched upon adding ATP. The sensitivity of the polymer to ATP increased with the density of the quaternary ammonium group. The study provides a general strategy for designing sensing systems for biomolecules with complex structures.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tianyang Han, Yajun Wang, Shengjie Ma, Mengfei Li, Ningning Zhu, Songyuan Tao, Jiajun Xu, Bin Sun, Yunlong Jia, Yuewei Zhang, Shoujun Zhu, Bai Yang
Summary: Carbon dots and carbonized polymer dots are a new class of optical materials with wide applications in optoelectronic devices, catalysis, detection, and bioimaging. Researchers have developed a two-step bottom-up strategy to synthesize NIR-CPDs that emit bright fluorescence in both the NIR-I and NIR-II transparent imaging windows. This synthesis method is simple, cost-efficient, and high-yielding, enabling high-performance noninvasive imaging and real-time imaging.
Article
Chemistry, Inorganic & Nuclear
Yang Wang, Ya-Hui Su, Si-Min Gong, Jie-Ru Wang, Rui-Sha Zhou, Wei-Zhou Jiao, Jiang-Feng Song
Summary: In this study, five new coordination compounds with isomorphic frameworks were successfully synthesized and characterized. One of the compounds was found to be a multifunctional fluorescence probe.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Jialong Wu, Yongwei Wu, Zepeng He, Zihua Li, Huahua Huang, Yongming Chen, Guodong Liang
Summary: This study reports a facile and highly efficient synthetic method for preparing organic photothermal materials, obtaining conjugated microporous polymers with abundant micropores and extended pi-conjugated skeleton through polymerization of commercial aromatic monomers. These materials exhibit outstanding NIR photothermal performance and can be used as photothermal fillers to control shape recovery of thermal-sensitive shape memory polymers.
SCIENCE CHINA-MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Meng Li, Zheng Li, Danni Yu, Ming Wang, Dong Wang, Bing Wang
Summary: Recently, there has been a focus on developing theranostic agents for the second near-infrared bio-window (NIR-II, 1000-1700 nm) due to its excellent tissue-penetration capabilities. In this study, conjugated polymer nanoparticles (PIS NPs) with a NIR-II absorption peak at 1026 nm were designed using a combination of strategies. Under irradiation at 1064 nm, PIS NPs demonstrated remarkable photothermal conversion performance for efficient ablation of tumor cells in vitro and in vivo. This research offers valuable insights into the rational design of organic NIR-II photothermal agents based on multiple strategies.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Polymer Science
Sultan Sacide Gelen, Tuvshinjargal Munkhbat, Zuale Rexhepi, Fatma Ozturk Kirbay, Hacer Azak, Dilek Odaci Demirkol
Summary: Conducting polymers can be used to prepare electrochemical and optical detection platforms for bioanalytical systems. In this study, a multifunctional monomer was synthesized for selective detection of H2O2, successfully immobilizing CAT on Poly(DTP-Trp) for target analyte detection. Surface characterization was done using SEM and EDX, confirming the presence of Poly(DTP-Trp)/CAT on ITO-PET surfaces.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Applied
Guangzhao Yang, Yi Wang, Shan Zhou, Lu Chen, Yang Chen, Yu Liu, Xin Liang, Chao Yin, Hui Zhou, Quli Fan
Summary: Fluorescence imaging in the second near-infrared (NIR-II) window is a promising method for cancer diagnosis due to its deep penetration depth and high signal to background ratio. The integration of NIR-II imaging and NIR-II photothermal therapy (PTT) has great potential in biomedical research and preclinical practice. Semiconducting polymers with easily tunable optical properties, high photostability, and reliable biocompatibility have advantages, but most formed using nanoprecipitation have high accumulation in reticulum endoplasmic system (RES) and maximum absorption in the first near-infrared (NIR-I) window. Developing new NIR-II emissive semiconducting polymer nanoparticles (SPNs) that can be triggered by NIR-II light for deep tissue PTT is required.
Article
Nanoscience & Nanotechnology
Rong Ma, Nuernisha Alifu, Zhong Du, Shuang Chen, Youqiang Heng, Jing Wang, Lijun Zhu, Cailing Ma, Xueliang Zhang
Summary: Indocyanine green (ICG) is a favorable fluorescence nanoprobe known for its strong NIR-I fluorescence emission and good photothermal capabilities. To enhance its therapeutic efficiency, ICG was encapsulated with bovine serum albumin (BSA) and loaded with the chemotherapeutic drug doxorubicin (DOX) to form the BSA@ICG-DOX theranostic nanoplatform. The resulting nanoplatform showed strong NIR-I fluorescence emission, excellent photothermal properties, biocompatibility, and tumor targeting ability, making it a promising tool for combined diagnosis and therapy of subcutaneous cervical tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yifei Jiang, Haobin Chen, Xiaoju Men, Zezhou Sun, Zhen Yuan, Xuanjun Zhang, Daniel T. Chiu, Changfeng Wu, Jason McNeill
Summary: A novel multimode superresolution method was developed to map the structure and measure the energy landscape of single carrier transport along conjugated polymer nanowires. By quenching of local emission and tracking the motion of a single photogenerated hole using blinking-assisted localization microscopy, the method successfully correlated structures with charge transport properties. The efficiency of inter- and intrachain hole transport inside the nanowires was compared, and the depth of carrier traps from torsional disorder and chemical defects was directly measured for the first time.
Article
Polymer Science
Axel-Laurenz Buckinx, Ashley M. Rozario, Toby D. M. Bell, Jasper J. Michels, Tanja Junkers
Summary: This study presents a novel method for synthesizing semi-conducting polymer nanoparticles (SPN) and demonstrates their potential as versatile theragnostic platforms for drug delivery and near infrared (NIR) imaging.
Article
Chemistry, Analytical
Siqi Zhang, Yu Zhang, Lihe Zhao, Lanlan Xu, Hao Han, Yibing Huang, Qiang Fei, Ying Sun, Pinyi Ma, Daqian Song
Summary: Mitochondrial viscosity is important for pathological activities, and JLQL can monitor viscosity effectively.
Article
Polymer Science
Shunichiro Ito, Yoshinori Ito, Tanaka Kazuo, Yoshiki Chujo
Summary: In this study, silicon-formazanate complexes and their conjugated polymers with near-infrared luminescence were synthesized. The photophysical properties of the complexes were found to be influenced by the types of axial ligands. Theoretical calculations revealed that the square-pyramidal structure at the coordination center facilitated efficient pi-conjugation.