期刊
MICROCHEMICAL JOURNAL
卷 110, 期 -, 页码 15-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.microc.2013.01.004
关键词
Cocrystal; Grinding; Portable Raman analyzer; Fiber optic probe
资金
- National Science Council, Taipei, Taiwan, ROC [NSC 100-2320-B-264-001-MY3]
A portable Raman analyzer with a fiber-optic probe was first used to rapidly screen and identify the cocrystal formation between drug and coformer. Indomethacin ((MC) and anhydrous theophylline (TP) were selected as model drugs, but saccharin (SAC) and anhydrous citric acid (CA) were chosen as model coformers. The cocrystal formation that occurred in the solid-state IMC-SAC or TP-CA system via mechanical grinding process was investigated. Differential scanning calorimetry (DSC) was also used to investigate the possible cocrystal formation. The present study indicates that this new portable fiber-opticRaman spectroscopic technique was an easy and fast real-time method to screen and identify the progressive cocrystal formation in solid-state IMC-SAC or TP-CA system in the process of mechanical grinding by inserting the probe directly into the ground mixtures. (C) 2013 Elsevier B.V. All rights reserved.
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