Article
Medicine, Legal
Hiroko Enomoto, Olivia A. Petritz, Andrea E. Thomson, Keven Flammer, Farha Ferdous, Emma Meyer, Lisa A. Tell, Ronald E. Baynes
Summary: The study aimed to determine the quantity and duration of sulfamethoxazole-trimethoprim residues in eggs and evaluate drug elimination parameters, to estimate withdrawal intervals for these substances in eggs more accurately.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Editorial Material
Critical Care Medicine
Jonah Rubin, Michelle L. Chiu, Mari Mino-Kenudson, Amita Sharma, Alison S. Witkin, Peter P. Moschovis, Yehuda Vogel, Kenneth Shelton, Jerome Crowley, Yuval Raz
Summary: This is a case of a 19-year-old male patient presenting with acute cough, high fever, and dyspnea. Other than a resolved seizure episode, he had no previous medical history. He had been taking montelukast and trimethoprim-sulfamethoxazole before admission. Animal exposures to a new puppy and a friend's bird were noted. His paternal grandmother had rheumatoid arthritis.
Article
Veterinary Sciences
Jili Zhang, Hongfei Si, Jichao Sun, Kun Lv, Biqing Yan, Bing Li, Xuzheng Zhou, Jiyu Zhang
Summary: The study successfully developed a method to quantify Myrislignan levels in mouse plasma and reported the pharmacokinetic parameters of Myrislignan in mice for the first time, as well as compared the differences after oral and intraperitoneal administration.
BMC VETERINARY RESEARCH
(2021)
Article
Environmental Sciences
Klaudia Stando, Aleksandra Czyz, Magdalena Gajda, Ewa Felis, Sylwia Bajkacz
Summary: Phytoremediation is an environmentally friendly and economical method for removing organic contaminants from water. This study investigated the phytoremediation of sulfamethoxazole (SMX) and trimethoprim (TRI) residues using Limnobium laevigatum. The results showed that various factors influenced the removal of contaminants from water and identified the transformation products of SMX and TRI.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemical Research Methods
Weijie Jiao, Nan Qin, Kun Wang, Dongmei Wu, Hongyan Yu, Lei Du, Guiyue Wu, Hong Wu, Xu Zhao
Summary: Aesculetin, a compound found in sancho tree and chicory, was measured in rat plasma using a UHPLC-ESI-MS/MS method. The method was validated and showed high accuracy and reliability. Pharmacokinetic parameters of aesculetin in rat plasma after oral administration were determined, providing preclinical information for future applications.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Biochemical Research Methods
Shengbo Huang, Yuanjin Zhang, Yanfang Zhang, Jie Liu, Zongjun Liu, Xin Wang
Summary: This study established an efficient and sensitive method for quantifying aloperine in rat plasma, and conducted pharmacokinetic studies in Sprague-Dawley rats. The method was validated in compliance with FDA bioanalytical method validation guidelines.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hongjiang Xu, Yanan Li, Jing Zhang, Jinhua Zhang, Jianguang Lu, Xiquan Zhang, Ling Yang, Wenjie Zhao, Jun Feng
Summary: A rapid UHPLC-MS/MS assay method was developed for the determination of CMS E2 and colistin E2 in human plasma. The method demonstrated speed and high accuracy, and was successfully applied to the analysis of plasma samples obtained from Chinese healthy volunteers.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Xun Fang, Qi Lu, Jichun Han
Summary: AZD7648 is a potent DNA-PK inhibitor being developed for ovarian cancer treatment. This study developed a simple and sensitive LC-MS/MS method for determining the concentration of AZD7648 in rat plasma. The method was validated and proven to be selective, sensitive, and reliable, and successfully applied to pharmacokinetic study.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemical Research Methods
Ting Yang, Wenwu Xu, Xiyu Wei, Zhenzhen Zhang, Yue Sun, Houru Liu, Peihua Yu, Wei Li, Dehong Yu
Summary: A simple, efficient, and sensitive method was developed and validated for the determination of GRh3 in rat plasma using LC-tandem mass spectrometry. The method demonstrated high accuracy, stability, and has been successfully applied to study the pharmacokinetics of GRh3 in rats.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Biochemical Research Methods
Dan Chen, Kaixin Du, Xiaochen Niu, Hongwei Zhang, Xue Zhang, Yu Tang, Jianchun Zhao
Summary: A sensitive LC-MS/MS method for the determination of amlexanox in rat plasma was successfully established and validated, and applied to pharmacokinetic study. The method involved the use of Capcell Pak C18 column and triple quadrupole mass in MRM for detection, with calibration curves ranging from 50 to 2000 ng/mL.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Biochemical Research Methods
Xianglan Jiang, Qingwang Liu, Shiyang Xue
Summary: A simple and sensitive LC-MS/MS method was developed and validated for the determination of Kansuinine A in rat plasma, showing excellent linearity and precision. The method was successfully applied in a pre-clinical pharmacokinetic study in rats.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Food Science & Technology
Sana Khajeh pour, Cynthia Blanton, Biwash Ghimire, Ali Aghazadeh-Habashi
Summary: This study developed a method to examine the effect of piperine on the bioavailability of curcumin. The results showed that piperine significantly increased the oral absorption of curcumin, reduced its systemic clearance, and improved its bioavailability.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemical Research Methods
Yuan Liang, Tiancheng Ma, Yuwei Li, Na Cai
Summary: Vanillic acid, a phenolic compound isolated from Angelica sinensis and green tea, was determined in rat plasma using a rapid and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry method. Pharmacokinetic study revealed that the oral bioavailability of vanillic acid in rat plasma ranged from 25.3% to 36.2%.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Infectious Diseases
Maxwell J. Lasko, Jennifer L. Tabor-Rennie, David P. Nicolau, Joseph L. Kuti
Summary: This study investigated the pharmacodynamics of trimethoprim/sulfamethoxazole against susceptible S. maltophilia strains using an in vitro chemostat model. The results showed that even at higher doses, trimethoprim/sulfamethoxazole monotherapy had limited activity against susceptible S. maltophilia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemical Research Methods
Hao Wang, Han Han, Ying Xu, Yishun Yang
Summary: In this study, a LC-MS/MS method was developed and validated for the quantification of polyphyllin VII in rat plasma. The method showed excellent linearity and sensitivity, and was successfully applied to the pharmacokinetic study of polyphyllin VII in rats.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Review
Dermatology
Archana George, Pranav S. Shrivastav
Summary: Photodynamic therapy is a powerful tool for treating dermatologic diseases, thanks to the development of flexible light sources and suitable photosensitizers. The use of light emitting fabric with optical fibers ensures uniform light transmission to infected skin areas, offering exciting possibilities for medical applications.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Chemistry, Physical
Vinay S. Sharma, Priyanka A. Shah, Anuj S. Sharma, Venkata Subba Rao Ganga, Pranav S. Shrivastav, Varsha Prajapat
Summary: In this study, four novel bowl-shaped aggregation-induced emission (AIE)-active liquid crystalline compounds were synthesized and their properties were extensively examined. The materials showed columnar self-assembly behavior and exhibited AIE and thermal stability.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemical Research Methods
Priyanka A. Shah, Vinay S. Sharma, Pravin G. Vanol, Mallika Sanyal, Pranav S. Shrivastav
Summary: A reliable and robust method using UPLC-MS/MS was developed to quantify neratinib in human plasma. The method successfully removed the interference of phospholipids and proteins, and demonstrated good precision and accuracy. This method is suitable for pharmacokinetic studies of neratinib.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Chemistry, Physical
Suryajit L. Rathod, Vinay S. Sharma, Anuj S. Sharma, Mohd Athar, Pranav S. Shrivastav, Hitesh M. Parekh
Summary: This study designed and synthesized cone-shaped thiacalixarene appended quinoline-based substitution compounds, and discussed the relationship between their properties and phase transition temperatures with peripheral alkoxy side chains. These materials exhibit columnar hexagonal phase at lower temperatures and smectic and nematic phases at higher temperatures, showing blue fluorescence in solid state.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Suryajit L. Rathod, Vinay S. Sharma, Kena R. Patel, Hitendra A. Mali, Pranav S. Shrivastav, Hitesh M. Parekh
Summary: A simple method was used to prepare bowl-shaped supramolecular mesogens based on resorcin[4]arene with different alkyl arm substitutes. The introduction of alkoxy tail group affects the mesogenic behavior, with lower alkyl arm substitutes showing SmC type properties and higher alkyl arm substitutes displaying columnar hexagonal type properties. The research suggests that calix[4]resorcinarene is a better candidate for fabricating supramolecular materials with higher thermal stability.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Instruments & Instrumentation
Archana George, Pranav S. S. Shrivastav
Summary: Fucoidan, a sulfated marine seaweed obtained from brown algae, has attracted significant interest due to its various biological activities and potential applications in drug delivery systems. This polysaccharide has been extensively studied for its regenerative properties, wound healing capabilities, and as a drug delivery vehicle. However, the main challenge lies in the variability of fucoidan extraction from different species, harvesting methods, and climatic factors. This review provides a comprehensive overview of fucoidan's origin, chemical structure, physicochemical and biological properties, and its role in nanodrug delivery systems.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Dharmesh J. Shah, Anuj S. Sharma, Vinay S. Sharma, Vinod Kumar Vishwakarma, Achalkumar Ammathnadu Sudhakar, Pranav S. Shrivastav, Rajender S. Varma
Summary: Ferrite nanoparticles (Fe3O4 NPs) supported on microcrystalline cellulose (MCC) were used as an active nanocatalyst for the synthesis of alpha-keto thioglyoxamides via microwave-assisted protocol. The catalyst showed consistent particle size and could be recycled for multiple cycles without significant loss in activity. The environmentally benign approach displayed good green chemistry metrics and was suitable for gram-scale synthesis of thioglyoxamides.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Hitendra Mali, Vinay S. Sharma, Suryajit L. Rathod, Anuj S. Sharma, Pranav S. Shrivastav, Hemant R. Prajapati
Summary: Four new liquid crystalline materials (HA1-HA4) with cholesteryl group and azo-ester linking group were synthesized and their structure and phase behavior were investigated. The materials showed smectic type mesogenic properties and displayed wide temperature range mesophase. The photoresponsive properties of the azo-based bi-substituted materials were also examined.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Ranjitsinh C. Dabhi, Vinay S. Sharma, Prashant S. Arya, Unnati P. Patel, Pranav S. Shrivastav, Jayesh J. Maru
Summary: This paper demonstrates the synthesis of novel bi-substituted coumarin-based symmetrical compounds (A1-A6) via a simple two-step reaction and investigates their liquid crystalline properties. The compounds exhibit different types of liquid crystalline properties depending on the alkyl chains substituted on the coumarin core. The synthesis method of these coumarin-based mesogens is simpler compared to other coumarin-based mesogens, and one of the compounds shows promising anticoagulant activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Editorial Material
Biochemical Research Methods
Priyanka A. Shah, Pranav S. Shrivastav, Vinay S. Sharma, Vishwajit Chavda
Article
Chemistry, Physical
Suryajit L. Rathod, Vinay S. Sharma, Anuj S. Sharma, Dhruvisha K. Patel, Pranav S. Shrivastav, Hitesh M. Parekh
Summary: In this study, multifunctional supramolecular systems based on A-pillar[5]arene were synthesized and characterized. The compounds exhibited nematic type liquid crystalline properties with a wide temperature range and thermal stability. The materials with higher alkyl chains showed nematic phase at lower temperatures.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Environmental
Anargha P. Nambiar, Rahul Pillai, Mallika Sanyal, Yugesh Vadikkeettil, Pranav S. Shrivastav
Summary: This study developed a biodegradable and naturally available composite flakes made of starch and halloysite nanotubes for treating water contaminated with methylene blue. The composite flakes showed high efficiency in adsorbing methylene blue without requiring pH modifications. The adsorption mechanism of the composite flakes followed the Langmuir isotherm model and pseudo second order kinetics, and the flakes exhibited excellent regeneration performance. Therefore, the combination of starch and halloysite nanotubes has the potential to be an effective strategy for removing dyes from wastewater.
ENVIRONMENTAL SCIENCE-ADVANCES
(2023)
Article
Chemistry, Organic
Nandish Talpada, Anuj S. Sharma, Vinay S. Sharma, Rajender S. Varma, Pranav S. Shrivastav, Rahul Ahmed, Achalkumar Ammathnadu Sudhakar
Summary: Graphitic carbon nitride (g-C3N4) is used as a heterogeneous catalyst for the visible light-mediated synthesis of imidazo[1,5-a]pyridines at room temperature without any additional solvent. The catalyst can be recycled for multiple cycles without significant loss of activity, making it suitable for gram-scale synthesis of imidazo[1,5-a]pyridines. This environmentally friendly method offers multiple advantages in terms of low environmental impact and high efficiency.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Hitendra Mali, Vinay S. Sharma, Anuj S. Sharma, Mohd Athar, Suryajit L. Rathod, Pranav S. Shrivastav, Hemant R. Prajapati
Summary: Eight newly synthesized liquid crystalline materials were designed and characterized. The study found that the length of the alkoxy side chains and the position of the terminal isonicotinic/nicotinic hydrazide core have significant impacts on the liquid crystalline properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Review
Chemistry, Organic
Jeky C. Makwana, Ranjitsinh C. Dabhi, Pranav S. Shrivastav, Jayesh J. Maru
Summary: Chalcones are important scaffolds in medicinal chemistry with clinical implications, and their synthesis has been advanced using environmentally friendly methods.
LETTERS IN ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Michel Rocha Baqueta, Augusto Cesar Costa-Santos, Ana Paula Rebellato, Gisele Marcondes Luz, Juliana Azevedo Lima Pallone, Federico Marini, Alexsandro Lara Teixeira, Douglas N. Rutledge, Patricia Valderrama
Summary: This study reports the essential element composition of new Brazilian Canephora coffees and applies chemometric tools for analysis. The results demonstrate the suitability of this method for origin and species discrimination based on the inorganic fraction of coffee.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mengjie Li, Jiapeng Wang, You Zhou, Yang Chen, Lingying Xia
Summary: A novel photoelectrochemical biosensor based on gold nanoparticles and specific structures was developed for highly sensitive detection of mercury ion. The multiple sandwich structures hindered electron supply and light harvesting, resulting in a weakened PEC signal, while the specific structures extinguished the PEC signal, enabling quantitative detection of Hg2+. The sensor exhibited high selectivity and stability, with potential applications in environmental detection, biological analysis, and medical research.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Mohamed A. Korany, Rasha M. Youssef, Marwa A. A. Ragab, Mostafa A. Afify
Summary: A stability-indicating fit-for-purpose method was developed for the determination of HC, TL, and PS in syrup dosage form. The method successfully separated CL from THY and quantified the analytes using HPLC-DAD. The robustness of the method was assessed through statistical analysis and self-validation.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Lingling Lin, Minyu Li, Ping Li, Chenqing Ye, Huanglong Zhuang, Shaohuang Weng, Feng Chen
Summary: This study developed a highly sensitive and selective electrochemical sensor for simultaneous detection of dopamine and uric acid. The sensor exhibited excellent anti-interference and stability, and could accurately measure dopamine and uric acid in human urine samples.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma
Summary: In this study, a high-performance SERS-active aptasensor was successfully developed for the quantitative analysis of AFB1 in cereal grains, which is of great significance in the field of food safety.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
E. Abas, C. Marina-Montes, C. Perez-Marin, J. Puimedon, J. Anzano
Summary: This study conducted a comprehensive measurement of natural and anthropogenic radionuclides in soil, water, and air in different locations around Deception Island in Antarctica. The results revealed significant levels of 210Pb and anthropogenic 137Cs in soil samples near old human settlements and facilities, as well as detectable levels of 137Cs and 60Co in water samples from old hunting areas. The findings also suggested potential resuspension processes based on higher-than-expected air quality results.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Joao Franciso Allochio, Nayara A. dos Santos, Nathalia dos S. Conceicao, Clara S. D. Baptista, Keyller B. Borges, Valdemar Lacerda Jr, Wanderson Roma
Summary: This study developed a fiber spray ionization mass spectrometry (FSI-MS) method, which shows great potential in detecting illicit drugs. Compared with paper spray ionization mass spectrometry (PSI-MS), FSI-MS demonstrates higher sensitivity in COC detection.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Dina A. Ahmed, Ola G. Hussein, Mamdouh R. Rezk, Mohamed Abdelkawy, Yasmin Rostom
Summary: The main goal of this study was to develop two green chromatographic techniques, HPLC and TLC, for the determination of alcaftadine (ALF) in pharmaceutical formulation and biological samples. The developed HPLC technique showed high efficiency and minimal environmental impact, successfully identifying ALF in the presence of its degradate. The TLC method provided a stability indicating study for ALF and was determined to be safe, green, and eco-friendly.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Abdullah Taner Bisgin
Summary: A green, speedy, and handy method for separation and determination of four commonly used food colorants was established using vortex assisted sequential-simultaneous liquid phase micro-extraction (VA-SS-LPME). The method does not require any instrumental chromatographic techniques. The procedure includes sequential separation steps using different extractants and simultaneous UV-vis spectrophotometric determination steps. The method is environmentally friendly and applicable for determination of colorants in food and pharmaceuticals.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Yifan Zhang, Tong Zhang, Wenjing Ba, Li Liu, Yuan Rao, Xiaodan Zhang, Hanhan Zhang, Xiu Jin
Summary: This paper proposes a novel spectral transfer modelling method based on neural network architecture searching for the asymptomatic prediction of Akizuki pear cork spot disorder. The experiments show that the model by this method is more effective, achieving an accuracy of 82.61%.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
P. K. Fathima Anjila, G. R. Tharani, Anand Sundaramoorthy, Venkat Kumar Shanmugam, Karthikeyan Subramani, Shanmugavel Chinnathambi, Ganesh N. Pandian, Vimala Raghavan, Andrews Nirmala Grace, Singaravelu Ganesan, Mangaiyarkarasi Rajendiran
Summary: This work proposes a rapid and sensitive spectroscopic method for detecting melamine in food products using rare-earth Terbium-doped Graphene Quantum Dots (Tb-GQDs) synthesized by microwave and simple chemical conjugation methods. The synthesized Tb-GQDs show a spherical shape with a size of approximately 6 nm and a quantum yield of 52%. The maximum detection limit for melamine concentration in milk and milk products is found to be 0.31 μM. The dual emitting Tb-GQDs provide a sensitive and effective platform for real-time detection of melamine in food samples, particularly in milk, and show promising potential in the food industry.
MICROCHEMICAL JOURNAL
(2024)
Review
Chemistry, Analytical
Piyush Dey, Mandeep Kaur, Akhil Khajuria, Dilmeet Kaur, Manpreet Singh, Hema Kumari Alajangi, Neha Singla, Gurpal Singh, Ravi Pratap Barnwal
Summary: Environmental issues, such as the uncontrolled release of dangerous pollutants, have significant impacts on human health. Traditional methods for detecting pollutants require specialized personnel and equipment, but nanotechnology has improved the performance of biosensors. This article discusses the use of nanotechnology in pollutant detection and the associated techniques.
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Sa Dong, Qiuyun Shi, Lingjun Guan, Yulong Wang, Pengyan Liu, Cunzheng Zhang, Jianguo Feng
Summary: In this study, a highly sensitive indirect competitive chemiluminescence enzyme immunoassay (icCLEIA) method was developed for the determination of sodium pentachlorophenolate (PCP-Na) and its metabolite pentachlorophenol (PCP). The method showed high specificity and affinity with a detection limit of 0.0032 ng/mL for PCP-Na and 0.0192 ng/mL for PCP. The method had no cross reaction with other chlorophenols compounds except for PCP. The average recoveries in chicken, pork and fish samples were 81.3-105.8% with low coefficient of variation (CV).
MICROCHEMICAL JOURNAL
(2024)
Article
Chemistry, Analytical
Palaniappan Ilayaraja, Murugan Manivannan, Paramasivam Parthiban
Summary: Nirmatrelvir, an antiviral drug used for the treatment of COVID-19, has been recommended by the World Health Organization. We developed an optimized analytical method for the quantification of Nirmatrelvir and its products, with high sensitivity and a wide linear range. The method also meets the requirements for greenness evaluation.
MICROCHEMICAL JOURNAL
(2024)