Article
Biochemistry & Molecular Biology
Miriam Algarabel, Celia Fernandez-Rubio, Katerina Musilova, Jose Pena-Guerrero, Andres Vacas, Esther Larrea, Paul A. Nguewa
Summary: Leishmaniasis is caused by Leishmania spp. and improving treatments and discovering new drugs are major goals. A gene called LmjPES, similar to the human oncogene PES1, plays a role in cell processes and showed increased infection rates when overexpressed in parasites. Mice infected with parasites overexpressing LmjPES had higher inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hadi Zadeh-Haghighi, Christoph Simon
Summary: This study investigates the mechanism of general anesthesia through the interaction between radical pairs and microtubule structures. The research finds that magnetic fields can modulate the spin dynamics of radical pairs in microtubules, thereby affecting the density of microtubules. The findings of this study provide a larger explanation space for the quantum theory of consciousness.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Multidisciplinary Sciences
J. E. Vonk, N. J. Speetjens, A. E. Poste
Summary: Despite the fact that over 99% of coastal arctic rivers drain small catchments, future projections of land-ocean fluxes are derived from data of large rivers. We advocate for the inclusion and increased focus on smaller catchments to facilitate representative assessments of arctic ecosystem change.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jordan Smith, Hadi Zadeh Haghighi, Dennis Salahub, Christoph Simon
Summary: This study investigates the xenon-induced general anesthesia process and suggests that the potency of xenon as a general anesthetic is influenced by isotopic dependence. They propose a mechanism where xenon nuclear spin may affect the recombination dynamics of radical pairs of electrons. Their model is able to reproduce the observed isotopic dependence in the potency of xenon as a general anesthetic, supporting the idea that radical pairs of electrons with entangled spins could play a role in consciousness.
SCIENTIFIC REPORTS
(2021)
Review
Toxicology
Xiaojiang Qin, Anqi Gao, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Lin Sun, Yuxuan Hao, Yiwei Shi
Summary: Pulmonary hypertension is a chronic progressive disease associated with cigarette smoke exposure and abnormal alterations in connexin expression. Smokers have a higher risk of developing PH and increased mortality. Current treatments are unable to reverse vascular remodeling associated with PH. Therefore, early intervention is crucial in preventing the development of PH.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Cheng Liang, Kai-Pi Cheng, Hsin-Yu Kuo, Chung-Teng Wang, Hsuan-Wen Chou, Kuan-Lin Huang, Hung-Tsung Wu, Horng-Yih Ou
Summary: This study used a mouse model of obese sarcopenia to investigate the factors contributing to its development. The researchers found that a high-fat diet led to decreased motor functions and muscle mass ratios. Additionally, they discovered that the expression of calsarcin-2 was significantly increased in the skeletal muscle of these mice. Further experiments revealed that calsarcin-2 facilitated myoblast differentiation and its serum concentration was negatively related to skeletal muscle mass index.
Article
Biochemistry & Molecular Biology
Ting-Wei Lai, Hsin-Lin Cheng, Tzu-Rong Su, Jiann-Jou Yang, Ching-Chyuan Su
Summary: This study aimed to investigate the protective effects of cichoric acid against neomycin-induced ototoxicity using transgenic zebrafish. Results showed that cichoric acid at a concentration of 5 µM under 2-hour treatment can protect against neomycin-induced hair cell death, but the protection diminishes over time. Cichoric acid ameliorated apoptotic signals and mechanotransduction machinery impairment caused by neomycin. Fish locomotor test revealed rescue due to cichoric acid pretreatment before neomycin exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Giovanni Federico, Carlo Cavaliere, Emanuelle Reynaud, Marco Salvatore, Maria Antonella Brandimonte, Francois Osiurak
Summary: The research indicates that technical reasoning may support the development of tools and technologies. The cortical thickness of the left Area Prostriata of the visual cortex, along with the left Area PF, predicts technical reasoning performance.
BEHAVIORAL AND BRAIN FUNCTIONS
(2022)
Article
Virology
Minu Nain, Apoorv Gupta, Sumit Malhotra, Amit Sharma
Summary: This study found that patients with COVID-19 have significantly low levels of high-density lipoprotein (HDL), while total cholesterol (TC) and low-density lipoproteins (LDL) levels are normal. This suggests that HDL may play an important role in COVID-19 infection and outcomes, and further research on this relationship is needed.
Article
Ophthalmology
Xiaotian Liang, Yingli Li, Ke Xiong, Shuze Chen, Zhenhao Li, Zhihan Zhang, Zhaoxia Xia, Guoguo Yi, Min Fu
Summary: Demodex infestation did not significantly affect the diversity of ocular surface microbial communities, but primarily changed the dominant flora and relative abundance of ocular surface microbial communities. Meibomian gland dysfunction may play an important role in this process.
OPHTHALMOLOGY AND THERAPY
(2021)
Review
Immunology
Elisa Maria Schunkert, Pranali Nitin Shah, Sherrie Jill Divito
Summary: Delayed-type drug hypersensitivity reactions (dtDHR) are immune-mediated reactions with a wide range of skin and visceral manifestations. The involvement of T cells, particularly resident memory T cells (T-RM), in the disease pathogenesis is believed to be significant, but remains unclear due to obstacles in defining, identifying, and testing T-RM in dtDHR. Further mechanistic interrogation is necessary to address unanswered questions and implications for prediction, diagnosis, and treatment of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Shichan Wang, Xiaoting Zheng, Qianqian Wei, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Chunyu Li, Huifang Shang
Summary: In our study, rare variants of the DNAJC7 gene were identified in ALS patients, indicating a potential correlation with disease onset and progression. However, there was no enrichment of rare damaging variants in ALS patients compared to controls. Further analysis is needed to understand the role of DNAJC7 in the pathogenicity of ALS.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Omer Akyol, Sumeyya Akyol, Mei-Chuan Chou, Shioulan Chen, Ching-Kuan Liu, Salih Selek, Jair C. Soares, Chu-Huang Chen
Summary: Alzheimer's disease and other types of dementia are significant public health issues with major societal, physical, and financial impacts. This study proposes a connection between lipids, particularly electronegative LDL, and the pathophysiology of Alzheimer's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Developmental Biology
Yawen Peng, Jiandong Shen, Yan Gao, Wangjuan Dai, Shuang Liang, Jing Chen, Li Gao, Yuting Lin, Lingbo Cai, Lianju Qin, Yugui Cui, Jiayin Liu, Feiyang Diao
Summary: This study identifies Nup37 as a key gene involved in preimplantation embryo development in mammals. It regulates nuclear pore permeability and nucleocytoplasmic transport, facilitating the nuclear import of YAP1 and activation of the YAP1-TEAD pathway.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Wen Jiang, Xiaqing Yu, Russell Oliver Kosik, Yingchun Song, Tingting Qiao, Junyu Tong, Simin Liu, Suyun Fan, Qiong Luo, Li Chai, Zhongwei Lv, Dan Li
Summary: This study identified differences in the composition and metabolism of gut microbiota in patients with autoimmune thyroid diseases, particularly Graves' disease. Lactobacillus may play a key role in the pathogenesis, and certain microbial genera showed significant correlations with thyroid function tests. The findings suggest that microbiota could be a potential noninvasive diagnostic tool for Graves' disease, and further research is needed to explore their role in autoimmune thyroid diseases.
Article
Multidisciplinary Sciences
Paul Dean, Sabine Quitard, David M. Bulmer, Andrew J. Roe, Brendan Kenny
SCIENTIFIC REPORTS
(2015)
Article
Biotechnology & Applied Microbiology
Jayde A. Gawthorne, Laurent Audry, Claire McQuitty, Paul Dean, John M. Christie, Jost Enninga, Andrew J. Roe
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2016)
Review
Microbiology
Paul Dean, Robert P. Hirt, T. Martin Embley
Article
Multidisciplinary Sciences
Sven-A. Freibert, Alina V. Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A. Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P. Hirt, John M. Lucocq, T. Martin Embley, Roland Lill
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
P. Dean, K. M. Sendra, T. A. Williams, A. K. Watson, P. Major, S. Nakjang, E. Kozhevnikova, A. V. Goldberg, E. R. S. Kunji, R. P. Hirt, T. M. Embley
NATURE COMMUNICATIONS
(2018)
Editorial Material
Microbiology
Brendan Kenny, Paul Dean
FUTURE MICROBIOLOGY
(2013)
Article
Multidisciplinary Sciences
Paul Dean, Lorna Young, Sabine Quitard, Brendan Kenny
Article
Cell Biology
Elvira Nieto-Pelegrin, Brendan Kenny, Narcisa Martinez-Quiles
CELL ADHESION & MIGRATION
(2014)
Article
Microbiology
Eva Heinz, Christian Hacker, Paul Dean, John Mifsud, Alina V. Goldberg, Tom A. Williams, Sirintra Nakjang, Alison Gregory, Robert P. Hirt, John M. Lucocq, Edmund R. S. Kunji, T. Martin Embley
Review
Plant Sciences
Paul Dean, Peter Major, Sirintra Nakjang, Robert P. Hirt, T. Martin Embley
FRONTIERS IN PLANT SCIENCE
(2014)
Review
Biochemistry & Molecular Biology
Paul Dean, Tiaan Heunis, Anetta Hartlova, Matthias Trost
CURRENT OPINION IN CHEMICAL BIOLOGY
(2019)
Article
Biology
Peter Major, Kacper M. Sendra, Paul Dean, Tom A. Williams, Andrew K. Watson, David T. Thwaites, T. Martin Embley, Robert P. Hirt
Article
Cell Biology
Yashaswini Seenappanahalli Nanjundaiah, David A. Wright, Anwar R. Baydoun, Zahangir Khaled, Zulfiqur Ali, Paul Dean, Mosharraf H. Sarker
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Paul Dean, Brendan Kenny