Article
Environmental Sciences
Jiawei Yang, Qiaoling Yu, Wanghong Su, Sijie Wang, Xiaochen Wang, Qian Han, Huan Li
Summary: Climate warming enhances the threat of antibiotic resistance genes (ARGs) to public health, and this study investigates the relationship between temperature and resistome in a water environment. The results show that temperature significantly influences ARG profiles and diversity, with certain ARGs and mobile genetic elements (MGEs) being sensitive to temperature. High-risk ARGs and opportunistic pathogens are positively correlated with temperature, indicating a potential increase in these biological or genetic pollutants under global warming. This study reveals the predictability of temperature on antibiotic resistance genes and provides a suitable approach to track their fate and spread in water environment under climate warming.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Ruoyue Huang, Chunyan Wang, Zhanxuan E. Wu, Qi Zhao, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li
Summary: This study investigated the hepatotoxicity of colchicine in vivo and found that it causes liver injury by inhibiting SULT1 and reducing the production of sulfated metabolites. Supplementation of endogenous sulfated metabolites can alleviate colchicine-induced liver injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Xiangmei Cao, Chunyan Wei, Wenyi Duan, Ying Gao, Jianfei Kuang, Mingchun Liu, Kunsong Chen, Harry Klee, Bo Zhang
Summary: Our study reveals a common regulatory mechanism in which NAC transcription factors activate the expression of alcohol acyltransferases (AATs) during fruit ripening, leading to the formation of volatile esters in multiple fruit species. The identification of key regulators such as PpNAC1 and PpAAT1 in peach, as well as their homologs in tomato and apple, sheds light on the transcriptional and epigenetic control of flavor-associated volatile synthesis pathways. Further research into these pathways could potentially lead to improved fruit flavor through targeted manipulation of these regulatory factors.
Article
Cell & Tissue Engineering
Francesca Rapino, Ted Natoli, Francesco Limone, Erin O'Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O'Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin
Summary: In the brain, the complement system is important in the immune response and synaptic elimination. This study identified pathways that regulate the production of complement component 4 (C4), linked to increased schizophrenia risk. A 3D protocol was developed to produce astrocytes, and a small-molecule screen identified regulators of C4 secretion. Additional regulatory pathways were predicted and validated, including one involving c-Jun-kinase. This research lays the foundation for developing therapies targeting the complement cascade in CNS diseases.
Article
Hematology
Youmna S. Kfoury, Fei Ji, Esha Jain, Michael Mazzola, Giulia Schiroli, Ani Papazian, Francois Mercier, David B. Sykes, Anna Kiem, Mark Randolph, Laura M. Calvi, Omar Abdel-Wahab, Ruslan I. Sadreyev, David T. Scadden
Summary: Myelodysplastic syndromes (MDS) are diseases that affect hematopoietic stem cells and can only be cured by stem cell transplantation. Research has shown that specific subsets of mesenchymal cells in the bone marrow microenvironment of MDS patients can have molecular perturbations. However, certain niche adaptations may limit disease progression and protect the host.
Article
Microbiology
Jiancheng Qi, Dongjie Cai, Yaocheng Cui, Tianyu Tan, Huawei Zou, Wei Guo, Yue Xie, Hongrui Guo, Shi-Yi Chen, Xiaoping Ma, Liping Gou, Hengmin Cui, Yi Geng, Ming Zhang, Gang Ye, Zhijun Zhong, Zhihua Ren, Yanchun Hu, Ya Wang, Junliang Deng, Shumin Yu, Suizhong Cao, Metha Wanapat, Jing Fang, Zhisheng Wang, Zhicai Zuo
Summary: This study investigated the correlation between starvation and nasopharynx microbial diversity for the first time, and found that severe starvation could decrease microbial diversity and increase the risk of respiratory diseases. The role of oral bacteria in maintaining nasopharynx microbial homeostasis was also emphasized, providing new insights for the prevention of respiratory diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lulu Li, Yichi Zhang, Tangchun Zheng, Xiaokang Zhuo, Ping Li, Like Qiu, Weichao Liu, Jia Wang, Tangren Cheng, Qixiang Zhang
Summary: The research on Prunus mume reveals that the weeping trait is due to differences in the histochemical characteristics of upright and weeping stems, as weeping stems lack phloem fibres and have less xylem. Transcriptome analysis shows that differentially expressed genes related to phenylpropanoid biosynthesis and phytohormone signal transduction pathways play a significant role in the formation of the weeping trait. Additionally, hormone treatments demonstrate that weeping stems have weaker response abilities to IAA but increased bending angles with GA(3) treatment compared to upright stems.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Savannah Gentry, Jeffrey M. Lorch, Julia S. Lankton, Anne Pringle
Summary: This experiment shows that the fungal pathogens causing yellow fungus disease and snake fungal disease can infect a wider range of hosts than previously known, including both corn snakes and bearded dragons.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Wei, Yulu Wang, Su Zhang, Tianyi Gu, Gabryel Steinmetz, Haiyan Yu, Guoguang Guo, Xin Liu, Shilong Fan, Fengzhong Wang, Yangnan Gu, Fengjiao Xin
Summary: Plant leucine-rich repeat (LRR) receptor-like kinases (RLKs) and LRR receptor-like proteins (RLPs) are important cell surface receptors that play critical roles in signal perception and transduction. Studying a regulatory LRR-RLK called SOBIR1, it was found that its activation mechanism involves phosphorylation events, with phosphorylation of Thr529 and the 03-ocC loop being essential for SOBIR1 function.
PLANT COMMUNICATIONS
(2022)
Article
Plant Sciences
Xiaotong Gai, Shuang Li, Ning Jiang, Qian Sun, Yuan Hu Xuan, Zhenyuan Xia
Summary: Fusarium oxysporum is a causative agent of tobacco root rot and its virulence is strongly correlated with the expression of ATP synthase genes, as confirmed by comparative transcriptome analysis and qRT-PCR. This study provides important insights into the virulence mechanism of F. oxysporum in tobacco and highlights the role of ATP synthases in regulating its virulence.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Yongqi Li, Taili Nie, Meng Zhang, Xuexian Zhang, Kashif Shahzad, Liping Guo, Tingxiang Qi, Huini Tang, Hailin Wang, Xiuqin Qiao, Juanjuan Feng, Zhongxu Lin, Jianyong Wu, Chaozhu Xing
Summary: This study investigated the roles of miRNA-target gene pairs in the occurrence of cytoplasmic male sterility (CMS) in cotton. By analyzing small RNA, transcriptome, and degradome sequencing data, the researchers identified novel miRNA and target gene pairs associated with male sterility. The findings provide new insights into the genetic control of CMS in cotton and have implications for breeding new sterile lines.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biology
Dongwei Huang, Haisheng Ding, Yuanlang Wang, Guanglong Cheng, Xiaofei Wang, Taishan Leng, Huiling Zhao
Summary: In this study, the diameter of coarse and fine wool in Wan strain Angora rabbits was analyzed, and it was found that coarse wool had a larger diameter compared to fine wool. High-throughput sequencing analysis identified differentially expressed genes related to hair structure. Enrichment analysis revealed the importance of skin development, epithelium development, and various signaling pathways in regulating hair structure. The findings provide valuable insights for molecular marker selection and gene-assisted selection of super-fine wool rabbits.
Article
Cell Biology
Ruohan Wang, Prashant Mishra, Spiros D. Garbis, Annie Moradian, Michael J. Sweredoski, David C. Chan
Summary: OPA1, a large GTPase, mediates mitochondrial fusion, maintains mitochondrial structure and function. Long forms of OPA1 anchored to the inner membrane are processed into short forms. The ratio of long-form to short-form OPA1 is highly sensitive to mitochondrial morphology, indicating the regulatory role of s-OPA1 in fusion.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Oncology
Stephany Correa, Francisco P. Lopes, Carolina Panis, Thais Basili, Renata Binato, Eliana Abdelhay
Summary: Research on miRNAs has increased our understanding of the complexity of pathways and signaling in breast cancer, identifying potential biomarkers and therapeutic targets. MiRNome profiling plays a crucial role in revealing important information about the molecular mechanisms involved in breast cancer. Quantitative evaluation of BC patient samples and datasets confirmed MYB and EZH2 as potential targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Xiu Liu, Yuzhu Sha, Weibing Lv, Guizhong Cao, Xinyu Guo, Xiaoning Pu, Jiqing Wang, Shaobin Li, Jiang Hu, Yuzhu Luo
Summary: This study comprehensively analyzed the molecular, metabolic, and microbial characteristics of Tibetan sheep during the cold season. The results showed adaptive changes in the rumen epithelial morphology of Tibetan sheep during the cold season, and differential gene expression in key pathways related to xenobiotic metabolism and legionellosis. Unique differential metabolites were identified, and an integrated analysis revealed the interaction between rumen epithelial genes, microbiota, and metabolites in cold season adaptation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jian Zhang, Youzhi Miao, Mohammad Javad Rahimi, Hong Zhu, Andrei Steindorff, Sabine Schiessler, Feng Cai, Guan Pang, Komal Chenthamara, Yu Xu, Christian P. Kubicek, Qirong Shen, Irina S. Druzhinina
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Mycology
Zhilin Yuan, Irina S. Druzhinina, Xinyu Wang, Xiaoguo Zhang, Long Peng, Jessy Labbe
Article
Mycology
Alene Alder-Rangel, Alexander Idnurm, Alexandra C. Brand, Alistair J. P. Brown, Anna Gorbushina, Christina M. Kelliher, Claudia B. Campos, David E. Levin, Deborah Bell-Pedersen, Ekaterina Dadachova, Florian F. Bauer, Geoffrey M. Gadd, Gerhard H. Braus, Gilberto U. L. Braga, Guilherme T. P. Brancini, Graeme M. Walker, Irina Druzhinina, Istvan Pocsi, Jan Dijksterhuis, Jesus Aguirre, John E. Hallsworth, Julia Schumacher, Koon Ho Wong, Laura Selbmann, Luis M. Corrochano, Martin Kupiec, Michelle Momany, Mikael Molin, Natalia Requena, Oded Yarden, Radames J. B. Cordero, Reinhard Fischer, Renata C. Pascon, Rocco L. Mancinelli, Tamas Emri, Thiago O. Basso, Drauzio E. N. Rangel
Article
Cell Biology
Yordanis Perez-Llano, Eya Caridad Rodriguez-Pupo, Irina S. Druzhinina, Komal Chenthamara, Feng Cai, Nina Gunde-Cimerman, Polona Zalar, Cene Gostincar, Rok Kostanjsek, Jorge Luis Folch-Mallol, Ramon Alberto Batista-Garcia, Maria del Rayo Sanchez-Carbente
Article
Biotechnology & Applied Microbiology
Renwei Gao, Mingyue Ding, Siqi Jiang, Zheng Zhao, Komal Chenthamara, Qirong Shen, Feng Cai, Irina S. Druzhinina
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Ecology
Feng Cai, Renwei Gao, Zheng Zhao, Mingyue Ding, Siqi Jiang, Civan Yagtu, Hong Zhu, Jian Zhang, Thomas Ebner, Michael Mayrhofer-Reinhartshuber, Philipp Kainz, Komal Chenthamara, Guenseli Bayram Akcapinar, Qirong Shen, Irina S. Druzhinina
Article
Biotechnology & Applied Microbiology
M. -Y. Ding, W. Chen, X. -C. Ma, B. -W. Lv, S. -Q. Jiang, Y. -N. Yu, M. J. Rahimi, R. -W. Gao, Z. Zhao, F. Cai, I. S. Druzhinina
Summary: The study isolated a library of fungi from the rhizosphere of halotolerant plants in tidal salt marshes in southeast China, revealing various fungal species including plant pathogens, saprotrophs, and mycoparasites. Mycoparasitic fungi, particularly those from the genus Trichoderma, show antagonistic activity against phytopathogens and growth promotion on tomato seedlings under saline agriculture conditions, indicating their potential as natural biological control agents in young soil ecosystems.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Correction
Microbiology
Tamas Marik, Chetna Tyagi, Dora Balazs, Peter Urban, Agnes Szepesi, Laszlo Bakacsy, Gabor Endre, David Rakk, Andras Szekeres, Maria A. Andersson, Heidi Salonen, Irina S. Druzhinina, Csaba Vagvolgyi, Laszlo Kredics
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Maria A. Andersson, Johanna Salo, Orsolya Kedves, Laszlo Kredics, Irina Druzhinina, Jarek Kurnitski, Heidi Salonen
Article
Biology
Laura Selbmann, Zsigmond Benko, Claudia Coleine, Sybren de Hoog, Claudio Donati, Irina Druzhinina, Tamas Emri, Cassie L. Ettinger, Amy S. Gladfelter, Anna A. Gorbushina, Igor V. Grigoriev, Martin Grube, Nina Gunde-Cimerman, Zsolt Akos Karanyi, Beatrix Kocsis, Tania Kubressoian, Ida Miklos, Marton Miskei, Lucia Muggia, Trent Northen, Monika Novak-Babic, Christa Pennacchio, Walter P. Pfliegler, Istvan Pocsi, Valeria Prigione, Meritxell Riquelme, Nicola Segata, Julia Schumacher, Ekaterina Shelest, Katja Sterflinger, Donatella Tesei, Jana M. U'Ren, Giovanna C. Varese, Xabier Vazquez-Campos, Vania A. Vicente, Emanuel M. Souza, Polona Zalar, Allison K. Walker, Jason E. Stajich
Article
Mycology
Feng Cai, Irina S. Druzhinina
Summary: Modern taxonomy is moving towards establishing global authoritative lists of species, but in fungi, species delimitation is often subjective, which complicates accurate identification. The genus Trichoderma offers insights into the challenges of species identification and highlights the need for cooperation among researchers in handling upcoming genomic data.
Article
Mycology
N. N. Wijayawardene, K. D. Hyde, D. Q. Dai, L. Z. Tang, A. Aptroot, R. F. Castaneda-Ruiz, I. S. Druzhinina, F. Cai, A. H. Ekanayaka, M. Erdogdu, P. O. Fiuza, E. Gentekaki, B. T. Goto, D. Haelewaters, S. Hongsanan, R. Jeewon, P. M. Kirk, R. G. U. Jayalal, S. C. Karunarathna, D. N. Wanasinghe, H. T. Lumbsch, H. Madrid, S. S. N. Maharachchikumbura, J. S. Monteiro, N. Shivaprakash, W. P. Pfliegler, A. J. L. Phillips, R. K. Saxena, M. Stadler, Q. Tian, Y. S. Tokarev, A. Tsurykau, D. Ertz, H. B. Lee, J. Etayo, A. Vizzini, E. B. G. Jones, C. G. Lin, W. J. Li, Y. C. Dai, X. L. Fan, E. H. C. McKenzie, R. G. Shivas, V Hustad, D. Leontyev, G. S. de Hoog, T. Niskanen, T. Boekhout, E. Gaya, M. Thines
Article
Mycology
Robert Luecking, M. Catherine Aime, Barbara Robbertse, Andrew N. Miller, Hiran A. Ariyawansa, Takayuki Aoki, Gianluigi Cardinali, Pedro W. Crous, Irina S. Druzhinina, David M. Geiser, David L. Hawksworth, Kevin D. Hyde, Laszlo Irinyi, Rajesh Jeewon, Peter R. Johnston, Paul M. Kirk, Elaine Malosso, Tom W. May, Wieland Meyer, Maarja Opik, Vincent Robert, Marc Stadler, Marco Thines, Duong Vu, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch
Article
Zoology
A. Laciny, H. L. Nemeschkal, H. Zettel, B. Metscher, I. S. Druzhinina
Article
Microbiology
Lorant Hatvani, Monika Homa, Komal Chenthamara, Feng Cai, Sandor Kocsube, Lea Atanasova, Emilija Mlinaric-Missoni, Palanisamy Manikandan, Rajaraman Revathi, Ilona Doczi, Gabor Bogats, Venkatapathy Narendran, Rita Buchner, Csaba Vagvolgyi, Irina S. Druzhinina, Laszlo Kredics
FEMS MICROBIOLOGY LETTERS
(2019)