Article
Microbiology
Hasan Tukenmez, Pardeep Singh, Souvik Sarkar, Melike Cakir, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jorgen Johansson
Summary: Bacteria resistant to antibiotics are a major problem, requiring the development of new antimicrobial drugs. In this study, the effectiveness of a new compound, PS900, in inhibiting virulence factor expression in Listeria monocytogenes was demonstrated. Furthermore, PS900 was found to potentiate the bactericidal effects of cholic acid and osmolytes, making it a promising candidate for future antibacterial drug design.
Article
Immunology
Josephine Moran, Liam Feltham, James Bagnall, Marie Goldrick, Elizabeth Lord, Catherine Nettleton, David G. Spiller, Ian Roberts, Pawel Paszek
Summary: The paper investigates the real-time interaction between the food-borne pathogen L. monocytogenes and host macrophages, revealing heterogeneous outcomes of infection and the impact of bacterial quantity on macrophage phagocytosis ability. It also highlights the role of population-level PrfA-mediated activity in regulating host-pathogen interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Manyun Yang, Xiaobo Liu, Yaguang Luo, Arne J. Pearlstein, Shilong Wang, Hayden Dillow, Kevin Reed, Zhen Jia, Arnav Sharma, Bin Zhou, Dan Pearlstein, Hengyong Yu, Boce Zhang
Summary: The system developed integrates paper chromogenic arrays (PCAs) and machine learning to automatically recognize PCA patterns on multiplexed viable pathogens with strain-level specificity. This approach has the potential to advance non-destructive pathogen detection and identification on food.
Article
Immunology
David R. Mains, Samuel J. Eallonardo, Nancy E. Freitag
Summary: The study shows that L. monocytogenes prfA* mutants exhibit significantly enhanced resistance to oxidative stress. Furthermore, transposon mutagenesis led to the identification of three novel gene targets required for full oxidative stress resistance only in the context of PrfA activation. Additionally, inactivation of cbpA and lmo0779 in a prfA* background resulted in reduced virulence in infected mice.
INFECTION AND IMMUNITY
(2021)
Article
Biotechnology & Applied Microbiology
Taran Skjerdal, Lars Erik Gangsei, Ole Alvseike, Kyrre Kausrud, Alessandra De Cesare, Elena-Alexandra Alexa, Avelino Alvarez-Ordonez, Lena Haugland Moen, Ane Mohr Osland, Cecilie From, Birgit Nordvik, Toril Lindback, Janne Kvello, Beate Folgero, Sissel Dommersnes, Sigrun J. Hauge
Summary: The study developed and validated a predictive model for the growth of Listeria monocytogenes in sliced roast beef, which provides a useful tool for food business operators to predict food shelf life. The model was successfully validated in four laboratories in three countries, demonstrating its reliability and accuracy.
Article
Biochemistry & Molecular Biology
Yidi Wang, Lili Li, Pingyao Cai, Rikke Heidemann Olsen, Shuai Peng, Hecheng Meng
Summary: We investigated the antimicrobial activity of sertraline against Listeria monocytogenes, and its effects on biofilm formation and virulence gene expression. Sertraline showed inhibitory effects on L. monocytogenes at concentrations between 16-32 μg/mL and a bactericidal effect at 64 μg/mL. Sertraline damaged the cell membrane, decreased ATP and intracellular pH, and reduced biofilm formation efficiency. Importantly, low concentrations of sertraline down-regulated the expression of various virulence genes in L. monocytogenes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Ryan D. Sheldon, Eric H. Ma, Lisa M. DeCamp, Kelsey S. Williams, Russell G. Jones
Summary: The protocol integrates traditional immunology infection models with whole-body metabolite infusion and mass-spectrometry-based metabolomic profiling to evaluate T-cell metabolism. Researchers can assess the metabolic substrate utilization of specific T-cell subpopulations in vivo using this method.
Article
Food Science & Technology
Lihan Huang, Cheng-An Hwang, Shiowshuh Sheen
Summary: This study examines the growth and survival of Listeria monocytogenes in cold smoked salmon (CSS) during refrigerated storage and temperature abuse. The results show that storage time and temperature can be used to predict the growth of L. monocytogenes in CSS and control listeriosis. This information is important for retailers and consumers to determine the safety of packaged products.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Microbiology
Thulani Sibanda, Elna M. Buys
Summary: This review explores the molecular basis of the connection between stress tolerance responses and pathogenesis of L. monocytogenes. It is found that stress-induced adaptive responses in food can protect the pathogen in the gastrointestinal tract and switch its gene expression from avirulent to virulent state. The review also discusses the overlapping and interlinked regulatory networks for SigB and PrfA.
Article
Food Science & Technology
Joo-Won Kim, Bhupendra Mistry, Han-Seung Shin, Seok-Seong Kang
Summary: The study demonstrated that N-Mannich bases of berberine linking piperazine (MBP), specifically MBP5 and MBP6, have significant anti-biofilm activity against Listeria monocytogenes. These compounds effectively reduced biofilm formation and viability of the bacteria on various surfaces, suggesting their potential use as promising anti-biofilm agents.
Article
Microbiology
Lixia Wang, Chunhui Ji, Xianzhu Xia, Xuepeng Cai, Qingling Meng, Jun Qiao
Summary: This study investigated the regulatory roles and mechanisms of sRNA Rli43 in Listeria monocytogenes. The results showed that Rli43 plays important roles in environmental adaptation, biofilm formation, and virulence modulation in L. monocytogenes.
Review
Microbiology
Nasim Khorshidian, Elham Khanniri, Mehrdad Mohammadi, Amir M. Mortazavian, Mojtaba Yousefi
Summary: The food industry faces the challenge of producing healthy and safe food products, leading researchers to focus on natural antimicrobial compounds such as bacteriocins due to consumer concerns about chemical preservatives. Pediocins, small unmodified peptides with low molecular weight, exhibit broad spectrum antimicrobial activity against Gram-positive bacteria, especially pathogenic bacteria like Listeria monocytogenes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Francis Muchaamba, Helena Stoffers, Ralf Blase, Ueli von Ah, Taurai Tasara
Summary: The study showed that using potassium lactate as a substitute for sodium chloride can effectively reduce salt content in salami products, mitigating the negative health impacts of a high salt diet. Comparison between the low salt plus KL combination and high salt concentration revealed similar anti-Listeria activity and product characteristics.
Article
Public, Environmental & Occupational Health
Sara Kazemi Rad, Mehdi Assmar, Mirsasan Mirpour, Mohamad Reza Razavi
Summary: This study aimed to isolate L. monocytogenes bacteria from vaginal samples of pregnant women and evaluate the effects of chitosan nanoparticles on them. The results showed that L. monocytogenes could be a causative agent of abortion in pregnant women and nano chitosan exhibited acceptable antibacterial activity against L. monocytogenes.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Microbiology
Inna L. Garmasheva, Ljubov T. Oleschenko
Summary: This study aimed to select bacteriocinogenic strains among Enterococcus strains isolated from Ukrainian traditional dairy products. Molasses and steep corn liquor were used as a low-cost media for screening. The results showed that 34 Enterococcus strains produced metabolites that inhibited the growth of indicator strains, and five strains were found to possess enterocin genes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ina Haeuslein, Christian Manske, Werner Goebel, Wolfgang Eisenreich, Hubert Hilbi
MOLECULAR MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Adrian Mehlitz, Eva Eylert, Claudia Huber, Buko Lindner, Nadine Vollmuth, Karthika Karunakaran, Werner Goebel, Wolfgang Eisenreich, Thomas Rudel
MOLECULAR MICROBIOLOGY
(2017)
Review
Immunology
Wolfgang Eisenreich, Thomas Rudel, Juergen Heesemann, Werner Goebel
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Kristina Schauer, Gernot Geginat, Chunguang Liang, Werner Goebel, Thomas Dandekar, Thilo M. Fuchs
Article
Microbiology
Jennifer Schaer, Regina Stoll, Kristina Schauer, Daniela I. M. Loeffler, Eva Eylert, Biju Joseph, Wolfgang Eisenreich, Thilo M. Fuchs, Werner Goebel
JOURNAL OF BACTERIOLOGY
(2010)
Article
Microbiology
Christiane Steinweg, Carsten T. Kuenne, Andre Billion, Mobarak A. Mraheil, Eugen Domann, Rohit Ghai, Sukhadeo B. Barbuddhe, Uwe Kaerst, Alexander Goesmann, Alfred Puehler, Bernd Weisshaar, Juergen Wehland, Robert Lampidis, Juergen Kreft, Werner Goebel, Trinad Chakraborty, Torsten Hain
JOURNAL OF BACTERIOLOGY
(2010)
Article
Microbiology
Regina Stoll, Werner Goebel
Review
Microbiology
Wolfgang Eisenreich, Thomas Dandekar, Juergen Heesemann, Werner Goebel
NATURE REVIEWS MICROBIOLOGY
(2010)
Article
Multidisciplinary Sciences
Andreas Goetz, Eva Eylert, Wolfgang Eisenreich, Werner Goebel
Article
Multidisciplinary Sciences
Nadine Gillmaier, Andreas Goetz, Anette Schulz, Wolfgang Eisenreich, Werner Goebel
Review
Immunology
Wolfgang Eisenreich, Juergen Heesemann, Thomas Rudel, Werner Goebel
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2013)
Article
Immunology
Stephanie Grubmueller, Kristina Schauer, Werner Goebel, Thilo M. Fuchs, Wolfgang Eisenreich
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2014)
Review
Immunology
Wolfgang Eisenreich, Thomas Rudel, Juergen Heesemann, Werner Goebel
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Microbiology
Wolfgang Eisenreich, Juergen Heesemann, Thomas Rudel, Werner Goebel
MICROBIOLOGY SPECTRUM
(2015)
Review
Microbiology
Thilo M. Fuchs, Wolfgang Eisenreich, Juergen Heesemann, Werner Goebel
FEMS MICROBIOLOGY REVIEWS
(2012)