Article
Food Science & Technology
Rui Dong, Xiaojie Qin, Shoukui He, Xiujuan Zhou, Yan Cui, Chunlei Shi, Yiping He, Xianming Shi
Summary: The study revealed that DsrA plays a crucial role in promoting oxidative stress resistance in S. Typhimurium by regulating the expression of antioxidant enzymes and maintaining intracellular redox balance.
Article
Microbiology
Yan Li, Pei Zhang, Pengcheng Du, Yujiao Mu, Shenghui Cui, Seamus Fanning, Zhiqiang Wang, Ruichao Li, Li Bai
Summary: Hybrid plasmids formed by fusion events in Salmonella enterica serovar 4,[5],12:i:- possess high plasticity and can recombine with other plasmids to form fusion plasmids of different sizes. The structural polymorphisms of plasmids are mainly mediated by insertion sequences and can rearrange the internal structures of the plasmids. This study provides insights into the transmission risk and evolution of multidrug resistance plasmids.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Han Du, Xu Zhang, Mingru Yao, Qingli Yang, Wei Wu
Summary: This study successfully constructed aptamer-guided luminous microspheres using carbon dots fluorescence, which can efficiently recognize and detect Salmonella enterica serovar Typhimurium. The method shows high sensitivity and has broad application prospects.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Microbiology
Manal Mohammed, Beata Orzechowska
Summary: The study aimed to characterize phage resistance mechanisms and genomic differences in S. Typhimurium DT104 and DT104b that may explain divergent phage reaction patterns, but found no unique genetic determinants. Experimental assessment of phage-specific receptors on the bacterial cell surface and analysis of bacterial transcriptome using RNA sequencing were suggested to further understand bacterial susceptibility to phages. The use of Anderson phage typing scheme of Salmonella Typhimurium can help improve the understanding of host-phage interactions and lead to the development of phage-based technologies for infection control.
Article
Multidisciplinary Sciences
Danielle J. Ingle, Rebecca L. Ambrose, Sarah L. Baines, Sebastian Duchene, Anders Goncalves da Silva, Darren Y. J. Lee, Miriam Jones, Mary Valcanis, George Taiaroa, Susan A. Ballard, Martyn D. Kirk, Benjamin P. Howden, Jaclyn S. Pearson, Deborah A. Williamson
Summary: Three distinct lineages of Salmonella 4,[5],12:i:- have emerged in Australia, likely reflecting differential antimicrobial selection pressures, with two lineages associated with travel to South-East Asia and the third lineage endemic to Australia. These antimicrobial-resistant lineages efficiently infect and survive in host cells, suggesting a suppression of host immune response facilitating their persistence.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Yu Han, Yu Li, Zhiwei Zeng, Wenjing Li, Saixiang Feng, Weisheng Cao
Summary: This study explores the resistance mechanism and activity of the antimicrobial peptide MccY against Salmonella strains. The deletion of Ton system genes resulted in resistance to MccY and mutants showed increased susceptibility to MccY under a low-iron condition. MccY may decrease the virulence of S. Typhimurium by altering multiple physiological properties.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Chong Ling, Shujie Liang, Yan Li, Qingyun Cao, Hui Ye, Changming Zhang, Zemin Dong, Dingyuan Feng, Weiwei Wang, Jianjun Zuo
Summary: This study reveals that STM0306 is an important adhesin/invasin in Salmonella enterica serovar typhimurium (S. Typhimurium), contributing to the pathogenicity and cellular inflammation of the host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Stephanie Paulini, Florian D. Fabiani, Anna S. Weiss, Ana Laura Moldoveanu, Sophie Helaine, Baerbel Stecher, Kirsten Jung
Summary: Pyruvate, the simplest of the alpha-keto acids, plays a crucial role in the metabolic pathways of bacteria and eukaryotes. This study identified two specific transporters, BtsT and CstA, in Salmonella enterica serovar Typhimurium, which are important for pyruvate uptake and have significant effects on bacterial survival, infection, and persistence.
Article
Immunology
Yunjia Shi, Xindi Chen, Jingyan Shu, Yang Liu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu
Summary: The study found that harmine can inhibit the infection caused by Salmonella, by suppressing the secretion and expression of the bacterium's virulence factor T3SS, thus reducing the severity of the infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Abraham F. Mechesso, Yixian Quah, Seung-Chun Park
Summary: The study found that ginsenoside Rg3 can significantly reduce the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium, as well as inhibit bacterial motility and nitrite release from infected macrophages. Treatment with Rg3 also affected gene expression related to adhesion, invasion, quorum sensing, and virulence of S. Typhimurium.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Microbiology
Jiwon Baek, Hyunjin Yoon
Summary: Cyclic di-GMP is a signaling molecule that controls the transition between motile and nonmotile lifestyles in bacteria. It regulates biofilm formation and dispersal, and it can alter carbon metabolic pathways in Salmonella enterica serovar Typhimurium.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
R. Kavi Bharathi, C. S. Srinandan, N. Sai Subramanian
Summary: This study investigates the cooperative ability and matrix sharing between specialist and generalist strains during biofilm formation. The results show that the matrix aids in survival during antibiotic, chlorine, and predatory stress, and possible sharing of the matrix occurs in co-culture.
Article
Food Science & Technology
Ji-Yeon Kim, Hana Song, Danbi Kim, Sun-Young Lee
Summary: Mild heat treatment can enhance the thermal resistance of S. Typhimurium and reduce membrane damage and heat-induced injury, leading to increased tolerance against heat, alcohol, and salt stress. Further research into the heat shock response mechanism of S. Typhimurium may provide insights for developing microbial control measures in food processing.
Article
Microbiology
Yunjia Shi, Zeyu Sun, Yang Liu, Jingyan Shu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu
Summary: The serious problem of bacterial drug resistance has led to the development of antivirulence agents. This study found that fraxetin inhibits the invasion of Salmonella Typhimurium by inhibiting the transcription of the type III secretion system (T3SS), and it has been demonstrated to be effective in protecting mice against Salmonella infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Feifei Sun, Caili Qi, Qiling Wei, Lin Zhang, Hengfeng Fu, Xidi Jiang, Fang Lu, Lin Li
Summary: In this study, different strains of Salmonella typhimurium (AT-P128) were constructed using CRISPR/Cas9 gene editing technology, and it was found that overexpression of baeR in the context of acrB gene deletion increased the susceptibility of the strain to polymyxin and altered the expression level of polymyxin resistance genes. These findings provide insights into the mechanism of polymyxin resistance of S. typhimurium.
VETERINARY MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Omkar Hegde, Ritika Chatterjee, Abdur Rasheed, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study demonstrates the control of biofluid droplet deposition and bacterial aggregation by manipulating the flow dynamics using non-contact vapor-mediated interactions. The findings show that the nucleation sites and crystal formation can be controlled through the preferential transfer of solutes in the droplets. This methodology has potential implications in biomedical applications such as disease detection and bacterial segregation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Kapudeep Karmakar, Rohan Bhattacharya, Abhishek Sharma, Kirti Parmar, Utpal Nath, Karaba N. Nataraja, N. Earanna, Gaurav Sharma, Dipshikha Chakravortty
Summary: The study analyzed the colonization of Salmonella in plant roots and the importance of attachment factors, finding that a competitive bacterium inhibited its biofilm to reduce colonization in roots. It classified Salmonella with Rdar morphotypes as good plant colonizers and suggested that Lysinibacillus macroides could serve as a biocontrol agent to reduce the burden of Salmonella in various vegetables.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Mechanics
Gautham Vadlamudi, S. K. Thirumalaikumaran, Dipshikha Chakravortty, Abhishek Saha, Saptarshi Basu
Summary: This study investigates the effectiveness of different types of masks in blocking droplet transmission. It shows that masks are not able to completely prevent the penetration of larger droplets and can cause atomization, leading to increased risk of virus transmission. The study also examines the filtration and entrapment of virus-like particles in masks, as well as their efficacy for susceptible individuals.
Article
Microbiology
Kasturi Chandra, Atish Roy Chowdhury, Ritika Chatterjee, Dipshikha Chakravortty
Summary: This study reveals the important role of chitinase in Salmonella pathogenesis. It promotes intestinal epithelium remodeling and host system access. In phagocytes, chitinase-mediated upregulation of nitric oxide inhibits MHC-I bound antigen presentation and CD8(+) T cell proliferation. The absence of chitinase impairs bacterial adhesion and colonization. In the murine host, chitinase prevents immune activation and antimicrobial responses. In C. elegans, Salmonella chitinase promotes bacterial attachment to the intestinal epithelium and enhances pathogen colonization and persistence.
Review
Biochemistry & Molecular Biology
Reshma Ramakrishnan, Ashish Kumar Singh, Simran Singh, Dipshikha Chakravortty, Debasis Das
Summary: Pathogenic microbes' resistance to drugs is a major concern for humanity. Microorganisms like bacteria and fungi have defense mechanisms, including biofilm formation, against drugs and the host immune system. Biofilms, which are made up of extracellular polymeric substances, contribute to 80% of chronic bacterial infections. Biofilms can increase the dosage of certain antibiotics needed to combat infection up to 1000-fold. Therefore, there is an urgent need for effective strategies to eliminate biofilms. This review discusses current strategies and challenges in combating biofilms and highlights the potential of enzymes, particularly polysaccharide degrading enzymes, in dispersing biofilms for antimicrobial treatment of biofilm-associated infections.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Physics, Applied
N. Punith, Ashish K. Singh, J. Ananthanarasimhan, Bhavadharini Boopathy, Ritika Chatterjee, M. Hemanth, Dipshikha Chakravortty, Lakshminarayana Rao
Summary: This study demonstrates the successful generation of neutral pH high-strength plasma-activated water through pin to water discharge, which exhibits excellent bactericidal activity against hypervirulent multidrug resistance pathogens.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Physical
Abdur Rasheed, Omkar Hegde, Ritika Chatterjee, Srinivas Rao Sampathirao, Dipshikha Chakravortty, Saptarshi Basu
Summary: In naturally evaporating droplets, bacteria self-assemble into unique patterns based on their spatial location, resulting in varying physical forces and affecting their viability and infectivity. Self-assembly favors bacteria at the edge of the droplet, which has significant implications for understanding bacterial infection through droplets.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jayantika Bhowmick, Manish Nag, Pritha Ghosh, Raju S. Rajmani, Ritika Chatterjee, Kapudeep Karmakar, Kasturi Chandra, Jayanta Chatterjee, Dipshikha Chakravortty, Raghavan Varadarajan
Summary: This study tests the effect of a 24-mer peptide derived from CcdB (CP1-WT) on bacterial growth in Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus, and a carbapenem- and tigecycline-resistant strain of Acinetobacter baumannii. The CP1-WT peptide shows significant improvement over ciprofloxacin in treating established infections of S. Typhimurium, S. aureus, and A. baumannii. The study validates the CcdB binding site on bacterial DNA Gyrase as a viable alternative target to the fluoroquinolone binding site.
Article
Immunology
Ritika Chatterjee, Debalina Chaudhuri, Subba Rao Gangi Setty, Dipshikha Chakravortty
Summary: Salmonella is a stealthy intracellular pathogen that evades host immune responses and establishes a replicative niche in hostile environments like macrophages. It escapes autophagy by inhibiting the fusion of Salmonella-containing vacuoles with lysosomes/autophagosomes and downregulates lysosomal biogenesis, facilitating its survival in macrophages and systemic dissemination.
MICROBES AND INFECTION
(2023)
Article
Cell Biology
Ritika Chatterjee, Abhilash Vijay Nair, Anmol Singh, Nishi Mehta, Subba Rao Gangi Setty, Dipshikha Chakravortty
Summary: Intracellular membrane fusion is mediated by SNARE complexes. Salmonella modulates host SNARE machinery to escape lysosomal fusion and maintain its division in the Salmonella-containing vacuole (SCV). Syntaxin 3 (STX3) is critical for bacterial proliferation and fusion of SCV with intracellular vesicles. The interaction of STX3 with SCV is impaired in SPI-2 encoded T3SS mutant. These findings highlight the importance of SPI-2 encoded effectors in the interaction with host SNAREs for Salmonella pathogenesis.
Article
Multidisciplinary Sciences
Vishnu Hariharan, Atish Roy Chowdhury, S. Srinivas Rao, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study reveals the impact of bacteria-laden droplets on solid surfaces and subsequent desiccation on the virulence of Salmonella typhimurium. The research explores the deformation, cell-cell interactions, adhesion energy, and roughness in bacteria induced by impact velocity and low moisture. The findings show that mechanical stress induced by impact velocity decreases the in vitro viability of Salmonella while promoting bacterial proliferation in macrophages. The role of phoP in sensing mechanical stress and maintaining the virulence of Salmonella is also highlighted.
Article
Microbiology
Kasturi Chandra, Abhilash Vijay Nair, Ritika Chatterjee, Prerana Muralidhara, Anmol Singh, Sathisha Kamanna, Utpal S. Tatu, Dipshikha Chakravortty
Summary: Salmonella is a widespread Gram negative bacteria that causes a significant proportion of global diarrheal morbidity and mortality. It can cause typhoid fever and gastroenteritis by entering the host gut through contaminated food and water. Salmonella's biofilm lifestyle allows it to resist antibiotics and persist in the host, and inhibiting biofilm initiation is challenging.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ritika Chatterjee, Atish Roy Chowdhury, Debapriya Mukherjee, Dipshikha Chakravortty
Summary: Salmonella Typhi is a serious threat to global health, causing typhoid fever in humans and resulting in high morbidity and mortality in developing countries. It can be transmitted to healthy individuals through contaminated food and water. This Review focuses on a comparative analysis of the virulence and pathogenesis of typhoidal and nontyphoidal serovars of Salmonella enterica.
Article
Chemistry, Physical
Siddhant Jain, Anmol Singh, Nivedita Tiwari, Aparna Naik, Ritika Chatterjee, Dipshikha Chakravortty, Saptarshi Basu
Summary: This study experimentally investigates the effects of stress generated by flowing fluid on bacterial morphology and virulence. The results show that increased stress conditions lead to significant changes in bacterial structure and decreased viability. Importantly, stressed bacteria proliferate faster inside macrophages. These findings shed light on the complex relationship between flow stresses and bacterial pathogenicity.
Review
Biochemistry & Molecular Biology
Sukriyo Chakraborty, Ritika Chatterjee, Dipshikha Chakravortty
Summary: Antimicrobial peptides, or host defense peptides, show promise as therapeutic candidates for combating infections, but their clinical trials have been hindered by toxicity and hemolytic activity. Rational peptide engineering based on evolutionary principles and activity determinants offers new avenues for developing peptides targeted at specific microbes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
