Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress

BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42

(2013) Jihoon Nah et al.   Autophagy

Age-Dependent Impairment of Eyeblink Conditioning in Prion Protein-Deficient Mice

(2013) Yasushi Kishimoto et al.   PLoS One

Prions, prionoids and pathogenic proteins in Alzheimer disease

(2013) Karen H. Ashe et al.   Prion

Neuroimmunoendocrine Regulation of the Prion Protein in Neutrophils

(2012) Rafael M. Mariante et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

(2012) Peter K. Stys et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endogenous Prion Protein Attenuates Experimentally Induced Colitis

(2011) Gary R. Martin et al.   AMERICAN JOURNAL OF PATHOLOGY

Depressive-like behaviour of mice lacking cellular prion protein

(2011) Vinicius M. Gadotti et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7–PSD-95 binding

(2011) Patricia Carulla et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular Prion Protein Protects from Inflammatory and Neuropathic Pain

(2011) Vinicius M Gadotti et al.   Molecular Pain

Threshold for epileptiform activity is elevated in prion knockout mice

(2011) S. Ratté et al.   NEUROSCIENCE

Involvement of the cellular prion protein in the migration of brain microvascular endothelial cells

(2011) Takuya Watanabe et al.   NEUROSCIENCE LETTERS

Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

(2010) Wei Hu et al.   BRAIN

Role of α7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-inducible Protein 1

(2010) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Glucose Tolerance in Mice Lacking Cellular Prion Protein

(2010) Alexander Strom et al.   PANCREAS

PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism

(2009) Matthew T Bishop et al.   BMC Medical Genetics

RNAi for the Treatment of Prion Disease: A Window for Intervention in Neurodegeneration?

(2009) Melanie White et al.   CNS & Neurological Disorders-Drug Targets

Brain proteins that mind metals: a neurodegenerative perspective

(2009) David R. Brown   DALTON TRANSACTIONS

Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism

(2009) Y. Macotela et al.   DIABETES

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

(2009) Manuel T. Silva   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular prion protein coupling to TACE-dependent TNF-α shedding controls neurotransmitter catabolism in neuronal cells

(2009) Elodie Pradines et al.   JOURNAL OF NEUROCHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport

(2009) Ajay Singh et al.   PLoS One

Antimicrobial Activity of Human Prion Protein Is Mediated by Its N-Terminal Region

(2009) Mukesh Pasupuleti et al.   PLoS One

Absence of the Cellular Prion Protein Exacerbates and Prolongs Neuroinflammation in Experimental Autoimmune Encephalomyelitis

(2008) Shigeki Tsutsui et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice

(2008) Y. Nasu-Nishimura et al.   ARCHIVES OF VIROLOGY

Cellular prion protein electron microscopy: attempts/limits and clues to a synaptic trait. Implications in neurodegeneration process

(2008) Jean-Guy Fournier   CELL AND TISSUE RESEARCH

CREB-dependent gene regulation by prion protein: Impact on MMP-9 and β-dystroglycan

(2008) Elodie Pradines et al.   CELLULAR SIGNALLING

All quiet on the neuronal front: NMDA receptor inhibition by prion protein: Figure 1.

(2008) Andrew D. Steele   JOURNAL OF CELL BIOLOGY

Prominent pancreatic endocrinopathy and altered control of food intake disrupt energy homeostasis in prion diseases

(2008) J D Bailey et al.   JOURNAL OF ENDOCRINOLOGY

Olfactory behavior and physiology are disrupted in prion protein knockout mice

(2008) Claire E Le Pichon et al.   NATURE NEUROSCIENCE

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

(2008) M. D. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunology of sepsis

(2007) S Sriskandan et al.   JOURNAL OF PATHOLOGY

Scrapie-Infected Mice and PrP Knockout Mice Share Abnormal Localization and Activity of Neuronal Nitric Oxide Synthase

(2003) Gilmor I. Keshet et al.   JOURNAL OF NEUROCHEMISTRY