Article
Biotechnology & Applied Microbiology
V. E. Mendez Utz, D. Perez Visnuk, G. Perdigon, A. de Moreno de LeBlanc
Summary: Fermented milk by L. casei CRL431 (PFM) reduces side effects of capecitabine, improves its toxicity on breast cancer cells, and maintains its anti-cancer/anti-metastasis effects in mouse models.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biology
Romina I. Carvajal, Fabiola Silva-Mieres, Alejandra Ilabaca, Jorge Rocha, Luciano Arellano-Arriagada, Felipe A. Zuniga Arbalti, Apolinaria Garcia-Cancino
Summary: The aim of this study was to find a probiotic that can improve the health of honeybee colonies by modulating their immune function. A strain of Lactobacillus casei A14.2 was found to have high immunomodulating activity. The use of this potential probiotic may increase the resistance of honeybees to infectious diseases caused by Nosema spp.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Szabolcs Muzsai, Ore-Matan Maryanovsky, Roland Ander, Gabor Koncz, Anett Mazlo, Attila Bacsi, Marta Toth
Summary: The cell-free supernatant (CFS) derived from Lactobacillus casei (L. casei), a member of human microbiota, enhances the sensitivity of mesenchymal-stromal-cell-like (MSCI) cells to viral stimuli and induces the development of dendritic cells (DCs) with anti-inflammatory and antiviral properties through pretreated MSCl cells. The presence of L. casei-derived extracellular vesicles in CFS during pretreatment is crucial for the production of INF & beta; and CXCL10 by MSCl cells upon viral stimulation. Moreover, L. casei CFS and/or poly (I:C)-conditioned MSCI cells alter the differentiation process and functional activities of freshly isolated monocytes and developing DCs.
Article
Agriculture, Dairy & Animal Science
Wenyan Hui, Wenyi Zhang, Jing Li, Lai-Yu Kwok, Heping Zhang, Jian Kong, Tiansong Sun
Summary: This study aimed to investigate the function of the BREX system in L. casei Zhang by inactivating its second methyltransferase gene. The mutant strain showed a higher cell density and less 5'-ACRC(m6)AG-3' methylation compared to the wildtype. Additionally, the mutant strain exhibited different transformation efficiencies for plasmids with and without cognate recognition sequences.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Immunology
Yuanhui He, Risu Na, Xiaoxi Niu, Bingbing Xiao, Huixia Yang
Summary: This study investigated the impact of Lactobacillus rhamnosus and Lactobacillus casei on Gardnerella species biofilm formation, finding that adding L. rhamnosus at different stages effectively suppressed biofilm formation. Additionally, the quantity of biofilm was found to be highest at a pH of 5.5 and after 36 hours.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Food Science & Technology
Liliana Luca, Mircea Oroian
Summary: This study examined the testing of three prebiotics and their effects on the properties and survival rates of microcapsules under different conditions. The extrusion encapsulation technique was found to be effective in producing microcapsules that meet the requirements of the food industry. Using prebiotic encapsulation matrix can increase cell viability and protection, indicating its potential use in probiotic microcapsule production for the food industry.
Article
Biochemistry & Molecular Biology
Guoqiang Yao, Chenxia Cao, Meng Zhang, Lai-Yu Kwok, Heping Zhang, Wenyi Zhang
Summary: The study showed that probiotics can help restore the balance of host gut microbiota and metabolome after antibiotic treatment, with increases in certain microbial populations and short-chain fatty acid levels after antibiotic and probiotic intervention, beneficial bacteria P. goldsteinii strongly correlated with lactobacilli, and probiotics also reduced inflammation levels in rats.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Microbiology
Alok K. Paul, Anita Paul, Rownak Jahan, Khoshnur Jannat, Tohmina A. Bondhon, Anamul Hasan, Veeranoot Nissapatorn, Maria L. Pereira, Polrat Wilairatana, Mohammed Rahmatullah
Summary: Rheumatoid arthritis is a chronic autoimmune disorder with various potential causes, and probiotics such as L. casei or L. acidophilus may have a beneficial role in its management.
Article
Food Science & Technology
Federico Bueno, Alexander Chouljenko, Subramaniam Sathivel
Summary: The addition of Lactobacilli to coffee kombucha shifted the proportion of microbial families and allowed them to survive in the beverage for 15 days, even after exposure to simulated gastrointestinal conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
F. Blanchet, L. Rault, V Peton, Y. Le Loir, C. Blondeau, L. Lenoir, M. Dubourdeaux, S. Even
Summary: The study evaluated the potential of live and heat-inactivated Lactobacillus gasseri LA806 in combating Staphylococcus aureus and Escherichia coli infections. Live LA806 significantly reduced S. aureus adhesion and internalization, as well as pro-inflammatory cytokine expression, while inactivated LA806 showed lower antibacterial ability but minimal impact on anti-inflammatory properties.
BENEFICIAL MICROBES
(2021)
Article
Biotechnology & Applied Microbiology
Mohammad Ali Shamshirgaran, Mehdi Golchin, Elham Mohammadi
Summary: In this study, a recombinant Lactobacillus casei strain expressing the NetB protein of Clostridium perfringens was used as a probiotic-based vector vaccine to immunize broiler chickens against necrotic enteritis. The vaccinated birds showed significant protection against the disease and developed strong antibody responses. This study suggests that a probiotic-based vector vaccine could be a promising candidate for controlling necrotic enteritis in broiler chickens.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xing Guo, Kai Zhong, LongFei Zou, Hao Xue, ShuLing Zheng, Jiang Guo, Hui Lv, Ke Duan, DengHua Huang, MeiYun Tan
Summary: This study found that antibiotic treatment leads to dysbiosis of the gut microbiota in mice, which in turn affects bone development and bone density. On the other hand, probiotic treatment promotes fracture healing in osteoporotic mice after dysbiosis, potentially through inhibiting the RAS/RANKL/RANK pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Nimcy Noemi Meza-Gutierrez, Paola Magallon-Servin, Rosendo Balois-Morales, Iza Fernanda Perez-Ramirez, Graciela Guadalupe Lopez-Guzman, Guillermo Berumen-Varela, Pedro Ulises Bautista-Rosales
Summary: The effect of soursop leaf extracts on the growth, motility, and biofilm formation of Lactobacillus casei were investigated. The extracts showed both growth-promoting and inhibitory effects, with different compounds being related to growth. The extracts also affected the motility of L. casei and inhibited biofilm formation.
Article
Biotechnology & Applied Microbiology
Jicheng Wang, Jiachao Zhang, Wenjun Liu, Heping Zhang, Zhihong Sun
Summary: This study reveals that ingested probiotics alter their transcription patterns to survive and adapt in the human gut, indicating a highly dynamic cross-talk between probiotics and the human gut microbiome.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Food Science & Technology
Tatiana Beldarrain-Iznaga, Ricardo Villalobos-Carvajal, Eva Sevillano-Armesto, Javier Leiva-Vega
Summary: In this study, Lactobacillus casei was encapsulated in multilayer microcapsules using a double emulsion and layer-by-layer electrostatic deposition technique with alginate and chitosan coatings. The alginate-chitosan layers provided additional protection to the probiotic cells, maintaining their viability and functional properties during simulated gastrointestinal transit. This encapsulation method not only ensures the presence of probiotics in the gastrointestinal tract, but also helps preserve their probiotic effect by enhancing resistance to digestive conditions.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Agricultural Engineering
Natalia Barbieri, Angeles Sanchez-Contreras, Azucena Canto, Juan Valerio Cauich-Rodriguez, Rossana Vargas-Coronado, Luz Maria Calvo-Irabien
INDUSTRIAL CROPS AND PRODUCTS
(2018)
Article
Biotechnology & Applied Microbiology
Natalia Barbieri, Susana Salva, Matias Herrera, Julio Villena, Susana Alvarez
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2020)
Article
Immunology
Valeria Garcia-Castillo, Ryoya Komatsu, Patricia Clua, Yuhki Indo, Michihiro Takagi, Susana Salva, Md. Aminul Islam, Susana Alvarez, Hideki Takahashi, Apolinaria Garcia-Cancino, Haruki Kitazawa, Julio Villena
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
L. P. Arce, M. F. Raya Tonetti, M. P. Raimondo, M. F. Mueller, S. Salva, S. Alvarez, A. Baiker, J. Villena, M. G. Vizoso Pinto
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2020)
Article
Immunology
Fernanda Raya Tonetti, Lorena Arce, Susana Salva, Susana Alvarez, Hideki Takahashi, Haruki Kitazawa, Maria Guadalupe Vizoso-Pinto, Julio Villena
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Patricia Clua, Mikado Tomokiyo, Fernanda Raya Tonetti, Md Aminul Islam, Valeria Garcia Castillo, Guillermo Marcial, Susana Salva, Susana Alvarez, Hideki Takahashi, Shoichiro Kurata, Haruki Kitazawa, Julio Villena
Article
Immunology
Andres Gramajo Lopez, Florencia Gutierrez, Lucila Saavedra, Elvira Maria Hebert, Susana Alvarez, Susana Salva
Summary: The study explores the effects of oral administration of viable and non-viable probiotics on reducing myelosuppression and immunosuppression induced by chemotherapy. Viable and non-viable Lr05 and Lp06 treatments were effective in promoting early recovery of bone marrow architecture and myeloid cells in mice treated with cyclophosphamide, with non-viable Lr05 showing potential as a resource for reducing chemotherapy-induced leukopenia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
M. A. Correa Deza, L. Diaz Vergara, S. Salva, M. A. Montenegro, G. Font de Valdez, C. L. Gerez
Summary: In this study, the use of an inorganic additive (MCM3) in the carrier and reconstitution media was found to enhance cell survival during spray drying of Lacticaseibacillus rhamnosus CRL1505. The presence of MCM3 led to higher cell counts and better recovery of dehydrated cells, indicating its potential as a promising technological alternative for probiotic processing.
CURRENT MICROBIOLOGY
(2021)
Article
Microbiology
Marcela Espinoza-Monje, Jorge Campos, Eduardo Alvarez Villamil, Alonso Jerez, Stefania Dentice Maidana, Mariano Elean, Susana Salva, Haruki Kitazawa, Julio Villena, Apolinaria Garcia-Cancino
Summary: The study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and demonstrate its beneficial effect in treating acne vulgaris. Both in vitro and in vivo studies showed that the UCO-SMC3 strain inhibited the growth of C. acnes and beneficially modulated the immune response against the skin pathogen, reducing pathogen replication and inflammatory response. Oral and topical administration of UCO-SMC3 strain showed promising results in reducing acne lesions.
Review
Nutrition & Dietetics
Susana Salva, Yanina Kolling, Maximiliano Ivir, Florencia Gutierrez, Susana Alvarez
Summary: This article discusses the relationship between malnutrition and secondary immunodeficiency, as well as the impact of immune cells on respiratory immunity. Research findings show that immunobiotics nasal administration can accelerate the recovery of the respiratory immune response in malnourished hosts, and the key cellular component for mucosal immunity is proposed to be a specific peptidoglycan from a particular immunobiotic Lactobacillus.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Susana Salva, Ines Tiscornia, Florencia Gutierrez, Susana Alvarez, Mariela Bollati-Fogolin
Summary: This study evaluated the immunoregulatory effect of Lactobacillus rhamnosus CRL1505 postbiotics in human intestinal epithelial cells (IECs) and dendritic cells (DCs) and identified the cell wall and peptidoglycan as key molecules for the immunobiotic properties of this strain. These findings could provide predictive tools for the in vivo efficacy of postbiotics and their potential future applications in immunocompromised patients.
Article
Biology
Maria A. Correa Deza, Antonieta Rodriguez de Olmos, Nadia E. Suarez, Graciela Font de Valdez, Susana Salva, Carla L. Gerez
Summary: This study demonstrated that the immunobiotic CRL1505 accumulates inorganic polyphosphate (polyP) in response to environmental stress, and polyP from CRL1505 can alleviate inflammatory responses in a murine model of acute respiratory inflammation induced by lipopolysaccharide (LPS).
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Microbiology
Julio Nicolas Arganaraz Aybar, Sonia Ortiz Mayor, Luis Olea, Juan Jose Garcia, Sebastian Nisoria, Yanina Kolling, Constanza Melian, Mirta Rachid, Rafael Torres Dimani, Cecilia Werenitzky, Cecilia Lorca, Susana Salva, Nadia Gobbato, Julio Villena, Juan C. Valdez
Summary: This study aimed to evaluate the effectiveness of using topical applications of Lactiplantibacillus plantarum cultures as an adjuvant treatment to surgical debridement in complicated diabetic foot ulcers. The results showed that L. plantarum enhanced fibroplasia, angiogenesis, and wound healing, while reducing bacterial counts.
Article
Biotechnology & Applied Microbiology
M. A. Correa Deza, S. Salva, M. Grillo-Puertas, G. M. Font, C. L. Gerez
Summary: The aim of this study was to optimize the production of Lacticaseibacillus rhamnosus CRL1505 depending on the target of the functional product. The culture parameters (pH, growth phase) were evaluated for their effect on cell viability, heat tolerance and polyphosphate accumulation. The appropriate culture conditions for the production of this strain were determined based on the potential application.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Immunology
Carlos Henrique Camargo, Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Claudio Tavares Sacchi, Alex Domingos Reis, Marlon Benedito Nascimento Santos, Denise Brandao de Assis, Eneas de Carvalho, Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Monique Ribeiro Tiba-Casas
Summary: This study reveals the silent spread of New Delhi metallo-beta-lactamase (NDM) carbapenemase in Brazil, particularly in Enterobacterales other than Klebsiella spp. It highlights the diverse species and coexistence of important resistance genes in these NDM-producing strains. Prompt detection and effective measures are crucial to mitigate the further dissemination of NDM carbapenemase and preserve antimicrobial therapy options in hospital settings.
MICROBIOLOGY AND IMMUNOLOGY
(2024)