Article
Environmental Sciences
Ashutosh Kabiraj, Urmi Halder, Annapurna Chitikineni, Rajeev K. Varshney, Rajib Bandopadhyay
Summary: Contamination of arsenic in drinking water and foods is a threat to human beings. Researchers have been studying the bioremediation of arsenic using potent bacteria to reduce its availability. In this study, a strain of Micrococcus luteus was isolated from arsenic-contaminated water in West Bengal, India. This strain showed tolerance to high concentrations of arsenic and other metals, as well as the ability to adsorb arsenic and promote plant growth. These findings suggest its potential application in arsenic bioremediation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Microbiology
Marco Antonio Lopez Marin, Michal Strejcek, Petra Junkova, Jachym Suman, Jiri Santrucek, Ondrej Uhlik
Summary: The study shows that using a Micrococcus luteus culture supernatant containing resuscitation-promoting factor (SRpf) can increase the number and diversity of cultured bacterial taxa from a nutrient-rich compost soil. After SRpf treatment, potentially novel bacterial species were isolated, demonstrating the effectiveness of SRpf in enhancing the growth of soil bacterial species.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Andrei V. V. Gannesen, Rustam H. H. Ziganshin, Evelina L. L. Zdorovenko, Alena I. I. Klimko, Elena A. A. Ianutsevich, Olga A. A. Danilova, Vera M. M. Tereshina, Maxim V. V. Gorbachevskii, Maria A. A. Ovcharova, Ekaterina D. D. Nevolina, Sergey V. V. Martyanov, Alexander S. S. Shashkov, Andrey S. S. Dmitrenok, Andrei A. A. Novikov, Marina V. V. Zhurina, Ekaterina A. A. Botchkova, Philipp V. V. Toukach, Vladimir K. K. Plakunov
Summary: The study investigates the effects of epinephrine on commensal microbiota and microbial biofilms, finding that epinephrine increases the amount of polysaccharides and extracellular DNA in the matrix, changes its composition, and has significant impact on biofilms and matrix composition.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mengqi Xie, Yilin Li, Luning Xu, Shusheng Zhang, Hongyu Ye, Faqian Sun, Rongwu Mei, Xiaomei Su
Summary: This study optimized Rpf production using the RSM method and found that the highest Rpf protein yield could be obtained under certain conditions. Additionally, the Phyre2 web portal characterized the structure of the Rpf domain to have shared homology with lysozymes, with the highest lysozyme activity achievable under specific conditions.
Article
Plant Sciences
Huan Long, Jinhua Fang, Lian Ye, Baolong Zhang, Colleen Hui, Xuan Deng, Sabeeha S. Merchant, Kaiyao Huang
Summary: This study optimized a method for purifying lysosome-related organelles (LROs) from two different populations of cells and discovered differences in morphology and function between them. It found that LROs in stationary phase cells had non-membrane-bound polyphosphate granules for phosphorus storage, while those in iron-overloaded cells were similar to acidocalcisomes with membrane boundaries and larger polyphosphate granules. Additionally, the study established a method for quantifying the sequestration capacity of LROs for trace metals and identified 113 putative acidocalcisome proteins through comparative proteomic analysis.
Article
Biochemistry & Molecular Biology
Cecilia Rocchi, Camille Louvat, Adriana Erica Miele, Julien Batisse, Christophe Guillon, Lionel Ballut, Daniela Lener, Matteo Negroni, Marc Ruff, Patrice Gouet, Francesca Fiorini
Summary: Recent evidence suggests that HIV-1 Integrase (IN) plays a critical role in the morphogenesis of the viral particle and the stability of viral genomic RNA (gRNA) in host cells. The C-terminal tail of IN interacts with the apical structure of TAR RNA, modifying its structure and facilitating the binding of HIV transcriptional trans-activator Tat to TAR. This process eventually displaces IN from TAR. These findings provide insights into the mechanism of IN in the early stages of proviral transcription and could contribute to the development of anti-HIV-1 therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Agnes Paulus, Anders Engdahl, Yiyi Yang, Antonio Boza-Serrano, Sara Bachiller, Laura Torres-Garcia, Alexander Svanbergsson, Megg G. Garcia, Gunnar K. Gouras, Jia-Yi Li, Tomas Deierborg, Oxana Klementieva
Summary: Alzheimer's disease is a terminal illness that affects millions of people globally and is characterized by the formation of amyloid aggregates. Studies using infrared microspectroscopy have demonstrated the ability to detect structural changes in proteins and lipids in cells, revealing that different amyloid signatures may be triggered by the specific cellular environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Lachlan Harris, Piero Rigo, Thomas Stiehl, Zachary B. Gaber, Sophie H. L. Austin, Maria del Mar Masdeu, Amelia Edwards, Noelia Urban, Anna Marciniak-Czochra, Francois Guillemot
Summary: The stabilization of neural stem cell numbers in young adults is a result of coordinated changes in stem cell behavior, with resting cells having a higher activation rate and greater contribution to neurogenesis. This change is associated with a progressive reduction in expression of the pro-activation protein ASCL1 due to increased post-translational degradation, providing insights into hippocampal NSC dynamics and neurogenesis rates in different mammalian species, including humans.
Article
Neurosciences
Marcus Augusto-Oliveira, Gabriela P. P. Arrifano, Caio G. G. Leal-Nazare, Leticia Santos-Sacramento, Amanda Lopes-Araujo, Luiz Fernando Freire Royes, Maria Elena Crespo-Lopez
Summary: Exercise affects the central nervous system, promoting cognitive improvements through changes in brain physiology and structure, ultimately enhancing quality of life.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Applied
Yangyang Feng, Xiaoli Ma, Baohua Kong, Qian Chen, Qian Liu
Summary: Ethanol treatments at different concentrations induced changes in the structural, morphological, and functional properties of native whey protein isolates. E-WPI prepared with an intermediate ethanol concentration (40% in this study) exhibited the highest emulsifying activity, emulsifying stability, foaming capacity, and surface hydrophobicity.
FOOD HYDROCOLLOIDS
(2021)
Article
Multidisciplinary Sciences
Yanfen Wang, Kai Xue, Ronghai Hu, Boyang Ding, Hong Zeng, Ruijin Li, Bin Xu, Zhe Pang, Xiaoning Song, Congjia Li, Jianqing Du, Xiuchun Yang, Zelin Zhang, Yanbin Hao, Xiaoyong Cui, Ke Guo, Qingzhu Gao, Yangjian Zhang, Juntao Zhu, Jian Sun, Yaoming Li, Lili Jiang, Huakun Zhou, Caiyun Luo, Zhenhua Zhang, Qingbo Gao, Shilong Chen, Baoming Ji, Xingliang Xu, Huai Chen, Qi Li, Liang Zhao, Shixiao Xu, Yali Liu, Linyong Hu, Jianshuang Wu, Qien Yang, Shikui Dong, Jinsheng He, Xinquan Zhao, Shiping Wang, Shilong Piao, Guirui Yu, Bojie Fu
Summary: This study utilized multivariate data fusion and deep learning to analyze the structural changes in plant communities in alpine grasslands on the Tibetan Plateau. The results revealed an increase in the proportion of alpine meadows, a strengthening of dominant vegetation types, and variations in the driving factors depending on the vegetation type.
Article
Multidisciplinary Sciences
Biljana Mojsoska, Melanie Ghoul, Gabriel G. Perron, Havard Jenssen, Fatima AlZahra'a Alatraktchi
Summary: This study explores the impact of sub-inhibitory antibiotic concentrations on the production of virulence factors in environmental Pseudomonas aeruginosa strains, showing that sub-inhibitory antibiotic concentrations can alter bacterial toxin production, with strain-specific effects. Additionally, biologically relevant measured toxin concentrations were found to decrease the viability of cultured epithelial cells. This suggests that antibiotic-induced virulence should be considered in routine pathogen testing.
Article
Public, Environmental & Occupational Health
P. Dhasarathan, Mohamad S. AlSalhi, Sandhanasamy Devanesan, Jeeva Subbiah, A. J. A. Ranjitsingh, Mohammed Binsalah, Akram A. Alfuraydi
Summary: The increasing azole drug resistance in fungal pathogens poses a pressing threat to global health care. Understanding the molecular changes in drug-resistant genes in Candida albicans isolated from chronic tuberculosis patients is vital for modifying treatment and designing alternative mechanisms to combat drug resistance. The study revealed significant resistance in isolated C. albicans from TB patients to multiple drugs, with molecular changes in MDR1 genes interfering with the efflux pump.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Yangyang Feng, Dongxue Yuan, Baohua Kong, Fangda Sun, Meijuan Wang, Hui Wang, Qian Liu
Summary: Ethanol treatment promotes aggregation and enhances antioxidant activities of whey protein isolates. Moderate ethanol concentration (40%) results in the highest antioxidant activities.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Review
Geriatrics & Gerontology
Jiseon Lee, Hee-Jin Kim
Summary: Aging brings about changes in the brain, leading to progressive cognitive decline. These changes include tissue atrophy, alterations in neurotransmitters, and accumulation of damage in the cellular environment. Understanding normal aging brain changes is crucial for further research.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ilya Letnik, Ron Avrahami, J. Stefan Rokem, Andreas Greiner, Eyal Zussman, Charles Greenblatt
Article
Biochemistry & Molecular Biology
Clio Der Sarkissian, Luca Ermini, Mikkel Schubert, Melinda A. Yang, Pablo Librado, Matteo Fumagalli, Hakon Jonsson, Gila Kahila Bar-Gal, Anders Albrechtsen, Filipe G. Vieira, Bent Petersen, Aurelien Ginolhac, Andaine Seguin-Orlando, Kim Magnussen, Antoine Fages, Cristina Gamba, Belen Lorente-Galdos, Sagi Polani, Cynthia Steiner, Markus Neuditschko, Vidhya Jagannathan, Claudia Feh, Charles L. Greenblatt, Arne Ludwig, Natalia I. Abramson, Waltraut Zimmermann, Renate Schafberg, Alexei Tikhonov, Thomas Sicheritz-Ponten, Eske Willerslev, Tomas Marques-Bonet, Oliver A. Ryder, Molly McCue, Stefan Rieder, Tosso Leeb, Montgomery Slatkin, Ludovic Orlando
Article
Biochemistry & Molecular Biology
Christian Knierim, Michaela Enzeroth, Patrick Kaiser, Christian Dams, David Nette, Andreas Seubert, Andreas Klingl, Charles L. Greenblatt, Valerie Jerome, Seema Agarwal, Ruth Freitag, Andreas Greiner
MACROMOLECULAR BIOSCIENCE
(2015)
Article
Immunology
Mark Spigelman, Helen D. Donoghue, Ziad Abdeen, Suheir Ereqat, Issa Sarie, Charles L. Greenblatt, Ildiko Pap, Ildiko Szikossy, Israel Hershkovitz, Gila Kahila Bar-Gal, Carney Matheson
Article
Biotechnology & Applied Microbiology
Ilya Letnik, Ron Avrahami, Rafi Port, Andreas Greiner, Eyal Zussman, J. Stefan Rokem, Charles Greenblatt
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2017)
Letter
Infectious Diseases
Suheir Ereqat, Gila Kahila Bar-Gal, Abedelmajeed Nasereddin, Kifaya Azmi, Issa Eshtaieh, Charles L. Greenblatt, Ziad Abdeen
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2013)
Article
Biochemistry & Molecular Biology
Christian Knierim, Charles L. Greenblatt, Seema Agarwal, Andreas Greiner
MACROMOLECULAR BIOSCIENCE
(2014)
Article
Infectious Diseases
Ben J. Marais, Bryce M. Buddle, Lin-Mari de Klerk-Lorist, Patrick Nguipdop-Djomo, Frederick Quinn, Charles Greenblatt
TRANSBOUNDARY AND EMERGING DISEASES
(2019)
Article
Medicine, Research & Experimental
Ofer N. Gofrit, Herve Bercovier, Benjamin Y. Klein, Irun R. Cohen, Tamir Ben-Hur, Charles L. Greenblatt
MEDICAL HYPOTHESES
(2019)
Article
Multidisciplinary Sciences
Ofer N. Gofrit, Benjamin Y. Klein, Irun R. Cohen, Tamir Ben-Hur, Charles L. Greenblatt, Herve Bercovier
Article
Biochemistry & Molecular Biology
Mahsa Mafi, Ariel Kushmaro, Charles Greenblatt, Seema Agarwal, Andreas Greiner
Summary: By encapsulating bacteria in chemically cross-linked poly(vinyl alcohol) hydrogel-microparticles followed by a pH-responsive and soft antibacterial shell, the study successfully addressed the issues of bacterial escape and metabolism product exchange within an aqueous environment.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Immunology
Danielle Klinger, Brian L. Hill, Noam Barda, Eran Halperin, Ofer N. Gofrit, Charles L. Greenblatt, Nadav Rappoport, Michal Linial, Herve Bercovier
Summary: BCG treatment in bladder cancer patients is associated with a significantly reduced risk of developing Alzheimer's disease and Parkinson's disease, especially in the elderly population aged 75 years or older. This beneficial effect may be attributed to the activation of long-term nonspecific immune effects.
Letter
Geriatrics & Gerontology
Charles L. Greenblatt, Herve Bercovier, Benjamin Y. Klein, Ofer N. Gofrit
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Microbiology
Coad Thomas Dow, Charles L. Greenblatt, Edward D. Chan, Jordan F. Dow
Summary: BCG vaccine has been used for 100 years to prevent tuberculosis. Recent population studies demonstrate lower prevalence of Alzheimer's disease (AD) in countries with high BCG coverage. Intravesicular instillation of BCG is also used to treat bladder cancer and has been shown to reduce the risk of developing AD.
Review
Geriatrics & Gerontology
Benjamin Y. Klein, Charles L. Greenblatt, Ofer N. Gofrit, Herve Bercovier
Summary: In this article, the author highlights the benefits of Bacillus Calmette-Guerin vaccine for bladder cancer and its potential impact on reducing the risk of Alzheimer's disease. The immune system's role in Alzheimer's disease is discussed, as well as the mechanisms by which BCG vaccine may affect the unfolded protein response signaling cascade and energy metabolism.
FRONTIERS IN AGING NEUROSCIENCE
(2022)