Article
Infectious Diseases
Candace Guzman-Cole, Fabian Santiago, Sona Garsevanyan, Suzanne Sindi, Miriam Barlow
Summary: This study revealed that local selective pressures have a greater influence on the population structure of resistance genes in bacterial populations than migration, indicating the potential for antibiotic resistance to be controlled at a regional level.
Article
Engineering, Environmental
Zahra Shamsizadeh, Mohammad Hassan Ehrampoush, Mahnaz Nikaeen, Mehdi Mokhtari, Mahsa Rahimi, Hossein Khanahmad, Farzaneh Mohammadi
Summary: The study found that agricultural reuse of treated wastewater may contribute to the dissemination of antibiotic-resistant bacteria and genes in the environment, posing a potential risk to public health.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Infectious Diseases
Wenjun Lu, Quedan Qiu, Keda Chen, Rongqing Zhao, Qingcao Li, Qiaoping Wu
Summary: The study found that class 1, 2, and 3 integrons are present in Proteus mirabilis isolates from patients, with class 2 integrons having low distribution but relatively conserved molecular characteristics. Three P. mirabilis isolates with functional class 2 integrons shared the same gene cassette but exhibited differences in homology and drug sensitivity.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Food Science & Technology
Fabio Sossai Possebon, Marcus Vinicius Niz Alvarez, Leila Sabrina Ullmann, Joao Pessoa Araujo Jr
Summary: The study evaluated the resistance genes and integrons in multidrug-resistant Salmonella strains isolated from swine mesenteric lymph nodes. The results showed different resistance genes for the same antimicrobial class in each strain with a genetic basis, and the presence of banned olaquindox resistance genes in some samples. Five isolates harbored class 1 integrons, reflecting the high selection pressure these bacterial lineages face along the pork production chain.
Article
Biotechnology & Applied Microbiology
S. Lengliz, S. Benlabidi, A. Raddaoui, S. Cheriet, N. Ben Chehida, T. Najar, M. S. Abbassi
Summary: The study focused on antibiotic susceptibility and the presence of ESBL/carbapenemase-producing E. coli isolates from rabbits in Tunisia. It was found that rabbits may serve as a reservoir for carbapenem-resistant E. coli, and the first report of bla(VIM) and bla(IMP) genes in livestock in Tunisia was identified.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nabi Jomehzadeh, Fateme Jahangirimehr, Sina Ahmadi Chegeni
Summary: This study investigated the virulence content and phylogenetic groups of carbapenemase-producing E. coli isolates in southwest Iran. The results showed that the most common carbapenemase gene in these isolates was bla(OXA-48), which was mainly found in urinary samples. Some virulence-associated genes were also detected. In addition, high resistance rates were identified as a significant issue to public health.
Article
Multidisciplinary Sciences
Tewachew Awoke, Brhanu Teka, Abraham Aseffa, Shemse Sebre, Aminu Seman, Biruk Yeshitela, Tamrat Abebe, Adane Mihret
Summary: This study investigated the prevalence of carbapenemase-producing K. pneumoniae in Ethiopia and found the emergence of bla(NDM) and bla(KPC) gene-carrying strains for the first time. The prevalence was worrisome and associated with previous use of carbapenem drugs.
Article
Medical Laboratory Technology
Nabi Jomehzadeh, Khadijeh Ahmadi, Mozhdeh Amiri Bahmanshiri
Summary: This study found significant quinolone resistance in Klebsiella pneumoniae isolates, with most strains showing resistance to nalidixic acid and ofloxacin. MIC analysis revealed a high percentage of isolates resistant to ciprofloxacin, with a majority harboring PMQR genes. The findings suggest a considerable level of resistance against quinolones, potentially due to their extensive and inappropriate use.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Jude Fonbah Leinyuy, Innocent Mbulli Ali, Karimo Ousenu, Christopher B. Tume
Summary: This study analyzed 200 Enterobacteriaceae isolates resistant and susceptible to ESBL, quinolones, and aminoglycosides. It found a high carriage of resistance genes, but the carriage of resistance genes may not always be correlated with phenotypic expression.
Article
Infectious Diseases
Fakhur Uddin, Syed Hadi Imam, Saeed Khan, Taseer Ahmed Khan, Zulfiqar Ahmed, Muhammad Sohail, Ashraf Y. Elnaggar, Ahmed M. Fallatah, Zeinhom M. El-Bahy
Summary: The worldwide spread and increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is of utmost concern and a problem for public health, as determined by this study that aimed to determine the dominance of NDM-producing Enterobacteriaceae at a teaching hospital in Karachi.
Article
Medicine, General & Internal
Beata Maczynska, Magdalena Frej-Madrzak, Jolanta Sarowska, Krystyna Woronowicz, Irena Choroszy-Krol, Agnieszka Jama-Kmiecik
Summary: In recent years, the use and overuse of broad-spectrum antimicrobial agents have led to a growing drug resistance among bacteria. This study aimed to analyze the changes in drug resistance of Gram-negative Enterobacterales over five years. The evaluation of these data will help determine changes in susceptibility to antibiotics used in the hospital and propose new therapeutic options for severe infections. The analysis revealed that the number of multi-resistant K. pneumoniae strains has been increasing, possibly due to the widespread use of broad-spectrum antibiotics during the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nabi Jomehzadeh, Khadijeh Ahmadi, Hazhir Javaherizadeh, Maryam Afzali
Summary: This study investigated the relationship between integron genes and class A extended-spectrum ESBLs genes in MDR E. coli strains isolated from children with diarrhea in southwestern Iran. The results showed that EPEC is one of the major causes of childhood diarrhea in the region, with a high prevalence of class 1 integrons and ESBLs in EPEC strains. Continuous monitoring of the emergence and expansion of MDR in EPEC strains is necessary.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
S. Harbaoui, S. Ferjani, M. S. Abbassi, M. Saidani, T. Gargueh, M. Ferjani, Y. Hammi, I Boutiba-Ben Boubaker
Summary: This study aimed to characterize cefotaxime-resistant Enterobacteriaceae (CTX-R-En) isolated from hospitalized children in a Tunisian paediatric ward.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Souad Loqman, Nabila Soraa, Seydina M. Diene, Jean-Marc Rolain
Summary: The study investigated the occurrence of carbapenem-resistant Enterobacteriaceae (CRE) among hospitalized patients in Mohamed VI University Hospital in Marrakech, Morocco. It found various bacterial strains resistant to carbapenems, with Klebsiella pneumoniae being the most common species. The study also identified several carbapenemase-producing isolates, with blaOXA-48 genes being documented for the first time in Citrobacter freundii and Citrobacter braakii in Morocco.
Article
Medicine, General & Internal
Raouaa Maaroufi, Olfa Dziri, Linda Hadjadj, Seydina M. Diene, Jean-Marc Rolain, Chedly Chouchani
Summary: This study investigated the presence of Gram-negative bacteria in a hospital environment in Northwestern Tunisia, identifying various resistant strains and characterizing the resistance genes involved. Carbapenem resistance was detected in several isolates, with different resistance genes such as bla(NDM-1) and bla(CTX-M) being identified. Whole-genome sequencing of a P. aeruginosa strain revealed the presence of bla(OXA-494) and other resistance genes. This new epidemiological data highlights the need for new surveillance strategies and strict hygiene rules to control the spread of multidrug-resistant bacteria.
Article
Microbiology
Laure Surgers, Anders Boyd, Pierre-Marie Girard, Guillaume Arlet, Dominique Decre
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2019)
Article
Infectious Diseases
Maria A. Jure, Marta E. Castillo, Humberto E. Musa, Carolina G. Lopez, Mariel A. Caceres, Silvana D. Mochi, Aurore A. Bousquet, Nathalie A. Genel, Guillaume A. Arlet, Dominique C. Decre
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2019)
Article
Infectious Diseases
Aziza Messaoudi, Marisa Haenni, Olfa Bouallegue, Estelle Saras, Pierre Chatre, Cherifa Chaouch, Noureddine Boujaafar, Wejdene Mansour, Jean-Yves Madec
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Letter
Infectious Diseases
Aziza Messaoudi, Estelle Saras, Raoudha Grami, Olfa Bouallegue, Noureddine Boujaafar, Jean-Yves Madec, Wejdene Mansour, Marisa Haenni
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Article
Genetics & Heredity
Catherine Branger, Alice Ledda, Typhaine Billard-Pomares, Benoit Doublet, Valerie Barbe, David Roche, Claudine Medigue, Guillaume Arlet, Erick Denamur
MICROBIAL GENOMICS
(2019)
Letter
Infectious Diseases
Cecile Emeraud, Khanh Villageois-Tran, Nathalie Genel, Laure Surgers, Wladimir Sougakoff, Guillaume Arlet, Remy A. Bonnin, Dominique Decre, Catherine Eckert
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Article
Microbiology
Salah Gallah, Khanh Villageois-Tran, Alexandre Godmer, Guillaume Arlet, Martin Rottman, Yahia Benzerara, Marc Garnier
Summary: The study validated a rapid detection method for carbapenemase-producing Gram-negative bacilli (C-PGNB) using rectal swabs, demonstrating high sensitivity and specificity in accurately detecting C-PGNB colonization in clinical settings.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Letter
Infectious Diseases
Aziza Messaoudi, Wejdene Mansour, Lamia Tilouche, Pierre Chatre, Antoine Drapeau, Chrifa Chaouch, Sana Azaiez, Olfa Bouallegue, Jean-Yves Madec, Marisa Haenni
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Microbiology
Muna F. Anjum, Heike Schmitt, Stefan Boerjesson, Thomas U. Berendonk, Eliana Guedes Stehling, Patrick Boerlin, Edward Topp, Claire Jardine, Xuewen Li, Bing Li, Monika Dolejska, Jean-Yves Madec, Christophe Dagot, Sebastian Guenther, Fiona Walsh, Laura Villa, Kees Veldman, Marianne Sunde, Pawel Krzeminski, Dariusz Wasyl, Magdalena Popowska, Josef Jaerhult, Stefan Oern, Olfa Mahjoub, Wejdene Mansour, Dinh Nho Thai, Josefine Elving, Karl Pedersen
Summary: The dynamics of antimicrobial resistance (AMR) are better understood through a One-Health perspective with surveillance playing a crucial role. Establishing environmental monitoring programs for AMR is urgently needed to complement existing systems in different sectors and to identify transmissions between human, animal, and environmental populations. Using antimicrobial resistant Escherichia coli as indicators for monitoring can help in assessing the occurrence and levels of AMR in the environment, including wildlife.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Rishma Amarsy, David Trystram, Emmanuelle Cambau, Catherine Monteil, Sandra Fournier, Juliette Oliary, Helga Junot, Pierre Sabatier, Raphael Porcher, Jerome Robert, Vincent Jarlier
Summary: This study measured the impact of the first wave of COVID-19 on the incidence of bloodstream infections at the largest multisite public healthcare institution in France. The results showed that the COVID-19 pandemic had a strong impact on hospital management and had unfavorable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Microbiology
Alain Philippon, Guillaume Arlet, Roger Labia, Bogdan I. Iorga
Summary: Class C β-lactamases exhibit molecular variability and can be categorized into two functional groups. These enzymes are encoded by chromosomal and inducible genes and are widely distributed among bacteria. Molecular identification is based on three catalytic motifs, and numerous conserved amino acid residues have been identified. The concept of natural ESACs is supported by the discovery of genetic modifications in pathogenic species and the emergence of resistance to carbapenems and inhibitors.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Microbiology
Gaelle Gruel, David Couvin, Stephanie Guyomard-Rabenirina, Guillaume Arlet, Jean-Christophe Bambou, Matthieu Pot, Xavier Roy, Antoine Talarmin, Benoit Tressieres, Severine Ferdinand, Sebastien Breurec
Summary: This study determines the prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in feces of household and shelter pets in Guadeloupe. The study finds that the only risk factor associated with a higher prevalence of ESBL-E rectal carriage is a stay in a shelter. The study also identifies ESBL-E as mainly Escherichia coli, with certain plasmids carrying antimicrobial resistance genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Mehdi Sola, Yosra Mani, Estelle Saras, Antoine Drapeau, Raoudha Grami, Mahjoub Aouni, Jean-Yves Madec, Marisa Haenni, Wejdene Mansour
Summary: This study examined the presence of multi-drug resistant (MDR) bacteria in farmed fish and Mediterranean clams. The results suggest that bacteria from hospital or farm effluents can contaminate nearby seafood and fish, highlighting the importance of monitoring water quality and MDR bacteria in seafood.
Article
Public, Environmental & Occupational Health
Rishma Amarsy, Sandra Fournier, David Trystram, Catherine Monteil, Xavier Raynaud, Vincent Jarlier, Jerome Robert
Summary: The impact of COVID-19 pandemic on bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals in Paris. The incidence rates of BSIs, which had been stable in 2018 and 2019, decreased for the two pathogens during the two lockdown periods in 2020. Containment policies such as social distancing, masking, and hand hygiene strengthening in community and hospital settings are likely to reduce BSIs caused by these pathogens.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Letter
Microbiology
Sana Ncir, Agnese Lupo, Antoine Drapeau, Pierre Chatre, Meriem Souguir, Sana Azaiez, Jean-Yves Madec, Wejdene Mansour, Marisa Haenni
MICROBIOLOGY SPECTRUM
(2022)