Article
Microbiology
David M. P. De Oliveira, Brian M. Forde, Minh-Duy Phan, Bernhard Steiner, Bing Zhang, Johannes Zuegg, Ibrahim M. El-deeb, Gen Li, Nadia Keller, Stephan Brouwer, Nichaela Harbison-Price, Amanda J. Cork, Michelle J. Bauer, Saleh F. Alquethamy, Scott A. Beatson, Jason A. Roberts, David L. Paterson, Alastair G. McEwan, Mark A. T. Blaskovich, Mark A. Schembri, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Summary: This study explores the use of PBT2 to break the resistance of A. baumannii to tetracycline class antibiotics, showing promising results in both in vitro and in vivo experiments.
Article
Microbiology
David M. P. De Oliveira, Brian M. Forde, Minh-Duy Phan, Bernhard Steiner, Bing Zhang, Johannes Zuegg, Ibrahim M. El-Deeb, Gen Li, Nadia Keller, Stephan Brouwer, Nichaela Harbison-Price, Amanda J. Cork, Michelle J. Bauer, Saleh F. Alquethamy, Scott A. Beatson, Jason A. Roberts, David L. Paterson, Alastair G. McEwan, Mark A. T. Blaskovich, Mark A. Schembri, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Summary: The study found that the combination of PBT2 and zinc with tetracycline class antibiotics can effectively combat multidrug-resistant A. baumannii, potentially serving as a treatment for overcoming strain resistance.
Article
Immunology
Wang Zhang, Yue Yao, Hua Zhou, Jintao He, Jingfen Wang, Li Li, Minsong Gao, Xiaochen Liu, Ya Shi, Jinzhong Lin, Jianzhao Liu, Huan Chen, Yu Feng, Zhihui Zhou, Yunsong Yu, Xiaoting Hua
Summary: This study investigated the pathoadaptation mechanism of Acinetobacter baumannii in response to selective pressure exerted by pulmonary epithelial cells. Through experimental evolution, phenotypic characterization, and multi-omics analysis, the study revealed that A. baumannii exhibited mutations that altered its adhesion ability, anti-phagocytic ability, ribosome translation efficiency, and outer membrane permeability. These mutations also affected the susceptibility of A. baumannii to various antimicrobial agents.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Marina Tyumentseva, Yulia Mikhaylova, Anna Prelovskaya, Aleksandr Tyumentsev, Lyudmila Petrova, Valeria Fomina, Mikhail Zamyatin, Andrey Shelenkov, Vasiliy Akimkin
Summary: This study analyzed clinical multidrug-resistant A. baumannii isolates using whole-genome sequencing, revealing specific characteristics of isolates with different CRISPR/Cas systems and comparing antibiotic resistance and virulence gene acquisition patterns. The data presented will contribute to further investigations in the field of antimicrobial resistance and CRISPR/Cas studies.
Article
Immunology
Ping Wang, Ren-Qing Li, Lei Wang, Wen-Tao Yang, Qing-Hua Zou, Di Xiao
Summary: This study utilized glycoproteomics analysis to identify 164 proteins with differential expression in multidrug-resistant and drug-susceptible Acinetobacter baumannii clinical isolates. The proteins were classified into six groups, providing insight into the mechanism of antibiotic resistance of multidrug-resistant Acinetobacter baumannii. Validation at the transcription level showed that four selected proteins correlated positively with the protein level.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Tomislav Ivankovic, Helena Turk, Jasna Hrenovic, Zdravko Schauperl, Marica Ivankovic, Antonia Ressler
Summary: A novel biomaterial utilizing silver ions within the hydroxyapatite lattice has been developed to address the issue of multi-drug resistance in Acinetobacter baumannii infections. The antibacterial activity of the biomaterial was examined against A. baumannii clinical isolates, showing strong efficacy. The concentration of silver ions in the biomaterial was found to impact the antibacterial effect.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Microbiology
Leena Al-Hassan, Hana Elbadawi, Einas Osman, Sara Ali, Kamal Elhag, Daire Cantillon, Julia Wille, Harald Seifert, Paul G. Higgins
Summary: The study conducted in four hospitals in Khartoum, Sudan, revealed a predominance of IC2 lineage A. baumannii with multiple antibiotic resistance genes, demonstrating rich molecular epidemiological features.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seok-Hyeon Na, Hyejin Jeon, Man-Hwan Oh, Yoo-Jeong Kim, Mingi Chu, Ill-Young Lee, Je-Chul Lee
Summary: The study evaluated the therapeutic potential of compound 62520 against CRAB isolates, demonstrating its ability to inhibit ompA expression and biofilm formation in A. baumannii. Compound 62520 also showed bacteriostatic activity against CRAB isolates and increased survival rates in infected mice, suggesting it as a promising agent for CRAB infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Benjamin Havenga, Brandon Reyneke, Thando Ndlovu, Wesaal Khan
Summary: This study compared the genotypic, phenotypic, and antibiotic resistance profiles of clinical and environmental Acinetobacter baumannii isolates. The clinical isolates showed higher biofilm formation capability and resistance to antibiotics compared to the environmental isolates, which had increased susceptibility to antibiotics. The environmental isolates were assigned to a novel sequence type, indicating their presence in extra-hospital reservoirs.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Sandra Sanchez-Urtaza, Alain Ocampo-Sosa, Ainhoa Molins-Bengoetxea, Mohammed A. A. El-Kholy, Marta Hernandez, David Abad, Sherine M. M. Shawky, Itziar Alkorta, Lucia Gallego
Summary: This study investigated the genetic characteristics and antimicrobial susceptibility profile of multidrug resistant Acinetobacter baumannii clinical isolates obtained from hospitals in Alexandria, Egypt. The results showed resistance to multiple antibiotics and the presence of various antibiotic resistance genes and virulence factors. The study highlights the importance of investigating molecular epidemiology to control the spread of these multidrug resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
L. Aguilar-Vega, L. E. Lopez-Jacome, B. Franco, S. Munoz-Carranza, N. Vargas-Maya, R. Franco-Cendejas, M. Hernandez-Duran, M. Otero-Zuniga, C. Campo-Beleno, J. G. Jimenez-Cortes, M. Martinez-Vazquez, J. S. Rodriguez-Zavala, T. Maeda, R. Zurabian, R. Garcia-Contreras
Summary: The study demonstrates that phenothiazine derivatives, especially chlorpromazine, exhibit attractive antibacterial properties against nosocomial multidrug-resistant strains of A. baumannii by generating reactive oxygen species (ROS) and causing cell membrane and DNA damage. Chlorpromazine also shows synergy with various antibiotics and is effective in treating experimentally infected Galleria mellonella when combined with ceftazidime. Repurposing phenothiazine derivatives for treating resistant infections by A. baumannii shows promising potential.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
Filomena Sannio, Antonella Brizzi, Rosita Del Prete, Marialuce Avigliano, Tiziana Simone, Carlotta Pagli, Teresa Ferraro, Filomena De Luca, Marco Paolino, Federico Corelli, Claudia Mugnaini, Jean-Denis Docquier
Summary: The diffusion of antibiotic-resistant Gram-negative pathogens is a global public health issue. Acinetobacter baumannii, despite causing fewer infections, often shows multidrug-resistance, including carbapenem resistance. In this study, a new series of pyrazole compounds was synthesized, some of which showed direct-acting antibacterial activity on Gram-positive organisms. Additionally, two highly active compounds against multidrug-resistant A. baumannii, including colistin-resistant isolates, were identified as potential antibiotic adjuvants. This work highlights the significance of pyrazole amides in developing synergistic antibacterial compounds against antibiotic-resistant Gram-negative pathogens.
Article
Materials Science, Multidisciplinary
Weijian Liu, Hua Gu, Bei Ran, Wenkai Liu, Wen Sun, Dongping Wang, Jianjun Du, Jiangli Fan, Xiaojun Peng
Summary: Red-carbon dots (R-CDs) synthesized in this study show intrinsic antibacterial activities and can effectively kill multidrug-resistant bacteria by generating reactive oxygen species. They can also inhibit the formation of MRAB biofilms with minimal side effects on normal cells. Furthermore, R-CDs have demonstrated potential in treating antibiotic-sensitive MRAB-induced infected wounds, suggesting a promising strategy for designing next-generation agents against drug-resistant bacteria.
SCIENCE CHINA-MATERIALS
(2022)
Article
Infectious Diseases
Federica Sacco, Camilla Bitossi, Bruno Casciaro, Maria Rosa Loffredo, Guendalina Fabiano, Luisa Torrini, Flavia Raponi, Giammarco Raponi, Maria Luisa Mangoni
Summary: Multidrug-resistant microbial infections and the scarcity of new antibiotics pose a serious threat to global health security. In this study, we found that a combination of a frog-skin antimicrobial peptide, Esc(1-21), and colistin exhibited synergistic effects against colistin-resistant Acinetobacter baumannii clinical isolates, suggesting a potential clinical application of this combination therapy.
Article
Infectious Diseases
Jinxin Zhao, Yan Zhu, Yu-Wei Lin, Heidi Yu, Hasini Wickremasinghe, Jiru Han, Tony Velkov, Michael J. McDonald, Jian Li
Summary: The concentration of polymyxin has a critical impact on the evolution of resistance in Acinetobacter baumannii. Below a certain threshold concentration, resistance may develop but is not fixed, while concentrations above this threshold lead to irreversible resistance.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Microbiology
Sharon Kleinschmidt, Flavia Huygens, Joan Faoagali, Irani U. Rathnayake, Louise M. Hafner
FUTURE MICROBIOLOGY
(2015)
Article
Pediatrics
Danny Wh Ko, Yvonne Zurynski, Gwendolyn L. Gilbert
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2015)
Article
Infectious Diseases
Sarah J. Wynwood, Mary-Anne A. Burns, Glenn C. Graham, Steven L. Weier, David B. Mckay, Scott B. Craig
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Veterinary Sciences
Sarah J. Wynwood, Mary-Anne Burns, Glenn C. Graham, Steven L. Weier, David B. Mckay, Sarah Peck, Scott B. Craig
JOURNAL OF WILDLIFE DISEASES
(2016)
Article
Surgery
D. J. Speicher, M. M. Sehu, P. Mollee, L. Shen, N. W. Johnson, J. L. Faoagali
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)
Article
Infectious Diseases
Hanna E. Sidjabat, Kwee Yong Seah, Lyndall Coleman, Anna Sartor, Petra Derrington, Claire Heney, Joan Faoagali, Graeme R. Nimmo, David L. Paterson
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2014)
Article
Chemistry, Multidisciplinary
Sarah A. M. Windsor, Kerry Rutter, David B. McKay, Noel Meyers
JOURNAL OF CHEMICAL EDUCATION
(2014)
Article
Microbiology
Geoffrey W. Coombs, Julie C. Pearson, Denise A. Daley, Tam Le, Owen J. Robinson, Thomas Gottlieb, Benjamin P. Howden, Paul D. R. Johnson, Catherine M. Bennett, Timothy P. Stinear, John D. Turnidge
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Public, Environmental & Occupational Health
J. D. Howard, C. Jowett, J. Faoagali, B. McKenzie
JOURNAL OF HOSPITAL INFECTION
(2014)
Article
Microbiology
Tara L. Vollmerhausen, Jasmine L. Woods, Joan Faoagali, Mohammad Katouli
JOURNAL OF MEDICAL MICROBIOLOGY
(2014)
Article
Public, Environmental & Occupational Health
Sarah Jane Wynwood, Glenn Charles Graham, Steven Lance Weier, Trudi Anne Collet, David Brian McKay, Scott Benjamin Craig
PATHOGENS AND GLOBAL HEALTH
(2014)
Article
Immunology
D. M. B. T. Disaanayake, Joan Faoagali, Hans Laroo, Gerald Hancock, Michael Whitehouse
INFLAMMOPHARMACOLOGY
(2014)
Article
Immunology
T. Tyll, M. Bilkova, A. Revinova, M. Mueller, M. Curdova, M. Zlamal, M. Holub
EPIDEMIOLOGIE MIKROBIOLOGIE IMUNOLOGIE
(2015)
Article
Parasitology
S. J. Wynwood, S. B. Craig, G. C. Graham, B. R. Blair, M. A. Burns, A. L. Weier, T. A. Collet, D. B. McKay
TROPICAL BIOMEDICINE
(2014)
Article
Infectious Diseases
John D. Turnidge, Thomas Gottlieb, David H. Mitchell, Geoffrey W. Coombs, Julie C. Pearson, Jan M. Bell
COMMUNICABLE DISEASES INTELLIGENCE
(2014)