Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Microbiology
Alina Iovleva, Mustapha M. Mustapha, Marissa P. Griffith, Lauren Komarow, Courtney Luterbach, Daniel R. Evans, Eric Cober, Sandra S. Richter, Kirsten Rydell, Cesar A. Arias, Jesse T. Jacob, Robert A. Salata, Michael J. Satlin, Darren Wong, Robert A. Bonomo, David van Duin, Vaughn S. Cooper, Daria Van Tyne, Yohei Doi
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAb) is a significant threat to public health, particularly for hospitalized patients. The Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP) conducted whole-genome sequencing (WGS) analysis of 120 CRAb patients from four U.S. centers, revealing the dominance of the ST2(Pas) lineage within clonal complex 2 (CC2), as well as the emergence of sublineages with different antibiotic resistance phenotypes. The study emphasizes the need for real-time surveillance and molecular epidemiology to understand CRAb dissemination and clinical impact.
Article
Immunology
Congcong Liu, Kaichao Chen, Yuchen Wu, Ling Huang, Yinfei Fang, Jiayue Lu, Yu Zeng, Miaomiao Xie, Edward Wai Chi Chan, Sheng Chen, Rong Zhang
Summary: Acinetobacter baumannii is a significant Gram-negative pathogen causing nosocomial infections. In China, a large portion of clinical A. baumannii strains are multidrug resistant, particularly towards carbapenems. Nationwide surveillance revealed a prevalence of carbapenem-resistant A. baumannii (CRAB) strains in intensive care units (ICUs), with clonal spread observed in some ICUs. Carbapenem-hydrolysing class D beta-lactamases (CHDL) were primarily responsible for carbapenem resistance, and the ST2 global clone was the predominant type of CRAB in China. Notably, CRAB isolates exhibited low resistance to colistin and tigecycline, but high resistance to ceftazidime-avibactam.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Frieder Fuchs, Federico Becerra-Aparicio, Kyriaki Xanthopoulou, Harald Seifert, Paul G. Higgins
Summary: This study investigated the in vitro activity of nitroxoline against carbapenem-resistant Acinetobacter baumannii. The results showed that nitroxoline exhibited excellent activity against a collection of carbapenem-resistant Acinetobacter baumannii isolates. This suggests that nitroxoline could be a promising drug for the treatment of lower urinary tract infections caused by this bacterium.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Bin Liu, Lei Liu
Summary: CRAB isolates from the ICU showed higher resistance to tigecycline and cefoperazone/sulbactam compared to RD. PCR detection revealed different ratios of resistance-associated genes in ICU and RD, while PFGE and MLST results also indicated variations in molecular epidemiology and resistance mechanisms between the two departments.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Paul G. Higgins, Meret Kniel, Sandra Rojak, Carsten Balczun, Holger Rohde, Hagen Frickmann, Ralf Matthias Hagen
Summary: The study investigated the molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolated by the German military medical service in Afghanistan. It found that most of the acquired carbapenem resistance in Afghanistan was associated with bla(OXA-23) and identified a variety of different clones from Afghan patients.
Article
Microbiology
Pooja Kumari, Grace Kaul, T. Anand Kumar, Abdul Akhir, Manjulika Shukla, Suraj Sharma, Siddhesh S. Kamat, Sidharth Chopra, Harinath Chakrapani
Summary: Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination with amikacin both in vitro and in animals, that too without inducing resistance. Further in depth analysis identified central metabolism to be a putative target. Taken together, these experiments lay down the foundation for effective management of infections caused due to highly MDR pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Minggui Wang, Lizhao Ge, Liang Chen, Lauren Komarow, Blake Hanson, Jinnethe Reyes, Eric Cober, Thamer Alenazi, Zhiyong Zong, Qing Xie, Zhengyin Liu, Lanjuan Li, Yunsong Yu, Hainv Gao, Souha S. Kanj, Jairo Figueroa, Erica Herc, Ezequiel Cordova, Gregory Weston, Paul Ananth Tambyah, Julia Garcia-Diaz, Keith S. Kaye, Sorabh Dhar, Jose M. Munita, Robert A. Salata, Samuel Vilchez, Martin E. Stryjewski, Maria Virginia Villegas Botero, Alina Iovleva, Scott R. Evans, Keri Baum, Carol Hill, Barry N. Kreiswirth, Robin Patel, David L. Paterson, Cesar A. Arias, Robert A. Bonomo, Henry F. Chambers, Vance G. Fowler, Michael J. Satlin, David van Duin, Yohei Doi
Summary: In this international, prospective observational cohort of 842 hospitalized patients with carbapenem-resistant Acinetobacter baumannii, infection types and clinical outcomes differed significantly across regions. Although clonal group 2 (CG2) strains were predominant, non-CG2 strains were associated with higher mortality.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Amir Nutman, Gabrielle D. Levi, Alona Keren-Paz, David Schwartz, Samira Masarwa, Vered Schechner, Yehuda Carmeli
Summary: The carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings and requires robust infection control measures. Our study found that the skin sponge method showed the highest sensitivity for detecting CRAB carriage, exceeding 90% in both acute care and post-acute care hospitals. Based on these findings, we recommend implementing the skin sponge method as the preferred approach for CRAB screening to optimize infection control strategies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Jose Cedano, Michelle Baez, Fernando Pasteran, Sabrina Daiana Montana, Grace Ra, Venjaminne Fua, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, Maria Soledad Ramirez
Summary: This study tested the efficacy of the combination of sulbactam and a novel DBO, zidebactam, against carbapenem-resistant A. baumannii isolates. The results showed that the sulbactam/zidebactam combination was able to restore sulbactam susceptibility in resistant isolates, including those resistant to the sulbactam/avibactam combination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jia Jie Woon, Azanna Ahmad Kamar, Cindy Shuan Ju Teh, Nuryana Idris, Rosliza Zhazali, Suzana Saaibon, Harvinderjit Kaur Basauhra Singh, Jasreena Kaur Gill Charanjeet Singh, Adeeba Kamarulzaman, Sasheela Ponnampalavanar
Summary: This study describes an epidemiological investigation into a carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in a neonatal intensive care unit (NICU) and the subsequent strengthening of infection control interventions. The investigation identified gaps in existing infection control measures and implementation of immediate actions successfully halted further CRAB transmission.
Article
Health Care Sciences & Services
Emma L. Doughty, Haiyang Liu, Robert A. Moran, Xiaoting Hua, Xiaoliang Ba, Feng Guo, Xiangping Chen, Linghong Zhang, Mark Holmes, Willem van Schaik, Alan Mcnally, Yunsong Yu
Summary: This study conducted a three-month observational study in a 28-bed intensive care unit (ICU) in Hangzhou, China, to explore the persistence and evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii (CRAB). The study found that the ICU population of CRAB was dominated by OXA-23-producing global clone 2 isolates, which could be divided into 20 distinct clusters through genome sequencing. The study emphasized the importance of environmental CRAB reservoirs in the epidemiology of ICUs and the unique challenges in containing the spread of CRAB.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Microbiology
Leticia Dias de Melo Carrasco, Andrei Nicoli Gebieluca Dabul, Camila Maria dos Santos Boralli, Gabriela Marinho Righetto, Iago de Carvalho Silva, Janaina Valerini Dornelas, Camila Pacheco Silveira Martins da Mata, Cesar Augusto de Araujo, Edna Marilea Meireles Leite, Nilton Lincopan, Ilana Lopes Baratella da Cunha Camargo
Summary: This study investigated carbapenem-resistant A. baumannii strains in a teaching hospital in Brazil, displaying extensively drug-resistant phenotypes, some of which were considered locally pan drug-resistant. Molecular analysis revealed various pulsotypes among these strains with different resistance patterns.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Samy Selim, Osama Ahmed Faried, Mohamed S. Almuhayawi, Osama A. Mohammed, Fayez M. Saleh, Mona Warrad
Summary: Acinetobacter baumannii is a nonfermenting Gram-negative bacterium associated with nosocomial infections. This study identified four distinct lineages of A. baumannii and found that genotype (A) isolates showed reduced effectiveness to certain antibiotics. Additionally, the binding affinity of imipenem towards Acinetobacter baumannii OXA beta-lactamase enzymes was investigated.
Article
Immunology
Hong-Bo Guo, Hua-Liang Huang, Yue-Yu Li
Summary: The study aimed to investigate the carrying status and homology of carbapenem resistant Acinetobacter baumannii (CRAB) in our hospital. A total of 52 strains of Acinetobacter baumannii isolated from the bacteria room of the clinical laboratory of Baogang hospital in Inner Mongolia from January 2015 to December 2017 were selected as the research object. Drug sensitivity, drug resistance gene detection, and homology analysis were conducted. The results showed high resistance of CRAB in the hospital, with OXA-23 and OXA-51 genes being the main factors causing drug resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
