期刊
MICROBIAL DRUG RESISTANCE
卷 14, 期 3, 页码 239-244出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2008.0836
关键词
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We investigated the farm-level impact of the use of several different antimicrobial agents on the population of antimicrobial-resistant commensal bacteria of animal origin to appropriately assess the release risk of resistance. This study was carried out based on the results of a survey on the history of anti-microbial drug use in 297 pig farms and antimicrobial susceptibility testing for the 545 Escherichia coli isolates (one or two isolates/pig/farm). A comparative analysis with the nonexposed herd revealed that ampicillin (ABPC) resistance in E. coli increased in the herds that were exposed to penicillin (relative risk [RR], 1.75) and penicillin-streptomycin (RR, 2.28); dihydrostreptomycin (DSM) resistance, in the penicillin-streptomycin-exposed herd (RR, 1.75); and trimethoprim (TMP) resistance in the methoprim-sulfonamide-exposed herd (RR, 2.10). On the other hand, ABPC and DSM resistances increased in the tetracycline-exposed herd (RR, 1.66 and 1.58, respectively); TMP resistance, in the penicillin-exposed herd (RR, 1.77); and oxytetracycline and kanamycin resistances, in the penicillin-streptomycin-exposed herd (RR, 1.28 and 2.22, respectively). These results demonstrated that the development of cross-resistance and coresistance, imposed by the therapeutic use of the antimicrobials studied, contributed the farm-level prevalence of antimicrobial-resistant E. coli and that the influence of coselection was characteristic to individual antimicrobial agents used.
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