期刊
MICROBES AND INFECTION
卷 15, 期 14-15, 页码 1005-1016出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2013.09.011
关键词
Ehrlichia; Human monocytotropic ehrlichiosis; Zoonosis; Effector; Nucleomodulin; Tandem repeat protein; Moonlighting protein; Type 1 secretion system; Post translational modification
资金
- National Institute of Allergy and Infectious Diseases (NIAID) [AI105536]
- Clayton Foundation for Research
- NIH Emerging Infectious Diseases and Biodefense Training grant [T32 AI007536]
Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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